ES463633A1 - Procedimiento de preparacion de derivados de la piperidina. - Google Patents

Procedimiento de preparacion de derivados de la piperidina.

Info

Publication number
ES463633A1
ES463633A1 ES463633A ES463633A ES463633A1 ES 463633 A1 ES463633 A1 ES 463633A1 ES 463633 A ES463633 A ES 463633A ES 463633 A ES463633 A ES 463633A ES 463633 A1 ES463633 A1 ES 463633A1
Authority
ES
Spain
Prior art keywords
piperidine derivatives
relates
salts
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463633A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anphar SA
Original Assignee
Anphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anphar SA filed Critical Anphar SA
Publication of ES463633A1 publication Critical patent/ES463633A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de las piperidina de fórmula general: ***(Ver fórmula I) en donde R representa un grupo alcoxi inferior o alqueniloxi inferior R1 y R2 iguales o diferentes entre si, son hidrógeno, halógeno, sulfonamido, amino, alquilamino inferior, dialquilamino inferior, alquilsulfonilo inferior, alquilsulfonamido inferior, o acilamino inferior en el cual el grupo acilo se deriva de un ácido carboxílico, estando el grupo acilo se deriva de un ácido carboxílico, estando el grupo representado por R1 en la posición 3 o 4 del anillo bencénico, con la salvedad de que R1 y R2 no representan átomos de hidrógeno a la vez; R3 representa un átomo de hidrógeno, un grupo alquilo inferior o alquenilo inferior, un grupo fenilo o un grupo cicloalquilo o cicloalquenilo con 3 o 7 átomos de carbono en el anillo.
ES463633A 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina. Expired ES463633A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45146/76A GB1586468A (en) 1976-10-29 1976-10-29 Piperidine derivatives

Publications (1)

Publication Number Publication Date
ES463633A1 true ES463633A1 (es) 1978-07-01

Family

ID=10436065

Family Applications (2)

Application Number Title Priority Date Filing Date
ES463632A Expired ES463632A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.
ES463633A Expired ES463633A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES463632A Expired ES463632A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.

Country Status (7)

Country Link
US (1) US4367232A (es)
JP (1) JPS5377069A (es)
CA (1) CA1095044A (es)
DE (1) DE2747960A1 (es)
ES (2) ES463632A1 (es)
FR (1) FR2369263A1 (es)
GB (1) GB1586468A (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057525A (en) * 1981-10-01 1991-10-15 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2534255B1 (fr) * 1982-10-11 1985-07-12 Delalande Sa Nouveaux derives de la 4-aroylamino piperidine, leur procede de preparation et leur application en therapeutique
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
GB9016580D0 (en) * 1990-07-27 1990-09-12 Ici Plc Fungicides
GB9016581D0 (en) * 1990-07-27 1990-09-12 Ici Plc Fungicides
TR27569A (tr) * 1992-01-24 1995-06-13 Ici Plc Yeni fungisidal asilaminobenzamidler, bunlarin hazirlanis islemleri ve bitkilerdeki mantar enfeksiyonlariyla mücadelede kullanimlari.
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5885983A (en) * 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN101230034A (zh) * 2000-03-06 2008-07-30 阿卡蒂亚药品公司 用于治疗5-羟色胺相关性疾病的氮杂环化合物
EP1296950A2 (en) * 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
EP1390084B1 (en) * 2001-05-01 2011-03-23 A.V. Topchiev Institute of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
NZ571695A (en) * 2001-12-28 2010-02-26 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
US7253186B2 (en) * 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
CA2490397A1 (en) * 2002-06-24 2003-12-31 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) * 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
US7601740B2 (en) 2003-01-16 2009-10-13 Acadia Pharmaceuticals, Inc. Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
TWI306864B (en) * 2003-02-10 2009-03-01 Nippon Catalytic Chem Ind Water-absorbing agent
SE0301369D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
BRPI0516063A (pt) * 2004-09-27 2008-08-19 Acadia Pharm Inc sìntese de n-(4-fluorbenzil)-n-(1-metilpiperidin-4-il)-n'-(4-(2-metilp ropi-loxi)fenilmetil)carbamida e seu sal tartarato e formas cristalinas
US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
MX2007007434A (es) * 2004-12-20 2007-07-17 Hoffmann La Roche Derivados de 4-aminopiperidina.
EP2134330B1 (en) 2007-03-19 2013-05-08 Acadia Pharmaceuticals Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
SI2200610T1 (en) * 2007-09-21 2018-06-29 Acadia Pharmaceuticals Inc. Co-administration of pimavanserin with other agents
SI3325444T1 (sl) 2015-07-20 2021-11-30 Acadia Pharmaceuticals Inc. Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US11464768B2 (en) 2016-12-20 2022-10-11 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
EP3675827A1 (en) 2017-08-30 2020-07-08 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2745837A (en) * 1954-01-21 1956-05-15 Schering Corp Benzhydryl ethers of alkyl piperidinols
NL270803A (es) * 1960-11-09
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
US3963745A (en) * 1972-04-03 1976-06-15 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
CA1046066A (en) * 1973-08-23 1979-01-09 Tomio Muro 1-(methylated piperidino (and pyrrolidin -1-yl)-3-(substituted phenoxy)-2-propanols
DE2513136C3 (de) 1974-03-21 1981-04-30 Anphar S.A., Madrid N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
JPS5377069A (en) 1978-07-08
DE2747960A1 (de) 1978-05-11
FR2369263A1 (fr) 1978-05-26
CA1095044A (en) 1981-02-03
FR2369263B1 (es) 1980-06-13
GB1586468A (en) 1981-03-18
ES463632A1 (es) 1978-07-16
US4367232A (en) 1983-01-04

Similar Documents

Publication Publication Date Title
ES463632A1 (es) Procedimiento de preparacion de derivados de la piperidina.
ZA7671B (en) Pharmaceutical composition
JPS5272829A (en) Pharmaceutical composition
PT67009B (en) Processes for the preparation of pharmaceutical compositions
AU502644B2 (en) Xanthine-containing pharmaceutical compositions
IL49280A (en) Pharmaceutical compositions containing substituted o-hydroxy-benzophenone derivatives
IL50542A (en) Substituted pyridinecarboxamides,their manufacture and pharmaceutical compositions containing them
AU504840B2 (en) Medicinal compositions
IL52134A0 (en) Uracil derivatives process for the preparation thereof and pharmaceutical compositions containing them
AU2574877A (en) Pharmaceutical compositions
ZA767215B (en) Pharmaceutical compositions
AU505476B2 (en) Pharmaceutical composition
ZA761880B (en) New pharmaceutical compositions
AU498557B2 (en) D-homosteroids & pharmaceutical compositions
NZ180863A (en) 3,5-bisoxygenated 2-(w-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acid derivatives and pharmaceutical compositions
IL49785A0 (en) Benzocycloheptathiophene derivatives,their production and pharmaceutical compositions containing them
ZA761012B (en) Pharmaceutical compositions
GB1552416A (en) Pharmaceutical compositions
IL51104A (en) 4a-phenyl-isoquinoline derivatives,their production and pharmaceutical compositions containing them
IL49806A0 (en) Benzocycloheptathiophene derivatives,their production and pharmaceutical compositions containing them
AU499217B2 (en) Pharmaceutical compositions
GB1547198A (en) Pharmaceutical compositions containing phenoxypropylamine derivatives
IE43955L (en) Pharmaceutical composition
IL51043A0 (en) Novel pharmaceutical compositions comprising ergot-type compounds
AU1172076A (en) Pharmaceutical compositions