SG11201807834WA - Bridged bicyclic inhibitors of menin-mll and methods of use - Google Patents
Bridged bicyclic inhibitors of menin-mll and methods of useInfo
- Publication number
- SG11201807834WA SG11201807834WA SG11201807834WA SG11201807834WA SG11201807834WA SG 11201807834W A SG11201807834W A SG 11201807834WA SG 11201807834W A SG11201807834W A SG 11201807834WA SG 11201807834W A SG11201807834W A SG 11201807834WA SG 11201807834W A SG11201807834W A SG 11201807834WA
- Authority
- SG
- Singapore
- Prior art keywords
- huron
- floor
- international
- ann arbor
- parkway
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662309362P | 2016-03-16 | 2016-03-16 | |
| US201662431387P | 2016-12-07 | 2016-12-07 | |
| PCT/US2017/022535 WO2017161002A1 (en) | 2016-03-16 | 2017-03-15 | Bridged bicyclic inhibitors of menin-mll and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807834WA true SG11201807834WA (en) | 2018-10-30 |
Family
ID=59851929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201807834WA SG11201807834WA (en) | 2016-03-16 | 2017-03-15 | Bridged bicyclic inhibitors of menin-mll and methods of use |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10752639B2 (de) |
| EP (1) | EP3429585B1 (de) |
| JP (1) | JP7000333B2 (de) |
| KR (1) | KR102419524B1 (de) |
| CN (1) | CN109640987B (de) |
| AU (1) | AU2017235462B2 (de) |
| BR (1) | BR112018068702A2 (de) |
| CA (1) | CA3015845A1 (de) |
| HK (1) | HK1258821A1 (de) |
| IL (1) | IL261625B (de) |
| MA (1) | MA43823A (de) |
| MX (1) | MX2018011092A (de) |
| PH (1) | PH12018501955A1 (de) |
| SG (1) | SG11201807834WA (de) |
| TW (1) | TWI743096B (de) |
| WO (1) | WO2017161002A1 (de) |
| ZA (1) | ZA201805845B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| EP3302057A4 (de) | 2015-06-04 | 2018-11-21 | Kura Oncology, Inc. | Verfahren und zusammensetzungen zur hemmung der interaktion von menin mit mll-proteinen |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| IL261606B (en) | 2016-03-16 | 2022-09-01 | Kura Oncology Inc | Inhibitors of converted menin-mll and methods of use |
| MA43823A (fr) | 2016-03-16 | 2018-11-28 | Kura Oncology Inc | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
| CA3022868A1 (en) | 2016-05-02 | 2017-11-09 | Shaomeng Wang | Piperidines as menin inhibitors |
| EP3512857B1 (de) | 2016-09-14 | 2021-02-24 | Janssen Pharmaceutica NV | Spiro-bizyklische inhibitoren von menin-mll-wechselwirkung |
| EP3512858B1 (de) | 2016-09-14 | 2023-11-08 | Janssen Pharmaceutica NV | Kondensierte bicyclische inhibitoren der menin-mll-interaktion |
| AU2017376599B2 (en) | 2016-12-15 | 2021-10-07 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-MLL interaction |
| EA201991448A1 (ru) | 2017-01-06 | 2019-12-30 | Янссен Фармацевтика Нв | Азепановые ингибиторы взаимодействия менин-mll |
| US11944627B2 (en) * | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| MX2019011412A (es) | 2017-03-31 | 2020-02-07 | Univ Michigan Regents | Piperidinas como inhibidores de menina covalentes. |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TW201920170A (zh) * | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| CN110204552B (zh) * | 2018-02-28 | 2021-08-17 | 中国科学院上海药物研究所 | 一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途 |
| US11325921B2 (en) | 2018-03-30 | 2022-05-10 | Sumitomo Dainippon Pharma Co., Ltd. | Optically active crosslinked cyclic secondary amine derivative |
| EP3856173A4 (de) * | 2018-09-26 | 2022-07-06 | Kura Oncology, Inc. | Behandlung hämatologischen malignitäten mit inhibitoren von menin |
| CN110964016B (zh) * | 2018-09-29 | 2021-05-28 | 南京药捷安康生物科技有限公司 | 氨基降茨烷衍生物及其制备方法与应用 |
| SG11202104243VA (en) * | 2018-12-06 | 2021-05-28 | Daiichi Sankyo Co Ltd | Cycloalkane-1,3-diamine derivative |
| TW202043205A (zh) | 2018-12-31 | 2020-12-01 | 美商拜歐米富士恩有限公司 | Menin-mll相互作用之抑制劑 |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| US20230165858A1 (en) * | 2020-04-07 | 2023-06-01 | Syndax Pharmaceuticals, Inc. | Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof |
| CN117321049A (zh) | 2021-05-08 | 2023-12-29 | 詹森药业有限公司 | 取代的螺环衍生物 |
