MX2017002277A - Anticuerpos que potencian el factor h y sus usos. - Google Patents
Anticuerpos que potencian el factor h y sus usos.Info
- Publication number
- MX2017002277A MX2017002277A MX2017002277A MX2017002277A MX2017002277A MX 2017002277 A MX2017002277 A MX 2017002277A MX 2017002277 A MX2017002277 A MX 2017002277A MX 2017002277 A MX2017002277 A MX 2017002277A MX 2017002277 A MX2017002277 A MX 2017002277A
- Authority
- MX
- Mexico
- Prior art keywords
- factor
- antibodies
- potentiating antibodies
- fragments
- potentiating
- Prior art date
Links
- 230000003389 potentiating effect Effects 0.000 title 1
- 230000024203 complement activation Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 102000016550 Complement Factor H Human genes 0.000 abstract 1
- 108010053085 Complement Factor H Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención se refiere a anticuerpos aislados, sintéticos o recombinantes y fragmentos de ellos específicos para el factor H. La invención se refiere además al uso de dichos anticuerpos y fragmentos para inhibir la activación del complemento y para el tratamiento de trastornos asociados con la activación del complemento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14181631 | 2014-08-20 | ||
PCT/NL2015/050584 WO2016028150A1 (en) | 2014-08-20 | 2015-08-20 | Factor h potentiating antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017002277A true MX2017002277A (es) | 2017-08-10 |
Family
ID=51357866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002277A MX2017002277A (es) | 2014-08-20 | 2015-08-20 | Anticuerpos que potencian el factor h y sus usos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US10112993B2 (es) |
EP (1) | EP3183266B1 (es) |
JP (2) | JP6965157B2 (es) |
KR (1) | KR20170058922A (es) |
CN (1) | CN107074939B (es) |
AU (1) | AU2015304079B2 (es) |
BR (2) | BR122023020102A2 (es) |
CA (1) | CA2958537C (es) |
ES (1) | ES2739609T3 (es) |
IL (1) | IL250667B2 (es) |
MX (1) | MX2017002277A (es) |
WO (1) | WO2016028150A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020007555A (es) | 2018-01-15 | 2021-01-15 | Stichting Sanquin Bloedvoorziening | Anticuerpos potenciadores del factor h y usos de los mismos. |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
CN114828886A (zh) * | 2019-07-17 | 2022-07-29 | 双子治疗分公司 | 因子h增强抗体及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090004183A1 (en) * | 2004-07-23 | 2009-01-01 | Taylor Ronald P | Compositions and Methods for Regulating the Alternative Pathway of Complement |
WO2007056227A2 (en) * | 2005-11-04 | 2007-05-18 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
FR2894145B1 (fr) | 2005-12-07 | 2008-10-17 | Lab Francais Du Fractionnement | Utilisation de facteur h du complement a titre de medicament |
KR101572700B1 (ko) * | 2007-06-07 | 2015-11-30 | 제넨테크, 인크. | 보체-관련 장애의 예방 및 치료를 위한 C3b 항체 및 방법 |
GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
CN107661491A (zh) * | 2010-09-15 | 2018-02-06 | 赛尔戴克斯治疗公司 | 用可溶性I型补体受体(sCR1)治疗慢性肾病 |
AU2013326932B2 (en) * | 2012-10-04 | 2019-06-06 | Novelmed Therapeutics, Inc. | Alternative pathway specific antibodies for treating hemolytic diseases |
TW201605904A (zh) * | 2013-11-07 | 2016-02-16 | 諾佛 儂迪克股份有限公司 | 治療凝血病變之新穎方法及抗體 |
US10357554B2 (en) * | 2013-11-11 | 2019-07-23 | The United States Of America, As Represented By The Secretary Of The Army | AMA-1 epitopes, antibodies, compositions, and methods of making and using the same |
-
2015
- 2015-08-20 WO PCT/NL2015/050584 patent/WO2016028150A1/en active Application Filing
- 2015-08-20 US US15/504,983 patent/US10112993B2/en active Active
- 2015-08-20 MX MX2017002277A patent/MX2017002277A/es unknown
- 2015-08-20 EP EP15787045.2A patent/EP3183266B1/en active Active
- 2015-08-20 JP JP2017508990A patent/JP6965157B2/ja active Active
- 2015-08-20 CA CA2958537A patent/CA2958537C/en active Active
- 2015-08-20 KR KR1020177006402A patent/KR20170058922A/ko not_active Application Discontinuation
- 2015-08-20 AU AU2015304079A patent/AU2015304079B2/en active Active
- 2015-08-20 IL IL250667A patent/IL250667B2/en unknown
- 2015-08-20 ES ES15787045T patent/ES2739609T3/es active Active
- 2015-08-20 BR BR122023020102-7A patent/BR122023020102A2/pt unknown
- 2015-08-20 BR BR112017003200-7A patent/BR112017003200B1/pt active IP Right Grant
- 2015-08-20 CN CN201580053289.6A patent/CN107074939B/zh active Active
-
2018
- 2018-10-29 US US16/173,787 patent/US20190194304A1/en not_active Abandoned
-
2021
- 2021-08-05 JP JP2021129121A patent/JP2021178857A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL250667B2 (en) | 2023-10-01 |
IL250667A0 (en) | 2017-04-30 |
BR122023020102A2 (pt) | 2023-12-12 |
CA2958537C (en) | 2023-04-25 |
US10112993B2 (en) | 2018-10-30 |
AU2015304079B2 (en) | 2021-05-13 |
BR112017003200A2 (pt) | 2017-11-28 |
KR20170058922A (ko) | 2017-05-29 |
US20170355753A1 (en) | 2017-12-14 |
ES2739609T3 (es) | 2020-02-03 |
IL250667B1 (en) | 2023-06-01 |
US20190194304A1 (en) | 2019-06-27 |
EP3183266B1 (en) | 2019-05-29 |
EP3183266A1 (en) | 2017-06-28 |
CA2958537A1 (en) | 2016-02-25 |
BR112017003200B1 (pt) | 2023-12-26 |
AU2015304079A1 (en) | 2017-04-06 |
CN107074939B (zh) | 2021-09-07 |
CN107074939A (zh) | 2017-08-18 |
WO2016028150A1 (en) | 2016-02-25 |
JP2017525362A (ja) | 2017-09-07 |
JP2021178857A (ja) | 2021-11-18 |
JP6965157B2 (ja) | 2021-11-10 |
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