SG11201908171TA - Compounds and compositions for treating hematological disorders - Google Patents
Compounds and compositions for treating hematological disordersInfo
- Publication number
- SG11201908171TA SG11201908171TA SG11201908171TA SG11201908171TA SG 11201908171T A SG11201908171T A SG 11201908171TA SG 11201908171T A SG11201908171T A SG 11201908171TA SG 11201908171T A SG11201908171T A SG 11201908171TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- bangalore
- pct
- rule
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000014951 hematologic disease Diseases 0.000 title 1
- 241000234479 Narcissus Species 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201741011785 | 2017-03-31 | ||
PCT/IB2018/052232 WO2018178947A2 (fr) | 2017-03-31 | 2018-03-30 | Composés et compositions pour le traitement de troubles hématologiques |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201908171TA true SG11201908171TA (en) | 2019-10-30 |
Family
ID=63677680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201908171T SG11201908171TA (en) | 2017-03-31 | 2018-03-30 | Compounds and compositions for treating hematological disorders |
Country Status (24)
Country | Link |
---|---|
US (2) | US11419875B2 (fr) |
EP (2) | EP4252853A3 (fr) |
JP (2) | JP7333136B2 (fr) |
KR (2) | KR20240019391A (fr) |
CN (1) | CN110691589A (fr) |
AU (1) | AU2018242623B2 (fr) |
BR (1) | BR112019018991A2 (fr) |
CA (1) | CA3056893A1 (fr) |
DK (1) | DK3600270T3 (fr) |
EA (1) | EA201992322A3 (fr) |
ES (1) | ES2950764T3 (fr) |
FI (1) | FI3600270T3 (fr) |
HR (1) | HRP20230657T8 (fr) |
HU (1) | HUE062648T2 (fr) |
IL (3) | IL305150A (fr) |
LT (1) | LT3600270T (fr) |
MX (2) | MX2019011158A (fr) |
PH (1) | PH12019502138A1 (fr) |
PL (1) | PL3600270T3 (fr) |
PT (1) | PT3600270T (fr) |
RS (1) | RS64411B1 (fr) |
SG (1) | SG11201908171TA (fr) |
SI (1) | SI3600270T1 (fr) |
WO (1) | WO2018178947A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3094329T1 (sl) | 2014-01-13 | 2019-02-28 | Aurigene Discovery Technologies Limited | Biciklični heterociklilni derivati kot inhibitorji IRAK4 |
CN110691589A (zh) | 2017-03-31 | 2020-01-14 | 奥列基因发现技术有限公司 | 用于治疗血液病的化合物和组合物 |
WO2019111218A1 (fr) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs d'irak4 |
EP3998264A4 (fr) * | 2019-07-10 | 2023-07-12 | Medshine Discovery Inc. | Composé oxazole utilisé en tant qu'inhibiteur multi-cible de l'irak 4 et de la btk |
CN112480101B (zh) * | 2019-09-12 | 2022-11-25 | 中国科学院上海药物研究所 | 一类irak4激酶抑制剂及其制备和应用 |
KR20220156535A (ko) | 2020-02-07 | 2022-11-25 | 가셔브룸 바이오, 인크. | 헤테로사이클릭 glp-1 작용제 |
CA3179378A1 (fr) | 2020-04-07 | 2021-10-14 | Bayer Aktiengesellschaft | Thiazolopyridines substituees, leurs sels et leur utilisation en tant que substances actives herbicides |
BR112023001861A2 (pt) * | 2020-08-03 | 2023-03-07 | Curis Inc | Composições e métodos para tratamento de doenças e distúrbios |
JP2024500247A (ja) * | 2020-12-25 | 2024-01-05 | メッドシャイン ディスカバリー インコーポレイテッド | アミドオキサゾール系化合物 |
BR112023020669A2 (pt) * | 2021-04-08 | 2023-12-12 | Curis Inc | Terapias de combinação para o tratamento de câncer |
CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
TW202328151A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途 |
TW202328150A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途 |
WO2023088435A1 (fr) * | 2021-11-19 | 2023-05-25 | 成都奥睿药业有限公司 | Préparation pour dérivé de pyridine trisubstituée et application en tant que modulateur de récepteur d'hydrocarbures aromatiques |
WO2023116866A1 (fr) * | 2021-12-23 | 2023-06-29 | 杭州多域生物技术有限公司 | Composé à cinq et six chaînons, son procédé de préparation et composition pharmaceutique et son utilisation |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
AU649421B2 (en) | 1990-05-18 | 1994-05-26 | Sanofi-Aventis Deutschland Gmbh | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
