SG11201810088SA - Recovering long-range linkage information from preserved samples - Google Patents

Recovering long-range linkage information from preserved samples

Info

Publication number
SG11201810088SA
SG11201810088SA SG11201810088SA SG11201810088SA SG11201810088SA SG 11201810088S A SG11201810088S A SG 11201810088SA SG 11201810088S A SG11201810088S A SG 11201810088SA SG 11201810088S A SG11201810088S A SG 11201810088SA SG 11201810088S A SG11201810088S A SG 11201810088SA
Authority
SG
Singapore
Prior art keywords
international
california
information
samples
pct
Prior art date
Application number
SG11201810088SA
Other languages
English (en)
Inventor
Christopher John Troll
Martin P Powers
Nicholas H Putnam
Marco Blanchette
Paul Hartley
Original Assignee
Dovetail Genomics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dovetail Genomics Llc filed Critical Dovetail Genomics Llc
Publication of SG11201810088SA publication Critical patent/SG11201810088SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/50Other enzymatic activities
    • C12Q2521/501Ligase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/101Crosslinking agents, e.g. psoralen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/161Modifications characterised by incorporating target specific and non-target specific sites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50Detection characterised by immobilisation to a surface
    • C12Q2565/514Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
SG11201810088SA 2016-05-13 2017-05-12 Recovering long-range linkage information from preserved samples SG11201810088SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662336252P 2016-05-13 2016-05-13
US201662410599P 2016-10-20 2016-10-20
PCT/US2017/032466 WO2017197300A1 (en) 2016-05-13 2017-05-12 Recovering long-range linkage information from preserved samples

Publications (1)

Publication Number Publication Date
SG11201810088SA true SG11201810088SA (en) 2018-12-28

Family

ID=60266720

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810088SA SG11201810088SA (en) 2016-05-13 2017-05-12 Recovering long-range linkage information from preserved samples

Country Status (11)

Country Link
US (2) US10947579B2 (ko)
EP (2) EP3455356B1 (ko)
JP (2) JP2019522487A (ko)
KR (1) KR102412442B1 (ko)
CN (1) CN109477101B (ko)
AU (1) AU2017263810B2 (ko)
CA (1) CA3023990A1 (ko)
DK (1) DK3455356T3 (ko)
IL (1) IL262946B2 (ko)
SG (1) SG11201810088SA (ko)
WO (1) WO2017197300A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10526641B2 (en) * 2014-08-01 2020-01-07 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
WO2016154540A1 (en) 2015-03-26 2016-09-29 Dovetail Genomics Llc Physical linkage preservation in dna storage
US10975417B2 (en) * 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
JP2019522487A (ja) * 2016-05-13 2019-08-15 ダブテイル ゲノミクス エルエルシー 保存されたサンプルからの長距離連鎖情報の回復
CN111655848A (zh) 2017-11-21 2020-09-11 阿瑞玛基因组学公司 在核酸模板中保留空间邻位邻接性和分子邻接性
CN113272441A (zh) * 2018-11-20 2021-08-17 阿瑞玛基因组学公司 保留空间邻近连续性信息的制备核酸的方法和组合物
JP2022541387A (ja) * 2019-06-27 2022-09-26 ダブテイル ゲノミクス エルエルシー 近接ライゲーションのための方法および組成物
EP4058573A4 (en) * 2019-11-15 2023-12-27 Phase Genomics Inc. CAPTURING CHROMOSOME CONFORMATION FROM TISSUE SAMPLES
IL294909A (en) 2020-02-13 2022-09-01 Zymergen Inc A metagenomic library and natural product discovery platform

Family Cites Families (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
CA2097708A1 (en) 1990-12-06 1992-06-07 Stephen P. A. Fodor Very large scale immobilized polymer synthesis
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
ATE241426T1 (de) 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung von polymerarrays
US6033854A (en) 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5348853A (en) 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5567583A (en) 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
ATE246702T1 (de) 1993-04-12 2003-08-15 Univ Northwestern Verfahren zur darstellung von oligonukleotiden
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6632598B1 (en) * 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
US6110709A (en) 1994-03-18 2000-08-29 The General Hospital Corporation Cleaved amplified modified polymorphic sequence detection methods
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
WO1997029212A1 (en) 1996-02-08 1997-08-14 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
CA2257109C (en) 1996-06-04 2009-10-06 University Of Utah Research Foundation Monitoring hybridization during pcr
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
WO1998041651A1 (en) 1997-03-18 1998-09-24 Hsc Research & Development Limited Partnership Method for preparing chromatin
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
EP2034031A1 (en) 1997-10-28 2009-03-11 Los Alamos National Security, LLC DNA polymorphism identity determination using flow cytometry
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US20040106110A1 (en) 1998-07-30 2004-06-03 Solexa, Ltd. Preparation of polynucleotide arrays
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
CA2340361A1 (en) 1998-08-21 2000-03-16 Peter C. Cheng Assays using crosslinkable immobilized nucleic acids
DK1137812T3 (da) 1998-12-02 2007-05-21 Adnexus Therapeutics Inc DNA-proteinfusioner og anvendelser deraf
US8367322B2 (en) 1999-01-06 2013-02-05 Cornell Research Foundation, Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US6994969B1 (en) 1999-04-30 2006-02-07 Methexis Genomics, N.V. Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6225109B1 (en) 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
US6448717B1 (en) 2000-07-17 2002-09-10 Micron Technology, Inc. Method and apparatuses for providing uniform electron beams from field emission displays
WO2002027029A2 (en) 2000-09-27 2002-04-04 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
US7001724B1 (en) 2000-11-28 2006-02-21 Applera Corporation Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
CA2460679A1 (en) 2001-05-11 2003-11-20 Michael Mcarthur Dna microarrays comprising active chromatin elements and comprehensive profiling therewith
GB0114853D0 (en) 2001-06-18 2001-08-08 Medical Res Council Happier Mapping
WO2003020968A2 (de) 2001-08-29 2003-03-13 Genovoxx Gmbh Verfahren zur analyse von nukleinsäurekettensequenzen und der genexpression
DE10246005A1 (de) 2001-10-04 2003-04-30 Genovoxx Gmbh Gerät zur Sequenzierung von Nukleinsäuremolekülen
DE10149786B4 (de) 2001-10-09 2013-04-25 Dmitry Cherkasov Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
EP1497455A4 (en) 2001-11-09 2005-12-28 Aclara Biosciences Inc DETECTION OF NUCLEIC ACID SEQUENCES BY CLEAVAGE AND SEPARATION OF MARKED STRUCTURES
US20050130161A1 (en) 2002-03-08 2005-06-16 Peter Fraser Tagging and recovery of elements associated with target molecules
US20030228627A1 (en) 2002-03-22 2003-12-11 Emerson Beverly M. Assay for p53 function in cells
DE10214395A1 (de) 2002-03-30 2003-10-23 Dmitri Tcherkassov Verfahren zur Analyse von Einzelnukleotidpolymorphismen
KR101038137B1 (ko) 2002-06-28 2011-05-31 프리메라디엑스, 인크. 서열 차이를 감지하는 방법
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US7414117B2 (en) 2002-12-26 2008-08-19 Ngk Insulators, Ltd. Nucleotide derivative and DNA microarray
JP4480715B2 (ja) 2003-01-29 2010-06-16 454 コーポレーション 二重末端シーケンシング
US20040197779A1 (en) 2003-04-03 2004-10-07 Apffel James Alexander Methods for analyzing mixtures of proteins
US8741577B2 (en) 2003-04-07 2014-06-03 Bio-Rad Laboratories Inc. Surface immobilised multilayer structure of vesicles
FI20030778A0 (fi) 2003-05-22 2003-05-22 Licentia Oy Taudin määrittäminen tai ennustaminen
WO2005001113A2 (en) 2003-06-27 2005-01-06 Thomas Jefferson University Methods for detecting nucleic acid variations
PT1639122E (pt) 2003-07-02 2009-04-09 Dsm Ip Assets Bv Sistema de teste aperfeiçoado para determinar a presença de um antibiótico num fluido
GB0316075D0 (en) 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
DE10356837A1 (de) 2003-12-05 2005-06-30 Dmitry Cherkasov Modifizierte Nukleotide und Nukleoside
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
DE102004009704A1 (de) 2004-02-27 2005-09-15 Dmitry Cherkasov Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung
US20050260624A1 (en) 2004-02-28 2005-11-24 Wang Chang N J Novel nucleic acid complexes and detection thereof
DE102004025745A1 (de) 2004-05-26 2005-12-15 Cherkasov, Dmitry Oberfläche für die Analysen an einzelnen Molekülen
DE102004025696A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten
DE102004025744A1 (de) 2004-05-26 2005-12-29 Dmitry Cherkasov Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen
DE102004025694A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten
DE102004025695A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten
DE102004025746A1 (de) 2004-05-26 2005-12-15 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
US7361468B2 (en) 2004-07-02 2008-04-22 Affymetrix, Inc. Methods for genotyping polymorphisms in humans
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060024678A1 (en) 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
GB0422730D0 (en) 2004-10-13 2004-11-17 Lingvitae As Method
JP2008527330A (ja) * 2004-12-30 2008-07-24 ベンタナ・メデイカル・システムズ・インコーポレーテツド 低温の脱パラフィン処理
EP1885876A2 (de) 2005-03-17 2008-02-13 Genovoxx GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7425415B2 (en) 2005-04-06 2008-09-16 City Of Hope Method for detecting methylated CpG islands
JP2006301289A (ja) 2005-04-20 2006-11-02 Tokyo Ohka Kogyo Co Ltd ネガ型レジスト組成物およびレジストパターン形成方法
US20090233291A1 (en) * 2005-06-06 2009-09-17 454 Life Sciences Corporation Paired end sequencing
WO2006138257A2 (en) 2005-06-15 2006-12-28 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20090264299A1 (en) * 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
KR101383593B1 (ko) 2005-07-04 2014-04-09 에라스무스 유니버시티 메디칼 센터 염색체 입체형태 칩-상-포착(4c) 에세이
DE102005060738A1 (de) * 2005-12-16 2007-06-21 Qiagen Gmbh Verfahren zur Extraktion von Biomolekülen aus fixierten Geweben
US20110027890A1 (en) 2005-12-26 2011-02-03 Kuraray Co., Ltd. Material for cell culture
US20070172839A1 (en) 2006-01-24 2007-07-26 Smith Douglas R Asymmetrical adapters and methods of use thereof
GB0603251D0 (en) 2006-02-17 2006-03-29 Isis Innovation DNA conformation
US8071296B2 (en) 2006-03-13 2011-12-06 Agency For Science, Technology And Research Nucleic acid interaction analysis
WO2007136874A2 (en) 2006-05-18 2007-11-29 President And Fellows Of Harvard College Genomic library construction
CA2661640A1 (en) 2006-08-24 2008-02-28 University Of Massachusetts Medical School Mapping of genomic interactions
MX2009003687A (es) 2006-10-04 2009-08-25 Brookhaven Science Ass Llc Conjuntos de nanoparticulas guiados por adn.
US8278112B2 (en) 2006-12-21 2012-10-02 The Regents Of The University Of California Site-specific installation of methyl-lysine analogues into recombinant histones
CN101688237A (zh) 2007-01-11 2010-03-31 伊拉兹马斯大学医疗中心 环状染色体构象捕获(4c)
WO2008097887A2 (en) 2007-02-02 2008-08-14 Emory University Methods of direct genomic selection using high density oligonucleotide microarrays
US9096906B2 (en) * 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
AU2008254986A1 (en) 2007-05-14 2008-11-27 Insight Genetics, Inc. Methods of screening nucleic acids for single nucleotide variations
US8951731B2 (en) 2007-10-15 2015-02-10 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
WO2009078386A1 (ja) * 2007-12-14 2009-06-25 Chugai Seiyaku Kabushiki Kaisha 組織形態保持および核酸品質保持に優れた新規標本作製法
US8263367B2 (en) 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
US20090269771A1 (en) 2008-04-24 2009-10-29 Life Technologies Corporation Method of sequencing and mapping target nucleic acids
US20090298064A1 (en) 2008-05-29 2009-12-03 Serafim Batzoglou Genomic Sequencing
GB0810051D0 (en) 2008-06-02 2008-07-09 Oxford Biodynamics Ltd Method of diagnosis
US8076070B2 (en) 2008-08-06 2011-12-13 University Of Southern California Genome-wide chromosome conformation capture
US9434985B2 (en) 2008-09-25 2016-09-06 University Of Massachusetts Methods of identifying interactions between genomic loci
EP2370594B1 (en) 2008-11-18 2014-01-08 BioNano Genomics, Inc. Polynucleotide mapping and sequencing
WO2010091060A1 (en) 2009-02-03 2010-08-12 New England Biolabs, Inc. Generation of random double strand breaks in dna using enzymes
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
