SG152273A1 - Pdx1 expressing endoderm - Google Patents
Pdx1 expressing endodermInfo
- Publication number
- SG152273A1 SG152273A1 SG200902871-3A SG2009028713A SG152273A1 SG 152273 A1 SG152273 A1 SG 152273A1 SG 2009028713 A SG2009028713 A SG 2009028713A SG 152273 A1 SG152273 A1 SG 152273A1
- Authority
- SG
- Singapore
- Prior art keywords
- pdxi
- endoderm cells
- positive
- disclosed
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56629304P | 2004-04-27 | 2004-04-27 | |
US58656604P | 2004-07-09 | 2004-07-09 | |
US58794204P | 2004-07-14 | 2004-07-14 | |
US11/021,618 US7510876B2 (en) | 2003-12-23 | 2004-12-23 | Definitive endoderm |
Publications (1)
Publication Number | Publication Date |
---|---|
SG152273A1 true SG152273A1 (en) | 2009-05-29 |
Family
ID=45319532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200902871-3A SG152273A1 (en) | 2004-04-27 | 2005-04-26 | Pdx1 expressing endoderm |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1740612B1 (fr) |
JP (6) | JP4926946B2 (fr) |
KR (2) | KR101395516B1 (fr) |
CN (1) | CN103103158B (fr) |
AU (1) | AU2005247869B2 (fr) |
CA (1) | CA2564114C (fr) |
DK (2) | DK1740612T3 (fr) |
EA (1) | EA011953B1 (fr) |
ES (2) | ES2751095T3 (fr) |
IL (1) | IL178847A (fr) |
MX (1) | MXPA06012445A (fr) |
NZ (1) | NZ550605A (fr) |
SG (1) | SG152273A1 (fr) |
WO (1) | WO2005116073A2 (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
US8586357B2 (en) | 2003-12-23 | 2013-11-19 | Viacyte, Inc. | Markers of definitive endoderm |
US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
EA200601231A1 (ru) | 2003-12-23 | 2007-06-29 | Китера, Инк. | Дефинитивная энтодерма |
CA2966883A1 (fr) * | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methodes d'identification de facteurs pour differencier l'endoderme definitif |
WO2006020919A2 (fr) | 2004-08-13 | 2006-02-23 | University Of Georgia Research Foundation, Inc. | Compositions et procedes d'auto-renouvellement et de differentiation dans des cellules souches embryonnaires humaines |
US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
EP1838843B1 (fr) * | 2004-12-23 | 2019-07-10 | Viacyte, Inc. | Expansion de cellules endodermiques definitives |
WO2006083782A2 (fr) * | 2005-01-31 | 2006-08-10 | Es Cell International Pte Ltd. | Differenciation dirigee de cellules souches embryonnaires et utilisations associees |
WO2006130851A2 (fr) * | 2005-06-02 | 2006-12-07 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Dispositifs prévascularisés et méthodes connexes |
CN101484575B (zh) | 2005-06-08 | 2013-10-02 | 森托科尔公司 | 用于眼变性的细胞疗法 |
DK2674485T3 (da) * | 2005-10-27 | 2019-08-26 | Viacyte Inc | Pdx-1 udtrykkende dorsal og ventral fortarm endoderm |
AU2012202481B2 (en) * | 2005-10-27 | 2015-07-02 | Viacyte, Inc. | PDX1-expressing dorsal and ventral foregut endoderm |
CN105802904B (zh) | 2006-02-23 | 2021-04-20 | 维亚赛特公司 | 用于培养可分化细胞的组合物和方法 |
US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
AU2007224116B2 (en) * | 2006-03-02 | 2013-11-07 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
US7989204B2 (en) | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
CA2984541C (fr) * | 2006-04-28 | 2022-04-12 | Lifescan, Inc. | Differentiation de cellules souches embryonnaires humaines |
US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
CN101910196A (zh) | 2007-12-28 | 2010-12-08 | 诺沃-诺迪斯克有限公司 | Ddr1-介导的从它们的祖细胞向胰腺内分泌细胞的细胞纯化 |
WO2009105570A2 (fr) | 2008-02-21 | 2009-08-27 | Centocor Ortho Biotech Inc. | Procédés, plaques à surface modifiée et compositions permettant la fixation, la culture et le détachement de cellules |
JP2011518547A (ja) | 2008-04-03 | 2011-06-30 | ノボ・ノルデイスク・エー/エス | 膵臓内分泌プレ前駆体細胞及びその子孫のdner媒介細胞精製 |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
US7939322B2 (en) | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
