SG11201702023QA - N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b - Google Patents

N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Info

Publication number
SG11201702023QA
SG11201702023QA SG11201702023QA SG11201702023QA SG11201702023QA SG 11201702023Q A SG11201702023Q A SG 11201702023QA SG 11201702023Q A SG11201702023Q A SG 11201702023QA SG 11201702023Q A SG11201702023Q A SG 11201702023QA SG 11201702023Q A SG11201702023Q A SG 11201702023QA
Authority
SG
Singapore
Prior art keywords
oxyaryl
nr2b
octahydro
cyclopenta
alkylaryl
Prior art date
Application number
SG11201702023QA
Other languages
English (en)
Inventor
David R Anderson
Robert A Volkmann
Frank S Menniti
Original Assignee
Luc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55581945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201702023Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Luc Therapeutics Inc filed Critical Luc Therapeutics Inc
Publication of SG11201702023QA publication Critical patent/SG11201702023QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
SG11201702023QA 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b SG11201702023QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462056284P 2014-09-26 2014-09-26
PCT/US2015/051694 WO2016049165A1 (fr) 2014-09-26 2015-09-23 Composés n-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole utilisés comme modulateurs allostériques négatifs de nr2b

Publications (1)

Publication Number Publication Date
SG11201702023QA true SG11201702023QA (en) 2017-04-27

Family

ID=55581945

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201702023QA SG11201702023QA (en) 2014-09-26 2015-09-23 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b

Country Status (40)

Country Link
US (4) US10239835B2 (fr)
EP (4) EP3683207B1 (fr)
JP (4) JP6473227B2 (fr)
KR (1) KR102479356B1 (fr)
CN (1) CN106795111B (fr)
AP (1) AP2017009832A0 (fr)
AR (1) AR103199A1 (fr)
AU (1) AU2015320721B2 (fr)
BR (1) BR112017006093B1 (fr)
CA (1) CA2962569C (fr)
CL (1) CL2017000474A1 (fr)
CO (1) CO2017002494A2 (fr)
CR (1) CR20170114A (fr)
CU (1) CU24482B1 (fr)
CY (1) CY1123533T1 (fr)
DK (1) DK3197868T3 (fr)
EA (1) EA034937B1 (fr)
EC (1) ECSP17025302A (fr)
ES (3) ES2956546T3 (fr)
GT (1) GT201700062A (fr)
HR (1) HRP20200959T1 (fr)
HU (1) HUE049698T2 (fr)
IL (1) IL250909B (fr)
JO (1) JO3579B1 (fr)
LT (1) LT3197868T (fr)
MX (1) MX2017003940A (fr)
MY (1) MY182342A (fr)
NZ (1) NZ729569A (fr)
PE (1) PE20170893A1 (fr)
PH (1) PH12017500513A1 (fr)
PL (1) PL3197868T3 (fr)
PT (1) PT3197868T (fr)
RS (1) RS60497B1 (fr)
SG (1) SG11201702023QA (fr)
SI (1) SI3197868T1 (fr)
TN (1) TN2017000076A1 (fr)
TW (1) TWI687407B (fr)
UY (1) UY36326A (fr)
WO (1) WO2016049165A1 (fr)
ZA (1) ZA201701061B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
AU2018351651B2 (en) 2017-10-20 2023-01-05 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
WO2019089676A1 (fr) 2017-10-31 2019-05-09 Vanderbilt University Antagonistes du récepteur muscarinique m4 à l'acétylcholine
US11414406B2 (en) 2018-02-02 2022-08-16 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
WO2020245136A1 (fr) * 2019-06-04 2020-12-10 Boehringer Ingelheim International Gmbh Dérivés de purine, utilisés en tant que modulateurs négatifs de nr2b et leur utilisation en tant que médicament, en particulier pour le traitement de troubles dépressifs
CN111481543A (zh) * 2020-05-21 2020-08-04 苏州健雄职业技术学院 Nr2b负变构调节剂联合gaba受体调节剂在制备治疗阿尔兹海默症的药物中的用途
EP4255419A1 (fr) 2020-12-04 2023-10-11 Novartis AG Régime posologique pour un modulateur allostérique négatif des récepteurs nr2b-nmda pour le traitement de la dépression
JP2021058765A (ja) * 2021-01-19 2021-04-15 株式会社藤商事 遊技機
CN117120053A (zh) * 2021-03-26 2023-11-24 诺华股份有限公司 新的环戊二烯并[c]吡咯NR2B负变构调节剂
AU2022244367A1 (en) * 2021-03-26 2023-09-07 Novartis Ag Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b
WO2023233357A1 (fr) 2022-06-02 2023-12-07 Novartis Ag Administration sous-cutanée d'onfasprodil et procédés de dosage destinés à être utilisés dans le traitement de troubles dépressifs

