SG11201808622SA - Chimeric receptors to flt3 and methods of use thereof - Google Patents

Chimeric receptors to flt3 and methods of use thereof

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Publication number
SG11201808622SA
SG11201808622SA SG11201808622SA SG11201808622SA SG11201808622SA SG 11201808622S A SG11201808622S A SG 11201808622SA SG 11201808622S A SG11201808622S A SG 11201808622SA SG 11201808622S A SG11201808622S A SG 11201808622SA SG 11201808622S A SG11201808622S A SG 11201808622SA
Authority
SG
Singapore
Prior art keywords
international
flt3
california
methods
chimeric receptors
Prior art date
Application number
SG11201808622SA
Other languages
English (en)
Inventor
Alice Bakker
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11201808622SA publication Critical patent/SG11201808622SA/en

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/42—Cancer antigens
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells

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SG11201808622SA 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof SG11201808622SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317219P 2016-04-01 2016-04-01
PCT/US2017/025613 WO2017173410A1 (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

Publications (1)

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SG11201808622SA true SG11201808622SA (en) 2018-10-30

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SG11201808622SA SG11201808622SA (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof
SG10201911963VA SG10201911963VA (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

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US (2) US20190183931A1 (enrdf_load_stackoverflow)
EP (1) EP3436479A1 (enrdf_load_stackoverflow)
JP (3) JP2019516352A (enrdf_load_stackoverflow)
KR (2) KR102694879B1 (enrdf_load_stackoverflow)
CN (1) CN109641956A (enrdf_load_stackoverflow)
AR (2) AR109626A1 (enrdf_load_stackoverflow)
AU (3) AU2017240801A1 (enrdf_load_stackoverflow)
BR (1) BR112018070187A8 (enrdf_load_stackoverflow)
CA (1) CA3019655A1 (enrdf_load_stackoverflow)
CL (1) CL2018002792A1 (enrdf_load_stackoverflow)
CO (1) CO2018011804A2 (enrdf_load_stackoverflow)
CR (2) CR20180518A (enrdf_load_stackoverflow)
EA (1) EA201892193A1 (enrdf_load_stackoverflow)
IL (2) IL296966A (enrdf_load_stackoverflow)
MA (1) MA44507A (enrdf_load_stackoverflow)
MX (1) MX2023013729A (enrdf_load_stackoverflow)
MY (1) MY201207A (enrdf_load_stackoverflow)
NZ (1) NZ746925A (enrdf_load_stackoverflow)
PE (2) PE20190201A1 (enrdf_load_stackoverflow)
PH (1) PH12018502118B1 (enrdf_load_stackoverflow)
SA (1) SA518400154B1 (enrdf_load_stackoverflow)
SG (2) SG11201808622SA (enrdf_load_stackoverflow)
TN (1) TN2018000337A1 (enrdf_load_stackoverflow)
TW (2) TWI776807B (enrdf_load_stackoverflow)
UA (1) UA128326C2 (enrdf_load_stackoverflow)
WO (1) WO2017173410A1 (enrdf_load_stackoverflow)

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