SG11202007896YA - Compounds having s1p5 receptor agonistic activity - Google Patents

Compounds having s1p5 receptor agonistic activity

Info

Publication number
SG11202007896YA
SG11202007896YA SG11202007896YA SG11202007896YA SG11202007896YA SG 11202007896Y A SG11202007896Y A SG 11202007896YA SG 11202007896Y A SG11202007896Y A SG 11202007896YA SG 11202007896Y A SG11202007896Y A SG 11202007896YA SG 11202007896Y A SG11202007896Y A SG 11202007896YA
Authority
SG
Singapore
Prior art keywords
compounds
agonistic activity
receptor agonistic
receptor
activity
Prior art date
Application number
SG11202007896YA
Other languages
English (en)
Inventor
Toshihide Watanabe
Kensuke Kusumi
Satomi Imaide
Toshimitsu Endo
Takaki Komiya
Naomi TSUBURAYA
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of SG11202007896YA publication Critical patent/SG11202007896YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/252Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11202007896YA 2018-02-22 2019-02-21 Compounds having s1p5 receptor agonistic activity SG11202007896YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018029549 2018-02-22
PCT/JP2019/006637 WO2019163917A1 (ja) 2018-02-22 2019-02-21 S1p5受容体作動活性を有する化合物

Publications (1)

Publication Number Publication Date
SG11202007896YA true SG11202007896YA (en) 2020-09-29

Family

ID=67688486

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202007896YA SG11202007896YA (en) 2018-02-22 2019-02-21 Compounds having s1p5 receptor agonistic activity

Country Status (17)

Country Link
US (3) US11198672B2 (ja)
EP (2) EP3757091B1 (ja)
JP (2) JP7211410B2 (ja)
KR (1) KR20200124668A (ja)
CN (1) CN111757869B (ja)
AU (1) AU2019224344B2 (ja)
BR (1) BR112020017036A2 (ja)
CA (1) CA3091216A1 (ja)
DK (1) DK3757091T3 (ja)
FI (1) FI3757091T3 (ja)
IL (1) IL276656A (ja)
MX (1) MX2020008523A (ja)
PH (1) PH12020551297A1 (ja)
PT (1) PT3757091T (ja)
SG (1) SG11202007896YA (ja)
TW (2) TWI789495B (ja)
WO (1) WO2019163917A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3757091T (pt) 2018-02-22 2024-09-11 Ono Pharmaceutical Co Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro
JP7409383B2 (ja) 2019-08-20 2024-01-09 小野薬品工業株式会社 S1p5受容体作動活性を有する化合物の塩および結晶形
WO2024006985A1 (en) * 2022-07-01 2024-01-04 Autobahn Therapeutics, Inc. Amide prodrugs and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005020882A (ja) 2003-06-25 2005-01-20 Matsushita Electric Works Ltd モータアクチュエータ装置
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
AU2004268455B2 (en) * 2003-08-29 2009-12-17 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
EP1765379A4 (en) 2004-06-17 2009-05-27 Transform Pharmaceuticals Inc CO-CRISTAL PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
JP2006064757A (ja) 2004-08-24 2006-03-09 Systec Kyowa:Kk ディスプレイ固定用スタンド
US7906549B2 (en) * 2004-12-13 2011-03-15 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
WO2007092638A1 (en) * 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
SI2672823T1 (sl) 2011-02-07 2017-01-31 Biogen Ma Inc. Modulatorji S1P
ES2852724T3 (es) * 2014-12-04 2021-09-14 Ono Pharmaceutical Co Derivados de dihidronaftaleno útiles en el tratamiento de enfermedades mediadas por S1P5
ES2975689T3 (es) * 2016-01-29 2024-07-11 Ono Pharmaceutical Co Derivado de tetrahidronaftaleno
JP2018029549A (ja) * 2016-08-26 2018-03-01 キユーピー株式会社 苦味低減方法
PT3757091T (pt) * 2018-02-22 2024-09-11 Ono Pharmaceutical Co Ácido 1-[[(3s)-3-metil-6-(4,4,4-trifluorobutoxi)-3,4-di-hidronaftalen-2-il]metil]azetidino-3-carboxílico com atividade agonista do recetor s1p5 para o tratamento de doenças neurodegenerativas e cancro
JP7409383B2 (ja) * 2019-08-20 2024-01-09 小野薬品工業株式会社 S1p5受容体作動活性を有する化合物の塩および結晶形

Also Published As

Publication number Publication date
WO2019163917A1 (ja) 2019-08-29
TWI821061B (zh) 2023-11-01
US20210087141A1 (en) 2021-03-25
TWI789495B (zh) 2023-01-11
EP3757091A1 (en) 2020-12-30
US20240327342A1 (en) 2024-10-03
PT3757091T (pt) 2024-09-11
FI3757091T3 (fi) 2024-09-13
JP7211410B2 (ja) 2023-01-24
JP7485103B2 (ja) 2024-05-16
NZ766972A (en) 2024-02-23
RU2020127745A3 (ja) 2022-03-22
CN111757869A (zh) 2020-10-09
CN111757869B (zh) 2024-03-08
EP4431157A2 (en) 2024-09-18
AU2019224344A1 (en) 2020-09-03
DK3757091T3 (da) 2024-09-23
EP3757091B1 (en) 2024-08-28
AU2019224344B2 (en) 2024-06-27
CA3091216A1 (en) 2019-08-29
IL276656A (en) 2020-09-30
RU2020127745A (ru) 2022-03-22
TW202000644A (zh) 2020-01-01
US20220055986A1 (en) 2022-02-24
EP3757091A4 (en) 2022-04-06
US11198672B2 (en) 2021-12-14
KR20200124668A (ko) 2020-11-03
MX2020008523A (es) 2020-09-18
JPWO2019163917A1 (ja) 2021-02-04
US12049445B2 (en) 2024-07-30
PH12020551297A1 (en) 2021-05-31
BR112020017036A2 (pt) 2020-12-15
TW202313002A (zh) 2023-04-01
JP2023029542A (ja) 2023-03-03

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