| EP4334320A1 (de) | 2021-05-08 | 2024-03-13 | JANSSEN Pharmaceutica NV | Substituierte spiroderivate |
| AR125866A1 (es) | 2021-05-14 | 2023-08-23 | Syndax Pharmaceuticals Inc | Inhibidores de la interacción de menina-mll |
| EP4347588A1 (de) | 2021-06-01 | 2024-04-10 | JANSSEN Pharmaceutica NV | Substituierte phenyl-1h-pyrrolo[2,3-c pyridin-derivate |
| CN117425659A (zh) | 2021-06-03 | 2024-01-19 | 詹森药业有限公司 | 哒嗪或被螺环胺取代的1,2,4-三嗪 |
| KR20240021808A (ko) | 2021-06-17 | 2024-02-19 | 얀센 파마슈티카 엔브이 | 암과 같은 질환의 치료를 위한 (r)-n-에틸-5-플루오로-n-아이소프로필-2-((5-(2-(6-((2-메톡시에틸)(메틸)아미노)-2-메틸헥산-3-일)-2,6-다이아자스피로[3.4]옥탄-6-일)-1,2,4-트라이아진-6-일)옥시)벤즈아미드 베실레이트 염 |
| WO2023220098A1 (en) * | 2022-05-09 | 2023-11-16 | Syndax Pharmaceuticals, Inc. | Menin-mll inhibitors for the treatment of cancer |
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| MA43823A (fr) | 2016-03-16 | 2018-11-28 | Kura Oncology Inc | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
| IL261606B (en) | 2016-03-16 | 2022-09-01 | Kura Oncology Inc | Inhibitors of converted menin-mll and methods of use |
| CA3022868A1 (en) | 2016-05-02 | 2017-11-09 | Shaomeng Wang | Piperidines as menin inhibitors |
| WO2017207387A1 (en) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction |
| MX2018015252A (es) | 2016-06-10 | 2019-04-25 | Vitae Pharmaceuticals Inc | Inhibidores de la interaccion de menina-leucemia de linaje mixto. |
| WO2018024602A1 (en) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro[4.4]nonanes |
| EP3512858B1 (de) | 2016-09-14 | 2023-11-08 | Janssen Pharmaceutica NV | Kondensierte bicyclische inhibitoren der menin-mll-interaktion |
| CA3033239A1 (en) | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-mll interaction |
| EP4230627A3 (de) | 2016-09-16 | 2023-11-15 | Vitae Pharmaceuticals, LLC | Inhibitoren der menin-mll-interaktion |
-
2017
- 2017-03-15 MA MA043823A patent/MA43823A/fr unknown
- 2017-03-15 SG SG11201807834WA patent/SG11201807834WA/en unknown
- 2017-03-15 CA CA3015845A patent/CA3015845A1/en active Pending
- 2017-03-15 JP JP2018544323A patent/JP7000333B2/ja active Active
- 2017-03-15 MX MX2018011092A patent/MX2018011092A/es unknown
- 2017-03-15 KR KR1020187029700A patent/KR102419524B1/ko active IP Right Grant
- 2017-03-15 TW TW106108619A patent/TWI743096B/zh active
- 2017-03-15 EP EP17767444.7A patent/EP3429585B1/de active Active
- 2017-03-15 US US16/082,645 patent/US10752639B2/en active Active
- 2017-03-15 AU AU2017235462A patent/AU2017235462B2/en active Active
- 2017-03-15 BR BR112018068702A patent/BR112018068702A2/pt not_active Application Discontinuation
- 2017-03-15 CN CN201780030449.4A patent/CN109640987B/zh active Active
- 2017-03-15 WO PCT/US2017/022535 patent/WO2017161002A1/en active Application Filing
-
2018
- 2018-08-30 ZA ZA2018/05845A patent/ZA201805845B/en unknown
- 2018-09-05 IL IL261625A patent/IL261625B/en unknown
- 2018-09-11 PH PH12018501955A patent/PH12018501955A1/en unknown
-
2019
- 2019-01-23 HK HK19101198.7A patent/HK1258821A1/zh unknown
-
2020
- 2020-07-13 US US16/927,844 patent/US11555041B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3015845A1 (en) | 2017-09-21 |
| AU2017235462A1 (en) | 2018-09-27 |
| JP7000333B2 (ja) | 2022-02-10 |
| JP2019508426A (ja) | 2019-03-28 |
| KR20180127406A (ko) | 2018-11-28 |
| US20210107917A1 (en) | 2021-04-15 |
| ZA201805845B (en) | 2023-03-29 |
| MX2018011092A (es) | 2018-11-22 |
| US10752639B2 (en) | 2020-08-25 |
| MA43823A (fr) | 2018-11-28 |
| CN109640987A (zh) | 2019-04-16 |
| TW201742870A (zh) | 2017-12-16 |
| CN109640987B (zh) | 2022-12-02 |
| EP3429585A4 (de) | 2019-10-09 |
| EP3429585A1 (de) | 2019-01-23 |
| TWI743096B (zh) | 2021-10-21 |
| AU2017235462B2 (en) | 2021-07-01 |
| WO2017161002A1 (en) | 2017-09-21 |
| KR102419524B1 (ko) | 2022-07-08 |
| HK1258821A1 (zh) | 2019-11-22 |
| PH12018501955A1 (en) | 2019-06-17 |
| BR112018068702A2 (pt) | 2019-01-15 |
| US11555041B2 (en) | 2023-01-17 |
| IL261625A (en) | 2018-10-31 |
| US20190092783A1 (en) | 2019-03-28 |
| IL261625B (en) | 2021-08-31 |
| EP3429585B1 (de) | 2021-11-24 |
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