BRPI0913925A2 (pt) * | 2008-06-30 | 2015-08-04 | Centocor Ortho Biotech Inc | Diferenciação de células-tronco pluripotentes |
JP5734183B2 (ja) | 2008-06-30 | 2015-06-17 | ヤンセン バイオテツク,インコーポレーテツド | 多能性幹細胞の分化 |
CA2742267C (fr) | 2008-10-31 | 2019-06-04 | Centocor Ortho Biotech Inc. | Differenciation de cellules souches embryonnaires humaines en la lignee endocrine pancreatique |
BRPI0919885A2 (pt) | 2008-10-31 | 2015-08-11 | Centocor Ortho Biotech Inc | Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática |
US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
CN105349517B (zh) | 2008-11-14 | 2021-05-04 | 维赛特公司 | 源于人多能干细胞的胰腺细胞的包封 |
AU2009316583B2 (en) | 2008-11-20 | 2016-04-21 | Janssen Biotech, Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
RU2555538C2 (ru) | 2008-11-20 | 2015-07-10 | Сентокор Орто Байотек Инк. | Культура плюрипотентных стволовых клеток на микроносителях |
RU2540021C2 (ru) | 2009-07-20 | 2015-01-27 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека |
EP2456862A4 (fr) | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | Différentiation de cellules souches embryonnaires humaines |
GB2485113B (en) | 2009-07-20 | 2016-12-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage |
RU2586506C2 (ru) | 2009-12-23 | 2016-06-10 | Янссен Байотек, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
CN102741395B (zh) | 2009-12-23 | 2016-03-16 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
AU2011223900A1 (en) | 2010-03-01 | 2012-09-13 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
WO2011140441A2 (fr) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Procédés et systèmes de conversion de cellules précurseurs en tissus intestinaux par différenciation dirigée |
MX351515B (es) | 2010-05-12 | 2017-10-17 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
US9528090B2 (en) | 2010-08-31 | 2016-12-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
CA2809305C (fr) | 2010-08-31 | 2019-06-11 | Janssen Biotech, Inc. | Differenciation de cellules souches pluripotentes |
AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
JP5888852B2 (ja) * | 2010-12-08 | 2016-03-22 | 学校法人近畿大学 | 免疫不全動物を用いた細胞の製法 |
JP2012143229A (ja) * | 2010-12-24 | 2012-08-02 | Chiba Univ | 多能性幹細胞培養用組成物およびその用途 |
ES2902650T3 (es) | 2011-06-21 | 2022-03-29 | Novo Nordisk As | Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes |
AU2012355698B2 (en) * | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
KR20140131999A (ko) | 2012-03-07 | 2014-11-14 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 증폭 및 유지를 위한 한정 배지 |
CN108103006A (zh) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌细胞的分化 |
KR102084561B1 (ko) | 2012-12-31 | 2020-03-04 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양 |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
KR102036780B1 (ko) | 2012-12-31 | 2019-10-25 | 얀센 바이오테크 인코포레이티드 | Hb9 조절제를 사용하는 인간 배아 줄기세포의 췌장 내분비 세포로의 분화 |
JP6529440B2 (ja) | 2012-12-31 | 2019-06-12 | ヤンセン バイオテツク,インコーポレーテツド | 膵内分泌細胞への分化のためのヒト多能性細胞の懸濁及びクラスタリング |
CA2949056A1 (fr) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Utilisation de petites molecules pour ameliorer l'expression du gene mafa dans des cellules endocrines pancreatiques |
AU2015267148B2 (en) * | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
EP3207123A1 (fr) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | Modèle in vivo d'intestin grêle humain faisant intervenir des cellules souches pluripotentes et ses procédés de fabrication et d'utilisation |
JP6954711B2 (ja) | 2015-04-24 | 2021-10-27 | ユニバーシティ オブ コペンハーゲン | 真正膵臓前駆細胞の単離 |
MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
WO2017192997A1 (fr) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Procédés de fabrication in vitro de tissu de fundus d'estomac et compositions associées à celui-ci |