CA2790941C (en) * 2010-02-26 2018-10-23 Qiagen Gmbh Method for isolating rna from a rna and dna containing sample
US20110287947A1 (en) 2010-05-18 2011-11-24 University Of Southern California Tethered Conformation Capture
RS57295B1 (sr) 2010-07-09 2018-08-31 Cergentis B V 3-d strategije sekvenciranja genomskog regiona od interesa
WO2012047726A1 (en) 2010-09-29 2012-04-12 The Broad Institute, Inc. Methods for chromatin immuno-precipitations
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US20120197533A1 (en) 2010-10-11 2012-08-02 Complete Genomics, Inc. Identifying rearrangements in a sequenced genome
ES2688458T5 (es) 2010-10-22 2022-04-13 Cold Spring Harbor Laboratory Recuento varietal de ácidos nucleicos para obtener información del número de copias genómicas
WO2012083225A2 (en) 2010-12-16 2012-06-21 Gigagen, Inc. System and methods for massively parallel analysis of nycleic acids in single cells
WO2012103442A2 (en) * 2011-01-28 2012-08-02 The Broad Institute, Inc. Paired end bead amplification and high throughput sequencing
EP2670894B1 (en) 2011-02-02 2017-11-29 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
US20140141442A1 (en) 2011-04-05 2014-05-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Linear dna amplification
WO2012142531A2 (en) 2011-04-14 2012-10-18 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
EP2710146A2 (en) 2011-05-18 2014-03-26 Life Technologies Corporation Chromosome conformation analysis
SG194745A1 (en) 2011-05-20 2013-12-30 Fluidigm Corp Nucleic acid encoding reactions
US20120330559A1 (en) 2011-06-21 2012-12-27 Life Technologies Corporation Systems and methods for hybrid assembly of nucleic acid sequences
WO2013078470A2 (en) 2011-11-22 2013-05-30 MOTIF, Active Multiplex isolation of protein-associated nucleic acids
EP2841601B1 (en) 2012-04-24 2019-03-06 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
KR101974577B1 (ko) 2012-05-21 2019-05-02 삼성전자주식회사 나노입자 제작용 주형 및 이를 이용한 나노입자의 제조 방법
ES2675167T3 (es) 2012-07-13 2018-07-09 X-Chem, Inc. Bibliotecas codificadas por ADN que tienen enlaces oligonucleotídicos codificantes no legibles por polimerasas
WO2014047561A1 (en) 2012-09-21 2014-03-27 The Broad Institute Inc. Compositions and methods for labeling of agents
WO2014087137A1 (en) * 2012-12-07 2014-06-12 Sarissa Biomedical Limited Device including biosensor and holder
EP3885446A1 (en) * 2013-02-01 2021-09-29 The Regents of The University of California Methods for genome assembly and haplotype phasing
US9411930B2 (en) * 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
TWI462930B (zh) * 2013-06-06 2014-12-01 Rbc Bioscience Corp 福馬林固定石蠟包埋樣本核酸分離方法
US10385401B2 (en) * 2013-11-21 2019-08-20 Assistance Publique Hopitaux De Paris Method for detecting chromosomal rearrangements
WO2015089243A1 (en) 2013-12-11 2015-06-18 The Regents For Of The University Of California Methods for labeling dna fragments to recontruct physical linkage and phase
US9822396B2 (en) 2014-02-13 2017-11-21 Bio-Rad Laboratories, Inc. Chromosome conformation capture in partitions
US10526641B2 (en) 2014-08-01 2020-01-07 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
WO2016044313A1 (en) * 2014-09-16 2016-03-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for the removal of aldehyde adducts and crosslinks from biomolecules
JP6443450B2 (ja) * 2014-09-19 2018-12-26 コニカミノルタ株式会社 画像処理装置、画像処理方法、及びプログラム
BR122021026779B1 (pt) * 2014-10-17 2023-12-19 Illumina Cambridge Limited Transposon de preservação de contiguidade
SG10202000731WA (en) 2015-02-17 2020-03-30 Dovetail Genomics Llc Nucleic acid sequence assembly
WO2016154540A1 (en) 2015-03-26 2016-09-29 Dovetail Genomics Llc Physical linkage preservation in dna storage
US11326159B2 (en) 2015-04-06 2022-05-10 The Regents Of The University Of California Methods and compositions for long-range haplotype phasing
US9658142B2 (en) * 2015-04-14 2017-05-23 Arizona Board Of Regents On Behalf Of Arizona State University Method and apparatus for extracting and collecting single cells from formalin-fixed paraffin embedded tissues
US11795496B2 (en) 2015-06-24 2023-10-24 Oxford BioDynamics PLC Epigenetic chromosome interactions
WO2017070123A1 (en) 2015-10-19 2017-04-27 Dovetail Genomics, Llc Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
SG10202108763UA (en) * 2015-12-04 2021-09-29 10X Genomics Inc Methods and compositions for nucleic acid analysis
JP6965272B2 (ja) * 2016-04-22 2021-11-10 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation 高スループット粒子捕捉および分析
JP2019522487A (ja) * 2016-05-13 2019-08-15 ダブテイル ゲノミクス エルエルシー 保存されたサンプルからの長距離連鎖情報の回復