ES2302881T3 (es) | 1997-07-29 | 2008-08-01 | Alcon Laboratories, Inc. | Composiciones oftalmicas que contienen polimeros de galactomanana y borato. |
WO1999038504A1 (fr) | 1998-01-29 | 1999-08-05 | Sepracor Inc. | Utilisations pharmaceutiques de (-)-bupropion optiquement pur |
US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
DE10023486C1 (de) | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
BRPI0409949A (pt) | 2003-05-01 | 2006-04-25 | Bristol Myers Squibb Co | compostos de pirazol amida aril-substituìda úteis como inibidores de cinase |
JP5279987B2 (ja) | 2003-05-20 | 2013-09-04 | 味の素株式会社 | アミド誘導体 |
JP2006526660A (ja) | 2003-06-05 | 2006-11-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Vr1レセプターのモジュレーター |
US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
WO2005034870A2 (fr) | 2003-10-07 | 2005-04-21 | Renovis, Inc. | Composes amides et ligands de canaux ioniques, et leurs utilisations |
WO2005107460A1 (fr) | 2004-04-22 | 2005-11-17 | Bayer Cropscience Lp | Procede et composition pour contrôle d'herbes |
EP1655297A1 (fr) | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Pyridineurées de nicotinamide commes inhibiteurs du recepteur kinase du facteur de croissance endothéliale vasculaire (VEGF) |
US7906533B2 (en) | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
JP2008519850A (ja) | 2004-11-10 | 2008-06-12 | シンタ ファーマシューティカルズ コーポレーション | Il−12調節化合物 |
DE602005009021D1 (de) * | 2004-12-17 | 2008-09-25 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
ATE446962T1 (de) | 2004-12-17 | 2009-11-15 | Lilly Co Eli | Thiazolopyridinon-derivate als mch- rezeptorantagonisten |
EP1674467A1 (fr) | 2004-12-22 | 2006-06-28 | 4Sc Ag | Derives benzazoles 2,5- et 2,6-disubstitues utiles comme des inhibiteurs de la proteine kinase |
WO2007058626A1 (fr) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Composes d'indazole |
EP2295432A1 (fr) | 2006-02-10 | 2011-03-16 | TransTech Pharma Inc. | Procédé pour la préparation de dérivés benzimidazoles aminés |
GB0606429D0 (en) | 2006-03-30 | 2006-05-10 | Novartis Ag | Organic compounds |
EP2001480A4 (fr) | 2006-03-31 | 2011-06-15 | Abbott Lab | Composés d'indazole |
US20080293785A1 (en) | 2006-04-11 | 2008-11-27 | Connolly Peter J | Substituted benzothiazole kinase inhibitors |
AU2007292929A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase |
EP2063962A2 (fr) | 2006-09-07 | 2009-06-03 | Biogen Idec MA Inc. | Irak modulateurs pour le traitement d'une condition inflammatoire,d'une trouble proliferatif,immunologique |
US20080153810A1 (en) | 2006-11-15 | 2008-06-26 | Forest Laboratories Holdings Limited | Indazole derivatives useful as melanin concentrating receptor ligands |
JP5399262B2 (ja) | 2006-12-08 | 2014-01-29 | エグゼリクシス パテント カンパニー エルエルシー | Lxrおよびfxrのモジュレーター |
JP4785881B2 (ja) | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
CN101772500A (zh) * | 2007-06-14 | 2010-07-07 | 先灵公司 | 作为蛋白质激酶抑制剂的咪唑并吡嗪 |
US20090069288A1 (en) | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
JP5364875B2 (ja) | 2007-07-16 | 2013-12-11 | アッヴィ・インコーポレイテッド | タンパク質キナーゼ阻害薬としてのインダゾール類、ベンゾイソオキサゾール類およびベンゾイソチアゾール類 |
MX2010001446A (es) | 2007-08-08 | 2010-03-01 | Merck Serono Sa | Derivados de 6-amino-pirimidina-4-carboxamida y compuestos relacionados que se enlazan a los receptores para esfingosina 1-fosfato (s1p) para el tratamiento de esclerosis multiple. |
AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
WO2010008847A2 (fr) * | 2008-06-24 | 2010-01-21 | Takeda Pharmaceutical Company Limited | Inhibiteurs de pi3k/m tor |
US8716312B2 (en) | 2008-11-19 | 2014-05-06 | Merck Sharp & Dohme Corporation | Inhibitors of diacylglycerol acyltransferase |
US8283360B2 (en) | 2008-12-19 | 2012-10-09 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic derivatives and methods of use thereof |
