CN114829583A - 间充质干细胞在治疗重症covid19肺炎中的用途 - Google Patents
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Abstract
提供了间充质干细胞在治疗重症COVID19肺炎中的用途。提供了一种ACE2阴性MSCs，向COVID‑19患者静脉注射所述MSCs是安全有效的，尤其是对危重患者。ACE2阴性MSCs可能通过对细胞因子风暴和免疫细胞的直接免疫调节作用发挥积极作用，从而能够保护肝脏与心肌功能。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020101162329 | 2020-02-25 | ||
| CN202010116232 | 2020-02-25 | ||
| PCT/CN2020/086653 WO2021169017A1 (zh) | 2020-02-25 | 2020-04-24 | 间充质干细胞在治疗重症covid19肺炎中的用途 |
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| CN114829583A true CN114829583A (zh) | 2022-07-29 |
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| CN202080079752.5A Pending CN114829583A (zh) | 2020-02-25 | 2020-04-24 | 间充质干细胞在治疗重症covid19肺炎中的用途 |
Country Status (2)
| Country | Link |
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| CN (1) | CN114829583A (zh) |
| WO (1) | WO2021169017A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20210308190A1 (en) * | 2020-04-07 | 2021-10-07 | Miguelangelo J. Perez-Cruet | Human umbilical cord blood mesenchymal stem cell transfusion immunotherapy for treatment of cytokine storm associated with coronavirus infection |
| WO2023063739A1 (ko) * | 2021-10-14 | 2023-04-20 | 재단법인대구경북과학기술원 | Ace2가 부착된 중간엽 줄기세포 유래 세포외소포체 및 이의 용도 |
| CN115089612B (zh) * | 2022-08-22 | 2022-11-22 | 中国药科大学 | 脐带间充质干细胞在预防病毒感染所致肺部疾病中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480410A (zh) * | 2009-02-18 | 2009-07-15 | 南京大学医学院附属鼓楼医院 | 脐带间质干细胞在制备治疗自身免疫性疾病药物中的应用 |
| WO2018074758A2 (ko) * | 2016-10-17 | 2018-04-26 | 사회복지법인 삼성생명공익재단 | 면역질환 치료를 위한 고효능 줄기세포 선별방법 |
| CN110548048A (zh) * | 2019-10-14 | 2019-12-10 | 广州吉帝生物科技有限公司 | 造血干细胞用于制备治疗病毒性疾病的制剂的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2785359T3 (en) * | 2011-11-30 | 2018-10-29 | Astellas Inst For Regenerative Medicine | MESENKYMAL STROMACELLES AND APPLICATIONS RELATED |
| US20200069740A1 (en) * | 2017-03-08 | 2020-03-05 | Rohto Pharmaceutical Co., Ltd. | Ror1-positive mesenchymal stem cell-containing pharmaceutical composition for preventing or treating disease associated with fibrosis, method for preparing same, and method for preventing or treating disease associated with fibrosis using ror1-positive mesenchymal stem cells |
| KR20210018218A (ko) * | 2018-04-13 | 2021-02-17 | 인사이트 코포레이션 | 이식편대숙주질환용 바이오마커 |
| WO2019231266A1 (ko) * | 2018-05-30 | 2019-12-05 | 주식회사 강스템바이오텍 | Hla 유전자가 제거된 인간 유도만능줄기세포 유래 중간엽줄기세포 및 그의 제조 방법 |
| CN110777113B (zh) * | 2019-09-10 | 2021-09-24 | 中山大学 | 一种用于日本血吸虫感染治疗的间质干细胞处理方法 |
-
2020
- 2020-04-24 WO PCT/CN2020/086653 patent/WO2021169017A1/zh active Application Filing
- 2020-04-24 CN CN202080079752.5A patent/CN114829583A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480410A (zh) * | 2009-02-18 | 2009-07-15 | 南京大学医学院附属鼓楼医院 | 脐带间质干细胞在制备治疗自身免疫性疾病药物中的应用 |
| WO2018074758A2 (ko) * | 2016-10-17 | 2018-04-26 | 사회복지법인 삼성생명공익재단 | 면역질환 치료를 위한 고효능 줄기세포 선별방법 |
| CN110548048A (zh) * | 2019-10-14 | 2019-12-10 | 广州吉帝生物科技有限公司 | 造血干细胞用于制备治疗病毒性疾病的制剂的应用 |
Non-Patent Citations (3)
| Title |
|---|
| XINTIAN XU 等: "Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission" * |
| ZIKUAN LENG 等: "Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia" * |
| 刘广洋 等: "间充质干细胞治疗新型冠状病毒肺炎的研究" * |
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| WO2021169017A1 (zh) | 2021-09-02 |
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