Also Published As

Publication number Publication date
JP2022095676A (ja) 2022-06-28
KR102412442B1 (ko) 2022-06-22
CN109477101B (zh) 2022-11-18
IL262946A (en) 2018-12-31
CA3023990A1 (en) 2017-11-16
JP2019522487A (ja) 2019-08-15
US20210371904A1 (en) 2021-12-02
AU2017263810A1 (en) 2018-12-20
KR20190037201A (ko) 2019-04-05
EP3954771A1 (en) 2022-02-16
IL262946B2 (en) 2023-03-01
US10947579B2 (en) 2021-03-16
EP3455356A4 (en) 2019-11-27
WO2017197300A1 (en) 2017-11-16
AU2017263810B2 (en) 2023-08-17
DK3455356T3 (da) 2021-11-01
IL262946B (en) 2022-11-01
US20190032113A1 (en) 2019-01-31
EP3455356A1 (en) 2019-03-20
CN109477101A (zh) 2019-03-15
EP3455356B1 (en) 2021-08-04

Similar Documents

Publication Publication Date Title
SG11201810088SA (en) Recovering long-range linkage information from preserved samples
SG11201809522WA (en) Method of nucleic acid sequence determination
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201810003UA (en) Using programmable dna binding proteins to enhance targeted genome modification
SG11201811048UA (en) Single-cell transcript sequencing
SG11201901563UA (en) De novo synthesized nucleic acid libraries
SG11201805805VA (en) Recombinogenic nucleic acid strands in situ
SG11201907855QA (en) Multispecific binding proteins targeting caix, ano1, mesothelin,trop2, cea, or claudin-18.2
SG11201903697WA (en) Liver organoid compositions and methods of making and using same
SG11201909011PA (en) Niraparib compositions
SG11201808476SA (en) Recycling of polymer matrix composite
SG11201806398YA (en) Optimized factor viii genes
SG11201809530PA (en) Method for recovery of phosphate
SG11201809374VA (en) Cd40l-fc fusion polypeptides and methods of use thereof
SG11202000312UA (en) Encapsulated polynucleotides and methods of use
SG11201903153PA (en) Metal recovery process
SG11201804180XA (en) High density rotomolding resin
SG11201805115PA (en) Detection and quantification of target nucleic acid sequence of a microorganism
SG11201811496RA (en) Hybrid polyols based on natural oil polyols
SG11201903883YA (en) System for fixing and transporting storage bags for motorcycles
SG11201804143WA (en) A process and apparatus for in-line blending of polymers
SG11201804770QA (en) Method and arrangement for recovery of salt
SG11201805497QA (en) Mutated truncated von willebrand factor
SG11201908127WA (en) Method for producing multispecific antibodies
SG11201810975UA (en) Method for stabilizing proteins