SG11201901306XA - Artificially engineered angiogenesis regulatory system - Google Patents

Artificially engineered angiogenesis regulatory system

Info

Publication number
SG11201901306XA
SG11201901306XA SG11201901306XA SG11201901306XA SG11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA SG 11201901306X A SG11201901306X A SG 11201901306XA
Authority
SG
Singapore
Prior art keywords
neovascularization
artificially
regulatory system
associated factor
artificially engineered
Prior art date
Application number
SG11201901306XA
Other languages
English (en)
Inventor
Jeong Hun Kim
Sung Wook Park
Seokjoong Kim
Dong Woo Song
Original Assignee
Toolgen Inc
Seoul Nat Univ R&Db Foundation
Seoul Nat Univ Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toolgen Inc, Seoul Nat Univ R&Db Foundation, Seoul Nat Univ Hospital filed Critical Toolgen Inc
Publication of SG11201901306XA publication Critical patent/SG11201901306XA/en

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SG11201901306XA 2016-08-19 2017-08-21 Artificially engineered angiogenesis regulatory system SG11201901306XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662376998P 2016-08-19 2016-08-19
PCT/KR2017/009078 WO2018034554A1 (ko) 2016-08-19 2017-08-21 인위적으로 조작된 신생혈관형성 조절 시스템

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Publication Number Publication Date
SG11201901306XA true SG11201901306XA (en) 2019-03-28

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SG11201901306XA SG11201901306XA (en) 2016-08-19 2017-08-21 Artificially engineered angiogenesis regulatory system

