SG11202010092XA - Biomarkers for graft-versus-host disease - Google Patents
Biomarkers for graft-versus-host diseaseInfo
- Publication number
- SG11202010092XA SG11202010092XA SG11202010092XA SG11202010092XA SG11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA
- Authority
- SG
- Singapore
- Prior art keywords
- biomarkers
- graft
- versus
- host disease
- host
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862657193P | 2018-04-13 | 2018-04-13 | |
| US201862773308P | 2018-11-30 | 2018-11-30 | |
| PCT/US2019/026884 WO2019200030A1 (fr) | 2018-04-13 | 2019-04-11 | Biomarqueurs pour une maladie du greffon contre l'hôte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202010092XA true SG11202010092XA (en) | 2020-11-27 |
Family
ID=66323933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202010092XA SG11202010092XA (en) | 2018-04-13 | 2019-04-11 | Biomarkers for graft-versus-host disease |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11372003B2 (fr) |
| EP (1) | EP3775923A1 (fr) |
| JP (1) | JP7378420B2 (fr) |
| KR (1) | KR20210018218A (fr) |
| CN (1) | CN112567247A (fr) |
| AU (1) | AU2019252259A1 (fr) |
| CA (1) | CA3097025A1 (fr) |
| IL (1) | IL277955A (fr) |
| MA (1) | MA52208A (fr) |
| MX (1) | MX2020010815A (fr) |
| PH (1) | PH12020551683A1 (fr) |
| SG (1) | SG11202010092XA (fr) |
| TW (1) | TW202012935A (fr) |
| WO (1) | WO2019200030A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015005428A (es) * | 2012-11-01 | 2015-07-21 | Incyte Corp | Derivados triciclicos fusionados de tiofeno como inhibidores de la cinasa janus (jak). |
| CA3091339A1 (fr) | 2018-02-16 | 2019-08-22 | Incyte Corporation | Inhibiteurs de la voie jak1 pour le traitement de troubles lies aux cytokines |
| MA52655A (fr) | 2018-03-30 | 2021-02-17 | Incyte Corp | Biomarqueurs pour maladie cutanée inflammatoire |
| MX2020010815A (es) | 2018-04-13 | 2020-12-11 | Incyte Corp | Biomarcadores para enfermedad de injerto contra hospedero. |
| MX2021004946A (es) | 2018-10-31 | 2021-07-15 | Incyte Corp | Terapia combinada para tratamiento de enfermedades hematológicas. |
| US11406640B2 (en) | 2019-03-05 | 2022-08-09 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
| WO2021072098A1 (fr) * | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarqueurs de la maladie du greffon contre l'hôte |
| US20210123930A1 (en) * | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| CN114829583A (zh) * | 2020-02-25 | 2022-07-29 | 上海大学 | 间充质干细胞在治疗重症covid19肺炎中的用途 |
| EP4259131A1 (fr) | 2020-12-08 | 2023-10-18 | Incyte Corporation | Inhibiteurs de la voie jak1 destinés au traitement du vitiligo |
| KR102378996B1 (ko) * | 2021-01-13 | 2022-03-25 | 단국대학교 천안캠퍼스 산학협력단 | 치수 줄기세포의 치아 분화능을 예측하기 위한 바이오 마커 조성물 |
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| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| WO2002085926A2 (fr) | 2001-04-19 | 2002-10-31 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Procede de production de series d'anticorps stables regenerables |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| US20070149506A1 (en) | 2005-09-22 | 2007-06-28 | Arvanitis Argyrios G | Azepine inhibitors of Janus kinases |
| TWI468162B (zh) | 2005-12-13 | 2015-01-11 | 英塞特公司 | 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶 |
| US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| SG10201509887UA (en) | 2007-06-13 | 2016-01-28 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| MY152948A (en) | 2007-11-16 | 2014-12-15 | Incyte Corp | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| ES2602577T3 (es) | 2008-03-11 | 2017-02-21 | Incyte Holdings Corporation | Derivados de azetidina y ciclobutano como inhibidores de JAK |
| CL2009001884A1 (es) | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| SG176111A1 (en) | 2009-05-22 | 2011-12-29 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| WO2011028685A1 (fr) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Dérivés hétérocycliques de pyrazol-4-yl-pyrrolo[2,3-d] pyrimidines en tant qu'inhibiteurs de janus kinase |
| US8486902B2 (en) | 2009-10-09 | 2013-07-16 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| US8570829B2 (en) | 2009-12-22 | 2013-10-29 | Pgs Geophysical As | Depth steerable seismic source array |
| JP5858434B2 (ja) | 2010-02-18 | 2016-02-10 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｎｕｓキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体 |
| MX347851B (es) | 2010-03-10 | 2017-05-16 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
| EP2574168B9 (fr) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Formulation topique pour inhibiteur de jak |
| US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
| WO2012068450A1 (fr) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Dérivés pyrrolopyridine et pyrrolopyrimidine à substitution cyclobutyle utilisés comme inhibiteurs des jak |
| AU2012219395B2 (en) | 2011-02-18 | 2017-05-25 | Incyte Corporation | mTOR/JAK inhibitor combination therapy |
| CA2839767A1 (fr) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Derives d'azetidinyl-phenyl-, de pyridyl- ou de pyrazinyl-carboxamide en tant qu'inhibiteurs des jak |
