NO20023151L - 4-fenyl-1-piperazinyl, -piperidinyl og - tetrahydropyridylderivater - Google Patents
4-fenyl-1-piperazinyl, -piperidinyl og - tetrahydropyridylderivaterInfo
- Publication number
- NO20023151L NO20023151L NO20023151A NO20023151A NO20023151L NO 20023151 L NO20023151 L NO 20023151L NO 20023151 A NO20023151 A NO 20023151A NO 20023151 A NO20023151 A NO 20023151A NO 20023151 L NO20023151 L NO 20023151L
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- piperazinyl
- piperidinyl
- bond
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse omhandler substituerte 4-fenyl-l-piperazinyl derivater som har formelen I. hvori W er C, CH eller N, og den stiplede linjen som utgår fra W indikerer en binding når W er C og ingen binding når W er N eller CH;ogvelges uavhengig fra hydrogen og halogen, forutsatt at minst én av Rog Rer et halogenatom;. X er CH, 0, S, CO, CS, SO eller S0; og. Q er en gruppe med formel (II). forutsatt at X ikke er 0 eller S når gruppen Q er forbundet via et N atom;. og enhver av dens enantiomerer og syreaddisjonssalter derav.Disse forbindelsene har høy affinitet for Dreseptorer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901887 | 1999-12-30 | ||
| PCT/DK2000/000728 WO2001049679A1 (en) | 1999-12-30 | 2000-12-22 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023151D0 NO20023151D0 (no) | 2002-06-28 |
| NO20023151L true NO20023151L (no) | 2002-08-02 |
| NO323401B1 NO323401B1 (no) | 2007-04-23 |
Family
ID=8108820
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023151A NO323401B1 (no) | 1999-12-30 | 2002-06-28 | Halogensubstituerte 4-fenyl-piperazinderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse. |
| NO20065681A NO20065681L (no) | 1999-12-30 | 2006-12-14 | 4-fenyl-1-piperazinyl, -piperidinyl og -tetrahydropyridylderivater |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20065681A NO20065681L (no) | 1999-12-30 | 2006-12-14 | 4-fenyl-1-piperazinyl, -piperidinyl og -tetrahydropyridylderivater |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7074796B2 (no) |
| EP (2) | EP1464641B1 (no) |
| JP (1) | JP2003519225A (no) |
| KR (2) | KR100729536B1 (no) |
| CN (2) | CN1244577C (no) |
| AR (1) | AR029461A1 (no) |
| AT (2) | ATE269857T1 (no) |
| AU (2) | AU783786B2 (no) |
| BG (1) | BG106960A (no) |
| BR (1) | BR0016953A (no) |
| CA (1) | CA2395869C (no) |
| CZ (1) | CZ20022603A3 (no) |
| DE (2) | DE60011817T2 (no) |
| DK (2) | DK1464641T3 (no) |
| EA (2) | EA005013B1 (no) |
| ES (2) | ES2302992T3 (no) |
| HK (1) | HK1055960A1 (no) |
| HR (1) | HRP20020567A2 (no) |
| HU (1) | HUP0203839A3 (no) |
| IL (3) | IL150366A0 (no) |
| IS (1) | IS6432A (no) |
| MX (1) | MXPA02006590A (no) |
| NO (2) | NO323401B1 (no) |
| NZ (2) | NZ530137A (no) |
| PL (1) | PL355502A1 (no) |
| PT (2) | PT1464641E (no) |
| SG (1) | SG152900A1 (no) |
| SK (1) | SK11072002A3 (no) |
| TR (2) | TR200201690T2 (no) |
| UA (1) | UA73756C2 (no) |
| WO (1) | WO2001049679A1 (no) |
| ZA (1) | ZA200205019B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2311012T3 (es) * | 2000-03-27 | 2009-02-01 | ABBOTT GMBH & CO. KG | Ligandos del receptor d3 de la dopamina para el tratamiento de la adiccion. |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| FR2831166B1 (fr) | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| ES2251624T3 (es) | 2001-12-28 | 2006-05-01 | Acadia Pharmaceuticals Inc. | Analogos de la tetrahidroquinolina como los agonistas muscarinicos. |
| US7550459B2 (en) | 2001-12-28 | 2009-06-23 | Acadia Pharmaceuticals, Inc. | Tetrahydroquinoline analogues as muscarinic agonists |
| BRPI0417858B1 (pt) * | 2003-12-23 | 2017-10-10 | H. Lundbeck A/S | Derivative compounds of aniline and pharmaceutical composition that understand it |
| DE102004027358A1 (de) * | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
| AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| FR2878524B1 (fr) * | 2004-12-01 | 2007-01-19 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
| AR054393A1 (es) | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| EP1870405A1 (en) * | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
| CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
| CN104725359B (zh) | 2013-12-20 | 2017-05-03 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (no) * | 1959-09-25 | 1900-01-01 | ||
| US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| DE2138865A1 (de) * | 1970-08-15 | 1973-02-22 | Sumitomo Chemical Co | 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel |
| FR2635104B1 (fr) * | 1988-08-03 | 1992-04-30 | Synthelabo | Derives d'indolone, leur preparation et leur application en therapeutique |
