GB2070606B - 2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them - Google Patents

2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
GB2070606B
GB2070606B GB8106335A GB8106335A GB2070606B GB 2070606 B GB2070606 B GB 2070606B GB 8106335 A GB8106335 A GB 8106335A GB 8106335 A GB8106335 A GB 8106335A GB 2070606 B GB2070606 B GB 2070606B
Authority
GB
United Kingdom
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
pyridinone derivatives
pyridinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8106335A
Other versions
GB2070606A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB2070606A publication Critical patent/GB2070606A/en
Application granted granted Critical
Publication of GB2070606B publication Critical patent/GB2070606B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8106335A 1980-03-03 1981-02-27 2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them Expired GB2070606B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH166880 1980-03-03
CH166980 1980-03-03
CH571780 1980-07-25
CH794780 1980-10-24

Publications (2)

Publication Number Publication Date
GB2070606A GB2070606A (en) 1981-09-09
GB2070606B true GB2070606B (en) 1984-02-29

Family

ID=27428258

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8106335A Expired GB2070606B (en) 1980-03-03 1981-02-27 2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
CA (1) CA1183533A (en)
CH (1) CH652395A5 (en)
DE (1) DE3106460A1 (en)
DK (1) DK94481A (en)
ES (1) ES8301469A1 (en)
FI (1) FI810558L (en)
FR (1) FR2477148A1 (en)
GB (1) GB2070606B (en)
IL (1) IL62246A (en)
IT (1) IT1142458B (en)
NL (1) NL8100964A (en)
NZ (1) NZ196385A (en)
PT (1) PT72596B (en)
SE (1) SE8101336L (en)
WO (1) WO1981002575A1 (en)
YU (1) YU51581A (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65278A0 (en) * 1981-03-30 1982-05-31 Sterling Drug Inc 3-amino-5-(substituted)-2(1h)-pyridinones and corresponding 3-cyano compounds,their preparation and pharmaceutical compositions containing them
US4515797A (en) * 1981-09-08 1985-05-07 Sterling Drug Inc. 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof
US4465686A (en) * 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
US4593028A (en) * 1981-10-26 1986-06-03 William H. Rorer, Inc. 5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure
US4432979A (en) * 1981-10-26 1984-02-21 William H. Rorer, Inc. Pyridone compounds
US4514400A (en) * 1981-10-26 1985-04-30 William H. Rorer, Inc. Cardiotonic 5-heteroaryl-pyridone
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
FR2527206B1 (en) * 1982-05-18 1986-12-05 Sandoz Sa NOVEL 2 (1H) -PYRIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
AT384021B (en) * 1982-05-18 1987-09-25 Sandoz Ag Process for the preparation of novel 2(1H)-pyridinone derivatives and their salts
FR2529891A1 (en) * 1982-07-12 1984-01-13 Nativelle Sa Ets PYRIDYL-3 ALCOXY-5 PYRAZOLE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC APPLICATION
US4503061A (en) * 1983-07-22 1985-03-05 Warner-Lambert Company Substituted phenyl-pyridinones as cardiotonic agents
IL69407A (en) * 1982-08-23 1987-10-20 Warner Lambert Co 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
IT8367883A0 (en) * 1982-08-23 1983-08-22 Rorer Int Overseas CARDIOTONIC COMPOUNDS OF SUBSTITUTED BICYCLIC 2 PYRIDONE 5 HETEROARYL AND RELATED PHARMACEUTICAL COMPOSITIONS
US4517192A (en) * 1983-01-31 1985-05-14 Sterling Drug Inc. 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics
ES8600746A1 (en) * 1983-04-20 1985-10-16 Quimicos Y Farmaceuticos Abel Process for the preparation of 5-pyridyl-pyridine-2(1H)-ones.
US4568751A (en) * 1983-04-29 1986-02-04 Merrell Dow Pharmaceuticals Inc. 5-Acyl-2-(1H)-pyridinones
DE3406329A1 (en) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt PYRIDONE
EP0200024B1 (en) 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-cyano-pyridines, process for their preparation and their pharmaceutical use
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
US4785005A (en) * 1986-06-25 1988-11-15 Rorer Pharmaceutical Corporation 6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
GB8809481D0 (en) * 1988-04-21 1988-05-25 Smith Kline French Lab Chemical compounds
US5254571A (en) * 1988-04-21 1993-10-19 Smith Kline & French Laboratories Ltd. Chemical compounds
GB8923131D0 (en) * 1989-10-13 1989-11-29 Smith Kline French Lab Chemical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355278A (en) * 1961-03-13 1967-11-28 Hooker Chemical Corp Herbicidal composition and method
NL6816241A (en) * 1967-12-01 1969-06-03
FR2050940A5 (en) * 1969-06-30 1971-04-02 Rhone Poulenc Sa
US3666765A (en) * 1969-10-27 1972-05-30 Union Carbide Corp Synthesis of 2-pyridones and derivatives thereof
BE758759A (en) * 1969-11-12 1971-05-10 Merck & Co Inc ANTI-INFLAMMATORY PYRIDONES
US3721676A (en) * 1969-11-12 1973-03-20 Merck & Co Inc Certain 3-amino-2(1h)pyridones
US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
YU51581A (en) 1983-12-31
NL8100964A (en) 1981-10-01
CA1183533A (en) 1985-03-05
FI810558L (en) 1981-09-04
IT1142458B (en) 1986-10-08
NZ196385A (en) 1983-12-16
ES499971A0 (en) 1982-12-01
CH652395A5 (en) 1985-11-15
ES8301469A1 (en) 1982-12-01
PT72596A (en) 1981-04-01
DK94481A (en) 1981-09-04
DE3106460A1 (en) 1982-01-28
PT72596B (en) 1982-07-13
IT8147920A0 (en) 1981-03-02
IL62246A0 (en) 1981-05-20
WO1981002575A1 (en) 1981-09-17
FR2477148B1 (en) 1983-09-02
IL62246A (en) 1984-09-30
GB2070606A (en) 1981-09-09
FR2477148A1 (en) 1981-09-04
SE8101336L (en) 1981-09-04

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee