SG11202105163UA - Agent for inhibiting iron uptake into cells - Google Patents

Agent for inhibiting iron uptake into cells

Info

Publication number
SG11202105163UA
SG11202105163UA SG11202105163UA SG11202105163UA SG11202105163UA SG 11202105163U A SG11202105163U A SG 11202105163UA SG 11202105163U A SG11202105163U A SG 11202105163UA SG 11202105163U A SG11202105163U A SG 11202105163UA SG 11202105163U A SG11202105163U A SG 11202105163UA
Authority
SG
Singapore
Prior art keywords
cells
agent
iron uptake
inhibiting iron
inhibiting
Prior art date
Application number
SG11202105163UA
Other languages
English (en)
Inventor
Lilin Zhang
Fumiko Nomura
Keiko Katsumi
Romi KOTAKA
Yuta OHIRA
Original Assignee
Perseus Proteomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseus Proteomics Inc filed Critical Perseus Proteomics Inc
Publication of SG11202105163UA publication Critical patent/SG11202105163UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202105163UA 2018-11-20 2019-11-19 Agent for inhibiting iron uptake into cells SG11202105163UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018217548 2018-11-20
JP2019167013 2019-09-13
PCT/JP2019/045227 WO2020105621A1 (ja) 2018-11-20 2019-11-19 細胞内への鉄の取り込み阻害剤

Publications (1)

Publication Number Publication Date
SG11202105163UA true SG11202105163UA (en) 2021-06-29

Family

ID=70774551

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105163UA SG11202105163UA (en) 2018-11-20 2019-11-19 Agent for inhibiting iron uptake into cells

Country Status (12)

Country Link
US (1) US20220332838A1 (es)
EP (1) EP3884959A4 (es)
JP (1) JP7410051B2 (es)
KR (1) KR20210093974A (es)
CN (1) CN113164594A (es)
AU (1) AU2019384781A1 (es)
BR (1) BR112021009768A2 (es)
CA (1) CA3120548A1 (es)
MX (1) MX2021005913A (es)
SG (1) SG11202105163UA (es)
WO (1) WO2020105621A1 (es)
ZA (1) ZA202103554B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116472282A (zh) 2020-10-08 2023-07-21 国立大学法人东海国立大学机构 抗转铁蛋白受体抗体的药效或感受性的判定方法
EP4393509A1 (en) 2021-08-26 2024-07-03 Perseus Proteomics Inc. Reactive oxygen species (ros) production promoter
US20240226314A1 (en) * 2022-12-05 2024-07-11 Sanofi Transferrin receptor binding proteins

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ アンティボディー テクノロジー リミティド 特異的な結合ペアーの構成員の製造方法
US5165424A (en) 1990-08-09 1992-11-24 Silverman Harvey N Method and system for whitening teeth
DE69229477T2 (de) 1991-09-23 1999-12-09 Cambridge Antibody Technology Ltd., Melbourn Methoden zur Herstellung humanisierter Antikörper
ES2313867T3 (es) 1991-12-02 2009-03-16 Medical Research Council Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos.
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
ATE208374T1 (de) 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
WO1993019172A1 (en) 1992-03-24 1993-09-30 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
KR100259828B1 (ko) 1995-09-11 2000-06-15 히라타 다다시 인체 인터루킨 5 수용체 알파-사슬에 대한 항체
PL1740616T3 (pl) 2004-04-30 2012-06-29 Inst Nat Sante Rech Med Przeciwciało przeciwko tfr
CN101245107B (zh) * 2007-02-14 2010-10-13 中国人民解放军军事医学科学院生物工程研究所 抗人转铁蛋白受体人源抗体及其应用
US20100093871A1 (en) * 2007-03-20 2010-04-15 Meiji Seika Kaisha, Ltd. Agent for prevention or treatment of iron overload disorders
ES2426098T3 (es) * 2009-07-16 2013-10-21 Institut National de la Santé et de la Recherche Médicale Composiciones farmacéuticas y su uso en el tratamiento del cáncer
JP5980202B2 (ja) 2011-05-09 2016-08-31 株式会社ペルセウスプロテオミクス トランスフェリン受容体を特異的に認識できる抗体
JP5939855B2 (ja) * 2012-03-23 2016-06-22 国立大学法人 宮崎大学 トランスフェリン受容体抗体
US20150197574A1 (en) * 2012-08-02 2015-07-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Use of transferrin receptor antagonist for the treatment of thalassemia
JP2014093958A (ja) * 2012-11-08 2014-05-22 Univ Of Miyazaki トランスフェリン受容体を特異的に認識できる抗体
PT2918603T (pt) * 2012-11-08 2018-10-30 Univ Miyazaki Anticorpo capaz de reconhecer especificamente o receptor da transferrina
WO2016081640A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
MX2018000305A (es) * 2015-06-24 2018-03-14 Japan Chem Res Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefalica.
JP2018024615A (ja) * 2016-08-10 2018-02-15 学校法人 聖マリアンナ医科大学 Htlv−1関連炎症性疾患を治療する医薬組成物

Also Published As

Publication number Publication date
EP3884959A4 (en) 2022-08-10
CN113164594A (zh) 2021-07-23
EP3884959A1 (en) 2021-09-29
AU2019384781A1 (en) 2021-06-10
JPWO2020105621A1 (ja) 2021-10-07
MX2021005913A (es) 2021-06-30
CA3120548A1 (en) 2020-05-28
BR112021009768A2 (pt) 2021-10-19
US20220332838A1 (en) 2022-10-20
WO2020105621A1 (ja) 2020-05-28
KR20210093974A (ko) 2021-07-28
ZA202103554B (en) 2023-01-25
JP7410051B2 (ja) 2024-01-09

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