SG11201811516QA - Liver delivery-based antiviral precursor drug nucleoside cyclophosphate compound and use thereof - Google Patents
Liver delivery-based antiviral precursor drug nucleoside cyclophosphate compound and use thereofInfo
- Publication number
- SG11201811516QA SG11201811516QA SG11201811516QA SG11201811516QA SG11201811516QA SG 11201811516Q A SG11201811516Q A SG 11201811516QA SG 11201811516Q A SG11201811516Q A SG 11201811516QA SG 11201811516Q A SG11201811516Q A SG 11201811516QA SG 11201811516Q A SG11201811516Q A SG 11201811516QA
- Authority
- SG
- Singapore
- Prior art keywords
- compound
- based antiviral
- precursor drug
- virus
- liver
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000000840 anti-viral effect Effects 0.000 title abstract 3
- 210000004185 liver Anatomy 0.000 title abstract 3
- 239000002777 nucleoside Substances 0.000 title abstract 3
- 150000003833 nucleoside derivatives Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- 208000037262 Hepatitis delta Diseases 0.000 abstract 2
- 241000724709 Hepatitis delta virus Species 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492624 | 2016-06-24 | ||
| CN201710254377.3A CN107540710B (zh) | 2016-06-24 | 2017-04-18 | 肝递送抗病毒前体药物核苷环磷酸酯化合物及应用 |
| PCT/CN2017/089850 WO2017220028A1 (zh) | 2016-06-24 | 2017-06-23 | 肝递送抗病毒前体药物核苷环磷酸酯化合物及应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201811516QA true SG11201811516QA (en) | 2019-01-30 |
Family
ID=60966227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201811516QA SG11201811516QA (en) | 2016-06-24 | 2017-06-23 | Liver delivery-based antiviral precursor drug nucleoside cyclophosphate compound and use thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10668090B2 (ja) |
| EP (1) | EP3476854B1 (ja) |
| JP (1) | JP6980779B2 (ja) |
| KR (1) | KR102434764B1 (ja) |
| CN (1) | CN107540710B (ja) |
| ES (1) | ES2880391T3 (ja) |
| HU (1) | HUE055833T2 (ja) |
| PH (1) | PH12018502735A1 (ja) |
| PL (1) | PL3476854T3 (ja) |
| PT (1) | PT3476854T (ja) |
| RS (1) | RS62144B1 (ja) |
| SG (1) | SG11201811516QA (ja) |
| ZA (1) | ZA201808616B (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109956975B (zh) * | 2017-12-22 | 2020-11-06 | 浙江柏拉阿图医药科技有限公司 | 肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用 |
| CN109956986B (zh) * | 2017-12-22 | 2021-04-27 | 浙江柏拉阿图医药科技有限公司 | 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用 |
| CN113683641B (zh) * | 2020-05-07 | 2023-09-01 | 西安新通药物研究股份有限公司 | 替诺福韦磷酸酯d晶型及其制备和应用 |
| WO2021223398A1 (zh) * | 2020-05-07 | 2021-11-11 | 西安新通药物研究股份有限公司 | 治疗肝病的晶型及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2401070T3 (es) * | 1998-03-06 | 2013-04-16 | Metabasis Therapeutics, Inc. | Nuevos profármacos para compuestos que contienen fósforo |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| NZ536328A (en) * | 2002-05-13 | 2007-11-30 | Metabasis Therapeutics Inc | Novel phosphonic acid based prodrugs of PMEA and its analogues |
| CN101475594B (zh) * | 2009-02-06 | 2012-05-30 | 廖国超 | 肝靶向抗病毒前体药物环状磷酸酯及其应用 |
| WO2013106344A1 (en) | 2012-01-12 | 2013-07-18 | Ligand Pharmaceuticals, Inc. | 2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5' |
| CN103333209B (zh) * | 2013-07-05 | 2015-09-30 | 西安新通药物研究有限公司 | 替诺福韦前药(hts)新晶体 |
| CN104710477A (zh) * | 2013-12-16 | 2015-06-17 | 安徽贝克联合制药有限公司 | 替诺福韦环膦酸酯化合物及其药学上可接受的盐和其制备方法及应用 |
-
2017
- 2017-04-18 CN CN201710254377.3A patent/CN107540710B/zh active Active
- 2017-06-23 KR KR1020187037490A patent/KR102434764B1/ko active IP Right Grant
- 2017-06-23 SG SG11201811516QA patent/SG11201811516QA/en unknown
- 2017-06-23 ES ES17814766T patent/ES2880391T3/es active Active
- 2017-06-23 JP JP2019520191A patent/JP6980779B2/ja active Active
- 2017-06-23 PL PL17814766T patent/PL3476854T3/pl unknown
- 2017-06-23 RS RS20210867A patent/RS62144B1/sr unknown
- 2017-06-23 HU HUE17814766A patent/HUE055833T2/hu unknown
- 2017-06-23 EP EP17814766.6A patent/EP3476854B1/en active Active
- 2017-06-23 PT PT178147666T patent/PT3476854T/pt unknown
-
2018
- 2018-12-20 ZA ZA2018/08616A patent/ZA201808616B/en unknown
- 2018-12-21 PH PH12018502735A patent/PH12018502735A1/en unknown
- 2018-12-22 US US16/231,497 patent/US10668090B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3476854T3 (pl) | 2021-11-02 |
| EP3476854A4 (en) | 2020-02-12 |
| ES2880391T3 (es) | 2021-11-24 |
| CN107540710B (zh) | 2020-10-16 |
| US10668090B2 (en) | 2020-06-02 |
| PT3476854T (pt) | 2021-08-06 |
| KR20190022556A (ko) | 2019-03-06 |
| JP6980779B2 (ja) | 2021-12-15 |
| RS62144B1 (sr) | 2021-08-31 |
| HUE055833T2 (hu) | 2021-12-28 |
| PH12018502735A1 (en) | 2019-10-28 |
| ZA201808616B (en) | 2019-08-28 |
| KR102434764B1 (ko) | 2022-08-19 |
| EP3476854A1 (en) | 2019-05-01 |
| JP2019524875A (ja) | 2019-09-05 |
| US20190125771A1 (en) | 2019-05-02 |
| CN107540710A (zh) | 2018-01-05 |
| EP3476854B1 (en) | 2021-05-12 |
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