SG11202002516WA - Systems and methods for nucleic acid sequencing - Google Patents

Systems and methods for nucleic acid sequencing

Info

Publication number
SG11202002516WA
SG11202002516WA SG11202002516WA SG11202002516WA SG11202002516WA SG 11202002516W A SG11202002516W A SG 11202002516WA SG 11202002516W A SG11202002516W A SG 11202002516WA SG 11202002516W A SG11202002516W A SG 11202002516WA SG 11202002516W A SG11202002516W A SG 11202002516WA
Authority
SG
Singapore
Prior art keywords
systems
methods
nucleic acid
acid sequencing
sequencing
Prior art date
Application number
SG11202002516WA
Other languages
English (en)
Inventor
Hesaam Esfandyarpour
Maryam Jouzi
Seth Stern
Paul Kenney
Original Assignee
Genapsys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genapsys Inc filed Critical Genapsys Inc
Publication of SG11202002516WA publication Critical patent/SG11202002516WA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122Massive parallel sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/30Detection characterised by liberation or release of label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
SG11202002516WA 2017-09-21 2018-09-20 Systems and methods for nucleic acid sequencing SG11202002516WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762561358P 2017-09-21 2017-09-21
US201862655083P 2018-04-09 2018-04-09
PCT/US2018/052072 WO2019060628A1 (en) 2017-09-21 2018-09-20 SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING

Publications (1)

Publication Number Publication Date
SG11202002516WA true SG11202002516WA (en) 2020-04-29

Family

ID=65810962

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002516WA SG11202002516WA (en) 2017-09-21 2018-09-20 Systems and methods for nucleic acid sequencing

Country Status (9)

Country Link
US (2) US10900075B2 (de)
EP (1) EP3684951A4 (de)
JP (2) JP2021500858A (de)
CN (1) CN111566224A (de)
CA (1) CA3076378A1 (de)
IL (1) IL273426A (de)
MX (1) MX2020003113A (de)
SG (1) SG11202002516WA (de)
WO (1) WO2019060628A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG189839A1 (en) 2010-10-04 2013-06-28 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
EP2785868B1 (de) 2011-12-01 2017-04-12 Genapsys Inc. Systeme und verfahren für hocheffiziente elektronische sequenzierung und nachweis
WO2014152625A1 (en) 2013-03-15 2014-09-25 Genapsys, Inc. Systems and methods for biological analysis
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
CN116397014A (zh) 2016-07-20 2023-07-07 测序健康公司 用于核酸测序的系统和方法
CN111566224A (zh) 2017-09-21 2020-08-21 吉纳普赛斯股份有限公司 用于核酸测序的系统和方法
WO2020210370A1 (en) * 2019-04-12 2020-10-15 Roche Sequencing Solutions, Inc. Nucleic acid sequencing by synthesis using magnetic sensor arrays
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
TWI803855B (zh) * 2020-04-21 2023-06-01 美商西方數位科技公司 用於定序核酸之系統及裝置、定序複數個s個核酸股之方法及減輕由於使用單分子感測器陣列之核酸定序程序而產生之定序資料之錯誤之方法

Family Cites Families (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1049467A (en) 1907-05-29 1913-01-07 Chadeloid Chemical Co Paint or varnish remover.
US1053321A (en) 1909-05-20 1913-02-18 Otto E Schrock Rotary pump and motor.
US1026689A (en) 1909-08-30 1912-05-21 Peter A Mccullough Trolley-harp.
US1009397A (en) 1911-01-21 1911-11-21 Henry W Falstrom Buckle.
US1012539A (en) 1911-02-09 1911-12-19 Geiser Mfg Company Set-works for sawmills.
US1010035A (en) 1911-02-23 1911-11-28 American Steel Foundries Reinforced car-truck.
US1047267A (en) 1911-06-21 1912-12-17 Jeffrey Mfg Co Anchor.
US1005998A (en) 1911-07-10 1911-10-17 Arthur Munchausen Berry-carrier.
