SG11202102489XA - Functionalized well plate, methods of preparation and use thereof - Google Patents

Functionalized well plate, methods of preparation and use thereof

Info

Publication number
SG11202102489XA
SG11202102489XA SG11202102489XA SG11202102489XA SG11202102489XA SG 11202102489X A SG11202102489X A SG 11202102489XA SG 11202102489X A SG11202102489X A SG 11202102489XA SG 11202102489X A SG11202102489X A SG 11202102489XA SG 11202102489X A SG11202102489X A SG 11202102489XA
Authority
SG
Singapore
Prior art keywords
preparation
methods
well plate
functionalized well
functionalized
Prior art date
Application number
SG11202102489XA
Other languages
English (en)
Inventor
Peter Beemiller
Alexander Mastroianni
Randall Lowe
Yelena Bronevetsky
Original Assignee
Berkeley Lights Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berkeley Lights Inc filed Critical Berkeley Lights Inc
Publication of SG11202102489XA publication Critical patent/SG11202102489XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11202102489XA 2018-09-21 2019-09-20 Functionalized well plate, methods of preparation and use thereof SG11202102489XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862734924P 2018-09-21 2018-09-21
US201962893712P 2019-08-29 2019-08-29
PCT/US2019/052228 WO2020061499A1 (en) 2018-09-21 2019-09-20 Functionalized well plate, methods of preparation and use thereof

Publications (1)

Publication Number Publication Date
SG11202102489XA true SG11202102489XA (en) 2021-04-29

Family

ID=69888950

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202102489XA SG11202102489XA (en) 2018-09-21 2019-09-20 Functionalized well plate, methods of preparation and use thereof

Country Status (11)

Country Link
US (1) US11993766B2 (ja)
EP (1) EP3853352A4 (ja)
JP (1) JP2022502017A (ja)
KR (1) KR20210063362A (ja)
CN (1) CN112996905A (ja)
AU (1) AU2019343994A1 (ja)
CA (1) CA3112813A1 (ja)
IL (1) IL281640A (ja)
SG (1) SG11202102489XA (ja)
TW (1) TW202027761A (ja)
WO (1) WO2020061499A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200026878A (ko) 2017-06-06 2020-03-11 지머젠 인코포레이티드 균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼
US11028401B2 (en) 2018-06-06 2021-06-08 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
EP4277974A1 (en) * 2021-01-12 2023-11-22 Berkeley Lights, Inc. Systems, apparatuses, and methods for cellular therapeutics manufacture
WO2023161961A1 (en) * 2022-02-24 2023-08-31 Lymphon Biologics Pvt. Ltd. A system and method for t cell activation and immunomodulation