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US (2) US20180237771A1 (de)
EP (2) EP4012032A1 (de)
JP (2) JP7050215B2 (de)
KR (2) KR102145092B1 (de)
CN (1) CN109844123A (de)
AU (2) AU2017313616B2 (de)
BR (1) BR112019003124A2 (de)
CA (1) CA3033939A1 (de)
RU (1) RU2019103691A (de)
SG (1) SG11201901306XA (de)
WO (1) WO2018034554A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020530279A (ja) * 2017-07-07 2020-10-22 ツールゲン インコーポレイテッドToolgen Incorporated 標的特異的なcrisprバリアント
EP3781196B1 (de) 2018-03-27 2024-03-06 G+Flas Life Sciences Sequenzspezifisches in-vivo-zelltargeting
US11865164B2 (en) 2018-03-27 2024-01-09 G+Flas Life Sciences Pharmaceutical composition for treating cancer, containing guide RNA and endonuclease as active ingredients
CN113195746B (zh) 2018-12-17 2023-10-20 日本制铁株式会社 炉内残留熔渣量的估计方法和估计装置
EP3914711A2 (de) 2019-01-23 2021-12-01 Regeneron Pharmaceuticals, Inc. Behandlung von ophthalmischen leiden mit angiopoietin-ähnlichen 7 (angptl7)-inhibitoren
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
CN112143701A (zh) * 2019-06-26 2020-12-29 中国科学院脑科学与智能技术卓越创新中心 基于rna定点编辑的抑制脉络膜新生血管形成的方法及试剂
WO2021243105A1 (en) * 2020-05-28 2021-12-02 University Of Southern California Composition and method for treating retinal vascular disease with vegf gene disruption
CN112662674B (zh) * 2021-01-12 2023-04-11 广州瑞风生物科技有限公司 靶向编辑VEGFA基因外显子区域的gRNA及其应用
CA3210480A1 (en) 2021-02-26 2022-09-01 Regeneron Pharmaceuticals, Inc. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors
CN114540325B (zh) * 2022-01-17 2022-12-09 广州医科大学 靶向dna去甲基化的方法、融合蛋白及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7795422B2 (en) * 2002-02-20 2010-09-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
ES2423060T3 (es) 2004-03-12 2013-09-17 Alnylam Pharmaceuticals, Inc. Agentes iRNA que tienen como diana al VEGF
JP2010519908A (ja) * 2007-03-02 2010-06-10 エムディーアールエヌエー,インコーポレイテッド Hif1a遺伝子の発現を抑制するための核酸化合物およびその使用
WO2008154482A2 (en) * 2007-06-08 2008-12-18 Sirnaomics, Inc. Sirna compositions and methods of use in treatment of ocular diseases
WO2010078517A2 (en) * 2008-12-31 2010-07-08 Sirnaomics, Inc. Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer
WO2012100172A2 (en) * 2011-01-22 2012-07-26 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of hif-1a by double stranded rna
US8697359B1 (en) * 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
SG10201912327SA (en) * 2012-12-12 2020-02-27 Broad Inst Inc Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation
CN110540991B (zh) * 2013-03-15 2023-10-24 通用医疗公司 使用截短的引导RNA(tru-gRNA)提高RNA引导的基因组编辑的特异性
KR20230136697A (ko) 2013-06-05 2023-09-26 듀크 유니버시티 Rna-가이드 유전자 편집 및 유전자 조절
EP3011034B1 (de) * 2013-06-17 2019-08-07 The Broad Institute, Inc. Freisetzung, verwendung und therapeutische anwendungen der crispr-cas-systeme und zusammensetzungen zur abzielung auf störungen und erkrankungen mit viralen komponenten
EP3971287A1 (de) 2013-07-11 2022-03-23 ModernaTX, Inc. Zusammensetzungen mit synthetischen polynukleotiden zur codierung von crispr-verwandten proteinen und synthetischen sgrnas und verfahren zur verwendung
US20160237455A1 (en) * 2013-09-27 2016-08-18 Editas Medicine, Inc. Crispr-related methods and compositions
AU2014346559B2 (en) * 2013-11-07 2020-07-09 Editas Medicine,Inc. CRISPR-related methods and compositions with governing gRNAs
MX2016007328A (es) * 2013-12-12 2017-07-19 Broad Inst Inc Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para edicion del genoma.
JP6715419B2 (ja) * 2014-08-06 2020-07-01 トゥールジェン インコーポレイテッド カンピロバクター・ジェジュニcrispr/casシステムに由来するrgenを使用したゲノム編集
ES2955957T3 (es) * 2015-01-28 2023-12-11 Caribou Biosciences Inc Polinucleótidos de ADN/ARN híbridos CRISPR y procedimientos de uso
CN108472314A (zh) * 2015-07-31 2018-08-31 明尼苏达大学董事会 修饰的细胞和治疗方法
TW201737944A (zh) 2015-11-12 2017-11-01 輝瑞大藥廠 使用crispr-cas9之組織特異性基因組工程
WO2017099494A1 (ko) * 2015-12-08 2017-06-15 기초과학연구원 Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
WO2018021855A1 (ko) 2016-07-28 2018-02-01 기초과학연구원 Cas9 단백질 및 가이드 RNA를 포함하는 안질환 치료용 약학 조성물
WO2018191750A2 (en) * 2017-04-14 2018-10-18 The Broad Institute Inc. Novel delivery of large payloads

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RU2019103691A (ru) 2020-09-22
JP2022058425A (ja) 2022-04-12
AU2022204172A1 (en) 2022-07-07
EP3502261A1 (de) 2019-06-26
US20180237771A1 (en) 2018-08-23
US20210254054A1 (en) 2021-08-19
AU2017313616B2 (en) 2022-12-08
JP7050215B2 (ja) 2022-04-08
KR20180020929A (ko) 2018-02-28
US11999952B2 (en) 2024-06-04
JP7276422B2 (ja) 2023-05-18
KR20200098441A (ko) 2020-08-20
KR102145092B1 (ko) 2020-08-14
CN109844123A (zh) 2019-06-04
CA3033939A1 (en) 2018-02-22
WO2018034554A1 (ko) 2018-02-22
KR102259006B1 (ko) 2021-05-31
BR112019003124A2 (pt) 2019-10-01
JP2019524847A (ja) 2019-09-05
EP3502261A4 (de) 2020-07-15
AU2017313616A1 (en) 2019-02-07
EP4012032A1 (de) 2022-06-15

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