PL3476854T3 - Związek cyklofosforanu nukleozydu stanowiący przeciwwirusowy lek prekursorowy oraz jego zastosowanie - Google Patents
Związek cyklofosforanu nukleozydu stanowiący przeciwwirusowy lek prekursorowy oraz jego zastosowanieInfo
- Publication number
- PL3476854T3 PL3476854T3 PL17814766T PL17814766T PL3476854T3 PL 3476854 T3 PL3476854 T3 PL 3476854T3 PL 17814766 T PL17814766 T PL 17814766T PL 17814766 T PL17814766 T PL 17814766T PL 3476854 T3 PL3476854 T3 PL 3476854T3
- Authority
- PL
- Poland
- Prior art keywords
- precursor drug
- antiviral
- compound
- cyclophosphate compound
- drug nucleoside
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492624 | 2016-06-24 | ||
| CN201710254377.3A CN107540710B (zh) | 2016-06-24 | 2017-04-18 | 肝递送抗病毒前体药物核苷环磷酸酯化合物及应用 |
| EP17814766.6A EP3476854B1 (en) | 2016-06-24 | 2017-06-23 | Antiviral precursor drug nucleoside cyclophosphate compound and use thereof |
| PCT/CN2017/089850 WO2017220028A1 (zh) | 2016-06-24 | 2017-06-23 | 肝递送抗病毒前体药物核苷环磷酸酯化合物及应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3476854T3 true PL3476854T3 (pl) | 2021-11-02 |
Family
ID=60966227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17814766T PL3476854T3 (pl) | 2016-06-24 | 2017-06-23 | Związek cyklofosforanu nukleozydu stanowiący przeciwwirusowy lek prekursorowy oraz jego zastosowanie |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10668090B2 (pl) |
| EP (1) | EP3476854B1 (pl) |
| JP (1) | JP6980779B2 (pl) |
| KR (1) | KR102434764B1 (pl) |
| CN (1) | CN107540710B (pl) |
| ES (1) | ES2880391T3 (pl) |
| HU (1) | HUE055833T2 (pl) |
| PH (1) | PH12018502735A1 (pl) |
| PL (1) | PL3476854T3 (pl) |
| PT (1) | PT3476854T (pl) |
| RS (1) | RS62144B1 (pl) |
| SG (1) | SG11201811516QA (pl) |
| ZA (1) | ZA201808616B (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109956986B (zh) * | 2017-12-22 | 2021-04-27 | 浙江柏拉阿图医药科技有限公司 | 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用 |
| CN109956975B (zh) * | 2017-12-22 | 2020-11-06 | 浙江柏拉阿图医药科技有限公司 | 肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用 |
| WO2021223398A1 (zh) * | 2020-05-07 | 2021-11-11 | 西安新通药物研究股份有限公司 | 治疗肝病的晶型及其应用 |
| CN112028940B (zh) * | 2020-05-07 | 2021-09-24 | 西安新通药物研究股份有限公司 | 替诺福韦磷酸酯晶型及其制备和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2322487C (en) * | 1998-03-06 | 2010-07-20 | Metabasis Therapeutics, Inc. | Novel prodrugs for phosphorus-containing compounds |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| WO2004037161A2 (en) * | 2002-05-13 | 2004-05-06 | Metabasis Therapeutics, Inc. | Cyclic prodrugs of pmea one of its analogues |
| CN101475594B (zh) * | 2009-02-06 | 2012-05-30 | 廖国超 | 肝靶向抗病毒前体药物环状磷酸酯及其应用 |
| US20140356325A1 (en) | 2012-01-12 | 2014-12-04 | Ligand Pharmaceuticals Incorporated | Novel 2'-c-methyl nucleoside derivative compounds |
| CN103333209B (zh) * | 2013-07-05 | 2015-09-30 | 西安新通药物研究有限公司 | 替诺福韦前药(hts)新晶体 |
| CN104710477A (zh) * | 2013-12-16 | 2015-06-17 | 安徽贝克联合制药有限公司 | 替诺福韦环膦酸酯化合物及其药学上可接受的盐和其制备方法及应用 |
-
2017
- 2017-04-18 CN CN201710254377.3A patent/CN107540710B/zh active Active
- 2017-06-23 JP JP2019520191A patent/JP6980779B2/ja active Active
- 2017-06-23 RS RS20210867A patent/RS62144B1/sr unknown
- 2017-06-23 KR KR1020187037490A patent/KR102434764B1/ko active IP Right Grant
- 2017-06-23 HU HUE17814766A patent/HUE055833T2/hu unknown
- 2017-06-23 EP EP17814766.6A patent/EP3476854B1/en active Active
- 2017-06-23 ES ES17814766T patent/ES2880391T3/es active Active
- 2017-06-23 SG SG11201811516QA patent/SG11201811516QA/en unknown
- 2017-06-23 PL PL17814766T patent/PL3476854T3/pl unknown
- 2017-06-23 PT PT178147666T patent/PT3476854T/pt unknown
-
2018
- 2018-12-20 ZA ZA2018/08616A patent/ZA201808616B/en unknown
- 2018-12-21 PH PH12018502735A patent/PH12018502735A1/en unknown
- 2018-12-22 US US16/231,497 patent/US10668090B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102434764B1 (ko) | 2022-08-19 |
| CN107540710B (zh) | 2020-10-16 |
| RS62144B1 (sr) | 2021-08-31 |
| PH12018502735A1 (en) | 2019-10-28 |
| PT3476854T (pt) | 2021-08-06 |
| JP6980779B2 (ja) | 2021-12-15 |
| EP3476854A4 (en) | 2020-02-12 |
| US20190125771A1 (en) | 2019-05-02 |
| JP2019524875A (ja) | 2019-09-05 |
| US10668090B2 (en) | 2020-06-02 |
| CN107540710A (zh) | 2018-01-05 |
| ZA201808616B (en) | 2019-08-28 |
| EP3476854A1 (en) | 2019-05-01 |
| EP3476854B1 (en) | 2021-05-12 |
| HUE055833T2 (hu) | 2021-12-28 |
| ES2880391T3 (es) | 2021-11-24 |
| SG11201811516QA (en) | 2019-01-30 |
| KR20190022556A (ko) | 2019-03-06 |
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