ES8301469A1 - Procedimiento para preparar derivados de 2(1h)-piridona - Google Patents

Procedimiento para preparar derivados de 2(1h)-piridona

Info

Publication number
ES8301469A1
ES8301469A1 ES499971A ES499971A ES8301469A1 ES 8301469 A1 ES8301469 A1 ES 8301469A1 ES 499971 A ES499971 A ES 499971A ES 499971 A ES499971 A ES 499971A ES 8301469 A1 ES8301469 A1 ES 8301469A1
Authority
ES
Spain
Prior art keywords
derivatives
pyridinone
preparation
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499971A
Other languages
English (en)
Other versions
ES499971A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES499971A0 publication Critical patent/ES499971A0/es
Publication of ES8301469A1 publication Critical patent/ES8301469A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 2(1H)-PIRIDONA, DE FORMULA GENERAL (I), EN DONDE R Y R , INDEPENDIENTEMENTE, SON HIDROGENO, ALQUILO O ARILO MONOCICLICO, FACULTATIVAMENTE SUSTITUIDO, CON LA CONDICION DE QUE POR LO MENOS UNO DE LOS RADICALES R O R ES ARILO, Y CUANDO R ES HIDROGENO O ALQUILO, ENTONCES R NO SIGNIFICA 2-, 3- O 4-PIRIDINILO NO SUSTITUIDO O SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO INFERIORES. CONSISTE EN AMINAR UN COMPUESTO DE FORMULA (II), EN DONDE R Y R TIENE LOS SIGNIFICADOS YA INDICADOS, Y R<018> ES UN GRUPO CAPAZ DE SER CONVERTIDO EN UN GRUPO AMINO PRIMARIO A TEMPERATURAS COMPRENDIDAS ENTRE 50 Y 100 GRADOS. DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS POR SU ACTIVIDAD CARDIOTONICA.
ES499971A 1980-03-03 1981-03-02 Procedimiento para preparar derivados de 2(1h)-piridona Expired ES8301469A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH166980 1980-03-03
CH166880 1980-03-03
CH571780 1980-07-25
CH794780 1980-10-24

Publications (2)

Publication Number Publication Date
ES499971A0 ES499971A0 (es) 1982-12-01
ES8301469A1 true ES8301469A1 (es) 1982-12-01

Family

ID=27428258

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499971A Expired ES8301469A1 (es) 1980-03-03 1981-03-02 Procedimiento para preparar derivados de 2(1h)-piridona

Country Status (16)

