SG11202000402PA - T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof - Google Patents

T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof

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Publication number
SG11202000402PA
SG11202000402PA SG11202000402PA SG11202000402PA SG11202000402PA SG 11202000402P A SG11202000402P A SG 11202000402PA SG 11202000402P A SG11202000402P A SG 11202000402PA SG 11202000402P A SG11202000402P A SG 11202000402PA SG 11202000402P A SG11202000402P A SG 11202000402PA
Authority
SG
Singapore
Prior art keywords
cells
methods
receptor
chimeric antigen
deficient chimeric
Prior art date
Application number
SG11202000402PA
Other languages
English (en)
Inventor
Takahiro Kamiya
Dario Campana
Original Assignee
Nat Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Singapore filed Critical Nat Univ Singapore
Publication of SG11202000402PA publication Critical patent/SG11202000402PA/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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SG11202000402PA 2017-08-10 2018-08-09 T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof SG11202000402PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762543735P 2017-08-10 2017-08-10
PCT/US2018/046137 WO2019032916A1 (fr) 2017-08-10 2018-08-09 Lymphocytes t récepteurs d'antigènes chimériques déficients en récepteurs de lymphocyte t et procédés d'utilisation correspondants

Publications (1)

Publication Number Publication Date
SG11202000402PA true SG11202000402PA (en) 2020-02-27

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ID=65231396

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SG11202000402PA SG11202000402PA (en) 2017-08-10 2018-08-09 T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof

Country Status (10)

Country Link
US (3) US11648269B2 (fr)
EP (1) EP3665270A4 (fr)
JP (1) JP2020530291A (fr)
KR (1) KR20200035304A (fr)
CN (1) CN111247241A (fr)
AU (1) AU2018313939A1 (fr)
CA (1) CA3071282A1 (fr)
SG (1) SG11202000402PA (fr)
WO (1) WO2019032916A1 (fr)
ZA (1) ZA202000852B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273283B2 (en) * 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
CN112175911B (zh) 2014-05-15 2023-10-13 新加坡国立大学 经修饰的自然杀伤细胞及其用途
SG11201706236SA (en) 2015-02-06 2017-08-30 Nat Univ Singapore Methods for enhancing efficacy of therapeutic immune cells
KR20240099512A (ko) 2016-11-22 2024-06-28 싱가포르국립대학교 T 세포 악성종양의 면역요법을 위한 키메라 항원 수용체 및 cd7 발현의 차단
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
AU2018246235B2 (en) 2017-03-27 2023-12-21 National University Of Singapore Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2019032916A1 (fr) 2017-08-10 2019-02-14 National University Of Singapore Lymphocytes t récepteurs d'antigènes chimériques déficients en récepteurs de lymphocyte t et procédés d'utilisation correspondants
SG11202104334SA (en) * 2018-11-14 2021-05-28 MediSix Therapeutics Pte Ltd Two-gene vectors for generating car-t cells and uses thereof
WO2020232247A1 (fr) 2019-05-14 2020-11-19 Provention Bio, Inc. Procédés et compositions pour la prévention du diabète de type 1
CN114746126A (zh) * 2019-10-11 2022-07-12 小利兰·斯坦福大学理事会 用于可调节细胞定位的重组多肽
CN113005088B (zh) * 2019-12-19 2024-06-04 苏州方德门达新药开发有限公司 工程改造的t细胞、其制备及应用
CN113088495B (zh) 2020-01-09 2024-08-16 苏州方德门达新药开发有限公司 工程改造的t细胞、其制备及应用
BR112022025381A2 (pt) 2020-06-11 2023-01-24 Provention Bio Inc Métodos e composições para prevenir diabetes tipo 1
CN111944850B (zh) * 2020-08-28 2023-03-31 澳门大学 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用
EP4178986A4 (fr) * 2020-09-13 2024-01-10 Shandong Boan Biotechnology Co., Ltd. Régulation à la baisse de protéines liées à une membrane par la technologie du récepteur tac
TW202413633A (zh) * 2022-08-11 2024-04-01 美商敏達斯治療公司 表現car及複數個蛋白質表現阻斷劑之工程化免疫細胞及其用途
WO2024097797A1 (fr) * 2022-11-02 2024-05-10 Medisix Therapeutics, Inc. Blocage de l'expression de cd3 et de récepteurs antigéniques chimériques pour l'immunothérapie

