SG11202110512WA - Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection - Google Patents
Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injectionInfo
- Publication number
- SG11202110512WA SG11202110512WA SG11202110512WA SG11202110512WA SG11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA SG 11202110512W A SG11202110512W A SG 11202110512WA
- Authority
- SG
- Singapore
- Prior art keywords
- variant
- drug
- pharmaceutical composition
- subcutaneous injection
- human hyaluronidase
- Prior art date
Links
- 101001041117 Homo sapiens Hyaluronidase PH-20 Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000010254 subcutaneous injection Methods 0.000 title 1
- 239000007929 subcutaneous injection Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190033880 | 2019-03-25 | ||
PCT/KR2020/003975 WO2020197230A1 (ko) | 2019-03-25 | 2020-03-24 | 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202110512WA true SG11202110512WA (en) | 2021-10-28 |
Family
ID=72611090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202110512WA SG11202110512WA (en) | 2019-03-25 | 2020-03-24 | Pharmaceutical composition, comprising human hyaluronidase ph20 variant and drug, for subcutaneous injection |
Country Status (23)
Country | Link |
---|---|
US (2) | US20210363270A1 (es) |
EP (1) | EP3785701A4 (es) |
JP (3) | JP7295150B2 (es) |
KR (3) | KR102650991B1 (es) |
CN (3) | CN112203642A (es) |
AU (2) | AU2020248612B9 (es) |
BR (1) | BR112021019076A2 (es) |
CA (1) | CA3131052A1 (es) |
CL (1) | CL2021002464A1 (es) |
CO (1) | CO2021012380A2 (es) |
CR (1) | CR20210489A (es) |
DO (1) | DOP2021000197A (es) |
EA (1) | EA202192588A1 (es) |
EC (1) | ECSP21070640A (es) |
IL (1) | IL286539A (es) |
JO (1) | JOP20210262A1 (es) |
MX (1) | MX2021011278A (es) |
NI (1) | NI202100085A (es) |
PE (1) | PE20220283A1 (es) |
SA (1) | SA521430398B1 (es) |
SG (1) | SG11202110512WA (es) |
WO (1) | WO2020197230A1 (es) |
ZA (2) | ZA202108027B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3130347T3 (da) | 2011-12-30 | 2019-10-14 | Halozyme Inc | PH20-polypeptidvarianter, formuleringer og anvendelser deraf |
WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
EP3790532A1 (en) | 2018-05-10 | 2021-03-17 | Regeneron Pharmaceuticals, Inc. | High concentration vegf receptor fusion protein containing formulations |
WO2020022791A1 (ko) * | 2018-07-25 | 2020-01-30 | (주)알테오젠 | 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물 |
WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
TW202140780A (zh) * | 2020-01-23 | 2021-11-01 | 南韓商阿特根公司 | 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物 |
BR112022025381A2 (pt) | 2020-06-11 | 2023-01-24 | Provention Bio Inc | Métodos e composições para prevenir diabetes tipo 1 |
IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Preparations containing an antibody against HER2/NEU and their use |
JP2024503265A (ja) | 2020-12-28 | 2024-01-25 | ブリストル-マイヤーズ スクイブ カンパニー | 抗体組成物およびその使用の方法 |
MX2023007650A (es) | 2020-12-28 | 2023-09-11 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
EP4380618A2 (en) | 2021-08-02 | 2024-06-12 | argenx BV | Subcutaneous unit dosage forms |
PE20241337A1 (es) | 2021-09-14 | 2024-07-03 | Takeda Pharmaceuticals Co | Administracion facilitada de formulaciones concentradas de anticuerpos mediante el uso de hialuronidasa |
KR20230064559A (ko) * | 2021-10-29 | 2023-05-10 | (주)알테오젠 | 인간 히알루로니다제 ph20과 약물을 포함하는 약학 조성물 |
WO2023168305A1 (en) | 2022-03-01 | 2023-09-07 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
WO2023169986A1 (en) * | 2022-03-07 | 2023-09-14 | Mabxience Research, S.L. | Stable formulations for antibodies |
WO2023204554A1 (ko) * | 2022-04-20 | 2023-10-26 | 주식회사 알토스바이오로직스 | 오크렐리주맙을 포함하는 약학적 조성물과 그의 용도 |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2023249408A1 (ko) * | 2022-06-22 | 2023-12-28 | (주)알테오젠 | N-말단 및/또는 c-말단이 절단된 가용성 ph20 폴리펩티드 및 이의 용도 |
WO2024005502A1 (ko) * | 2022-06-29 | 2024-01-04 | 주식회사 오디스젠 | 중성 ph에서 활성을 나타내는 히알루로니다제 hyal1 변이체 |
KR20240038901A (ko) * | 2022-09-16 | 2024-03-26 | (주)피앤피바이오팜 | 신규한 히알루로니다제 ph-20 변이체 및 그 용도 |
WO2024117476A1 (ko) * | 2022-11-28 | 2024-06-06 | 주식회사 대웅제약 | 생체이용률이 개선된 니클로사마이드 함유 조성물 |
KR102554775B1 (ko) * | 2023-02-07 | 2023-07-12 | 한국코러스 주식회사 | 히알루로니다제의 안정화제 및 이를 포함하는 히알루로니다제 제형 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2335005T5 (es) * | 2003-03-05 | 2013-04-17 | Halozyme, Inc. | Glicoproteína hialuronidasa soluble (shasegp), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden |
US20070166788A1 (en) * | 2005-11-10 | 2007-07-19 | Pei Jin | Methods for production of receptor and ligand isoforms |
TWI489994B (zh) * | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
CA2721229C (en) * | 2008-04-14 | 2022-08-23 | Halozyme, Inc. | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
EA022752B1 (ru) * | 2008-12-09 | 2016-02-29 | Галозим, Инк. | Длинные растворимые полипептиды рн20 и их использование |
US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
DK3130347T3 (da) * | 2011-12-30 | 2019-10-14 | Halozyme Inc | PH20-polypeptidvarianter, formuleringer og anvendelser deraf |
TW201534726A (zh) * | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
JP6537076B2 (ja) * | 2014-07-31 | 2019-07-03 | 国立大学法人神戸大学 | 分泌シグナルペプチドならびにそれを利用したタンパク質の分泌および細胞表層提示 |
HUE043847T2 (hu) * | 2014-08-28 | 2019-09-30 | Halozyme Inc | Hialuronán-lebontó enzimmel és egy immun checkpoint inhibitorral végzett kombinációs terápia |
US11660354B2 (en) * | 2016-11-30 | 2023-05-30 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
EP3589661B1 (en) * | 2017-03-02 | 2023-11-01 | Genentech, Inc. | Adjuvant treatment of her2-positive breast cancer |
JOP20190260A1 (ar) * | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
WO2020022791A1 (ko) * | 2018-07-25 | 2020-01-30 | (주)알테오젠 | 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물 |
-
2020
- 2020-03-24 CN CN202080003052.8A patent/CN112203642A/zh active Pending
- 2020-03-24 KR KR1020207030248A patent/KR102650991B1/ko active IP Right Grant
- 2020-03-24 CA CA3131052A patent/CA3131052A1/en active Pending
- 2020-03-24 KR KR1020237007559A patent/KR20230037691A/ko active Search and Examination
- 2020-03-24 SG SG11202110512WA patent/SG11202110512WA/en unknown
- 2020-03-24 AU AU2020248612A patent/AU2020248612B9/en active Active
- 2020-03-24 JP JP2020569741A patent/JP7295150B2/ja active Active
- 2020-03-24 CN CN202310416462.0A patent/CN116870164B/zh active Active
- 2020-03-24 CR CR20210489A patent/CR20210489A/es unknown
- 2020-03-24 JO JOP/2021/0262A patent/JOP20210262A1/ar unknown
- 2020-03-24 KR KR1020227016935A patent/KR102507853B1/ko active IP Right Grant
- 2020-03-24 CN CN202310758097.1A patent/CN117100867A/zh active Pending
- 2020-03-24 EP EP20776465.5A patent/EP3785701A4/en active Pending
- 2020-03-24 PE PE2021001563A patent/PE20220283A1/es unknown
- 2020-03-24 WO PCT/KR2020/003975 patent/WO2020197230A1/ko active Application Filing
- 2020-03-24 EA EA202192588A patent/EA202192588A1/ru unknown