| WO2013023119A1 (fr) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Polythérapie par jak p13k/mtor |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US20130115232A1 (en) * | 2011-10-03 | 2013-05-09 | Fred Hutchinson Cancer Research Center | Methods for detecting graft-versus-host disease |
| EP2634185B1 (fr) * | 2012-03-02 | 2016-01-13 | Sareum Limited | Inhibiteurs de la kinase TYK2 |
| US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| US20150197525A1 (en) | 2012-06-15 | 2015-07-16 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
| AU2013302519B2 (en) | 2012-08-17 | 2017-11-02 | Concert Pharmaceuticals, Inc. | Deuterated baricitinib |
| MX2015005428A (es) | 2012-11-01 | 2015-07-21 | Incyte Corp | Derivados triciclicos fusionados de tiofeno como inhibidores de la cinasa janus (jak). |
| BR112015010663B1 (pt) | 2012-11-15 | 2022-12-06 | Incyte Holdings Corporation | Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo |
| CN105189509B (zh) | 2013-03-06 | 2017-12-19 | 因赛特公司 | 用于制备jak抑制剂的方法及中间体 |
| TR201905814T4 (tr) | 2013-05-17 | 2019-05-21 | Incyte Corp | Jak inhibitörü olarak bipirazol tuzu. |
| RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
| TW201529074A (zh) | 2013-08-20 | 2015-08-01 | Incyte Corp | 在ｃ-反應蛋白含量較高之實體腫瘤患者中的存活益處 |
| DK3110409T3 (en) | 2014-02-28 | 2018-10-22 | Incyte Corp | JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES |
| MA39987A (fr) | 2014-04-30 | 2017-03-08 | Incyte Corp | Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées |
| WO2015184305A1 (fr) | 2014-05-30 | 2015-12-03 | Incyte Corporation | Traitement de la leucémie neutrophile chronique (cnl) et de la leucémie myéloïde chronique atypique (acml) par des inhibiteurs de jak1 |
| WO2016085866A1 (fr) | 2014-11-25 | 2016-06-02 | Indiana University Research And Technology Corporation | Biomarqueurs et essai pour détecter la maladie du greffon contre l'hôte chronique |
| MX2018011831A (es) * | 2016-04-04 | 2019-02-13 | Chemocentryx Inc | Antagonistas solubles de receptor de c5aa(c5ar). |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| WO2019152374A1 (fr) | 2018-01-30 | 2019-08-08 | Incyte Corporation | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) |
| CA3091339A1 (fr) | 2018-02-16 | 2019-08-22 | Incyte Corporation | Inhibiteurs de la voie jak1 pour le traitement de troubles lies aux cytokines |
| MX2022012285A (es) | 2018-03-30 | 2023-08-15 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
| MA52655A (fr) | 2018-03-30 | 2021-02-17 | Incyte Corp | Biomarqueurs pour maladie cutanée inflammatoire |
| MX2020010815A (es) | 2018-04-13 | 2020-12-11 | Incyte Corp | Biomarcadores para enfermedad de injerto contra hospedero. |
| MX2021004946A (es) | 2018-10-31 | 2021-07-15 | Incyte Corp | Terapia combinada para tratamiento de enfermedades hematológicas. |
| CA3123596A1 (fr) | 2018-12-19 | 2020-06-25 | Incyte Corporation | Inhibiteurs de la voie jak1 pour le traitement d'une maladie gastro-intestinale |
| US20210123930A1 (en) | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| WO2021072098A1 (fr) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarqueurs de la maladie du greffon contre l'hôte |
-
2019
- 2019-04-11 MX MX2020010815A patent/MX2020010815A/es unknown
- 2019-04-11 WO PCT/US2019/026884 patent/WO2019200030A1/fr unknown
- 2019-04-11 MA MA052208A patent/MA52208A/fr unknown
- 2019-04-11 AU AU2019252259A patent/AU2019252259A1/en active Pending
- 2019-04-11 CN CN201980037746.0A patent/CN112567247A/zh active Pending
- 2019-04-11 SG SG11202010092XA patent/SG11202010092XA/en unknown
- 2019-04-11 JP JP2020555876A patent/JP7378420B2/ja active Active
- 2019-04-11 EP EP19720251.8A patent/EP3775923A1/fr active Pending
- 2019-04-11 KR KR1020207032759A patent/KR20210018218A/ko not_active Application Discontinuation
- 2019-04-11 CA CA3097025A patent/CA3097025A1/fr active Pending
- 2019-04-11 US US16/381,158 patent/US11372003B2/en active Active
- 2019-04-12 TW TW108112848A patent/TW202012935A/zh unknown
-
2020
- 2020-10-12 PH PH12020551683A patent/PH12020551683A1/en unknown
- 2020-10-12 IL IL277955A patent/IL277955A/en unknown
-
2022
- 2022-05-20 US US17/749,376 patent/US20230027606A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202012935A (zh) | 2020-04-01 |
| KR20210018218A (ko) | 2021-02-17 |
| US11372003B2 (en) | 2022-06-28 |
| JP2021521442A (ja) | 2021-08-26 |
| MX2020010815A (es) | 2020-12-11 |
| CN112567247A (zh) | 2021-03-26 |
| US20190331697A1 (en) | 2019-10-31 |
| AU2019252259A1 (en) | 2020-12-03 |
| JP7378420B2 (ja) | 2023-11-13 |
| CA3097025A1 (fr) | 2019-10-17 |
| IL277955A (en) | 2020-11-30 |
| WO2019200030A1 (fr) | 2019-10-17 |
| MA52208A (fr) | 2021-02-17 |
| EP3775923A1 (fr) | 2021-02-17 |
| US20230027606A1 (en) | 2023-01-26 |
| PH12020551683A1 (en) | 2021-08-16 |
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| GB201809858D0 (en) | Biomarkers | |
| GB201809854D0 (en) | Biomarkers | |
| GB201809878D0 (en) | Biomarkers | |
| GB201809869D0 (en) | Biomarkers |