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
JP2618497B2 (ja) 1989-10-03 1997-06-11 鐘淵化学工業株式会社 腫瘍障害細胞誘導剤および腫瘍障害細胞誘導デバイス
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
ATE240119T1 (de) 1995-03-08 2003-05-15 Scripps Research Inst Antigen präsentierendes system und aktivierung von t-zellen
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
AU4328801A (en) 2000-02-24 2001-09-03 Xcyte Therapies Inc Simultaneous stimulation and concentration of cells
JP2004511753A (ja) 2000-05-04 2004-04-15 イエール　ユニバーシティー タンパク質活性のスクリーニング用タンパク質チップ
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
ITTO20010411A1 (it) 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
WO2003067210A2 (en) * 2001-07-10 2003-08-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of the multiple proteins in single cells
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6984485B2 (en) 2002-04-23 2006-01-10 Beckman Coulter, Inc. Polymer-coated substrates for immobilization of biomolecules and cells
US7507579B2 (en) 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
EP1551449B1 (en) 2002-07-12 2010-10-06 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
WO2004017042A2 (en) * 2002-08-16 2004-02-26 Zyomyx, Inc. Methods and reagents for surface functionalization
US7790443B2 (en) 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
WO2004065618A2 (en) 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
US20050274456A1 (en) 2003-02-03 2005-12-15 Roitman Daniel B Fluid-channel device with covalently bound hard and soft structural components
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
US20060240548A1 (en) 2003-06-26 2006-10-26 Mordechai Deutsch Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof
US20050164402A1 (en) 2003-07-14 2005-07-28 Belisle Christopher M. Sample presentation device
JP4328168B2 (ja) 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
WO2005072399A2 (en) 2004-01-29 2005-08-11 Massachusetts Institute Of Technology Microscale sorting cytometer
WO2005080606A1 (en) 2004-02-18 2005-09-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
WO2005100541A2 (en) 2004-04-12 2005-10-27 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
FR2872912B1 (fr) 2004-07-09 2007-03-02 Centre Nat Rech Scient Cnrse Nouveau systeme microfluidique et procede de capture de cellules
WO2006011378A1 (ja) 2004-07-27 2006-02-02 Nsk Ltd. ステアリングコラム装置
US20060091015A1 (en) 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
EP1814580B1 (en) 2004-11-24 2016-08-10 Fred Hutchinson Cancer Research Center Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
TWI265864B (en) 2005-05-20 2006-11-11 Univ Nat Cheng Kung Hydrophilic surface structure of non-hydrophilic substrate and fabricating method for the same
ES2865180T3 (es) 2005-07-07 2021-10-15 Univ California Aparato para formación de cultivo celular
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
WO2007108205A1 (ja) 2006-03-17 2007-09-27 Sanyo Chemical Industries, Ltd. 細胞培養用担体
US8137626B2 (en) 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
EP2027257A4 (en) 2006-05-24 2010-10-20 Agency Science Tech & Res BIOACTIVE SURFACE FOR HEPATOCYTE-BASED APPLICATIONS
CN101529251B (zh) 2006-11-01 2014-04-02 贝克曼考尔特公司 用于亲合分析的结合性表面
US20080153134A1 (en) 2006-12-22 2008-06-26 Willy Wiyatno Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
WO2008121375A2 (en) * 2007-03-29 2008-10-09 Pacific Biosciences Of California, Inc. Modified surfaces for immobilization of active molecules
ATE554859T1 (de) 2007-05-24 2012-05-15 Univ California Integrierte fluidische vorrichtungen mit magnetischer sortierung
WO2009045308A2 (en) 2007-10-03 2009-04-09 Fred Hutchinson Cancer Research Center Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression
JP5404638B2 (ja) 2007-11-07 2014-02-05 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア マイクロ流体デバイスおよびその使用方法
EP2279238A2 (en) 2008-04-21 2011-02-02 Cell Kinetics, Ltd. Flat cell carriers with cell traps
CN101275114A (zh) 2008-04-22 2008-10-01 北京大学 一种微流细胞培养阵列及其应用
KR100991752B1 (ko) 2008-07-15 2010-11-03 한국과학기술원 단일 평면 광전자 소자를 이용한 미세입자 구동장치 및구동방법
GB2464300A (en) 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
EP2414539B1 (en) 2009-04-03 2020-12-16 The Regents of The University of California Apparatus and method for sorting cells and other biological particulates
US20100273681A1 (en) 2009-04-27 2010-10-28 Wisconsin Alumni Research Foundation Combinatorial chemistry reaction cell with optical tweezers
GB0909923D0 (en) 2009-06-09 2009-07-22 Oxford Gene Tech Ip Ltd Picowell capture devices for analysing single cells or other particles
US20130146459A1 (en) 2009-06-16 2013-06-13 Massachusetts Institute Of Technology Multiphase non-linear electrokinetic devices
