EA201992322A3 - Соединения и композиции для лечения гематологических расстройств - Google Patents

Соединения и композиции для лечения гематологических расстройств

Info

Publication number
EA201992322A3
EA201992322A3 EA201992322A EA201992322A EA201992322A3 EA 201992322 A3 EA201992322 A3 EA 201992322A3 EA 201992322 A EA201992322 A EA 201992322A EA 201992322 A EA201992322 A EA 201992322A EA 201992322 A3 EA201992322 A3 EA 201992322A3
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
hematological disorders
compositions
treatment
flt
Prior art date
Application number
EA201992322A
Other languages
English (en)
Other versions
EA201992322A2 (ru
Inventor
Венкатешвар Рао Гуммади
Сусанта Самадждар
Кавита Неллоре
Гириш Дагинакатте
Весли Рой Баласубраманиан
Original Assignee
Ориджин Дискавери Текнолоджиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ориджин Дискавери Текнолоджиз Лимитед filed Critical Ориджин Дискавери Текнолоджиз Лимитед
Publication of EA201992322A2 publication Critical patent/EA201992322A2/ru
Publication of EA201992322A3 publication Critical patent/EA201992322A3/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к способам лечения гематологических нарушений, таких как острый миелоидный лейкоз, с применением замещенных гетероциклических соединений и их фармацевтически приемлемых солей. Соединения ингибируют киназы IRAK4 и FLT-3.
EA201992322A 2017-03-31 2018-03-30 Соединения и композиции для лечения гематологических расстройств EA201992322A3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741011785 2017-03-31
PCT/IB2018/052232 WO2018178947A2 (en) 2017-03-31 2018-03-30 Compounds and compositions for treating hematological disorders

Publications (2)

Publication Number Publication Date
EA201992322A2 EA201992322A2 (ru) 2020-07-31
EA201992322A3 true EA201992322A3 (ru) 2020-09-30

Family

ID=63677680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992322A EA201992322A3 (ru) 2017-03-31 2018-03-30 Соединения и композиции для лечения гематологических расстройств

Country Status (24)

Country Link
US (2) US11419875B2 (ru)
EP (2) EP3600270B1 (ru)
JP (2) JP7333136B2 (ru)
KR (2) KR102633530B1 (ru)
CN (1) CN110691589A (ru)
AU (2) AU2018242623B2 (ru)
BR (1) BR112019018991A2 (ru)
CA (1) CA3056893A1 (ru)
DK (1) DK3600270T3 (ru)
EA (1) EA201992322A3 (ru)
ES (1) ES2950764T3 (ru)
FI (1) FI3600270T3 (ru)
HR (1) HRP20230657T8 (ru)
HU (1) HUE062648T2 (ru)
IL (3) IL305150A (ru)
LT (1) LT3600270T (ru)
MX (2) MX2019011158A (ru)
PH (1) PH12019502138A1 (ru)
PL (1) PL3600270T3 (ru)
PT (1) PT3600270T (ru)
RS (1) RS64411B1 (ru)
SG (1) SG11201908171TA (ru)
SI (1) SI3600270T1 (ru)
WO (1) WO2018178947A2 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3466955T3 (da) * 2014-01-13 2021-02-01 Aurigene Discovery Tech Ltd Fremgangsmåde til fremstilling af oxazol[4,5-b]pyridin og thiazol[4,5-b]pyridinderivater som irak4-hæmmere til behandling af cancer
PL3600270T3 (pl) 2017-03-31 2023-09-25 Aurigene Oncology Limited Związki i kompozycje do leczenia zaburzeń hematologicznych
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
EP3998264A4 (en) * 2019-07-10 2023-07-12 Medshine Discovery Inc. OXAZOLE COMPOUND AS A MULTI-TARGETED INHIBITOR OF IRAK4 AND BTK
WO2021047677A1 (zh) * 2019-09-12 2021-03-18 中国科学院上海药物研究所 一类irak4激酶抑制剂及其制备和应用
TW202142538A (zh) 2020-02-07 2021-11-16 美商迦舒布魯姆生物有限公司 雜環ｇｌｐ－１促效劑
AU2021251341A1 (en) 2020-04-07 2022-11-03 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
MX2023001296A (es) * 2020-08-03 2023-02-22 Curis Inc Composiciones y metodos para tratar enfermedades y trastornos.
WO2022135338A1 (zh) * 2020-12-25 2022-06-30 南京明德新药研发有限公司 酰胺噁唑类化合物
AU2022254933A1 (en) * 2021-04-08 2023-11-09 Curis, Inc. Combination therapies for the treatment of cancer
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
WO2023088435A1 (zh) * 2021-11-19 2023-05-25 成都奥睿药业有限公司 三取代吡啶衍生物的制备及作为芳香烃受体调节物的应用
WO2023116866A1 (zh) * 2021-12-23 2023-06-29 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US5494911A (en) 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
PT999825E (pt) 1997-07-29 2004-02-27 Alcon Lab Inc Composicoes oftalmicas contendo polimeros de galactomanano e borato
AU2483599A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
NZ543375A (en) 2003-05-01 2009-05-31 Bristol Myers Squibb Co Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
EP2281823A3 (en) 2003-05-20 2011-09-07 Ajinomoto Co., Inc. Anti-inflammatory and analgesic piperidine derivatives
US20050004133A1 (en) 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
JP2007525482A (ja) 2003-10-07 2007-09-06 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド化合物およびその使用
MXPA06012104A (es) 2004-04-22 2007-01-25 Bayer Cropscience Lp Metodo y composicion para controlar malas hierbas.
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1819341A4 (en) 2004-11-10 2011-06-29 Synta Pharmaceuticals Corp IL-12 MODULATORY CONNECTIONS
ES2333243T3 (es) 2004-12-17 2010-02-18 Eli Lilly And Company Derivados de tiazolopiridinona como antagonistas del receptor de mch.
EP1828177B1 (en) * 2004-12-17 2008-08-13 Eli Lilly And Company Novel mch receptor antagonists
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
EP1987028A2 (en) 2006-02-10 2008-11-05 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
US8008481B2 (en) 2006-03-31 2011-08-30 Ericsson Anna M Indazole compounds
US20080293785A1 (en) 2006-04-11 2008-11-27 Connolly Peter J Substituted benzothiazole kinase inhibitors
CN101594909A (zh) 2006-09-07 2009-12-02 比奥根艾迪克Ma公司 用于治疗炎性病症、细胞增殖性失调、免疫失调的irak调节剂
NZ575410A (en) 2006-09-07 2012-03-30 Biogen Idec Inc 2-(1H-Indazol-3-ylamino)-1H-benzimidazole derivatives
WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
JP5399262B2 (ja) 2006-12-08 2014-01-29 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒおよびｆｘｒのモジュレーター
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
