SG11202009170UA - Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy - Google Patents
Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapyInfo
- Publication number
- SG11202009170UA SG11202009170UA SG11202009170UA SG11202009170UA SG11202009170UA SG 11202009170U A SG11202009170U A SG 11202009170UA SG 11202009170U A SG11202009170U A SG 11202009170UA SG 11202009170U A SG11202009170U A SG 11202009170UA SG 11202009170U A SG11202009170U A SG 11202009170UA
- Authority
- SG
- Singapore
- Prior art keywords
- immunotherapy
- processes
- production
- same
- tumor infiltrating
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/940,901 US10918666B2 (en) | 2017-03-29 | 2018-03-29 | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| PCT/US2018/040474 WO2019190579A1 (en) | 2018-03-29 | 2018-06-29 | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202009170UA true SG11202009170UA (en) | 2020-10-29 |
Family
ID=63013105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202009170UA SG11202009170UA (en) | 2018-03-29 | 2018-06-29 | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP4386080A2 (pt) |
| KR (1) | KR20200138329A (pt) |
| CN (1) | CN112513254A (pt) |
| AU (1) | AU2018415814A1 (pt) |
| BR (1) | BR112020019496A2 (pt) |
| CA (1) | CA3094957A1 (pt) |
| DK (1) | DK3775165T3 (pt) |
| EA (1) | EA202092319A1 (pt) |
| ES (1) | ES2982509T3 (pt) |
| FI (1) | FI3775165T3 (pt) |
| HR (1) | HRP20240850T1 (pt) |
| IL (1) | IL277592A (pt) |
| LT (1) | LT3775165T (pt) |
| MD (1) | MD3775165T2 (pt) |
| MX (1) | MX2020010264A (pt) |
| PL (1) | PL3775165T3 (pt) |
| PT (1) | PT3775165T (pt) |
| RS (1) | RS65674B1 (pt) |
| SG (1) | SG11202009170UA (pt) |
| SI (1) | SI3775165T1 (pt) |
| WO (1) | WO2019190579A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| CA3164986A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| EP4107173A1 (en) * | 2020-02-17 | 2022-12-28 | Board of Regents, The University of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| WO2022111571A1 (zh) | 2020-11-25 | 2022-06-02 | 上海君赛生物科技有限公司 | 肿瘤浸润淋巴细胞培养基及其应用 |
| EP4263808A2 (en) * | 2020-12-18 | 2023-10-25 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
| JP2024500748A (ja) * | 2020-12-18 | 2024-01-10 | インスティル バイオ （ユーケイ） リミテッド | 腫瘍浸潤リンパ球の処理 |
| CN114686430A (zh) * | 2020-12-31 | 2022-07-01 | 上海赛比曼生物科技有限公司 | 一种制备til的方法 |
| JP2024512978A (ja) * | 2021-03-30 | 2024-03-21 | ネオジェント コーポレーション | 免疫細胞組成物を生成するための方法 |
| WO2022263673A1 (en) * | 2021-06-17 | 2022-12-22 | CBio A/S | Multistep process for culturing tumor-infiltrating lymphocytes for therapeutic use |
| WO2023218399A1 (en) * | 2022-05-11 | 2023-11-16 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Method of preparing and expanding a population of immune cells for cancer therapy, potency assay for tumor recognition, biological vaccine preparation and epitope target for antibodies |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US6362325B1 (en) | 1988-11-07 | 2002-03-26 | Advanced Research And Technology Institute, Inc. | Murine 4-1BB gene |
| US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| WO1996032495A1 (en) | 1995-04-08 | 1996-10-17 | Lg Chemicals Ltd. | Monoclonal antibody specific for human 4-1bb and cell line producing same |
| RU2192281C2 (ru) | 1996-10-11 | 2002-11-10 | Бристол-Маерс Сквибб Компани | Способы и композиции для иммуномодуляции |
| ATE537845T1 (de) | 2000-10-31 | 2012-01-15 | Pr Pharmaceuticals Inc | Verfahren zur herstellung von formulierungen zur verbesserten abgabe von bioaktiven molekülen |
| AU2003259294A1 (en) | 2002-07-30 | 2004-02-16 | Bristol-Myers Squibb Company | Humanized antibodies against human 4-1bb |
| CN103173354B (zh) | 2003-10-08 | 2017-07-14 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| CN117534755A (zh) | 2005-05-09 | 2024-02-09 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| EP1894940A1 (en) | 2006-08-28 | 2008-03-05 | Apogenix GmbH | TNF superfamily fusion proteins |
| EP2176288B1 (en) | 2007-07-10 | 2015-11-04 | Apogenix GmbH | Tnf superfamily collectin fusion proteins |
| WO2010003766A2 (en) | 2008-06-17 | 2010-01-14 | Apogenix Gmbh | Multimeric tnf receptors |
| CA3092223C (en) | 2008-07-21 | 2023-01-03 | Apogenix Ag | Tnfsf single chain molecules |
| WO2010042433A1 (en) | 2008-10-06 | 2010-04-15 | Bristol-Myers Squibb Company | Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases |
| US8664366B2 (en) | 2009-01-09 | 2014-03-04 | Apogenix Gmbh | Fusion proteins forming trimers |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| SG181559A1 (en) | 2009-12-08 | 2012-07-30 | Wolf Wilson Mfg Corp | Improved methods of cell culture for adoptive cell therapy |
| US20130115617A1 (en) | 2009-12-08 | 2013-05-09 | John R. Wilson | Methods of cell culture for adoptive cell therapy |
| US8956860B2 (en) | 2009-12-08 | 2015-02-17 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| NZ714128A (en) | 2010-09-09 | 2017-10-27 | Pfizer | 4-1bb binding molecules |
| US8962804B2 (en) | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CA3144697A1 (en) | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| WO2012177788A1 (en) | 2011-06-20 | 2012-12-27 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
| CN102816734A (zh) * | 2012-05-09 | 2012-12-12 | 阮润生 | 一种肿瘤抗原特异性t细胞的获取方法 |
| JP6386447B2 (ja) | 2012-05-18 | 2018-09-05 | ウィルソン ウォルフ マニュファクチャリング コーポレイションＷｉｌｓｏｎ Ｗｏｌｆ Ｍａｎｕｆａｃｔｕｒｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ | 養子細胞療法のための改良された細胞培養法 |
| EP2859093A4 (en) | 2012-06-11 | 2016-08-17 | Wolf Wilson Mfg Corp | IMPROVED METHODS FOR CELL CULTURES FOR ADOPTIVE CELL THERAPIES |
| ES2859678T3 (es) | 2013-03-01 | 2021-10-04 | Us Health | Métodos para producir poblaciones enriquecidas de células T reactivas a tumores a partir de un tumor |
| SG11201510526VA (en) | 2013-06-24 | 2016-01-28 | Wolf Wilson Mfg Corp | Closed system device and methods for gas permeable cell culture process |
| EP3686219A1 (en) | 2014-02-04 | 2020-07-29 | Pfizer Inc | Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer |
| US20170044496A1 (en) * | 2014-04-10 | 2017-02-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy |
| MX2016016251A (es) | 2014-06-11 | 2017-07-11 | Polybiocept Ab | Expansion de linfocitos con composicion de citocinas para inmunoterapia celular activa. |
| FR3040396A1 (fr) * | 2015-06-30 | 2017-03-03 | Chu Nantes | Procede de cryoconservation de lymphocytes infiltrant la tumeur |
| JOP20190224A1 (ar) * | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
-
2018
- 2018-06-29 DK DK18745741.1T patent/DK3775165T3/da active
- 2018-06-29 LT LTEPPCT/US2018/040474T patent/LT3775165T/lt unknown
- 2018-06-29 FI FIEP18745741.1T patent/FI3775165T3/fi active
- 2018-06-29 KR KR1020207031071A patent/KR20200138329A/ko not_active Application Discontinuation
- 2018-06-29 SG SG11202009170UA patent/SG11202009170UA/en unknown
- 2018-06-29 CA CA3094957A patent/CA3094957A1/en active Pending
- 2018-06-29 RS RS20240724A patent/RS65674B1/sr unknown
- 2018-06-29 EP EP24156606.6A patent/EP4386080A2/en active Pending
- 2018-06-29 MD MDE20210111T patent/MD3775165T2/ro unknown
- 2018-06-29 SI SI201831115T patent/SI3775165T1/sl unknown
- 2018-06-29 EA EA202092319A patent/EA202092319A1/ru unknown
- 2018-06-29 PT PT187457411T patent/PT3775165T/pt unknown
- 2018-06-29 AU AU2018415814A patent/AU2018415814A1/en active Pending
- 2018-06-29 WO PCT/US2018/040474 patent/WO2019190579A1/en active Application Filing
- 2018-06-29 EP EP18745741.1A patent/EP3775165B1/en active Active
- 2018-06-29 HR HRP20240850TT patent/HRP20240850T1/hr unknown
- 2018-06-29 PL PL18745741.1T patent/PL3775165T3/pl unknown
- 2018-06-29 BR BR112020019496-4A patent/BR112020019496A2/pt unknown
- 2018-06-29 ES ES18745741T patent/ES2982509T3/es active Active
- 2018-06-29 CN CN201880094012.1A patent/CN112513254A/zh active Pending
- 2018-06-29 MX MX2020010264A patent/MX2020010264A/es unknown
-
2020
- 2020-09-24 IL IL277592A patent/IL277592A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS65674B1 (sr) | 2024-07-31 |
| LT3775165T (lt) | 2024-07-10 |
| FI3775165T3 (fi) | 2024-07-01 |
| DK3775165T3 (da) | 2024-07-08 |
| EP4386080A2 (en) | 2024-06-19 |
| SI3775165T1 (sl) | 2024-09-30 |
| HRP20240850T1 (hr) | 2024-09-27 |
| MD3775165T2 (ro) | 2024-09-30 |
| PL3775165T3 (pl) | 2024-08-19 |
| AU2018415814A1 (en) | 2020-10-22 |
| IL277592A (en) | 2020-11-30 |
| EP3775165B1 (en) | 2024-03-27 |
| KR20200138329A (ko) | 2020-12-09 |
| WO2019190579A1 (en) | 2019-10-03 |
| CN112513254A (zh) | 2021-03-16 |
| CA3094957A1 (en) | 2019-10-03 |
| EP3775165A1 (en) | 2021-02-17 |
| PT3775165T (pt) | 2024-07-17 |
| ES2982509T3 (es) | 2024-10-16 |
| EA202092319A1 (ru) | 2021-03-04 |
| MX2020010264A (es) | 2020-11-06 |
| BR112020019496A2 (pt) | 2021-01-12 |
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