NZ753873A (en) | 2016-12-05 | 2023-01-27 | Children’S Hospital Medical Center | Colonic organoids and methods of making and using same |
CA2983845C (fr) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation de cellules beta reagissant au glucose |
CN114401752B (zh) | 2019-05-31 | 2023-04-04 | W.L.戈尔及同仁股份有限公司 | 具有受控氧扩散距离的细胞封装装置 |
CA3139591C (fr) | 2019-05-31 | 2024-01-16 | Timothy M. BRUHN | Composite a membrane biocompatible |
EP3975926A1 (fr) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | Composite à membrane biocompatible |
CN114173837A (zh) | 2019-05-31 | 2022-03-11 | W.L.戈尔及同仁股份有限公司 | 生物相容性膜复合材料 |
EP4196611A1 (fr) | 2020-08-15 | 2023-06-21 | Regeneron Pharmaceuticals, Inc. | Traitement de l'obésité chez des sujets ayant des molécules d'acide nucléique variantes codant pour le récepteur de la calcitonine (calcr) |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3945846B2 (ja) * | 1995-11-09 | 2007-07-18 | 武田薬品工業株式会社 | 膵臓機能改善剤 |
US6331406B1 (en) * | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
IL144654A0 (en) * | 1999-02-10 | 2002-05-23 | Curis Inc | Pancreatic progenitor cells, methods and uses related thereto |
JP4426064B2 (ja) * | 2000-05-31 | 2010-03-03 | 独立行政法人科学技術振興機構 | 脊椎動物の膵臓のインビトロ形成方法 |
JP2004502425A (ja) * | 2000-06-30 | 2004-01-29 | アムサイト, インコーポレイテッド | 指定された中間発生段階を有する膵臓幹細胞の培養 |
IL154159A0 (en) * | 2000-08-01 | 2003-07-31 | Yissum Res Dev Co | Directed differentiation of ebryonic cells |
CA2430627A1 (fr) * | 2000-11-30 | 2002-12-27 | Stemron, Inc. | Cellules souches homozygotes isolees, cellules differenciees derivees de ces cellules souches, et materiaux et procedes permettant de les fabriquer et de les utiliser |
EP1366148A2 (fr) * | 2001-01-24 | 2003-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Differenciation de cellules souches par rapport aux ilots pancreatiques |
WO2002092756A2 (fr) * | 2001-05-15 | 2002-11-21 | Rappaport Family Institute For Research In The Medical Sciences | Cellules produisant de l'insuline derivees de cellules souches embryonnaires humaines |
WO2002096203A1 (fr) * | 2001-05-25 | 2002-12-05 | Cythera, Inc. | Differentiation de cellules souches |
WO2002102982A2 (fr) * | 2001-06-14 | 2002-12-27 | Regents Of The University Of California | Compositions a base d'hoxd3 et procedes pour ameliorer la cicatrisation |
EP1298201A1 (fr) * | 2001-09-27 | 2003-04-02 | Cardion AG | Procédé de production de cellules présentant un état similaire à celui d'une cellule beta d'ilot pancréatique |
CA2468292A1 (fr) * | 2001-11-26 | 2003-06-05 | Advanced Cell Technology, Inc. | Procedes de production et d'utilisation de noyaux de cellules somatiques humaines reprogrammees et de cellules souches humaines autologues et isogeniques |
KR101089591B1 (ko) * | 2001-12-07 | 2011-12-05 | 제론 코포레이션 | 인간 배아 줄기세포 유래의 섬세포 |
US20030138949A1 (en) * | 2001-12-12 | 2003-07-24 | Anil Bhushan | Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells |
US20030162290A1 (en) * | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
CA2483010A1 (fr) * | 2002-04-19 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cellules souches placentaires et utilisations |
EP1516925A1 (fr) * | 2003-09-18 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Production de cellules suches embryonaires humaines a partir de zygotes triploid |
EP1730268A2 (fr) * | 2004-04-01 | 2006-12-13 | Wisconsin Alumni Research Foundation | Differenciation de cellules souches en lignee endodermique et pancreatique |
-
2005
- 2005-04-26 CN CN201210431212.6A patent/CN103103158B/zh active Active
- 2005-04-26 DK DK05780039.3T patent/DK1740612T3/da active
- 2005-04-26 ES ES05780039T patent/ES2751095T3/es active Active
- 2005-04-26 CA CA2564114A patent/CA2564114C/fr active Active
- 2005-04-26 ES ES10012385T patent/ES2801001T3/es active Active
- 2005-04-26 KR KR1020107004283A patent/KR101395516B1/ko active IP Right Grant