| US4950664A (en) * | 1988-09-16 | 1990-08-21 | Rugby-Darby Group Companies, Inc. | Nasal administration of benzodiazepine hypnotics |
| DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
| US5556857A (en) * | 1991-05-08 | 1996-09-17 | Otsuka Pharmaceutical Co., Ltd. | Disturbance-of-consciousness improving agent |
| IT1255178B (it) * | 1992-06-26 | 1995-10-20 | Pierrel Spa | N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica |
| US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
| PT1153603E (pt) * | 1993-06-28 | 2007-01-31 | Wyeth Corp | Novos tratamentos utilizando derivados de fenetilamina |
| WO1996017831A1 (de) * | 1994-12-07 | 1996-06-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Uracilderivate |
| WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
| CA2297486C (en) * | 1997-08-15 | 2005-05-03 | Pfizer Products Inc. | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor |
| US6355644B1 (en) * | 1999-06-14 | 2002-03-12 | Neurogen Corporation | Benzylpiperazinyl-indolinylethanones |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| TW580446B (en) * | 2003-05-15 | 2004-03-21 | Benq Corp | Color electrode array printer |
-
2000
- 2000-12-22 HU HU0203839A patent/HUP0203839A3/hu unknown
- 2000-12-22 PT PT04007739T patent/PT1464641E/pt unknown
- 2000-12-22 NZ NZ530137A patent/NZ530137A/en unknown
- 2000-12-22 WO PCT/DK2000/000728 patent/WO2001049679A1/en active Application Filing
- 2000-12-22 EP EP04007739A patent/EP1464641B1/en not_active Expired - Lifetime
- 2000-12-22 EP EP00984931A patent/EP1246817B1/en not_active Expired - Lifetime
- 2000-12-22 AU AU21527/01A patent/AU783786B2/en not_active Ceased
- 2000-12-22 TR TR2002/01690T patent/TR200201690T2/xx unknown
- 2000-12-22 PL PL00355502A patent/PL355502A1/xx not_active IP Right Cessation
- 2000-12-22 CN CNB00819145XA patent/CN1244577C/zh not_active Expired - Fee Related
- 2000-12-22 DE DE60011817T patent/DE60011817T2/de not_active Expired - Fee Related
- 2000-12-22 MX MXPA02006590A patent/MXPA02006590A/es active IP Right Grant
- 2000-12-22 AT AT00984931T patent/ATE269857T1/de not_active IP Right Cessation
- 2000-12-22 IL IL15036600A patent/IL150366A0/xx active IP Right Grant
- 2000-12-22 DE DE60038911T patent/DE60038911D1/de not_active Expired - Fee Related
- 2000-12-22 BR BR0016953-6A patent/BR0016953A/pt not_active Application Discontinuation
- 2000-12-22 UA UA2002065264A patent/UA73756C2/uk unknown
- 2000-12-22 SK SK1107-2002A patent/SK11072002A3/sk unknown
- 2000-12-22 AT AT04007739T patent/ATE395333T1/de not_active IP Right Cessation
- 2000-12-22 KR KR1020027008576A patent/KR100729536B1/ko not_active IP Right Cessation
- 2000-12-22 CZ CZ20022603A patent/CZ20022603A3/cs unknown
- 2000-12-22 SG SG200405552-1A patent/SG152900A1/en unknown
- 2000-12-22 PT PT00984931T patent/PT1246817E/pt unknown
- 2000-12-22 DK DK04007739T patent/DK1464641T3/da active
- 2000-12-22 TR TR2004/02408T patent/TR200402408T4/xx unknown
- 2000-12-22 ES ES04007739T patent/ES2302992T3/es not_active Expired - Lifetime
- 2000-12-22 DK DK00984931T patent/DK1246817T3/da active
- 2000-12-22 NZ NZ519740A patent/NZ519740A/en unknown
- 2000-12-22 KR KR1020077000879A patent/KR100792186B1/ko not_active IP Right Cessation
- 2000-12-22 JP JP2001550219A patent/JP2003519225A/ja active Pending
- 2000-12-22 ES ES00984931T patent/ES2223628T3/es not_active Expired - Lifetime
- 2000-12-22 EA EA200200729A patent/EA005013B1/ru not_active IP Right Cessation
- 2000-12-22 EA EA200400641A patent/EA008627B1/ru not_active IP Right Cessation
- 2000-12-22 CN CNA2005101310970A patent/CN1803784A/zh active Pending
- 2000-12-22 CA CA002395869A patent/CA2395869C/en not_active Expired - Fee Related
- 2000-12-28 AR ARP000106991A patent/AR029461A1/es not_active Application Discontinuation
-
2002
- 2002-06-19 IS IS6432A patent/IS6432A/is unknown
- 2002-06-21 ZA ZA200205019A patent/ZA200205019B/en unknown
- 2002-06-23 IL IL150366A patent/IL150366A/en not_active IP Right Cessation
- 2002-06-27 US US10/186,339 patent/US7074796B2/en not_active Expired - Fee Related
- 2002-06-28 NO NO20023151A patent/NO323401B1/no unknown
- 2002-07-03 HR HR20020567A patent/HRP20020567A2/hr not_active Application Discontinuation
- 2002-07-26 BG BG106960A patent/BG106960A/bg unknown
-
2003
- 2003-11-13 HK HK03108252A patent/HK1055960A1/xx unknown
-
2006
- 2006-03-08 AU AU2006201000A patent/AU2006201000A1/en not_active Abandoned
- 2006-03-15 US US11/377,772 patent/US7223765B2/en not_active Expired - Fee Related
- 2006-12-14 NO NO20065681A patent/NO20065681L/no not_active Application Discontinuation
-
2007
- 2007-10-25 IL IL186954A patent/IL186954A0/en unknown
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