JP2012513435A (ja) | 2008-12-23 | 2012-06-14 | エフ.ホフマン−ラ ロシュ アーゲー | P2x7調節薬としてのジヒドロピリドンアミド |
CN102480966B (zh) * | 2009-06-12 | 2015-09-16 | 达娜-法勃肿瘤研究所公司 | 融合的杂环化合物及其用途 |
JP2013502429A (ja) * | 2009-08-19 | 2013-01-24 | アムビト ビオスシエンセス コルポラチオン | ビアリール化合物及びその使用方法 |
CA2777565C (fr) | 2009-10-13 | 2019-06-18 | Ligand Pharmaceuticals Inc. | Composes de petite molecule de diphenylamine mimetique du facteur de croissance hematopoietique et leurs utilisations |
US8822447B2 (en) | 2010-04-22 | 2014-09-02 | Janssen Pharmaceutica Nv | Indazole compounds useful as ketohexokinase inhibitors |
US20130053382A1 (en) | 2010-04-30 | 2013-02-28 | Sunil Paliwal | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) |
PT2585064T (pt) | 2010-06-24 | 2017-08-08 | Chemocentryx Inc | Antagonistas do c5ar |
JP5985473B2 (ja) | 2010-07-13 | 2016-09-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | IRAK4モジュレーターとしてのピラゾロ[1,5a]ピリミジン及びチエノ[3,2b]ピリミジン誘導体 |
JP6005050B2 (ja) | 2010-11-19 | 2016-10-12 | リガンド ファーマシューティカルズ インコーポレイテッド | 複素環式アミンおよびその使用 |
WO2012084704A1 (fr) | 2010-12-20 | 2012-06-28 | Merck Serono S.A. | Dérivés d'indazolyl triazole en tant qu'inhibiteurs d'irak |
AU2012242926B2 (en) | 2011-04-12 | 2016-07-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria |
WO2013042137A1 (fr) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Hétérocycles bicycliques convenant comme inhibiteurs de l'irak4 |
SI2766359T1 (sl) * | 2011-10-14 | 2016-09-30 | Ambit Biosciences Corporation | Heterociklične spojine in njihova uporaba kot modulatorjev receptorja tirozin kinaze tipa III |
CA2852936A1 (fr) | 2011-10-20 | 2013-04-25 | Glaxosmithkline Llc | Azaheterocycles bicycliques substitues et analogues comme modulateurs de la sirtuine |
GB201119401D0 (en) | 2011-11-10 | 2011-12-21 | Ucb Pharma Sa | Therapeutic agents |
KR101385603B1 (ko) | 2012-05-17 | 2014-04-21 | 한국원자력의학원 | 벤조티아졸 유도체 및 암 치료를 위한 그의 용도 |
WO2014003483A1 (fr) | 2012-06-29 | 2014-01-03 | Hanmi Pharm. Co., Ltd. | Dérivés de pyrimidine fusionnés ayant une activité inhibitrice sur les fms kinase |
WO2014011902A1 (fr) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Inhibiteurs d'irak et leurs utilisations |
US9334249B2 (en) | 2012-11-03 | 2016-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
CA2907960C (fr) | 2013-05-22 | 2021-10-19 | Children's Hospital Medical Center | Polytherapie pour mds |
TWI652014B (zh) | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
SG11201605408RA (en) | 2014-01-10 | 2016-07-28 | Aurigene Discovery Tech Ltd | Indazole compounds as irak4 inhibitors |
SI3094329T1 (sl) | 2014-01-13 | 2019-02-28 | Aurigene Discovery Technologies Limited | Biciklični heterociklilni derivati kot inhibitorji IRAK4 |
WO2015119998A1 (fr) | 2014-02-06 | 2015-08-13 | Abbvie, Inc. | 6-hétéroaryloxy- et 6-aryloxy-quinoléine-2-carboxamides et leurs utilisations |
CA2952188A1 (fr) | 2014-06-20 | 2015-12-23 | Aurigene Discovery Technologies Limited | Composes d'imidazole substitues en tant qu'inhibiteurs de l'irak4 |
JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
BR112018000624A2 (pt) | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
US20180208605A1 (en) | 2015-07-15 | 2018-07-26 | Aurigene Discovery Technologies Limited | Substituted Aza Compounds as IRAK-4 Inhibitors |
US10065946B2 (en) | 2015-08-04 | 2018-09-04 | Rigel Pharmaceuticals, Inc. | Benzazole compounds and methods for making and using the compounds |
WO2018081738A1 (fr) | 2016-10-28 | 2018-05-03 | Children's Hospital Medical Center | Traitement de maladies associées à irak activé |
CN110691589A (zh) | 2017-03-31 | 2020-01-14 | 奥列基因发现技术有限公司 | 用于治疗血液病的化合物和组合物 |
WO2019089580A1 (fr) | 2017-10-31 | 2019-05-09 | Curis, Inc. | Composés et compositions pour le traitement de troubles hématologiques |
-
2018
- 2018-03-30 CN CN201880022870.5A patent/CN110691589A/zh active Pending
