JPS57102866A - Nicotinic acid derivative and its preparation - Google Patents
Nicotinic acid derivative and its preparationInfo
- Publication number
- JPS57102866A JPS57102866A JP55180751A JP18075180A JPS57102866A JP S57102866 A JPS57102866 A JP S57102866A JP 55180751 A JP55180751 A JP 55180751A JP 18075180 A JP18075180 A JP 18075180A JP S57102866 A JPS57102866 A JP S57102866A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- acid derivative
- nicotinic acid
- nicotinic
- formulai
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title 1
- NMMKTQVGRBFRRS-UHFFFAOYSA-N 2-[4-[(4-chlorophenyl)methoxy]phenyl]ethyl pyridine-3-carboxylate Chemical compound C1=CC(Cl)=CC=C1COC(C=C1)=CC=C1CCOC(=O)C1=CC=CN=C1 NMMKTQVGRBFRRS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- -1 phenylalkyl ester Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55180751A JPS57102866A (en) | 1980-12-19 | 1980-12-19 | Nicotinic acid derivative and its preparation |
| AU78179/81A AU542504B2 (en) | 1980-12-19 | 1981-12-02 | Nicotinic acid derivatives |
| ZA818376A ZA818376B (en) | 1980-12-19 | 1981-12-03 | Nicotinic acid derivatives and preparations thereof |
| CA000391733A CA1154020A (en) | 1980-12-19 | 1981-12-08 | 4-(4-halogen phenylalkyloxy)-phenylalkyl nicotinate |
| BE0/206820A BE891462A (fr) | 1980-12-19 | 1981-12-14 | Derives d'acide nicotinique et leurs preparations |
| DE3149928A DE3149928C2 (de) | 1980-12-19 | 1981-12-16 | Nicotinsäurederivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen |
| FR8123486A FR2496658B1 (fr) | 1980-12-19 | 1981-12-16 | Derives de l'acide nicotinique, leur preparation et medicament contenant ces substances |
| AR287840A AR229111A1 (es) | 1980-12-19 | 1981-12-17 | Procedimiento para la preparacion de nicotinatos de 4-(fenilalquiloxi 4-sustituido)fenilalquilo |
| ES508144A ES508144A0 (es) | 1980-12-19 | 1981-12-18 | Procedimiento para preparar derivados del acido nicotinico. |
| GB8138421A GB2093019B (en) | 1980-12-19 | 1981-12-21 | Nicotinic acid derivatives and preparations thereof |
| US06/544,897 US4556715A (en) | 1980-12-19 | 1983-10-24 | Nicotinic acid derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55180751A JPS57102866A (en) | 1980-12-19 | 1980-12-19 | Nicotinic acid derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57102866A true JPS57102866A (en) | 1982-06-26 |
Family
ID=16088673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55180751A Pending JPS57102866A (en) | 1980-12-19 | 1980-12-19 | Nicotinic acid derivative and its preparation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4556715A (ja) |
| JP (1) | JPS57102866A (ja) |
| AR (1) | AR229111A1 (ja) |
| AU (1) | AU542504B2 (ja) |
| BE (1) | BE891462A (ja) |
| CA (1) | CA1154020A (ja) |
| DE (1) | DE3149928C2 (ja) |
| ES (1) | ES508144A0 (ja) |
| FR (1) | FR2496658B1 (ja) |
| GB (1) | GB2093019B (ja) |
| ZA (1) | ZA818376B (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE450381B (sv) * | 1979-02-08 | 1987-06-22 | Merz & Co | Estrar av nikotinsyra och 2-(p-klorfenoxi)-isosmorsyra till anvendning som lipidsenkande medel |
| CN102399148B (zh) * | 2010-09-14 | 2014-03-05 | 中国科学院成都生物研究所 | 一类降血脂化合物及其制备方法和用途 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5259160A (en) * | 1975-11-08 | 1977-05-16 | Kyorin Seiyaku Kk | Preparation method of nicotinic acid44*44chlorobenzyloxy*benzyl ester |
| CH630879A5 (de) * | 1977-08-29 | 1982-07-15 | Siegfried Ag | Verfahren zur herstellung lipidsenkender alkylenglykolderivate. |
-
1980
- 1980-12-19 JP JP55180751A patent/JPS57102866A/ja active Pending
-
1981
- 1981-12-02 AU AU78179/81A patent/AU542504B2/en not_active Ceased
- 1981-12-03 ZA ZA818376A patent/ZA818376B/xx unknown
- 1981-12-08 CA CA000391733A patent/CA1154020A/en not_active Expired
- 1981-12-14 BE BE0/206820A patent/BE891462A/fr not_active IP Right Cessation
- 1981-12-16 FR FR8123486A patent/FR2496658B1/fr not_active Expired
- 1981-12-16 DE DE3149928A patent/DE3149928C2/de not_active Expired
- 1981-12-17 AR AR287840A patent/AR229111A1/es active
- 1981-12-18 ES ES508144A patent/ES508144A0/es active Granted
- 1981-12-21 GB GB8138421A patent/GB2093019B/en not_active Expired
-
1983
- 1983-10-24 US US06/544,897 patent/US4556715A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA818376B (en) | 1982-11-24 |
| FR2496658B1 (fr) | 1985-06-07 |
| GB2093019A (en) | 1982-08-25 |
| US4556715A (en) | 1985-12-03 |
| AU542504B2 (en) | 1985-02-21 |
| FR2496658A1 (fr) | 1982-06-25 |
| DE3149928C2 (de) | 1986-08-21 |
| ES8300707A1 (es) | 1982-11-01 |
| ES508144A0 (es) | 1982-11-01 |
| AR229111A1 (es) | 1983-06-15 |
| CA1154020A (en) | 1983-09-20 |
| AU7817981A (en) | 1982-06-24 |
| BE891462A (fr) | 1982-03-31 |
| GB2093019B (en) | 1985-02-20 |
| DE3149928A1 (de) | 1982-07-08 |
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