JP2011000079A (ja) 2009-06-19 2011-01-06 Univ Of Tokyo 粒子を操作する方法及びマイクロ流体装置
US20110186165A1 (en) 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US8651158B2 (en) 2009-11-17 2014-02-18 The United States Of America, As Represented By The Secretary Of The Navy Processing microtitre plates for covalent immobilization chemistries
CN103180730B (zh) 2010-05-14 2016-03-02 综合医院公司 鉴定肿瘤特异性新抗原的组合物和方法
WO2011149032A1 (ja) 2010-05-26 2011-12-01 東ソー株式会社 生体試料固定装置
TW201144805A (en) 2010-06-08 2011-12-16 Academia Sinica Microfluidic device
CN101947124B (zh) 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US20130115606A1 (en) 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
WO2012037030A2 (en) 2010-09-14 2012-03-22 The Regents Of The University Of California Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices
US9511151B2 (en) * 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US8581167B2 (en) 2010-11-16 2013-11-12 Palo Alto Research Center Incorporated Optically patterned virtual electrodes and interconnects on polymer and semiconductive substrates
US9891157B2 (en) 2010-12-03 2018-02-13 Cellply S.R.L. Microanalysis of cellular function
US10571475B2 (en) 2010-12-03 2020-02-25 Cellply S.R.L. Rapid screening of monoclonal antibodies
CN103889556A (zh) 2011-01-06 2014-06-25 Gpb科学有限责任公司 在引入亲和性和大小两者的微流体芯片上的循环肿瘤细胞捕获
WO2012109068A2 (en) 2011-02-11 2012-08-16 Corning Incorporated Enzyme cleavable cell release polymeric surface
TWI438273B (zh) 2011-03-08 2014-05-21 Univ Chang Gung High-throughput perfusative microfluidic cell culture wafers for miniaturized three-dimensional cell culture
US9902990B2 (en) 2011-05-27 2018-02-27 The University Of British Columbia Microfluidic cell trap and assay apparatus for high-throughput analysis
US9227200B2 (en) 2011-06-03 2016-01-05 The Regents Of The University Of California Microfluidic devices with flexible optically transparent electrodes
ES2797448T3 (es) 2011-08-01 2020-12-02 Bio Rad Laboratories Sistema de captura de células
US9050593B2 (en) 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
US10626435B2 (en) 2012-03-28 2020-04-21 Northeastern University Nanofluidic device for isolating, growing, and characterizing microbial cells
TWI512383B (zh) 2012-07-04 2015-12-11 Ind Tech Res Inst 光學感應式介電泳裝置
US9702873B2 (en) 2012-08-13 2017-07-11 Uvic Industry Partnerships Inc. System for trapping, interacting and modifying single protein molecules using a double-nanohole structure
US9857333B2 (en) 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
US9453838B2 (en) 2013-03-12 2016-09-27 Asociación Centro de Investigación Cooperative en Biomateriales Methods for making microarrays and their uses
JP6524055B2 (ja) 2013-03-15 2019-06-05 ラッシュ・ユニバーシティ・メディカル・センター 有足突起培養物およびその使用
AU2014245806B2 (en) 2013-03-28 2019-10-31 The University Of British Columbia Microfluidic devices and methods for use thereof in multicellular assays of secretion
IL283153B2 (en) 2013-10-22 2023-04-01 Berkeley Lights Inc Microfluidic devices with isolation pens and methods for testing microbiological items using them
SG11201602336UA (en) 2013-10-22 2016-05-30 Berkeley Lights Inc Micro-fluidic devices for assaying biological activity
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
SI3134095T1 (sl) 2014-04-25 2020-08-31 Bluebird Bio, Inc. Izboljšani postopki za izdelavo adoptivnih celičnih terapij
WO2016094308A1 (en) 2014-12-08 2016-06-16 Berkeley Lights, Inc. Microfluidic device comprising lateral/vertical transistor structures and process of making and using same
WO2016094715A2 (en) 2014-12-10 2016-06-16 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
CN116869964A (zh) * 2014-12-24 2023-10-13 耐克西缪恩有限公司 用于免疫疗法的纳米颗粒组合物和方法
CA3176115A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Microfluidic device for culturing biological cells and methods of use thereof
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
CN108698814A (zh) 2015-12-30 2018-10-23 伯克利之光生命科技公司 用于光学驱动的对流和移位的微流体设备、试剂盒及其方法
EP3922716A1 (en) 2016-03-17 2021-12-15 Berkeley Lights, Inc. Selection and cloning of t lymphocytes in a microfluidic device
CA3020976A1 (en) 2016-04-15 2017-10-19 Berkeley Lights, Inc. Methods, systems and kits for in-pen assays
CN109070083A (zh) 2016-04-22 2018-12-21 贝克顿迪金森公司 用于阵列产生的高密度沉积
SG11201809539RA (en) 2016-05-26 2018-12-28 Berkeley Lights Inc Covalently modified surfaces, kits, and methods of preparation and use
AU2017298545B2 (en) 2016-07-21 2022-10-27 Berkeley Lights, Inc. Sorting of T lymphocytes in a microfluidic device
AU2018304543A1 (en) 2017-07-21 2020-02-13 Berkeley Lights, Inc. Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated T cells, and uses thereof