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532243A (en) 1992-02-14 1996-07-02 The Dupont Merck Pharmaceutical Company Antipsychotic nitrogen-containing bicyclic compounds
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5726172A (en) * 1996-01-16 1998-03-10 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US6369076B1 (en) * 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
JP4845873B2 (ja) 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
AU2005251891A1 (en) 2004-06-09 2005-12-22 F. Hoffmann-La Roche Ag Octahydro-pyrrolo[3,4-C] derivatives and their use as antiviral compounds
JP2008507543A (ja) 2004-07-22 2008-03-13 グラクソ グループ リミテッド 抗細菌剤
HUP0401523A3 (en) 2004-07-29 2007-05-02 Richter Gedeon Vegyeszet Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
CN101163482A (zh) * 2005-04-19 2008-04-16 默克公司 N-烷基-氮杂环烷基nmda/nr2b拮抗剂
CA2640806A1 (fr) 2006-04-28 2007-11-15 Laboratorios Del Dr. Esteve, S.A. Composes bicycliques de tetrahydropyrrole
EP1849772A1 (fr) 2006-04-28 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés bicyclic de Tetrahydopyrrole
TW200845977A (en) 2007-03-30 2008-12-01 Targacept Inc Sub-type selective azabicycloalkane derivatives
JP2011500727A (ja) 2007-10-22 2011-01-06 シェーリング コーポレイション Gpr119の活性のモジュレーターとしての二環式ヘテロ環誘導体およびその使用
RU2487866C2 (ru) 2008-01-23 2013-07-20 Цзянсу Хэнсох Фармасьютикал Ко., Лтд. Производные дициклоазаалкана, способы их получения и их применение в медицине
MX2011006169A (es) 2008-12-12 2011-06-27 Univ Vanderbilt Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos.
FR2945534B1 (fr) * 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
MX2012007935A (es) 2010-01-07 2012-08-15 Du Pont Compuestos heterociclicos fungicidas.
WO2011149993A2 (fr) 2010-05-25 2011-12-01 Abbott Laboratories Octahydrocyclopenta [c] pyrroles substitués utilisés en tant que modulateurs des canaux calciques
CN102432598A (zh) * 2010-09-29 2012-05-02 江苏恒瑞医药股份有限公司 三环化合物、其制备方法及其在医药上的应用
US8501768B2 (en) 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
WO2013091539A1 (fr) 2011-12-21 2013-06-27 江苏恒瑞医药股份有限公司 Dérivé pyrrole de cycle hétéroaryle à six chaînons, procédé de préparation de celui-ci, et ses utilisations médicinales
SI2900669T1 (sl) * 2012-09-25 2019-12-31 F. Hoffmann-La Roche Ag Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US9418332B2 (en) 2013-08-16 2016-08-16 Qualcomm Incorporated Post ghost plasticity
JP6546596B2 (ja) 2013-09-26 2019-07-17 カデント セラピューティクス,インコーポレーテッド Nr2bの選択的オクタヒドロ−シクロペンタ[c]ピロール負調節因子
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول

Also Published As

Publication number Publication date
EP4282412A3 (fr) 2024-01-17
KR20170063599A (ko) 2017-06-08
DK3197868T3 (da) 2020-06-22
CU24482B1 (es) 2020-03-04
CR20170114A (es) 2017-08-21
EA201790713A1 (ru) 2017-07-31
UY36326A (es) 2016-04-29
IL250909A0 (en) 2017-04-30
CA2962569A1 (fr) 2016-03-31
CN106795111B (zh) 2020-04-07
EP4282412A2 (fr) 2023-11-29
HUE049698T2 (hu) 2020-10-28
MY182342A (en) 2021-01-20
EP3974420A1 (fr) 2022-03-30
ES2956546T3 (es) 2023-12-22
BR112017006093B1 (pt) 2023-03-21
EP3197868A4 (fr) 2018-04-25
JP2019077713A (ja) 2019-05-23
HRP20200959T1 (hr) 2020-10-02
PL3197868T3 (pl) 2020-11-02
CO2017002494A2 (es) 2017-08-31
US20200369610A1 (en) 2020-11-26
ECSP17025302A (es) 2018-11-30
AP2017009832A0 (en) 2017-03-31
JP2017528502A (ja) 2017-09-28
RS60497B1 (sr) 2020-08-31
AU2015320721A1 (en) 2017-03-30
ES2791327T3 (es) 2020-11-03
PE20170893A1 (es) 2017-07-12
US10781174B2 (en) 2020-09-22
JP2023052515A (ja) 2023-04-11
KR102479356B1 (ko) 2022-12-19
GT201700062A (es) 2019-09-30
EP3683207B1 (fr) 2021-12-29
EP3974420B1 (fr) 2023-08-16
SI3197868T1 (sl) 2020-10-30
CA2962569C (fr) 2023-09-19
WO2016049165A1 (fr) 2016-03-31
ES2911004T3 (es) 2022-05-17
US20180111902A1 (en) 2018-04-26
LT3197868T (lt) 2020-09-10
IL250909B (en) 2019-06-30
JO3579B1 (ar) 2020-07-05
TN2017000076A1 (en) 2018-07-04
ZA201701061B (en) 2019-07-31
CN106795111A (zh) 2017-05-31
CL2017000474A1 (es) 2017-08-18
AU2015320721B2 (en) 2020-01-30
JP6473227B2 (ja) 2019-02-20
US20220274925A1 (en) 2022-09-01
CU20170037A7 (es) 2017-08-08
NZ729569A (en) 2019-06-28
EP3197868B1 (fr) 2020-04-15
BR112017006093A2 (pt) 2017-12-19
EP3683207A1 (fr) 2020-07-22
EP3197868A1 (fr) 2017-08-02
US20190152912A1 (en) 2019-05-23
TW201625528A (zh) 2016-07-16
TWI687407B (zh) 2020-03-11
US10239835B2 (en) 2019-03-26
PT3197868T (pt) 2020-05-21
MX2017003940A (es) 2018-03-01
JP7216060B2 (ja) 2023-01-31
JP2021006554A (ja) 2021-01-21
AR103199A1 (es) 2017-04-26
PH12017500513A1 (en) 2017-08-07
EA034937B1 (ru) 2020-04-08
JP6772307B2 (ja) 2020-10-21
CY1123533T1 (el) 2022-03-24

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