EP2170892A2 (en) * 2007-06-14 2010-04-07 Schering Corporation Imidazopyrazines as protein kinase inhibitors
CN101754955A (zh) 2007-07-16 2010-06-23 雅培制药有限公司 作为蛋白激酶抑制剂的吲唑、苯并异*唑和苯并异噻唑化合物
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
US8399448B2 (en) 2007-08-08 2013-03-19 Merck Serono Sa 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
JP5496915B2 (ja) 2008-02-13 2014-05-21 シージーアイ ファーマシューティカルズ，インコーポレーテッド ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法
EP2303886A2 (en) * 2008-06-24 2011-04-06 Takeda Pharmaceutical Company Limited Pi3k/m tor inhibitors
AU2009316786A1 (en) 2008-11-19 2010-05-27 Merck Sharp & Dohme Corp. Inhibitors of diacylglycerol acyltransferase
EP2379564A1 (en) 2008-12-19 2011-10-26 Schering Corporation Bicyclic heterocyclic derivatives and methods of use thereof
CN102264701A (zh) 2008-12-23 2011-11-30 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮脲
WO2010144909A1 (en) * 2009-06-12 2010-12-16 Novartis Ag Fused heterocyclic compounds and their uses
CA2770454A1 (en) 2009-08-19 2011-02-24 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
JP5819305B2 (ja) 2009-10-13 2015-11-24 リガンド・ファーマシューティカルズ・インコーポレイテッド 造血成長因子模倣小分子化合物およびそれらの使用
AU2011242711C1 (en) 2010-04-22 2016-04-21 Janssen Pharmaceutica Nv Indazole compounds useful as ketohexokinase inhibitors
US20130053382A1 (en) 2010-04-30 2013-02-28 Sunil Paliwal Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1)
CN103068385B (zh) 2010-06-24 2015-04-29 凯莫森特里克斯股份有限公司 C5aR拮抗剂
CA2802641C (en) 2010-07-13 2019-03-12 Nidhi Arora Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators
PT2730564T (pt) 2010-11-19 2018-07-24 Ligand Pharm Inc Aminas heterocíclicas e suas utilizações
HUE029617T2 (en) 2010-12-20 2017-03-28 Merck Serono Sa Indazolyl triazole derivatives as IRAK inhibitors
WO2012142125A2 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
JP6162130B2 (ja) * 2011-10-14 2017-07-12 アムビト ビオスシエンセス コルポラチオン Ｉｉｉ型受容体チロシンキナーゼの調節因子としての複素環式化合物及びその使用
CN104394869A (zh) 2011-10-20 2015-03-04 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
US9085586B2 (en) 2012-07-11 2015-07-21 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
JP6372666B2 (ja) 2012-11-03 2018-08-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
EP2999470B1 (en) 2013-05-22 2017-08-16 Children's Hospital Medical Center Combination therapy for mds
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
EP3092226B1 (en) 2014-01-10 2019-03-13 Aurigene Discovery Technologies Limited Indazole compounds as irak4 inhibitors
DK3466955T3 (da) * 2014-01-13 2021-02-01 Aurigene Discovery Tech Ltd Fremgangsmåde til fremstilling af oxazol[4,5-b]pyridin og thiazol[4,5-b]pyridinderivater som irak4-hæmmere til behandling af cancer
BR112016017996A2 (pt) 2014-02-06 2017-08-08 Abbvie Inc 6-heteroariloxi- or 6-ariloxi-quinolina-2-carboxamidas e método de uso
EA201692418A1 (ru) 2014-06-20 2017-04-28 Ауриджен Дискавери Текнолоджиз Лимитед Замещенные индазольные соединения в качестве irak4 ингибиторов
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
EA201890307A1 (ru) 2015-07-15 2018-10-31 Ориджин Дискавери Текнолоджиз Лимитед Индазольные и азаиндазольные соединения как ингибиторы irak-4
WO2017009806A1 (en) * 2015-07-15 2017-01-19 Aurigene Discovery Technologies Limited Substituted aza compounds as irak-4 inhibitors
EP3719016A1 (en) 2015-08-04 2020-10-07 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
CA3038130A1 (en) 2016-10-28 2018-05-03 Children's Hospital Medical Center Treatment of diseases associated with activated irak
PL3600270T3 (pl) 2017-03-31 2023-09-25 Aurigene Oncology Limited Związki i kompozycje do leczenia zaburzeń hematologicznych
EP3704108B1 (en) 2017-10-31 2024-04-24 Curis, Inc. Irak4 inhibitor in combination with a bcl-2 inhibitor for use in treating cancer