- 2005-04-26 EA EA200601995A patent/EA011953B1/ru not_active IP Right Cessation
- 2005-04-26 JP JP2007510879A patent/JP4926946B2/ja active Active
- 2005-04-26 MX MXPA06012445A patent/MXPA06012445A/es active IP Right Grant
- 2005-04-26 WO PCT/US2005/014239 patent/WO2005116073A2/fr active Application Filing
- 2005-04-26 AU AU2005247869A patent/AU2005247869B2/en active Active
- 2005-04-26 DK DK10012385.0T patent/DK2377922T3/da active
- 2005-04-26 KR KR1020067022588A patent/KR101278421B1/ko active IP Right Grant
- 2005-04-26 NZ NZ550605A patent/NZ550605A/en not_active IP Right Cessation
- 2005-04-26 EP EP05780039.3A patent/EP1740612B1/fr active Active
- 2005-04-26 SG SG200902871-3A patent/SG152273A1/en unknown
-
2006
- 2006-10-24 IL IL178847A patent/IL178847A/en active IP Right Grant
-
2011
- 2011-07-01 JP JP2011147598A patent/JP5669681B2/ja active Active
-
2014
- 2014-08-22 JP JP2014168939A patent/JP6158152B2/ja active Active
-
2015
- 2015-06-01 JP JP2015111656A patent/JP6265942B2/ja active Active
-
2017
- 2017-02-16 JP JP2017026645A patent/JP6605520B2/ja active Active
-
2018
- 2018-09-06 JP JP2018167312A patent/JP6709262B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG152273A1 (en) | Pdx1 expressing endoderm | |
WO2007051038A3 (fr) | Endoderme d'intestin anterieur dorsal et ventral exprimant pdx1 | |
SG149061A1 (en) | Definitive endoderm | |
WO2005021728A3 (fr) | Populations de cellules progenitrices et de cellules souches pancreatiques enrichies, methodes d'identification, d'isolement et d'enrichissement de ces populations | |
WO2006070370A3 (fr) | Systemes de culture de cellules souches | |
GB2441718A (en) | Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells | |
MX348414B (es) | Poblaciones de celula madre de la placenta. | |
IL150789A0 (en) | Multipotent neural stem cells from peripheral tissues and uses thereof | |
WO2003010243A3 (fr) | Cellules souches pluripotentes provenant de tissus peripheriques et leurs utilisations | |
WO2007103282A3 (fr) | Cellules precurseurs endocrines, cellules exprimant des hormones pancreatiques et procedes de productions associes | |
TW200741001A (en) | Method for production of t cell population | |
WO2007016485A3 (fr) | Emploi d'un inhibiteur de gsk-3 dans le but de conserver leur puissance a des cellules cultivees | |
WO2006044204A3 (fr) | Progeniteurs neuronaux obtenus par culture de cellules souches embryonnaires humaines sans cellules nourricieres | |
WO2005105984A3 (fr) | Conditions de culture et facteurs de croissance modifiant une determination de devenir, autorenouvellement et dilatation de cellules souches spermatogoniales de souris | |
TW200734462A (en) | Regulating stem cells | |
WO2005094353A3 (fr) | Techniques de production de lymphocytes t regulateurs et utilisation de ceux-ci | |
WO2006047743A8 (fr) | Cellules souches adultes de porc | |
WO2007016366A3 (fr) | Conditions definies de culture de cellules souches embryonnaires humaines | |
WO2004015077A3 (fr) | Compositions et methodes de differentiation neuronale de cellules souches embryonnaires humaines | |
EP2377922A3 (fr) | Endoderme exprimant PDX1 | |
WO2004020597A3 (fr) | Populations enrichies de cellules souches et progenitrices du systeme nerveux central, et procedes d'identification, d'isolement et d'enrichissement de telles populations | |
WO2000047762A3 (fr) | Cellule souche enrichie de systeme nerveux central et populations de geniteurs, et methodes d'identification, d'isolation et d'enrichissement de telles populations | |
WO2005030040A3 (fr) | Identification et isolation de cellules souches hematopoietiques | |
WO2009058451A3 (fr) | Cellules progénitrices neuronales et procédés de dérivation et de purification de cellules progénitrices neuronales de cellules souches embryonnaires | |
WO2004072262A3 (fr) | Cellules presentant l'antigene cd14+ de culture |