MX2022000056A - Peptidos anti-microbianos estabilizados. - Google Patents

Peptidos anti-microbianos estabilizados.

Info

Publication number
MX2022000056A
MX2022000056A MX2022000056A MX2022000056A MX2022000056A MX 2022000056 A MX2022000056 A MX 2022000056A MX 2022000056 A MX2022000056 A MX 2022000056A MX 2022000056 A MX2022000056 A MX 2022000056A MX 2022000056 A MX2022000056 A MX 2022000056A
Authority
MX
Mexico
Prior art keywords
microbial peptides
stabilized anti
designing
stabilized
microbial
Prior art date
Application number
MX2022000056A
Other languages
English (en)
Inventor
Loren D Walensky
Rida Mourtada
Gregory H Bird
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of MX2022000056A publication Critical patent/MX2022000056A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona métodos para diseñar y elaborar péptidos antimicrobianos estabilizados estructuralmente basados en la secuencia de aminoácidos de magainina II para la profilaxis y tratamiento de infección (por ejemplo, con un microbio, por ejemplo, una bacteria). De manera más específica, la invención proporciona un compuesto que tiene la fórmula (I) y compuestos y péptidos basados en el péptido de magainina II. Los péptidos antimicrobianos estabilizados son líticos/citotóxicos de manera selectiva a bacterias, lo que permite el uso interno de péptidos antimicrobianos sin ruptura de la membrana del mamífero y citotoxicidad. Las composiciones de los mismos se pueden usar en varias aplicaciones, por ejemplo en la profilaxis y tratamiento de infección, en composiciones que contienen uno o más de cualquiera de los péptidos antimicrobianos estabilizados estructuralmente para usarse en un producto alimenticio o bebida, en un dispositivo médico o higiénico. Las composiciones o usos también involucran uno o más antibióticos. También se proporciona un método para inhibir el crecimiento de, o la destrucción de un organismo microbiano extracelular o intracelular que involucra poner en contacto al organismo microbiano con uno o más de cualquiera de los péptidos antimicrobianos estabilizados estructuralmente. (ver Fórmula).
MX2022000056A 2015-07-02 2017-12-13 Peptidos anti-microbianos estabilizados. MX2022000056A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562188448P 2015-07-02 2015-07-02
US201662301518P 2016-02-29 2016-02-29

Publications (1)

Publication Number Publication Date
MX2022000056A true MX2022000056A (es) 2022-03-11

Family

ID=57609337

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017016251A MX2017016251A (es) 2015-07-02 2016-07-01 Peptidos anti-microbianos estabilizados.
MX2022000056A MX2022000056A (es) 2015-07-02 2017-12-13 Peptidos anti-microbianos estabilizados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017016251A MX2017016251A (es) 2015-07-02 2016-07-01 Peptidos anti-microbianos estabilizados.

Country Status (12)

Country Link
US (2) US10464975B2 (es)
EP (1) EP3317294B1 (es)
JP (2) JP6918712B2 (es)
KR (1) KR20180022971A (es)
CN (1) CN108026146A (es)
AU (2) AU2016287754B2 (es)
BR (1) BR112017028413A2 (es)
CA (1) CA2989311A1 (es)
HK (1) HK1252893A1 (es)
IL (2) IL256395B (es)
MX (2) MX2017016251A (es)
WO (1) WO2017004591A2 (es)

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Publication number Publication date
IL256395A (en) 2018-02-28
BR112017028413A2 (pt) 2018-08-28
CN108026146A (zh) 2018-05-11
WO2017004591A2 (en) 2017-01-05
JP7360419B2 (ja) 2023-10-12
EP3317294A4 (en) 2019-07-17
JP2018527306A (ja) 2018-09-20
US20200231638A1 (en) 2020-07-23
EP3317294B1 (en) 2023-03-15
WO2017004591A3 (en) 2017-02-23
HK1252893A1 (zh) 2019-06-06
AU2021203223A1 (en) 2021-06-10
US10464975B2 (en) 2019-11-05
IL289250A (en) 2022-02-01
AU2016287754B2 (en) 2021-02-25
AU2016287754A1 (en) 2018-01-18
CA2989311A1 (en) 2017-01-05
IL256395B (en) 2022-05-01
US20170015716A1 (en) 2017-01-19
MX2017016251A (es) 2018-04-20
EP3317294A2 (en) 2018-05-09
JP6918712B2 (ja) 2021-08-11
JP2021155423A (ja) 2021-10-07
KR20180022971A (ko) 2018-03-06

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