SG11202011776RA - Solubilized apyrases, methods and use - Google Patents

Solubilized apyrases, methods and use

Info

Publication number
SG11202011776RA
SG11202011776RA SG11202011776RA SG11202011776RA SG11202011776RA SG 11202011776R A SG11202011776R A SG 11202011776RA SG 11202011776R A SG11202011776R A SG 11202011776RA SG 11202011776R A SG11202011776R A SG 11202011776RA SG 11202011776R A SG11202011776R A SG 11202011776RA
Authority
SG
Singapore
Prior art keywords
apyrases
solubilized
methods
solubilized apyrases
Prior art date
Application number
SG11202011776RA
Other languages
English (en)
Inventor
Agostino Cirillo
Hilmar Ebersbach
Boerje Haraldsson
Thomas Huber
Guido Junge
Regina Link
Max Warncke
Chao Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11202011776RA publication Critical patent/SG11202011776RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y306/00Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01005Apyrase (3.6.1.5), i.e. ATP diphosphohydrolase
SG11202011776RA 2018-07-18 2019-07-17 Solubilized apyrases, methods and use SG11202011776RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18184269 2018-07-18
PCT/IB2019/056117 WO2020016804A1 (en) 2018-07-18 2019-07-17 Solubilized apyrases, methods and use

Publications (1)

Publication Number Publication Date
SG11202011776RA true SG11202011776RA (en) 2021-02-25

Family

ID=62985993

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011776RA SG11202011776RA (en) 2018-07-18 2019-07-17 Solubilized apyrases, methods and use

Country Status (26)

Country Link
US (1) US20220356455A1 (es)
EP (1) EP3824079A1 (es)
JP (2) JP7425784B2 (es)
KR (1) KR20210035806A (es)
CN (1) CN112424346A (es)
AR (1) AR115790A1 (es)
AU (1) AU2019306821B2 (es)
BR (1) BR112021000586A2 (es)
CA (1) CA3103684A1 (es)
CL (1) CL2021000129A1 (es)
CO (1) CO2021000210A2 (es)
CR (1) CR20210021A (es)
CU (1) CU20210008A7 (es)
EA (1) EA202190057A1 (es)
EC (1) ECSP21002804A (es)
IL (1) IL280191A (es)
JO (1) JOP20210008A1 (es)
MA (1) MA53177A (es)
MX (1) MX2021000542A (es)
PE (1) PE20210185A1 (es)
PH (1) PH12021550122A1 (es)
SG (1) SG11202011776RA (es)
TW (1) TW202016299A (es)
UY (1) UY38299A (es)
WO (1) WO2020016804A1 (es)
ZA (1) ZA202007187B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021243173A1 (en) * 2020-05-28 2021-12-02 Charm Sciences, Inc. Methods and assemblies for sample analysis
TW202404627A (zh) 2022-07-29 2024-02-01 瑞士商諾華公司 使用cd39、重組cd39用於急性器官損傷的治療
WO2024023746A1 (en) 2022-07-29 2024-02-01 Novartis Ag Improved production of cd39 variants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020002277A1 (en) * 1998-10-16 2002-01-03 Maliszewski Charles Richard Inhibitors of platelet activation and recruitment
CA2345382A1 (en) 1998-10-16 2000-04-27 Immunex Corporation Inhibitors of platelet activation and recruitment
US6867177B2 (en) 1999-08-13 2005-03-15 The Trustees Of Columbia University In The City Of New York CD39/ECTO-adpase as a treatment for thrombotic and ischemic disorders
US7247300B1 (en) 2002-11-07 2007-07-24 Apt Therapeutics, Inc. Therapeutic use of soluble CD39L3
CA2578908C (en) 2005-03-17 2020-05-26 Yves Durocher Expression vectors for enhanced transient gene expression and mammalian cells expressing them
US8535662B2 (en) * 2010-01-13 2013-09-17 Apt Therapeutics, Inc. Apyrase therapy for bleeding conditions
US11242551B2 (en) 2013-12-20 2022-02-08 Novartis Ag Eukaryotic cells and methods for recombinantly expressing a product of interest
KR102288857B1 (ko) 2013-12-20 2021-08-11 노파르티스 아게 신규한 진핵 세포 및 관심 생성물의 재조합 발현 방법

Also Published As

Publication number Publication date
CN112424346A (zh) 2021-02-26
TW202016299A (zh) 2020-05-01
CO2021000210A2 (es) 2021-01-18
BR112021000586A2 (pt) 2021-04-06
CL2021000129A1 (es) 2021-08-20
JP7425784B2 (ja) 2024-01-31
UY38299A (es) 2020-02-28
EA202190057A1 (ru) 2021-08-24
CR20210021A (es) 2021-03-23
KR20210035806A (ko) 2021-04-01
EP3824079A1 (en) 2021-05-26
ZA202007187B (en) 2022-06-29
CU20210008A7 (es) 2021-08-06
JP2024023297A (ja) 2024-02-21
CA3103684A1 (en) 2020-01-23
US20220356455A1 (en) 2022-11-10
JOP20210008A1 (ar) 2021-01-12
PH12021550122A1 (en) 2021-09-27
MA53177A (fr) 2021-05-26
JP2021529550A (ja) 2021-11-04
PE20210185A1 (es) 2021-02-02
AR115790A1 (es) 2021-02-24
ECSP21002804A (es) 2021-04-29
MX2021000542A (es) 2021-03-29
AU2019306821A1 (en) 2020-12-24
AU2019306821B2 (en) 2022-09-29
WO2020016804A1 (en) 2020-01-23
IL280191A (en) 2021-03-01

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