ES8300707A1 - Procedimiento para preparar derivados del acido nicotinico. - Google Patents
Procedimiento para preparar derivados del acido nicotinico.Info
- Publication number
- ES8300707A1 ES8300707A1 ES508144A ES508144A ES8300707A1 ES 8300707 A1 ES8300707 A1 ES 8300707A1 ES 508144 A ES508144 A ES 508144A ES 508144 A ES508144 A ES 508144A ES 8300707 A1 ES8300707 A1 ES 8300707A1
- Authority
- ES
- Spain
- Prior art keywords
- acid derivatives
- nicotinic acid
- inclusive
- integer
- nicotinates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- -1 phenylalkyl nicotinates Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO NICOTINICO Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMETE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES CLORO O FLUOR; N VALE DE 2 A 6; Y M VALE DE 1 A 6. CONSISTE EN LA REACCION DE UN ALCOHOL 4-(4-SUSTITUIDO-FENIL-ALQUILOXI) FENILALQUILICO CON UN HALURO DE NICOTINOILO O SU HIDROHALURO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, TAL COMO UNA AMINA, A UNA TEMPERATURA COMPRENDIDA ENTRE 0<025>C Y 150<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD HIPOLIPIDEMICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55180751A JPS57102866A (en) | 1980-12-19 | 1980-12-19 | Nicotinic acid derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8300707A1 true ES8300707A1 (es) | 1982-11-01 |
| ES508144A0 ES508144A0 (es) | 1982-11-01 |
Family
ID=16088673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508144A Granted ES508144A0 (es) | 1980-12-19 | 1981-12-18 | Procedimiento para preparar derivados del acido nicotinico. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4556715A (es) |
| JP (1) | JPS57102866A (es) |
| AR (1) | AR229111A1 (es) |
| AU (1) | AU542504B2 (es) |
| BE (1) | BE891462A (es) |
| CA (1) | CA1154020A (es) |
| DE (1) | DE3149928C2 (es) |
| ES (1) | ES508144A0 (es) |
| FR (1) | FR2496658B1 (es) |
| GB (1) | GB2093019B (es) |
| ZA (1) | ZA818376B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE450381B (sv) * | 1979-02-08 | 1987-06-22 | Merz & Co | Estrar av nikotinsyra och 2-(p-klorfenoxi)-isosmorsyra till anvendning som lipidsenkande medel |
| CN102399148B (zh) * | 2010-09-14 | 2014-03-05 | 中国科学院成都生物研究所 | 一类降血脂化合物及其制备方法和用途 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5259160A (en) * | 1975-11-08 | 1977-05-16 | Kyorin Seiyaku Kk | Preparation method of nicotinic acid44*44chlorobenzyloxy*benzyl ester |
| CH630879A5 (de) * | 1977-08-29 | 1982-07-15 | Siegfried Ag | Verfahren zur herstellung lipidsenkender alkylenglykolderivate. |
-
1980
- 1980-12-19 JP JP55180751A patent/JPS57102866A/ja active Pending
-
1981
- 1981-12-02 AU AU78179/81A patent/AU542504B2/en not_active Ceased
- 1981-12-03 ZA ZA818376A patent/ZA818376B/xx unknown
- 1981-12-08 CA CA000391733A patent/CA1154020A/en not_active Expired
- 1981-12-14 BE BE0/206820A patent/BE891462A/fr not_active IP Right Cessation
- 1981-12-16 DE DE3149928A patent/DE3149928C2/de not_active Expired
- 1981-12-16 FR FR8123486A patent/FR2496658B1/fr not_active Expired
- 1981-12-17 AR AR287840A patent/AR229111A1/es active
- 1981-12-18 ES ES508144A patent/ES508144A0/es active Granted
- 1981-12-21 GB GB8138421A patent/GB2093019B/en not_active Expired
-
1983
- 1983-10-24 US US06/544,897 patent/US4556715A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2496658A1 (fr) | 1982-06-25 |
| AU7817981A (en) | 1982-06-24 |
| GB2093019B (en) | 1985-02-20 |
| ZA818376B (en) | 1982-11-24 |
| CA1154020A (en) | 1983-09-20 |
| FR2496658B1 (fr) | 1985-06-07 |
| US4556715A (en) | 1985-12-03 |
| ES508144A0 (es) | 1982-11-01 |
| GB2093019A (en) | 1982-08-25 |
| DE3149928C2 (de) | 1986-08-21 |
| JPS57102866A (en) | 1982-06-26 |
| AU542504B2 (en) | 1985-02-21 |
| AR229111A1 (es) | 1983-06-15 |
| BE891462A (fr) | 1982-03-31 |
| DE3149928A1 (de) | 1982-07-08 |
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