Also Published As

Publication number Publication date
PT3600270T (pt) 2023-07-25
RS64411B1 (sr) 2023-09-29
EP3600270B1 (en) 2023-06-14
IL293783A (en) 2022-08-01
MX2019011158A (es) 2019-10-17
EP3600270A4 (en) 2020-08-26
NZ757707A (en) 2023-09-29
MX2022001343A (es) 2022-03-17
EA201992322A2 (ru) 2020-07-31
WO2018178947A2 (en) 2018-10-04
IL305150A (en) 2023-10-01
PL3600270T3 (pl) 2023-09-25
KR20240019391A (ko) 2024-02-14
LT3600270T (lt) 2023-08-25
IL269536A (en) 2019-11-28
HRP20230657T1 (hr) 2023-10-13
HUE062648T2 (hu) 2023-11-28
ES2950764T3 (es) 2023-10-13
EP3600270A2 (en) 2020-02-05
DK3600270T3 (da) 2023-07-10
EP4252853A3 (en) 2023-12-13
AU2018242623B2 (en) 2024-05-02
AU2024203943A1 (en) 2024-07-04
PH12019502138A1 (en) 2020-06-29
JP2023154005A (ja) 2023-10-18
CA3056893A1 (en) 2018-10-04
AU2018242623A1 (en) 2019-10-17
JP7333136B2 (ja) 2023-08-24
SI3600270T1 (sl) 2023-10-30
KR20190130023A (ko) 2019-11-20
FI3600270T3 (fi) 2023-07-20
SG11201908171TA (en) 2019-10-30
HRP20230657T8 (hr) 2023-11-10
JP2020512343A (ja) 2020-04-23
IL293783B2 (en) 2024-01-01
BR112019018991A2 (pt) 2020-04-14
IL269536B (en) 2022-07-01
US20210290628A1 (en) 2021-09-23
US20220339161A1 (en) 2022-10-27
KR102633530B1 (ko) 2024-02-02
EP4252853A2 (en) 2023-10-04
CN110691589A (zh) 2020-01-14
IL293783B1 (en) 2023-09-01
US11419875B2 (en) 2022-08-23

Similar Documents

Publication Publication Date Title
EA201992322A3 (ru) Соединения и композиции для лечения гематологических расстройств
SA520420458B1 (ar) نظائر رابامايسين مرتبطة بـ C40، C28، وC32 mTOR كمثبطات
MX2023007581A (es) Analogos de rapamicina unidos a c26 como inhibidores de mtor.
PH12018502102A1 (en) Pyrrolotriazine compounds as tam inhibitors
EA201991198A1 (ru) АМИНОТИАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
PH12018500041A1 (en) Substituted aza compoounds as irak-4 inhibitors
EA202092442A3 (ru) Новые гетероциклические производные, применимые в качестве ингибиторов shp2
EA201891910A1 (ru) Гетероарильные ингибиторы pad4
EA201991197A1 (ru) БЕНЗИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
EA202090497A1 (ru) Соединения и композиции для лечения гематологических нарушений
MD20170016A2 (ru) Аминопиримидиновые соединения в качестве ингибиторов JAK
EA201691302A1 (ru) Новые гетероциклические соединения
EA201592199A1 (ru) Производные бипиразола в качестве ингибиторов jak
EA201891251A1 (ru) Бициклические ингибиторы pad4
EA201692268A1 (ru) Ингибиторы фосфатидилинозитол-3-киназы
MX2020001757A (es) Compuestos, sales de los mismos y metodos para el tratamiento de enfermedades.
EA201692114A1 (ru) Замещенные дигидроизохинолиноновые соединения
EA201692267A1 (ru) Ингибиторы фосфатидилинозитол-3-киназы
MX2018012085A (es) Compuestos agonistas de gpr119 y metodo para tratar enfermedades y afecciones mediado a traves de gpr119.
UY37466A (es) N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa
EA201891347A1 (ru) Аза-бензимидазольные ингибиторы pad4
EA201692260A1 (ru) Соединения 1,3,4-тиадиазола и их применение в лечении рака
EA201792425A1 (ru) Трициклические соединения и их применение в качестве ингибиторов фосфодиэстераз
EA202190464A1 (ru) Замещенные бензимидазолы в качестве ингибиторов pad4
PH12020551343A1 (en) 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer