SG11201901306XA - Artificially engineered angiogenesis regulatory system - Google Patents
Artificially engineered angiogenesis regulatory systemInfo
- Publication number
- SG11201901306XA SG11201901306XA SG11201901306XA SG11201901306XA SG11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA
- Authority
- SG
- Singapore
- Prior art keywords
- neovascularization
- artificially
- regulatory system
- associated factor
- artificially engineered
- Prior art date
Links
- 230000001105 regulatory effect Effects 0.000 title abstract 6
- 230000033115 angiogenesis Effects 0.000 title abstract 2
- 206010029113 Neovascularisation Diseases 0.000 abstract 8
- 101150054149 ANGPTL4 gene Proteins 0.000 abstract 1
- 102100034608 Angiopoietin-2 Human genes 0.000 abstract 1
- 102000045205 Angiopoietin-Like Protein 4 Human genes 0.000 abstract 1
- 108700042530 Angiopoietin-Like Protein 4 Proteins 0.000 abstract 1
- 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 abstract 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 abstract 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 abstract 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 abstract 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 abstract 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 abstract 1
- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 abstract 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662376998P | 2016-08-19 | 2016-08-19 | |
PCT/KR2017/009078 WO2018034554A1 (ko) | 2016-08-19 | 2017-08-21 | 인위적으로 조작된 신생혈관형성 조절 시스템 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201901306XA true SG11201901306XA (en) | 2019-03-28 |
Family
ID=61196886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901306XA SG11201901306XA (en) | 2016-08-19 | 2017-08-21 | Artificially engineered angiogenesis regulatory system |
Country Status (11)
Country | Link |
---|---|
US (2) | US20180237771A1 (de) |
EP (2) | EP4012032A1 (de) |
JP (2) | JP7050215B2 (de) |
KR (2) | KR102145092B1 (de) |
CN (1) | CN109844123A (de) |
AU (2) | AU2017313616B2 (de) |
BR (1) | BR112019003124A2 (de) |
CA (1) | CA3033939A1 (de) |
RU (1) | RU2019103691A (de) |
SG (1) | SG11201901306XA (de) |
WO (1) | WO2018034554A1 (de) |
Families Citing this family (11)
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JP2020530279A (ja) * | 2017-07-07 | 2020-10-22 | ツールゲン インコーポレイテッドToolgen Incorporated | 標的特異的なcrisprバリアント |
EP3781196B1 (de) | 2018-03-27 | 2024-03-06 | G+Flas Life Sciences | Sequenzspezifisches in-vivo-zelltargeting |
US11865164B2 (en) | 2018-03-27 | 2024-01-09 | G+Flas Life Sciences | Pharmaceutical composition for treating cancer, containing guide RNA and endonuclease as active ingredients |
CN113195746B (zh) | 2018-12-17 | 2023-10-20 | 日本制铁株式会社 | 炉内残留熔渣量的估计方法和估计装置 |
EP3914711A2 (de) | 2019-01-23 | 2021-12-01 | Regeneron Pharmaceuticals, Inc. | Behandlung von ophthalmischen leiden mit angiopoietin-ähnlichen 7 (angptl7)-inhibitoren |
US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
CN112143701A (zh) * | 2019-06-26 | 2020-12-29 | 中国科学院脑科学与智能技术卓越创新中心 | 基于rna定点编辑的抑制脉络膜新生血管形成的方法及试剂 |
WO2021243105A1 (en) * | 2020-05-28 | 2021-12-02 | University Of Southern California | Composition and method for treating retinal vascular disease with vegf gene disruption |
CN112662674B (zh) * | 2021-01-12 | 2023-04-11 | 广州瑞风生物科技有限公司 | 靶向编辑VEGFA基因外显子区域的gRNA及其应用 |
CA3210480A1 (en) | 2021-02-26 | 2022-09-01 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors |
CN114540325B (zh) * | 2022-01-17 | 2022-12-09 | 广州医科大学 | 靶向dna去甲基化的方法、融合蛋白及其应用 |
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US7795422B2 (en) * | 2002-02-20 | 2010-09-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
ES2423060T3 (es) | 2004-03-12 | 2013-09-17 | Alnylam Pharmaceuticals, Inc. | Agentes iRNA que tienen como diana al VEGF |
