SG11201810628XA - Nasal pharmaceutical compositions with a porous excipient - Google Patents

Nasal pharmaceutical compositions with a porous excipient

Info

Publication number
SG11201810628XA
SG11201810628XA SG11201810628XA SG11201810628XA SG11201810628XA SG 11201810628X A SG11201810628X A SG 11201810628XA SG 11201810628X A SG11201810628X A SG 11201810628XA SG 11201810628X A SG11201810628X A SG 11201810628XA SG 11201810628X A SG11201810628X A SG 11201810628XA
Authority
SG
Singapore
Prior art keywords
international
porous excipient
applicant
pharmaceutical compositions
nasal pharmaceutical
Prior art date
Application number
SG11201810628XA
Other languages
English (en)
Inventor
Claudia Mattern
Original Assignee
M et P Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M et P Pharma AG filed Critical M et P Pharma AG
Publication of SG11201810628XA publication Critical patent/SG11201810628XA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Ceramic Engineering (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
SG11201810628XA 2016-06-03 2017-06-02 Nasal pharmaceutical compositions with a porous excipient SG11201810628XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662345369P 2016-06-03 2016-06-03
PCT/IB2017/053288 WO2017208209A1 (en) 2016-06-03 2017-06-02 Nasal pharmaceutical compositions with a porous excipient

Publications (1)

Publication Number Publication Date
SG11201810628XA true SG11201810628XA (en) 2018-12-28

Family

ID=59078127

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810628XA SG11201810628XA (en) 2016-06-03 2017-06-02 Nasal pharmaceutical compositions with a porous excipient

Country Status (11)

Country Link
US (1) US11903951B2 (zh)
EP (1) EP3463375A1 (zh)
JP (2) JP2019517590A (zh)
KR (1) KR102387241B1 (zh)
CN (1) CN109803663A (zh)
AU (1) AU2017274649B2 (zh)
CA (1) CA3026041A1 (zh)
EA (1) EA201892595A1 (zh)
MX (1) MX2018014906A (zh)
SG (1) SG11201810628XA (zh)
WO (1) WO2017208209A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019008656A (es) * 2017-01-20 2019-11-21 M et P Pharma AG Composiciones farmaceuticas nasales para reducir los riesgos de la exposicion a los contaminantes del aire.
RU2020126425A (ru) 2018-01-11 2022-02-11 М Эт П Фарма Аг Лечение демиелинизирующих заболеваний
CN110536680B (zh) * 2018-01-22 2021-02-26 北京茵诺医药科技有限公司 用于靶向活化cd44分子的树枝状聚合物纳米载体递送系统、其制备方法和用途
EP3781129A1 (en) * 2018-04-17 2021-02-24 M Et P Pharma AG Compositions and methods for intranasal delivery of pregnenolone
WO2020037236A1 (en) 2018-08-17 2020-02-20 Massachusetts Institute Of Technology Degradable polymers of a cyclic silyl ether and uses thereof
WO2021109880A1 (zh) * 2019-12-06 2021-06-10 上海医药集团股份有限公司 药物组合物、成套药盒及其应用
RS63725B1 (sr) 2020-05-18 2022-12-30 Orexo Ab Nova farmaceutska kompozicija za davanje leka
JP2021000483A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
JP2021000484A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
JP2021000481A (ja) * 2020-09-15 2021-01-07 株式会社三洋物産 遊技機
CN112263546B (zh) * 2020-09-29 2021-08-10 南京大学 通过鼻腔给药的佐匹克隆混悬液纳米制剂及其制备方法
CN112972428B (zh) * 2021-03-09 2022-03-08 石河子大学 两性离子聚合物膜包覆的介孔硅基药物载体及制备方法
CN113456576B (zh) * 2021-06-28 2022-09-16 华中科技大学 纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用
AR127780A1 (es) 2021-11-25 2024-02-28 Orexo Ab Nueva composición farmacéutica que comprende adrenalina
TW202345837A (zh) * 2022-04-01 2023-12-01 美商安納萊爾治療公司 呼吸道刺激劑鼻用調配物
CN115505052B (zh) * 2022-08-23 2023-05-23 安徽普利药业有限公司 一种β-环糊精衍生物的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002597A (en) 1989-04-03 1991-03-26 Invent Ag Aerodynamic filter
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
DE19701912C1 (de) 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
DE10064950A1 (de) 2000-12-23 2002-07-11 Impetus Ag Basel Thixotropes Nasenspray
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
US7563451B2 (en) * 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
US8784869B2 (en) 2003-11-11 2014-07-22 Mattern Pharma Ag Controlled release delivery system for nasal applications and methods of treatment
PT1530965E (pt) 2003-11-11 2006-05-31 Udo Mattern Sistema de administracao de libertacao controlada de hormonas sexuais para aplicacao nasal
US20060140820A1 (en) 2004-12-28 2006-06-29 Udo Mattern Use of a container of an inorganic additive containing plastic material
WO2007041079A2 (en) 2005-09-30 2007-04-12 Alza Corporation Banded controlled release nanoparticle active agent formulation dosage forms and methods
PT2068825E (pt) * 2006-10-04 2011-02-11 M & P Patent Ag Sistema de administração de libertação controlada para aplicação nasal de neurotransmissores
US8258137B2 (en) * 2008-01-29 2012-09-04 Katholieke Universiteit Leuven Process for release of biologically active species from mesoporous oxide systems
MY162982A (en) * 2008-09-23 2017-07-31 Laboratory Skin Care Inc Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same
JP2012506904A (ja) * 2008-10-28 2012-03-22 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 難水溶性成分のためのメソ多孔性材料賦形剤
CA2835911C (en) 2011-05-13 2022-08-30 Trimel Biopharma Srl Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US20130040922A1 (en) 2011-05-13 2013-02-14 Trimel Pharmaceuticals Corporation Intranasal 0.45% and 0.48% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
PL2714006T4 (pl) 2011-05-15 2021-08-16 Acerus Biopharma Inc. Donosowe bio-adhezyjne formulacje żelu testosteronowego i ich zastosowanie w leczeniu hipogonadyzmu
ITTO20111242A1 (it) * 2011-12-30 2013-07-01 Miso S R L Composizioni per il trattamento di patologie delle mucose
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US20150297733A1 (en) * 2012-11-14 2015-10-22 Trimel Biopharma Srl Controlled release topical testosterone formulations and methods
US20150290217A1 (en) * 2012-11-21 2015-10-15 Trimel Biopharma Srl Male testosterone titration methods, male intranasal testosterone bio-adhesive gel formulations and use thereof for treating hypogonadism and trt
EP3065717A1 (en) 2013-11-04 2016-09-14 Biopharmx, Inc. Dosage form comprising an active ingredient and a plurality of solid porous microcarriers
US20170246111A1 (en) * 2014-09-15 2017-08-31 Pharmasol Gmbh Active-loaded particulate materials for topical administration
US11123391B2 (en) 2015-08-04 2021-09-21 Inqpharm Group Sdn Bhd Nasal composition
US20180250656A1 (en) 2015-09-09 2018-09-06 King Abdullah University Of Science And Technology Functionalized sio2 microspheres for extracting oil from produced water
MX2019008656A (es) 2017-01-20 2019-11-21 M et P Pharma AG Composiciones farmaceuticas nasales para reducir los riesgos de la exposicion a los contaminantes del aire.

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