US1026009A (en) 1911-09-23 1912-05-14 Tetsusaburo Watanabe Fountain paint-brush.
US1053952A (en) 1911-11-25 1913-02-18 Basf Ag Process of manufacturing ammonia.
US1061209A (en) 1912-04-22 1913-05-06 William Monroe White Life-saving device.
US1054445A (en) 1912-11-16 1913-02-25 Jan Orlowski Umbrella.
US1057044A (en) 1913-01-16 1913-03-25 Benjamin Douglass Jr Pneumatic antislip device for power-driven vehicles.
US2014761A (en) 1929-12-05 1935-09-17 Waldhof Zellstoff Fab Process for the manufacture of solutions from cellulose
SE407115B (sv) 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
US4959615A (en) 1988-05-31 1990-09-25 Micro Encoder, Inc. Electrode structure for capacitance-type measurement transducers
US5612181A (en) 1989-06-21 1997-03-18 Fourmentin-Guilbert; Jean E. R. Method for arranging a polynucleotide on a substrate for point-by-point analysis of the bases thereof
US5407799A (en) * 1989-09-14 1995-04-18 Associated Universities, Inc. Method for high-volume sequencing of nucleic acids: random and directed priming with libraries of oligonucleotides
JP3025027B2 (ja) 1991-01-21 2000-03-27 株式会社日立製作所 酸素センサ
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
AU2907092A (en) 1991-10-21 1993-05-21 James W. Holm-Kennedy Method and device for biochemical sensing
GB9208733D0 (en) 1992-04-22 1992-06-10 Medical Res Council Dna sequencing method
US5602042A (en) 1994-04-14 1997-02-11 Cytyc Corporation Method and apparatus for magnetically separating biological particles from a mixture
JP3339026B2 (ja) 1994-05-11 2002-10-28 ジェネラ テクノロジーズ リミテッド 液体から種を捕獲する方法及び分析手法
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US5861295A (en) 1997-01-02 1999-01-19 Life Technologies, Inc. Nucleic acid-free thermostable enzymes and methods of production thereof
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
AU6846698A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid amplification
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
DE60044490D1 (de) 1999-02-23 2010-07-15 Caliper Life Sciences Inc Manipulation von mikroteilchen in mikrofluiden systemen
CN1181337C (zh) 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6046097A (en) 1999-03-23 2000-04-04 United Microelectronics Corp. Deposition method with improved step coverage
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
EP1208240A4 (de) 1999-08-26 2006-10-04 Univ Princeton Mikrofluidische und makrofluidische elektronische geräte zur detektion von änderungen der kapazität von flüssigkeiten und verfahren zu deren verwendung.
EP1218543A2 (de) 1999-09-29 2002-07-03 Solexa Ltd. Polynukleotidsequenzierung
US6616819B1 (en) 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
AU4504001A (en) 1999-11-04 2001-06-04 Princeton University Electrodeless dielectrophoresis for polarizable particles
DE60025529T2 (de) 1999-11-17 2006-08-24 Roche Diagnostics Gmbh Magnetische glasteilchen, herstellungsverfahren und benutzung
EP1238114A2 (de) 1999-12-09 2002-09-11 Motorola, Inc. Methode und zusammensetzungen für den elektrischen nachweis von nukleinesäure reaktionen
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
EP1320922A2 (de) 2000-09-27 2003-06-25 Aviva Biosciences Corporation Apparat zur umschalten und behandlen von teilchen und benutzungsverfahren dieses apparates
EP1337541B1 (de) * 2000-10-06 2007-03-07 The Trustees of Columbia University in the City of New York Massives Parallelverfahren zur Dekodierung von DNA und RNA
CN1481441A (zh) 2000-10-20 2004-03-10 斯坦福大学受托管理委员会 根据瞬时电信号表征样品中分子间相互作用和运动的方法和设备
JPWO2002034907A1 (ja) 2000-10-27 2004-03-04 栄研化学株式会社 1本鎖核酸の合成方法
US20030209432A1 (en) 2000-12-11 2003-11-13 Choong Vi-En Methods and compositions relating to electrical detection of nucleic acid reactions
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
WO2002061146A1 (en) 2001-02-01 2002-08-08 The Trustees Of Columbia University In The City Of New York Use of electrical fields to control interactions between proteins and nucleic acid constructions immobilized on solid supports
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US8114591B2 (en) 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
US20040023253A1 (en) 2001-06-11 2004-02-05 Sandeep Kunwar Device structure for closely spaced electrodes
US20030096268A1 (en) 2001-07-06 2003-05-22 Michael Weiner Method for isolation of independent, parallel chemical micro-reactions using a porous filter
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US8152991B2 (en) 2005-10-27 2012-04-10 Nanomix, Inc. Ammonia nanosensors, and environmental control system
US8154093B2 (en) 2002-01-16 2012-04-10 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
EP2290096B1 (de) 2002-02-21 2014-11-19 Alere San Diego, Inc. Rekombinase-Polymerase-Amplifikationsverfahren unter Verwendung eines temperaturempfindlichen Rekombinationsmittels
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US6953958B2 (en) 2002-03-19 2005-10-11 Cornell Research Foundation, Inc. Electronic gain cell based charge sensor
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
DE10221799A1 (de) 2002-05-15 2003-11-27 Fujitsu Ltd Silicon-on-Insulator-Biosensor
US20050019784A1 (en) 2002-05-20 2005-01-27 Xing Su Method and apparatus for nucleic acid sequencing and identification
GB0211564D0 (en) 2002-05-21 2002-06-26 Tournaz Technology Ltd Reference circuit
AU2003245322A1 (en) 2002-05-29 2003-12-19 Arizona Board Of Regents, Acting On Behalf Of Arizona State University Nanoscale ink-jet printing
WO2004003535A1 (en) 2002-06-27 2004-01-08 Nanosys Inc. Planar nanowire based sensor elements, devices, systems and methods for using and making same
KR100479128B1 (ko) 2002-07-22 2005-03-28 학교법인 한양학원 디앤에이 교배 검출을 위한 자기변형 바이오센서 및 그 제조방법
TWI234584B (en) 2002-08-16 2005-06-21 Univ Nat Taiwan Normal Nucleic acid sequencing method
US20040197793A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for biomolecule detection, identification, quantification and/or sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
AU2003267140A1 (en) 2002-09-17 2004-04-08 Pharmacia Corporation Isolation of genetic molecules from a complex biological construct for use in genetic expression analysis
US7095010B2 (en) 2002-12-04 2006-08-22 California Institute Of Technology Silicon on insulator resonator sensors and modulators and method of operating the same
US7932025B2 (en) 2002-12-10 2011-04-26 Massachusetts Institute Of Technology Methods for high fidelity production of long nucleic acid molecules with error control
US20060147955A1 (en) 2004-11-03 2006-07-06 Third Wave Technologies, Inc. Single step detection assay
KR20050100367A (ko) 2003-01-02 2005-10-18 바이오포스 나노사이언스, 인크. 소용적 샘플 내의 분자 분석용 방법 및 장치
EP2159285B1 (de) 2003-01-29 2012-09-26 454 Life Sciences Corporation Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren
CN1791682B (zh) 2003-02-26 2013-05-22 凯利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
US20050123937A1 (en) 2003-03-07 2005-06-09 Thorp H. H. Methods for the electrochemical detection of target compounds
US20050136419A1 (en) 2003-03-28 2005-06-23 The Regents Of The University Of California Method and apparatus for nanogap device and array
DE10319045A1 (de) 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
US7291496B2 (en) 2003-05-22 2007-11-06 University Of Hawaii Ultrasensitive biochemical sensor
PL1633888T3 (pl) 2003-06-17 2009-10-30 Keygene Nv Środki i sposoby detekcji docelowych sekwencji nukleotydowych z użyciem oznaczeń ligacji i par ulepszonych sond oligonukleotydowych
US20050053980A1 (en) 2003-06-20 2005-03-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005019798A2 (en) 2003-08-13 2005-03-03 The Regents Of The University Of Michigan Biochemical sensors with micro-resonators
US20050084980A1 (en) 2003-10-17 2005-04-21 Intel Corporation Method and device for detecting a small number of molecules using surface-enhanced coherant anti-stokes raman spectroscopy
WO2005042785A1 (en) 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
WO2005043160A2 (en) 2003-10-31 2005-05-12 University Of Hawaii Ultrasensitive biochemical sensing platform
US7294246B2 (en) 2003-11-06 2007-11-13 3M Innovative Properties Company Electrode for electrochemical sensors
WO2005108612A2 (en) 2003-11-28 2005-11-17 Genorx, Inc. Nanoscale biosensor device, system and technique
EP1697534B1 (de) 2003-12-01 2010-06-02 Life Technologies Corporation Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US20050129526A1 (en) 2003-12-10 2005-06-16 Dukhin Andrei S. Method of using unbalanced alternating electric field in microfluidic devices
JP3903183B2 (ja) 2004-02-03 2007-04-11 独立行政法人物質・材料研究機構 遺伝子検出電界効果デバイスおよびこれを用いた遺伝子多型解析方法
US20050218464A1 (en) 2004-03-18 2005-10-06 Holm-Kennedy James W Biochemical ultrasensitive charge sensing
US7238536B1 (en) 2004-03-22 2007-07-03 Florida State University Research Foundation, Inc. Controlled transport through multiple reversible interaction point membranes
US7622281B2 (en) 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
ES2718482T3 (es) 2004-06-01 2019-07-02 Alere San Diego Inc Kit para amplificación de recombinasa polimerasa
CN101120098A (zh) 2004-06-10 2008-02-06 通用电气医疗集团生物科学公司 核酸分析方法
GB0413082D0 (en) 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
GB2416210B (en) 2004-07-13 2008-02-20 Christofer Toumazou Ion sensitive field effect transistors
WO2006022370A1 (ja) 2004-08-27 2006-03-02 National Institute For Materials Science 電界効果デバイスを用いたdna塩基配列解析方法及び塩基配列解析装置
US7851205B2 (en) * 2004-08-30 2010-12-14 Japan Science And Technology Agency DNA sensor
JP2008519265A (ja) 2004-11-01 2008-06-05 メディミューン,インコーポレーテッド 超ハイスループットキャプチャーリフトスクリーニング法
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
EP1831670A4 (de) 2004-12-28 2010-09-15 Nanomix Inc Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen
WO2006070004A1 (en) 2004-12-30 2006-07-06 Medivir Ab Compounds useful in the treatment of hiv
JP2008528040A (ja) 2005-02-01 2008-07-31 アジェンコート バイオサイエンス コーポレイション ビーズベースの配列決定のための試薬、方法およびライブラリー
EP1866434B1 (de) 2005-02-19 2013-06-05 Avacta Group plc Isotherme nukleinsäureamplifikation
US9040237B2 (en) 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US8940143B2 (en) 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
EP2829615B1 (de) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit zur Multiplexierung einer Rekombinase-Polymerase-Verstärkung
ATE550441T1 (de) 2005-09-06 2012-04-15 Gen Probe Inc Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
JP2009509549A (ja) 2005-09-30 2009-03-12 カリパー・ライフ・サイエンシズ・インク. 磁気ビーズを用いて生体成分を精製するためのマイクロ流体デバイス