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2018248A1 (fr) 1989-06-07 1990-12-07 Clyde W. Shearman Anticorps monoclonaux contre le recepteur alpha-beta de cellules t humaines, leur production et leur utilisation
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
EP1015616A2 (fr) 1997-09-19 2000-07-05 Dana Farber Cancer Institute, Inc. Regulation a mediation intracorps de reactions immunitaires.
AU2002361390A1 (en) 2001-12-14 2003-06-30 Friedrich-Alexander-Universitaet Erlangen-Nuernberg Anti-cd7 immunotoxin as fusion protein
US20090191213A9 (en) 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
PT1639013E (pt) 2003-07-02 2012-12-03 Innate Pharma Anticorpos contra receptor nk pan-kir2dl e a sua utilização em diagnóstico e terapêutica
WO2005017163A2 (fr) 2003-08-15 2005-02-24 Imperial College Innovations Limited Inactivation phenotypique de proteines de surface cellulaire
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
AU2005259221B2 (en) 2004-07-01 2011-02-10 Innate Pharma Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use
EP1814567A4 (fr) 2004-10-27 2009-05-06 Medimmune Inc Utilisation de modulateurs de epha2 et de ephrina1 pour traiter et la prevenir des infections
WO2006072625A2 (fr) 2005-01-06 2006-07-13 Novo Nordisk A/S Procedes et traitements combines anti-kir
US20070036773A1 (en) 2005-08-09 2007-02-15 City Of Hope Generation and application of universal T cells for B-ALL
CA2625998C (fr) 2005-10-06 2015-12-01 Xencor, Inc. Anticorps anti-cd30 optimises
ES2582386T3 (es) 2007-03-01 2016-09-12 Symphogen A/S Composiciones de anticuerpos recombinantes contra el receptor del factor de crecimiento epidérmico
CA2698287A1 (fr) 2007-09-07 2009-03-12 Agensys, Inc. Anticorps et molecules apparentees qui se lient aux proteines 24p4c12
JP5774312B2 (ja) 2008-01-24 2015-09-09 ノボ・ノルデイスク・エー／エス ヒト化抗ヒトｎｋｇ２ａモノクローナル抗体
DK2488867T3 (da) 2009-10-14 2020-11-09 Janssen Biotech Inc Fremgangsmåder til affinitetsmodning af antistoffer
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
SG190997A1 (en) 2010-12-09 2013-07-31 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
ES2859522T3 (es) 2012-07-13 2021-10-04 Univ Pennsylvania Control de la toxicidad para la actividad antitumoral de CAR
EP2906684B8 (fr) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. Composés modifiant les lymphocytes t et leurs utilisations
KR101521224B1 (ko) 2012-12-20 2015-05-19 한양대학교 산학협력단 T 세포 특이적인 인간화 단일조각항체 전달체
EP2938627B1 (fr) 2012-12-27 2019-03-20 Aduro Biotech, Inc. Partenaires de fusion de type peptides signal favorisant l'expression de séquences antigéniques dans les bactéries du genre listeria et leurs procédés de préparation et d'utilisation
CA3115383A1 (fr) 2013-02-06 2014-08-14 Celgene Corporation Lymphocytes t modifies ayant une specificite amelioree
ES2861501T3 (es) 2013-11-21 2021-10-06 Autolus Ltd Célula
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
KR20170032406A (ko) 2014-07-15 2017-03-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료를 위한 조작된 세포
MX2017004603A (es) 2014-10-07 2017-06-30 Cellectis Metodo para modular actividad de celulas inmunes inducidas por car.
EP3215168B1 (fr) 2014-10-31 2023-08-02 The Trustees of the University of Pennsylvania Modification de l'expression génétique dans des lymphocytes t modifiés et utilisations associées
RU2768019C2 (ru) 2014-12-24 2022-03-23 Отолус Лимитед Клетка
SG11201706236SA (en) 2015-02-06 2017-08-30 Nat Univ Singapore Methods for enhancing efficacy of therapeutic immune cells
SG11201706774WA (en) 2015-02-27 2017-09-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
JP6336684B2 (ja) 2015-03-02 2018-06-06 イノベイティブ セルラー セラピューティクス シーオー．，エルティディ．Ｉｎｎｏｖａｔｉｖｅ Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．，Ｌｔｄ． Ｐｄ−ｌ１によって誘導される免疫寛容の低減
EP3310915A4 (fr) 2015-06-19 2019-04-10 Massachusetts Institute of Technology Immunothérapie tumorale
WO2017222593A1 (fr) 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Récepteurs d'antigènes chimériques (car), compositions et procédés associés
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
IL258931B (en) 2015-10-06 2022-09-01 Univ Minnesota Medicinal compounds and methods
WO2017213979A1 (fr) 2016-06-06 2017-12-14 St. Jude Children's Research Hospital Récepteur d'antigène chimérique anti-cd7 et son procédé d'utilisation
CA2937157A1 (fr) * 2016-07-25 2018-01-25 Ucl Business Plc Ecrasement de recepteur de cellule t fonde sur une proteine
WO2018027036A1 (fr) 2016-08-03 2018-02-08 Dipersio John F Édition génétique des cellules car-t pour le traitement de malignités des lymphocytes t avec des récepteurs d'antigènes chimériques
GB201622044D0 (en) 2016-12-22 2017-02-08 Ucl Business Plc T cell-targeted T cells
EP3568467A4 (fr) 2017-01-10 2020-11-25 The General Hospital Corporation Lymphocytes t modifiés et leurs procédés d'utilisation
WO2019032916A1 (fr) 2017-08-10 2019-02-14 National University Of Singapore Lymphocytes t récepteurs d'antigènes chimériques déficients en récepteurs de lymphocyte t et procédés d'utilisation correspondants

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ZA202000852B (en) 2023-10-25
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JP2020530291A (ja) 2020-10-22
US20230364140A1 (en) 2023-11-16
US11648269B2 (en) 2023-05-16
CA3071282A1 (fr) 2019-02-14
AU2018313939A1 (en) 2020-02-06
KR20200035304A (ko) 2020-04-02
WO2019032916A1 (fr) 2019-02-14
US20190046571A1 (en) 2019-02-14
EP3665270A4 (fr) 2021-04-21

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