- 2018-03-30 FI FIEP18777745.3T patent/FI3600270T3/fi active
- 2018-03-30 KR KR1020247003678A patent/KR20240019391A/ko active Application Filing
- 2018-03-30 IL IL305150A patent/IL305150A/en unknown
- 2018-03-30 MX MX2019011158A patent/MX2019011158A/es unknown
- 2018-03-30 LT LTEPPCT/IB2018/052232T patent/LT3600270T/lt unknown
- 2018-03-30 BR BR112019018991A patent/BR112019018991A2/pt unknown
- 2018-03-30 JP JP2019552983A patent/JP7333136B2/ja active Active
- 2018-03-30 SI SI201830946T patent/SI3600270T1/sl unknown
- 2018-03-30 ES ES18777745T patent/ES2950764T3/es active Active
- 2018-03-30 EP EP23173240.5A patent/EP4252853A3/fr active Pending
- 2018-03-30 AU AU2018242623A patent/AU2018242623B2/en active Active
- 2018-03-30 IL IL293783A patent/IL293783B2/en unknown
- 2018-03-30 WO PCT/IB2018/052232 patent/WO2018178947A2/fr active Application Filing
- 2018-03-30 HR HRP20230657TT patent/HRP20230657T8/hr unknown
- 2018-03-30 SG SG11201908171T patent/SG11201908171TA/en unknown
- 2018-03-30 EP EP18777745.3A patent/EP3600270B1/fr active Active
- 2018-03-30 DK DK18777745.3T patent/DK3600270T3/da active
- 2018-03-30 CA CA3056893A patent/CA3056893A1/fr active Pending
- 2018-03-30 KR KR1020197032104A patent/KR102633530B1/ko active IP Right Grant
- 2018-03-30 EA EA201992322A patent/EA201992322A3/ru unknown
- 2018-03-30 IL IL269536A patent/IL269536B/en unknown
- 2018-03-30 PL PL18777745.3T patent/PL3600270T3/pl unknown
- 2018-03-30 HU HUE18777745A patent/HUE062648T2/hu unknown
- 2018-03-30 RS RS20230544A patent/RS64411B1/sr unknown
- 2018-03-30 US US16/498,866 patent/US11419875B2/en active Active
- 2018-03-30 PT PT187777453T patent/PT3600270T/pt unknown
-
2019
- 2019-09-18 PH PH12019502138A patent/PH12019502138A1/en unknown
- 2019-09-19 MX MX2022001343A patent/MX2022001343A/es unknown
-
2022
- 2022-06-29 US US17/853,299 patent/US20220339161A1/en active Pending
-
2023
- 2023-08-09 JP JP2023129903A patent/JP2023154005A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201908171TA (en) | Compounds and compositions for treating hematological disorders | |
SG11201804915RA (en) | Methods for treating huntington's disease | |
SG11201810423XA (en) | Pd-1 / pd-l1 inhibitors for cancer treatment | |
SG11201900480YA (en) | Anti-tim-3 antibodies | |
SG11201803920TA (en) | Compounds and compositions useful for treating disorders related to ntrk | |
SG11201809857TA (en) | Anti-CTLA-4 Antibodies | |
SG11201804758QA (en) | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab | |
SG11201809132RA (en) | Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | |
SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
SG11201804901WA (en) | Compounds for the treatment of cancer and inflammatory disease | |
SG11201809499UA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
SG11201907023UA (en) | Method of reducing neutropenia | |
SG11201807794VA (en) | Naphthene-containing distillate stream compositions and uses thereof | |
SG11201903076QA (en) | Carbamoyl phenylalaninol compounds and uses therof | |
SG11201805001UA (en) | Method of treating influenza a | |
SG11201807523PA (en) | Ilt7 binding molecules and methods of using the same | |
SG11201903061YA (en) | Combination treatments comprising administration of imidazopyrazinones | |
SG11201809534UA (en) | Methods of treating autoimmune disease using allogeneic t cells | |
SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same | |
SG11201806393QA (en) | Use of gabaa receptor modulators for treatment of itch | |
SG11201900043TA (en) | Antibody formulations | |
SG11201806424TA (en) | Therapeutic compounds | |
SG11201900214UA (en) | Iso-citrate dehydrogenase (idh) inhibitor | |
SG11201809551TA (en) | Selection of bacterial strains useful in allergy treatment | |
SG11201900515PA (en) | Succinate forms and compositions of bruton's tyrosine kinase inhibitors |