SG11201702463YA - Mono- or di-substituted indole derivatives as dengue viral replication inhibitors - Google Patents

Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Info

Publication number
SG11201702463YA
SG11201702463YA SG11201702463YA SG11201702463YA SG11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA
Authority
SG
Singapore
Prior art keywords
mono
viral replication
indole derivatives
substituted indole
replication inhibitors
Prior art date
Application number
SG11201702463YA
Other languages
English (en)
Inventor
Bart Rudolf Romanie Kesteleyn
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54199687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201702463Y(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of SG11201702463YA publication Critical patent/SG11201702463YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201702463YA 2014-10-01 2015-09-30 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors SG11201702463YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14187374 2014-10-01
EP15159164 2015-03-16
PCT/EP2015/072551 WO2016050841A1 (en) 2014-10-01 2015-09-30 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
SG11201702463YA true SG11201702463YA (en) 2017-04-27

Family

ID=54199687

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201702463YA SG11201702463YA (en) 2014-10-01 2015-09-30 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Country Status (31)

Country Link
US (1) US9944598B2 (es)
EP (1) EP3201176B1 (es)
JP (1) JP6732736B2 (es)
KR (1) KR102478311B1 (es)
CN (1) CN107001264B (es)
AU (1) AU2015326930B2 (es)
BR (1) BR112017006299A2 (es)
CA (1) CA2959573A1 (es)
CL (1) CL2017000782A1 (es)
CY (1) CY1121874T1 (es)
DK (1) DK3201176T3 (es)
EA (1) EA032546B1 (es)
ES (1) ES2714074T3 (es)
HR (1) HRP20190199T1 (es)
HU (1) HUE041888T2 (es)
IL (1) IL251396A0 (es)
LT (1) LT3201176T (es)
MA (1) MA40768B1 (es)
ME (1) ME03360B (es)
MX (1) MX2017004299A (es)
PH (1) PH12017500571A1 (es)
PL (1) PL3201176T3 (es)
PT (1) PT3201176T (es)
RS (1) RS58461B1 (es)
SG (1) SG11201702463YA (es)
SI (1) SI3201176T1 (es)
TW (1) TWI681951B (es)
UA (1) UA121119C2 (es)
UY (1) UY36340A (es)
WO (1) WO2016050841A1 (es)
ZA (1) ZA201702301B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
TW201619130A (zh) * 2014-10-01 2016-06-01 健生醫藥公司 作為登革熱病毒複製抑制劑之單-或二-取代吲哚
AU2015327345B9 (en) 2014-10-01 2020-06-18 Merck Patent Gmbh Boronic acid derivatives
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180495A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Deribados de indol sustituidos como inhibidores de replicación viral del dengue
EA201892216A1 (ru) 2016-03-31 2019-03-29 Янссен Фармасьютикалз, Инк. Замещенные производные индолина в качестве ингибиторов репликации вирусов денге
AU2017240076A1 (en) * 2016-04-01 2018-08-09 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN110691773B (zh) * 2017-05-22 2023-06-23 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物
EP3630724B1 (en) * 2017-05-22 2021-04-28 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors

Also Published As

Publication number Publication date
UY36340A (es) 2016-04-01
EA032546B1 (ru) 2019-06-28
EA201790758A1 (ru) 2017-07-31
CY1121874T1 (el) 2020-10-14
SI3201176T1 (sl) 2019-05-31
AU2015326930B2 (en) 2020-03-26
CN107001264B (zh) 2021-06-15
TWI681951B (zh) 2020-01-11
HRP20190199T1 (hr) 2019-04-05
EP3201176B1 (en) 2018-12-12
WO2016050841A1 (en) 2016-04-07
ES2714074T3 (es) 2019-05-27
KR20170063802A (ko) 2017-06-08
JP2017531619A (ja) 2017-10-26
ZA201702301B (en) 2018-12-19
EP3201176A1 (en) 2017-08-09
HUE041888T2 (hu) 2019-06-28
US9944598B2 (en) 2018-04-17
MA40768B1 (fr) 2019-03-29
RS58461B1 (sr) 2019-04-30
BR112017006299A2 (pt) 2018-01-16
PH12017500571A1 (en) 2017-08-30
JP6732736B2 (ja) 2020-07-29
TW201630879A (zh) 2016-09-01
MX2017004299A (es) 2017-07-19
DK3201176T3 (en) 2019-03-25
KR102478311B1 (ko) 2022-12-15
PT3201176T (pt) 2019-03-04
CA2959573A1 (en) 2016-04-07
PL3201176T3 (pl) 2019-06-28
UA121119C2 (uk) 2020-04-10
CL2017000782A1 (es) 2017-11-03
IL251396A0 (en) 2017-05-29
ME03360B (me) 2019-10-20
MA40768A (fr) 2017-09-08
US20170298017A1 (en) 2017-10-19
WO2016050841A9 (en) 2016-06-02
CN107001264A (zh) 2017-08-01
AU2015326930A1 (en) 2017-03-16
LT3201176T (lt) 2019-03-25

Similar Documents

Publication Publication Date Title
ZA202002435B (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HRP20190199T1 (hr) Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa
HRP20190139T1 (hr) Mono- ili di-supstituirani indoli kao inhibitori replikacije denga virusa
HK1258320A1 (zh) 作為登革熱病毒複製抑制劑的單取代或二取代吲哚衍生物
HK1257842A1 (zh) 作為登革熱病毒複製抑制劑的單取代的或二取代的吲哚衍生物
HK1246688A1 (zh) 作為登革熱病毒複製抑制劑的吲哚衍生物
PT3294738T (pt) Derivados mono ou di-substituídos de indol como inibidores da replicação viral da dengue