Country Link
CA (1) CA1183533A (es)
CH (1) CH652395A5 (es)
DE (1) DE3106460A1 (es)
DK (1) DK94481A (es)
ES (1) ES8301469A1 (es)
FI (1) FI810558L (es)
FR (1) FR2477148A1 (es)
GB (1) GB2070606B (es)
IL (1) IL62246A (es)
IT (1) IT1142458B (es)
NL (1) NL8100964A (es)
NZ (1) NZ196385A (es)
PT (1) PT72596B (es)
SE (1) SE8101336L (es)
WO (1) WO1981002575A1 (es)
YU (1) YU51581A (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65278A0 (en) * 1981-03-30 1982-05-31 Sterling Drug Inc 3-amino-5-(substituted)-2(1h)-pyridinones and corresponding 3-cyano compounds,their preparation and pharmaceutical compositions containing them
US4465686A (en) * 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
US4515797A (en) * 1981-09-08 1985-05-07 Sterling Drug Inc. 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof
US4593028A (en) * 1981-10-26 1986-06-03 William H. Rorer, Inc. 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure
US4432979A (en) * 1981-10-26 1984-02-21 William H. Rorer, Inc. Pyridone compounds
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
US4514400A (en) * 1981-10-26 1985-04-30 William H. Rorer, Inc. Cardiotonic 5-heteroaryl-pyridone
FR2527206B1 (fr) * 1982-05-18 1986-12-05 Sandoz Sa Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments
AT384021B (de) * 1982-05-18 1987-09-25 Sandoz Ag Verfahren zur herstellung neuer 2(1h)-pyridinon- derivate und ihrer salze
FR2529891A1 (fr) * 1982-07-12 1984-01-13 Nativelle Sa Ets Derives du pyridyl-3 alcoxy-5 pyrazole, procede de preparation et application en therapeutique
IT8367883A0 (it) * 1982-08-23 1983-08-22 Rorer Int Overseas Composti cardiotonici del 2 piridone 5 biciclico eteroaril sostituito e relative composizioni farmaceutiche
IL69407A (en) * 1982-08-23 1987-10-20 Warner Lambert Co 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
US4503061A (en) * 1983-07-22 1985-03-05 Warner-Lambert Company Substituted phenyl-pyridinones as cardiotonic agents
US4517192A (en) * 1983-01-31 1985-05-14 Sterling Drug Inc. 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics
ES8600746A1 (es) * 1983-04-20 1985-10-16 Quimicos Y Farmaceuticos Abel Un nuevo procedimiento para la preparacion de 5-azinil-1,2-dihidroazin-2-onas.
US4568751A (en) * 1983-04-29 1986-02-04 Merrell Dow Pharmaceuticals Inc. 5-Acyl-2-(1H)-pyridinones
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
DE3685840D1 (de) 1985-04-30 1992-08-06 Dresden Arzneimittel 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
US4785005A (en) * 1986-06-25 1988-11-15 Rorer Pharmaceutical Corporation 6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
US5254571A (en) * 1988-04-21 1993-10-19 Smith Kline & French Laboratories Ltd. Chemical compounds
GB8809481D0 (en) * 1988-04-21 1988-05-25 Smith Kline French Lab Chemical compounds
GB8923131D0 (en) * 1989-10-13 1989-11-29 Smith Kline French Lab Chemical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355278A (en) * 1961-03-13 1967-11-28 Hooker Chemical Corp Herbicidal composition and method
NL6816241A (es) * 1967-12-01 1969-06-03
FR2050940A5 (es) * 1969-06-30 1971-04-02 Rhone Poulenc Sa
US3666765A (en) * 1969-10-27 1972-05-30 Union Carbide Corp Synthesis of 2-pyridones and derivatives thereof
US3721676A (en) * 1969-11-12 1973-03-20 Merck & Co Inc Certain 3-amino-2(1h)pyridones
BE758759A (fr) * 1969-11-12 1971-05-10 Merck & Co Inc Pyridones anti-inflammatoires
US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
FR2477148A1 (fr) 1981-09-04
NL8100964A (nl) 1981-10-01
GB2070606A (en) 1981-09-09
IT8147920A0 (it) 1981-03-02
CH652395A5 (de) 1985-11-15
ES499971A0 (es) 1982-12-01
IL62246A0 (en) 1981-05-20
NZ196385A (en) 1983-12-16
YU51581A (en) 1983-12-31
GB2070606B (en) 1984-02-29
FI810558L (fi) 1981-09-04
DK94481A (da) 1981-09-04
DE3106460A1 (de) 1982-01-28
IL62246A (en) 1984-09-30
SE8101336L (sv) 1981-09-04
WO1981002575A1 (en) 1981-09-17
IT1142458B (it) 1986-10-08
PT72596B (en) 1982-07-13
FR2477148B1 (es) 1983-09-02
PT72596A (en) 1981-04-01
CA1183533A (en) 1985-03-05

Similar Documents

Publication Publication Date Title
ES8301469A1 (es) Procedimiento para preparar derivados de 2(1h)-piridona
ES8407025A1 (es) Un procedimiento para preparar derivados de nicotinamida.
ES8704481A1 (es) Procedimiento para la preparacion de nuevos derivados de pi-colina
ES463633A1 (es) Procedimiento de preparacion de derivados de la piperidina.
MY101721A (en) 6-vinyl-furo-(3,4-c)-pyridine derivatives
ES8203888A1 (es) Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo
ES8601965A1 (es) Un procedimiento para la preparacion de una nueva serie de derivados de (1-piperidinilalquil)pirimidinona
ES8207169A1 (es) Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.
IL51797A (en) Antihistaminic or antianaphylactic pharmaceutical compositions containing n-(4-substituted piperid-1-yl and piperaz-1-yl)alkyl-aza-cyclic derivatives,some novel such compounds and their preparation
IL75115A (en) 3-oxadiazolyl-beta-carboline derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE3273782D1 (en) Pyrimidinone derivatives and pharmaceutical compositions containing them
ES8106891A1 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
IL75116A0 (en) Beta-carboline-3-carboxylic acid derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
SE8405588D0 (sv) New compounds
ES8800214A1 (es) Procedimiento para preparar derivados de bencimidazol substituidos
ES8704468A1 (es) Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos
ES8106003A1 (es) Procedimiento para la obtencion de acido fosfonohidroxiace- tico
GB1252847A (es)
PH19511A (en) N-substituted nicotinamide 1-oxide,its salts,process for their preparation and pharmaceutical compositions containing them
ES8305717A1 (es) Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina sustituidos.
GB1428626A (en) Trisubstituted 1,2,4-triazoles
ES8602764A1 (es) Un procedimiento para preparar derivados de tiadiazina
ZA835728B (en) N-substituted nicotinamide 1-oxide,its salts,process for their preparation and pharmaceutical compositions containing them
GB1430719A (en) 3-substituted phenoxy-2-propanols and pharmaceutical compositions containing them
ES8203843A1 (es) Procedimiento para la obtencion de amidas de acido 1,4-dihi-dropiridin-4-carboxilico