JP2010519908A (ja) * | 2007-03-02 | 2010-06-10 | エムディーアールエヌエー,インコーポレイテッド | Hif1a遺伝子の発現を抑制するための核酸化合物およびその使用 |
WO2008154482A2 (en) * | 2007-06-08 | 2008-12-18 | Sirnaomics, Inc. | Sirna compositions and methods of use in treatment of ocular diseases |
WO2010078517A2 (en) * | 2008-12-31 | 2010-07-08 | Sirnaomics, Inc. | Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer |
WO2012100172A2 (en) * | 2011-01-22 | 2012-07-26 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of hif-1a by double stranded rna |
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SG10201912327SA (en) * | 2012-12-12 | 2020-02-27 | Broad Inst Inc | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
CN110540991B (zh) * | 2013-03-15 | 2023-10-24 | 通用医疗公司 | 使用截短的引导RNA(tru-gRNA)提高RNA引导的基因组编辑的特异性 |
KR20230136697A (ko) | 2013-06-05 | 2023-09-26 | 듀크 유니버시티 | Rna-가이드 유전자 편집 및 유전자 조절 |
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CN108472314A (zh) * | 2015-07-31 | 2018-08-31 | 明尼苏达大学董事会 | 修饰的细胞和治疗方法 |
TW201737944A (zh) | 2015-11-12 | 2017-11-01 | 輝瑞大藥廠 | 使用crispr-cas9之組織特異性基因組工程 |
WO2017099494A1 (ko) * | 2015-12-08 | 2017-06-15 | 기초과학연구원 | Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도 |
WO2018021855A1 (ko) | 2016-07-28 | 2018-02-01 | 기초과학연구원 | Cas9 단백질 및 가이드 RNA를 포함하는 안질환 치료용 약학 조성물 |
WO2018191750A2 (en) * | 2017-04-14 | 2018-10-18 | The Broad Institute Inc. | Novel delivery of large payloads |
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2017
- 2017-08-21 CN CN201780064951.7A patent/CN109844123A/zh active Pending
- 2017-08-21 EP EP21210792.4A patent/EP4012032A1/de active Pending
- 2017-08-21 RU RU2019103691A patent/RU2019103691A/ru not_active Application Discontinuation
- 2017-08-21 JP JP2019510289A patent/JP7050215B2/ja active Active
- 2017-08-21 WO PCT/KR2017/009078 patent/WO2018034554A1/ko unknown
- 2017-08-21 AU AU2017313616A patent/AU2017313616B2/en active Active
- 2017-08-21 BR BR112019003124A patent/BR112019003124A2/pt not_active Application Discontinuation
- 2017-08-21 KR KR1020170105303A patent/KR102145092B1/ko active IP Right Grant
- 2017-08-21 CA CA3033939A patent/CA3033939A1/en not_active Abandoned
- 2017-08-21 SG SG11201901306XA patent/SG11201901306XA/en unknown
- 2017-08-21 EP EP17841736.6A patent/EP3502261A4/de active Pending
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2018
- 2018-04-13 US US15/953,141 patent/US20180237771A1/en not_active Abandoned
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2020
- 2020-07-22 KR KR1020200090852A patent/KR102259006B1/ko active IP Right Grant
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2021
- 2021-04-21 US US17/236,660 patent/US11999952B2/en active Active
- 2021-12-27 JP JP2021212083A patent/JP7276422B2/ja active Active
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2022
- 2022-06-15 AU AU2022204172A patent/AU2022204172A1/en active Pending
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RU2019103691A (ru) | 2020-09-22 |
JP2022058425A (ja) | 2022-04-12 |
AU2022204172A1 (en) | 2022-07-07 |
EP3502261A1 (de) | 2019-06-26 |
US20180237771A1 (en) | 2018-08-23 |
US20210254054A1 (en) | 2021-08-19 |
AU2017313616B2 (en) | 2022-12-08 |
JP7050215B2 (ja) | 2022-04-08 |
KR20180020929A (ko) | 2018-02-28 |
US11999952B2 (en) | 2024-06-04 |
JP7276422B2 (ja) | 2023-05-18 |
KR20200098441A (ko) | 2020-08-20 |
KR102145092B1 (ko) | 2020-08-14 |
CN109844123A (zh) | 2019-06-04 |
CA3033939A1 (en) | 2018-02-22 |
WO2018034554A1 (ko) | 2018-02-22 |
KR102259006B1 (ko) | 2021-05-31 |
BR112019003124A2 (pt) | 2019-10-01 |
JP2019524847A (ja) | 2019-09-05 |
EP3502261A4 (de) | 2020-07-15 |
AU2017313616A1 (en) | 2019-02-07 |
EP4012032A1 (de) | 2022-06-15 |
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