SG11202104080UA - Novel urea 6,7-dihydro-4h-pyrazolo[4,3-c]pyridines active against the hepatitis b virus (hbv) - Google Patents
Novel urea 6,7-dihydro-4h-pyrazolo[4,3-c]pyridines active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202104080UA SG11202104080UA SG11202104080UA SG11202104080UA SG11202104080UA SG 11202104080U A SG11202104080U A SG 11202104080UA SG 11202104080U A SG11202104080U A SG 11202104080UA SG 11202104080U A SG11202104080U A SG 11202104080UA SG 11202104080U A SG11202104080U A SG 11202104080UA
- Authority
- SG
- Singapore
- Prior art keywords
- hbv
- pyrazolo
- pyridines
- hepatitis
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18000874 | 2018-11-02 | ||
| PCT/EP2019/079958 WO2020089452A1 (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[4,3-c]pyridines active against the hepatitis b virus (hbv) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104080UA true SG11202104080UA (en) | 2021-05-28 |
Family
ID=64362284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104080UA SG11202104080UA (en) | 2018-11-02 | 2019-11-01 | Novel urea 6,7-dihydro-4h-pyrazolo[4,3-c]pyridines active against the hepatitis b virus (hbv) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220009922A1 (ko) |
| EP (1) | EP3873899A1 (ko) |
| JP (1) | JP2022512873A (ko) |
| KR (1) | KR20210098984A (ko) |
| CN (1) | CN112969702A (ko) |
| AR (1) | AR116946A1 (ko) |
| AU (1) | AU2019373677B2 (ko) |
| CA (1) | CA3118379A1 (ko) |
| EA (1) | EA202191220A1 (ko) |
| IL (1) | IL282687A (ko) |
| SG (1) | SG11202104080UA (ko) |
| TW (1) | TW202031655A (ko) |
| UY (1) | UY38439A (ko) |
| WO (1) | WO2020089452A1 (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY38437A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
| AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
| AU768560B2 (en) | 1999-04-23 | 2003-12-18 | Extenday Ip Limited | Sheet fastening and anchoring component |
| AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
| MXPA05000947A (es) | 2002-07-25 | 2005-05-16 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
| WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
| EP3085368A1 (en) | 2011-07-01 | 2016-10-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| US8629274B2 (en) | 2011-12-21 | 2014-01-14 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| EP2800742B1 (en) | 2012-01-06 | 2016-04-06 | Janssen Sciences Ireland UC | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
| BR112015004161B8 (pt) | 2012-08-28 | 2022-11-08 | Janssen Sciences Ireland Uc | Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende |
| UY34993A (es) | 2012-08-28 | 2014-02-28 | Janssen R & D Ireland | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b |
| US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| LT2997019T (lt) | 2013-05-17 | 2018-11-26 | Janssen Sciences Ireland Uc | Sulfamoiltiofenamido dariniai ir jų panaudojimas kaip vaistų hepatito b gydymui |
| JP6533217B2 (ja) | 2013-05-17 | 2019-06-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂ型肝炎ウイルス感染症の治療および予防のための６−架橋ヘテロアリールジヒドロピリミジン類 |
| SG11201600522UA (en) | 2013-07-25 | 2016-02-26 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| CA2927560A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
| KR20160127714A (ko) | 2013-11-14 | 2016-11-04 | 노비라 테라퓨틱스, 인코포레이티드 | 아제판 유도체 및 b형 간염 감염의 치료 방법 |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| WO2015133428A1 (ja) | 2014-03-06 | 2015-09-11 | 株式会社テイエルブイ | 蒸気システム |
| HUE041734T2 (hu) | 2014-03-07 | 2019-05-28 | Hoffmann La Roche | Új, 6-tagú gyûrûvel kondenzált heteroarildihidropirimidinek hepatitisz B vírusfertõzés kezelésére és megelõzésére |
| US10183936B2 (en) | 2014-03-13 | 2019-01-22 | Indiana University Research And Technology Corporation | Hepatitis B core protein allosteric modulators |
| KR20160133563A (ko) | 2014-03-28 | 2016-11-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
| AU2015255656A1 (en) | 2014-05-09 | 2016-11-10 | Assembly Biosciences, Inc. | Methods and compositions for treating hepatitis B virus infections |
| RU2664329C1 (ru) | 2014-08-14 | 2018-08-16 | Ф. Хоффманн-Ля Рош Аг | Новые пиридазоны и триазиноны для лечения и профилактики заражения вирусом гепатита b |
| AU2015358561A1 (en) | 2014-12-02 | 2017-06-08 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for HBV treatment |
| KR20170118706A (ko) | 2014-12-30 | 2017-10-25 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염 감염을 치료하는 유도체 및 그 방법 |
| MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
| KR102139708B1 (ko) | 2015-03-16 | 2020-07-31 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EP3292120B1 (en) | 2015-05-04 | 2019-06-19 | H. Hoffnabb-La Roche Ag | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017013046A1 (en) | 2015-07-21 | 2017-01-26 | F. Hoffmann-La Roche Ag | Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
| WO2017015451A1 (en) | 2015-07-22 | 2017-01-26 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| TWI721016B (zh) | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| AR106192A1 (es) | 2015-09-29 | 2017-12-20 | Novira Therapeutics Inc | Formas cristalinas de un agente antiviral contra la hepatitis b |
| US10787462B2 (en) * | 2015-10-23 | 2020-09-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3372606B1 (en) | 2015-11-04 | 2020-04-08 | Qilu Pharmaceutical Co., Ltd | Crystal form, preparation method and intermediate of dihydropyrido ring compound |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| EP3426245B1 (en) | 2016-03-07 | 2022-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017198744A1 (en) | 2016-05-20 | 2017-11-23 | F. Hoffmann-La Roche Ag | Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases |
| EP3478692B1 (en) * | 2016-06-29 | 2020-06-17 | Novira Therapeutics Inc. | Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections |
| CN114057739A (zh) * | 2016-06-29 | 2022-02-18 | 诺维拉治疗公司 | 二氮杂酮衍生物及其在治疗乙型肝炎感染中的用途 |
| WO2018011160A1 (en) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
| JP7051804B2 (ja) | 2016-07-14 | 2022-04-11 | エフ．ホフマン－ラ ロシュ アーゲー | 感染症の治療のための６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物と６，７－ジヒドロ－４Ｈ－トリアゾロ［１，５－ａ］ピラジン化合物 |
| JP7034133B2 (ja) | 2016-07-14 | 2022-03-11 | エフ．ホフマン－ラ ロシュ アーゲー | 感染性疾患の処置のためのカルボキシ ６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3036245C (en) | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
| SG11201908012SA (en) | 2017-03-02 | 2019-09-27 | Assembly Biosciences Inc | Cyclic sulfamide compounds and methods of using same |
| AU2018238138A1 (en) | 2017-03-21 | 2019-10-17 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
-
2019
- 2019-10-31 AR ARP190103178A patent/AR116946A1/es unknown
- 2019-10-31 UY UY0001038439A patent/UY38439A/es unknown
- 2019-11-01 US US17/290,354 patent/US20220009922A1/en active Pending
- 2019-11-01 SG SG11202104080UA patent/SG11202104080UA/en unknown
- 2019-11-01 TW TW108139835A patent/TW202031655A/zh unknown
- 2019-11-01 EP EP19801503.4A patent/EP3873899A1/en not_active Withdrawn
- 2019-11-01 KR KR1020217016295A patent/KR20210098984A/ko not_active Application Discontinuation
- 2019-11-01 EA EA202191220A patent/EA202191220A1/ru unknown
- 2019-11-01 WO PCT/EP2019/079958 patent/WO2020089452A1/en unknown
- 2019-11-01 JP JP2021523661A patent/JP2022512873A/ja active Pending
- 2019-11-01 AU AU2019373677A patent/AU2019373677B2/en not_active Expired - Fee Related
- 2019-11-01 CA CA3118379A patent/CA3118379A1/en not_active Abandoned
- 2019-11-01 CN CN201980072932.8A patent/CN112969702A/zh active Pending
-
2021
- 2021-04-27 IL IL282687A patent/IL282687A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019373677B2 (en) | 2022-03-31 |
| UY38439A (es) | 2020-05-29 |
| CN112969702A (zh) | 2021-06-15 |
| US20220009922A1 (en) | 2022-01-13 |
| EP3873899A1 (en) | 2021-09-08 |
| TW202031655A (zh) | 2020-09-01 |
| EA202191220A1 (ru) | 2021-07-29 |
| JP2022512873A (ja) | 2022-02-07 |
| KR20210098984A (ko) | 2021-08-11 |
| CA3118379A1 (en) | 2020-05-07 |
| AU2019373677A1 (en) | 2021-05-27 |
| AR116946A1 (es) | 2021-06-30 |
| IL282687A (en) | 2021-06-30 |
| WO2020089452A1 (en) | 2020-05-07 |
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