Also Published As

Publication number Publication date
TW202027761A (zh) 2020-08-01
WO2020061499A8 (en) 2020-05-07
US11993766B2 (en) 2024-05-28
US20200123491A1 (en) 2020-04-23
EP3853352A1 (en) 2021-07-28
AU2019343994A1 (en) 2021-05-13
CN112996905A (zh) 2021-06-18
EP3853352A4 (en) 2022-08-10
JP2022502017A (ja) 2022-01-11
CA3112813A1 (en) 2020-03-26
IL281640A (en) 2021-05-31
WO2020061499A1 (en) 2020-03-26
KR20210063362A (ko) 2021-06-01

Similar Documents

Publication Publication Date Title
IL281640A (en) Transformed multi-well plates, methods of their production and their uses
IL263274A (en) Covalently adapted surfaces, kits and methods for their production and uses
IL266560A (en) Endophytes, related preparations and methods of using them
IL280963A (en) Anti-5gdf1 antibodies, compounds and methods of use
IL261289A (en) Active compression device, methods of installing it and methods of using it
EP3384077A4 (en) FUNCTIONALIZED SURFACES AND THEIR PREPARATION
EP3313404A4 (en) THERAPEUTIC COMPOSITIONS, ASSOCIATIONS AND METHODS OF USE
WO2017059196A3 (en) Antagonistic antibodies specifically binding human cd40 and methods of use
EP3161124A4 (en) Endophytes, associated compositions, and methods of use thereof
HUE053950T2 (hu) Vízoldható film, a filmet tartalmazó felhasználó csomagok és azok elõállítására és alkalmazására vonatkozó eljárások
HK1259372A1 (zh) 治療化合物、其組合物及使用方法
HUE059621T2 (hu) Vízoldható film, a filmet hasznosító csomagolások, és eljárások ezek elõállítására és használatára
IL280809B (en) New preparations, their use and methods of their creation
EP3094606A4 (en) Cement compositions, structures, and methods of use
EP3617218A4 (en) DIHYDROARTEMISININ STEROID CONJUGATE AND METHOD OF MANUFACTURING AND USES THEREOF
EP3411128A4 (en) CONTINUOUS ROTARY PLATE FILTER AND METHODS OF USE
GB201706325D0 (en) STA-19 Anew member of the GME family of molecular sieve zeotypes, methods of preparation and use
SG11202106282RA (en) Biochip, method of preparation and use thereof
EP3538250A4 (en) PC STRUCTURES WITH SUPPORTED POLYAMINES AND METHOD FOR PRODUCING THE SUPPORTED POLYAMINS
HK1255559A1 (zh) Mg53突變體及其製備方法和用途
EP3491083A4 (en) COMPOSITIONS AND METHODS FOR CREATING FUNCTIONALIZED ROUGH SURFACES AND METHODS FOR CREATING REPULSIVE SURFACES
GB2572610B (en) Composition, methods for its production, and its use
EP3492466A4 (en) ORAL SOLID PREPARATION AND USE THEREOF
SG11202011227VA (en) Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof
EP3723874A4 (en) Dumbbell set