US8179296B2 (en) 2005-09-30 2012-05-15 The Massachusetts Institute Of Technology Digital readout method and apparatus
US7615382B2 (en) 2005-11-09 2009-11-10 The Board Of Trustees Of The Leland Stanford Junior University Magnetic sifter
JP5808515B2 (ja) 2006-02-16 2015-11-10 454 ライフ サイエンシーズ コーポレイション 核酸配列データのプライマー伸長誤差を補正するためのシステムおよび方法
SG10201405158QA (en) 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
WO2007107710A1 (en) 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
CN101405083A (zh) 2006-03-21 2009-04-08 皇家飞利浦电子股份有限公司 具有场电极的微电子装置
JP2009530634A (ja) 2006-03-21 2009-08-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ フィールド電極群を備えたマイクロエレクトロニクスデバイス
AU2007298650B2 (en) 2006-05-04 2013-10-17 Abbott Diagnostics Scarborough, Inc. Recombinase polymerase amplification
US20100105035A1 (en) 2006-11-22 2010-04-29 Syed Anwar Hashsham Electroluminescent-based fluorescence detection device
US7989396B2 (en) 2006-12-05 2011-08-02 The Board Of Trustees Of The Leland Stanford Junior University Biomolecule immobilization on biosensors
US9188594B2 (en) 2006-12-06 2015-11-17 Yale University Nanoelectronic-enzyme linked immunosorbent assay system and method
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
EP2118660A4 (de) 2007-01-24 2011-06-01 Arrayomics Inc Sortieren von mikrovorrichtungen
JP2010516285A (ja) 2007-01-26 2010-05-20 イルミナ インコーポレイテッド 核酸配列決定システムおよび方法
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US8003319B2 (en) 2007-02-02 2011-08-23 International Business Machines Corporation Systems and methods for controlling position of charged polymer inside nanopore
US7731414B2 (en) 2007-02-08 2010-06-08 Instrumentation Laboratory Company Reagent cartridge mixing tube
US9063117B2 (en) 2007-02-21 2015-06-23 Paul L. Gourley Micro-optical cavity with fluidic transport chip for bioparticle analysis
JP4945279B2 (ja) 2007-03-23 2012-06-06 株式会社日立製作所 Dna分析方法および分析装置
JP2008245612A (ja) 2007-03-30 2008-10-16 Hitachi Ltd 試料調製法および装置
US9034637B2 (en) 2007-04-25 2015-05-19 Nxp, B.V. Apparatus and method for molecule detection using nanopores
EP2150350B1 (de) 2007-05-24 2012-04-25 The Regents of the University of California Integrierte fluidische vorrichtungen mit magnetischer sortierung
JP2009002808A (ja) 2007-06-21 2009-01-08 Hitachi Ltd Dna計測システム及びdna計測方法
JP4876031B2 (ja) 2007-06-22 2012-02-15 株式会社日立製作所 分析装置
EP2173467B1 (de) 2007-07-13 2016-05-04 The Board Of Trustees Of The Leland Stanford Junior University Verfahren und vorrichtung unter verwendung eines elektrischen felds für verbesserte biologische assays
US7901889B2 (en) 2007-07-26 2011-03-08 Pacific Biosciences Of California, Inc. Molecular redundant sequencing
EP2212683A4 (de) 2007-10-17 2011-08-31 Advanced Liquid Logic Inc Manipulation von kügelchen in tröpfchen
US20110008775A1 (en) 2007-12-10 2011-01-13 Xiaolian Gao Sequencing of nucleic acids
US20100273166A1 (en) 2007-12-13 2010-10-28 Nxp B.V. biosensor device and method of sequencing biological particles
US8372585B2 (en) 2007-12-31 2013-02-12 Intel Corporation Electronic sensing for nucleic acid sequencing
US8067176B2 (en) 2008-01-25 2011-11-29 Shimadzu Corporation Microchemistry reaction method
US8173080B2 (en) 2008-02-14 2012-05-08 Illumina, Inc. Flow cells and manifolds having an electroosmotic pump
US9017973B2 (en) * 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
GB0805814D0 (en) 2008-03-31 2008-04-30 Cambridge Entpr Ltd Biosensor for analyte detection
ATE530497T1 (de) 2008-03-31 2011-11-15 Sony Deutschland Gmbh Verfahren zur herstellung einer membran mit konischer pore
US8940142B2 (en) 2008-05-05 2015-01-27 The Regents Of The University Of California Functionalized nanopipette biosensor
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8389768B2 (en) 2008-05-19 2013-03-05 The University Of North Carolina At Chapel Hill Methods and compositions comprising novel cationic lipids
LT2660336T (lt) 2008-06-11 2017-10-10 Orion Pharma (Uk) Limited Izoterminė nukleorūgšties amplifkacija
JP5667049B2 (ja) 2008-06-25 2015-02-12 ライフ テクノロジーズ コーポレーション 大規模なfetアレイを用いて分析物を測定するための方法および装置
CN102177250B (zh) 2008-06-30 2015-05-06 生命科技公司 由粗制核酸样品直接扩增的方法
CA2730068A1 (en) 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Base-detecting pore
US20100035252A1 (en) 2008-08-08 2010-02-11 Ion Torrent Systems Incorporated Methods for sequencing individual nucleic acids under tension
JP5818683B2 (ja) 2008-09-03 2015-11-18 クワンタムディーエックス・グループ・リミテッド 核酸配列決定のための方法およびキット
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
WO2010037085A1 (en) 2008-09-29 2010-04-01 The Board Of Trustees Of The University Of Illinois Dna sequencing and amplification systems using nanoscale field effect sensor arrays
US8392126B2 (en) 2008-10-03 2013-03-05 Illumina, Inc. Method and system for determining the accuracy of DNA base identifications
US20110212440A1 (en) 2008-10-10 2011-09-01 Cnrs-Dae Cell sorting device
CN102301228A (zh) 2008-10-22 2011-12-28 生命技术公司 用于生物和化学分析的集成式传感器阵列
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100112588A1 (en) 2008-11-04 2010-05-06 Caerus Molecular Diagnostics, Inc. Methods for sanger sequencing using particle associated clonal amplicons and highly parallel electrophoretic size-based separation
WO2010075188A2 (en) 2008-12-23 2010-07-01 Illumina Inc. Multibase delivery for long reads in sequencing by synthesis protocols
US8563240B2 (en) 2008-12-31 2013-10-22 Intel Corporation Nucleic acid sequencing and electronic detection
US8691509B2 (en) 2009-04-02 2014-04-08 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
EP3301104B1 (de) 2009-05-29 2019-10-30 Life Technologies Corporation Nukleinsäuregerüstpolymerpartikel und verfahren zur herstellung und verwendung
EP3360974A1 (de) 2009-06-05 2018-08-15 Alere San Diego, Inc. Reagentien zur rekombinase polymerase amplifikation
WO2010141390A2 (en) 2009-06-05 2010-12-09 Life Technologies Corporation Nucleotide transient binding for sequencing methods
CN102666872A (zh) 2009-09-25 2012-09-12 艾利尔圣迭戈公司 粗基质中的核酸的检测
US8962279B2 (en) 2009-12-30 2015-02-24 Intel Corporation Solid-phase chelators and electronic biosensors
EP4378584A2 (de) 2010-02-19 2024-06-05 Pacific Biosciences Of California, Inc. Integriertes analytisches system und verfahren zur fluoreszenzmessung
WO2011106556A2 (en) 2010-02-24 2011-09-01 Life Technologies Corporation Systems and methods for adaptive recursive sequencing
US8524064B2 (en) 2010-04-22 2013-09-03 Lawrence Livermore National Security, Llc Three dimensional microelectrode system for dielectrophoresis
US20110287432A1 (en) 2010-05-21 2011-11-24 454 Life Science Corporation System and method for tailoring nucleotide concentration to enzymatic efficiencies in dna sequencing technologies
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US9309569B2 (en) * 2010-08-26 2016-04-12 Intelligent Bio-Systems, Inc. Methods and compositions for sequencing nucleic acid using charge
US8444835B2 (en) 2010-09-09 2013-05-21 Intel Corporation Electronic and fluidic interface
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
WO2012040387A1 (en) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
SG189839A1 (en) 2010-10-04 2013-06-28 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
CN110079588B (zh) 2010-12-17 2024-03-15 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
US20130090860A1 (en) 2010-12-30 2013-04-11 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
US10241075B2 (en) 2010-12-30 2019-03-26 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
GB2488600B (en) 2011-03-04 2013-05-29 Hm Technology Internat Ltd A force sensor
CA2831140C (en) 2011-04-07 2017-11-07 Alere San Diego, Inc. Monitoring recombinase polymerase amplification mixtures
US20120264617A1 (en) 2011-04-14 2012-10-18 Pettit John W Dna sequencing employing nanomaterials
US20130059762A1 (en) 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
CN106912197B (zh) 2011-04-28 2022-01-25 生命技术公司 用于多重pcr的方法和组合物
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
EP2714935B1 (de) * 2011-05-27 2017-03-15 Genapsys Inc. Systeme und verfahren für genetische und biologische analysen
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
US9347900B2 (en) 2011-10-14 2016-05-24 Pacific Biosciences Of California, Inc. Real-time redox sequencing
AU2012328662B2 (en) 2011-10-28 2015-12-17 Illumina, Inc. Microarray fabrication system and method
US9689835B2 (en) 2011-10-31 2017-06-27 Taiwan Semiconductor Manufacturing Company, Ltd. Amplified dual-gate bio field effect transistor
EP2785868B1 (de) 2011-12-01 2017-04-12 Genapsys Inc. Systeme und verfahren für hocheffiziente elektronische sequenzierung und nachweis
US8795605B2 (en) 2012-01-12 2014-08-05 Fred C. Senftleber Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths
WO2013119765A1 (en) 2012-02-10 2013-08-15 The University Of North Carolina At Chapel Hill Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
CN104350162A (zh) 2012-06-15 2015-02-11 吉尼亚科技公司 芯片设置和高精确度核酸测序
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
EP3388533A1 (de) 2012-07-13 2018-10-17 Life Technologies Corporation Menschenidentifikation unter verwendung einer snps-tafel
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
CN104838249B (zh) 2012-10-16 2018-06-22 雅培制药有限公司 包括局部脱盐系统的生物传感器设备和方法
CN102980922A (zh) 2012-11-21 2013-03-20 济南大学 可寻址电化学传感器阵列的制备及用于多种肿瘤标志物的检测和癌症筛查
WO2014152625A1 (en) 2013-03-15 2014-09-25 Genapsys, Inc. Systems and methods for biological analysis
US10106842B2 (en) * 2013-03-15 2018-10-23 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
CN111187811B (zh) * 2013-05-06 2024-03-08 加利福尼亚太平洋生物科学股份有限公司 实时电子测序
US20150316502A1 (en) * 2013-12-03 2015-11-05 FemtoDx Debye length modulation
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
EP3117221B1 (de) 2014-03-13 2020-09-09 Genapsys Inc. Mikrofluidische vorrichtungen und verfahren zur probenvorbereitung und -analyse
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
EP3828279B1 (de) 2014-07-15 2022-11-16 Illumina, Inc. Biochemisch aktivierte elektronische vorrichtung
WO2016127077A2 (en) * 2015-02-06 2016-08-11 Genapsys, Inc Systems and methods for detection and analysis of biological species
EP3332032B1 (de) * 2015-08-06 2023-12-27 Pacific Biosciences Of California, Inc. Integrierte schaltungen zur selektiven adressierung spärlich angeordneter, elektronischer messvorrichtungen
JP2019503174A (ja) * 2016-01-04 2019-02-07 クァンタムディーエックス グループ リミテッドQuantumdx Group Limited 電荷量タグを含む合成ヌクレオチドのデザイン、合成、および使用
CN116397014A (zh) 2016-07-20 2023-07-07 测序健康公司 用于核酸测序的系统和方法
CN111566224A (zh) 2017-09-21 2020-08-21 吉纳普赛斯股份有限公司 用于核酸测序的系统和方法

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