- 2020-03-24 US US17/052,952 patent/US20210363270A1/en active Pending
- 2020-03-24 BR BR112021019076A patent/BR112021019076A2/pt unknown
- 2020-03-24 MX MX2021011278A patent/MX2021011278A/es unknown
-
2021
- 2021-09-19 IL IL286539A patent/IL286539A/en unknown
- 2021-09-22 EC ECSENADI202170640A patent/ECSP21070640A/es unknown
- 2021-09-22 NI NI202100085A patent/NI202100085A/es unknown
- 2021-09-22 DO DO2021000197A patent/DOP2021000197A/es unknown
- 2021-09-22 CO CONC2021/0012380A patent/CO2021012380A2/es unknown
- 2021-09-22 CL CL2021002464A patent/CL2021002464A1/es unknown
- 2021-09-24 SA SA521430398A patent/SA521430398B1/ar unknown
- 2021-10-20 ZA ZA2021/08027A patent/ZA202108027B/en unknown
-
2022
- 2022-04-18 JP JP2022068166A patent/JP7166478B2/ja active Active
- 2022-05-13 US US17/744,575 patent/US20220289864A1/en active Pending
- 2022-08-22 ZA ZA2022/09369A patent/ZA202209369B/en unknown
-
2023
- 2023-02-24 JP JP2023026863A patent/JP2023078146A/ja active Pending
-
2024
- 2024-02-23 AU AU2024201238A patent/AU2024201238A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL286539A (en) | A pharmaceutical preparation containing human hyaluronidase ph20 variant and a drug for subcutaneous administration | |
EP3819004A4 (en) | AGENT INJECTION TIP, HANDPIECE AND SKIN TREATMENT DEVICE | |
IL279040A (en) | Pharmaceutical combination, the composition and preparation of a combination containing a glucokinase activator and a biguanide drug for hypoglycemia, a method of their preparation and use | |
MY189466A (en) | Methods of modulating drug plasma levels using erythrohydroxybupropion | |
EP3941399A4 (en) | IMPLANTABLE OCULAR MEDICATION DELIVERY DEVICES AND METHODS | |
IL275220A (en) | Oral administration of active drug substances | |
WO2015165413A8 (zh) | 一种新型的稳定型抗体药物耦联物及其制备方法和用途 | |
PH12018502738A1 (en) | Compositions, devices, and methods for the treatment of alcohol use disorder | |
MX2021010041A (es) | Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt. | |
EP3858846A4 (en) | NUCLEIC ACID NANO-CARRIER MEDICINE, METHOD FOR PREPARING IT, PHARMACEUTICAL COMPOSITION THEREOF, AND CORRESPONDING USE | |
EP3962661A4 (en) | NASAL MEDICATION DELIVERY DEVICES AND METHODS | |
KR102079818B9 (ko) | 레이저를 이용한 피부의 약물 주입방법과 약물 주입기 | |
EP4173657A4 (en) | NEEDLELESS SYRINGE | |
EP3982942A4 (en) | DRUG DELIVERY METHODS AND COMPOSITIONS | |
EP4082589A4 (en) | WIRE RELEASE DEVICE AND MEDICAL FLUID INJECTION DEVICE | |
EP3995165A4 (en) | DRUG INJECTION CARTRIDGE AND DRUG INJECTOR CONTAINING THEM | |
EP4059567A4 (en) | O-GLCNACYLATED PROTEIN SUBSTANCE AND THERAPEUTIC DRUG AGAINST FIBROSIS CONTAINING SAME | |
MX2020008129A (es) | Composicion farmaceutica que comprende un derivado acilado de un analogo de insulina humana y metodo de preparacion de la misma. | |
IL313742A (en) | A system for administering drugs and methods for using it | |
GB2608691B (en) | Drug Injection Device | |
IL282842A (en) | Medicinal compounds for subcutaneous control | |
IL291283A (en) | Formulations for drug delivery | |
EP4045087A4 (en) | POLYMER DRUG DELIVERY CONJUGATES AND METHODS OF MANUFACTURE AND USE THEREOF | |
EP3795170C0 (en) | PHARMACEUTICAL COMPOSITION COMPRISING CCN5 USED AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF RETINAL DISEASE | |
EP3530269A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF DIABETES AND / OR HYPERLIPIDEMIA COMPRISING MIDORINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT |