SG11201608667SA - Mdm2 inhibitors and therapeutic methods using the same - Google Patents

Mdm2 inhibitors and therapeutic methods using the same

Info

Publication number
SG11201608667SA
SG11201608667SA SG11201608667SA SG11201608667SA SG11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA SG 11201608667S A SG11201608667S A SG 11201608667SA
Authority
SG
Singapore
Prior art keywords
same
therapeutic methods
mdm2 inhibitors
mdm2
inhibitors
Prior art date
Application number
SG11201608667SA
Other languages
English (en)
Inventor
Shaomeng Wang
Angelo Aguilar
Liu Liu
Jianfeng Lu
Donna Mceachern
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of SG11201608667SA publication Critical patent/SG11201608667SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201608667SA 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same SG11201608667SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461980747P 2014-04-17 2014-04-17
PCT/US2015/026098 WO2015161032A1 (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Publications (1)

Publication Number Publication Date
SG11201608667SA true SG11201608667SA (en) 2016-11-29

Family

ID=54321424

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201608667SA SG11201608667SA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same
SG10201913742TA SG10201913742TA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201913742TA SG10201913742TA (en) 2014-04-17 2015-04-16 Mdm2 inhibitors and therapeutic methods using the same

Country Status (12)

Country Link
US (1) US9745314B2 (US07846941-20101207-C00217.png)
EP (1) EP3131544B1 (US07846941-20101207-C00217.png)
JP (2) JP6694827B2 (US07846941-20101207-C00217.png)
KR (2) KR102389552B1 (US07846941-20101207-C00217.png)
CN (2) CN111718354A (US07846941-20101207-C00217.png)
AU (1) AU2015247646B2 (US07846941-20101207-C00217.png)
CA (1) CA2945527C (US07846941-20101207-C00217.png)
ES (1) ES2712973T3 (US07846941-20101207-C00217.png)
IL (2) IL248211B (US07846941-20101207-C00217.png)
MX (2) MX2016013457A (US07846941-20101207-C00217.png)
SG (2) SG11201608667SA (US07846941-20101207-C00217.png)
WO (1) WO2015161032A1 (US07846941-20101207-C00217.png)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
AU2015247646B2 (en) * 2014-04-17 2019-06-06 The Regents Of The University Of Michigan MDM2 inhibitors and therapeutic methods using the same
US9962380B2 (en) * 2015-09-23 2018-05-08 Wisconsin Alumni Research Foundation Methods for treating cognitive deficits associated with fragile X syndrome
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
BR112018070549A2 (pt) * 2016-04-06 2019-02-12 The Regents Of The University Of Michigan degradantes de proteína mdm2
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
KR20200105837A (ko) * 2017-12-29 2020-09-09 간 앤 리 파마슈티칼스 종양 억제제로 사용될 수 있는 화합물 및 이의 제조방법과 용도
EP3511334A1 (en) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
KR102039696B1 (ko) 2018-04-23 2019-11-04 충남대학교산학협력단 세포내 결핵균 제어를 위한 p53 발현 조절 가능한 조성물 (K279-1558) 또는 방법
TWI725488B (zh) 2018-07-31 2021-04-21 大陸商蘇州亞盛藥業有限公司 Bcl-2抑制劑與化療藥的組合產品及其在預防及/或治療疾病中的用途
CN110772639B (zh) * 2018-07-31 2021-04-13 苏州亚盛药业有限公司 Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途
CN110772521A (zh) 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
US11554127B2 (en) 2018-07-31 2023-01-17 Ascentage Pharma (Suzhou) Co., Ltd. Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP
BR112021002303A2 (pt) * 2018-08-08 2021-05-04 Ascentage Pharma (Suzhou) Co., Ltd. combinação de imunoterapias com inibidores de mdm2
EP3697411A4 (en) 2018-11-23 2021-08-18 Ascentage Pharma Group Corp Limited NEW PHARMACEUTICAL COMPOSITION AND ITS USE
WO2020119614A1 (en) 2018-12-14 2020-06-18 Ascentage Pharma (Suzhou) Co., Ltd. A compound for treating osteoarthritis
WO2020169073A1 (en) * 2019-02-24 2020-08-27 Ascentage Pharma (Suzhou) Co., Ltd. Treatment methods and biomarkers for mdm2 inhibitors
TWI750728B (zh) * 2019-07-11 2021-12-21 大陸商蘇州亞盛藥業有限公司 2-吲哚啉螺環酮類化合物的製備方法及其中間體
TW202116301A (zh) * 2019-07-19 2021-05-01 大陸商蘇州亞盛藥業有限公司 藥物組合及其用途
TW202118488A (zh) * 2019-07-26 2021-05-16 大陸商蘇州亞盛藥業有限公司 Mdm2抑制劑的藥物組合物及其在預防和/或治療疾病中的用途
TW202134239A (zh) * 2019-11-27 2021-09-16 大陸商蘇州亞盛藥業有限公司 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物
US11850239B2 (en) 2019-12-19 2023-12-26 Ascentage Pharma (Suzhou) Co., Ltd. MDM2 inhibitor and a platinum compound for cancer treatment
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
CN113149998B (zh) * 2020-01-23 2024-05-31 苏州亚盛药业有限公司 2-吲哚啉螺环酮类化合物或其盐、溶剂合物的无定形形式或结晶形式
CN113337602A (zh) * 2020-03-02 2021-09-03 苏州亚盛药业有限公司 Mdm2抑制剂的治疗方法和生物标志物
US20230149356A1 (en) * 2020-04-14 2023-05-18 Ascentage Pharma (Suzhou) Co., Ltd. Novel medical use of mdm2 inhibitors
CN113801120B (zh) * 2020-06-15 2024-03-22 苏州亚盛药业有限公司 Mdm2抑制剂的微悬浮液以及治疗应用
JP2023539867A (ja) 2020-08-27 2023-09-20 大塚製薬株式会社 Ｍｄｍ２アンタゴニストを用いた癌治療に関するバイオマーカー
CN112022812B (zh) * 2020-11-03 2021-01-29 上海亚盛医药科技有限公司 一种包含杂环类化合物的组合物、其制备方法和应用
WO2022170108A1 (en) * 2021-02-04 2022-08-11 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof in prevention of radiation injury
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
WO2023011488A1 (zh) 2021-08-02 2023-02-09 苏州亚盛药业有限公司 一种药物组合及其用途
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2023134707A1 (en) * 2022-01-11 2023-07-20 Ascentage Pharma (Suzhou) Co., Ltd. Methods for treating aml-mrc and mds

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US6605712B1 (en) 1990-12-20 2003-08-12 Arch Development Corporation Gene transcription and ionizing radiation: methods and compositions
SG176463A1 (en) 2005-02-22 2011-12-29 Univ Michigan Small molecule inhibitors of mdm2 and uses thereof
KR101109437B1 (ko) 2005-12-01 2012-01-31 에프. 호프만-라 로슈 아게 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린유도체
ES2350504T3 (es) * 2006-03-13 2011-01-24 F. Hoffmann-La Roche Ag Derivados de espiroindolinona.
DE602007011902D1 (de) * 2006-03-13 2011-02-24 Hoffmann La Roche Spiroindolinon-derivate
CA2661354C (en) * 2006-08-30 2012-12-18 The Regents Of The University Of Michigan New small molecule inhibitors of mdm2 and the uses thereof
US7737174B2 (en) 2006-08-30 2010-06-15 The Regents Of The University Of Michigan Indole inhibitors of MDM2 and the uses thereof
US8222288B2 (en) 2006-08-30 2012-07-17 The Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof
US20080206794A1 (en) 2006-09-15 2008-08-28 Renovar Incorporated Systems And Methods For Characterizing Contrast Induced-Nephropathy
US20080188506A1 (en) * 2007-02-07 2008-08-07 Qingjie Ding Spiroindolinone derivatives
ES2398342T3 (es) 2008-09-18 2013-03-15 F. Hoffmann-La Roche Ag Pirrolidina-2-carboxamidas sustituidas
US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US8076482B2 (en) * 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
PE20121282A1 (es) 2009-11-12 2012-10-12 Univ Michigan Antagonistas de espiro-oxindol de mdm2
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
MX2012011600A (es) * 2010-04-09 2012-11-30 Univ Michigan Biomarcadores para inhibidores de mdm2 para su uso en el tratamiento de enfermedad.
US8217044B2 (en) * 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US20120046306A1 (en) 2010-08-18 2012-02-23 David Joseph Bartkovitz Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists
NZ611866A (en) 2010-11-12 2015-04-24 Univ Michigan Spiro-oxindole mdm2 antagonists
AU2012226890B2 (en) * 2011-03-10 2016-10-06 Daiichi Sankyo Company, Limited Dispiropyrrolidine derivative
AU2012253339B2 (en) * 2011-05-11 2016-03-31 Sanofi Spiro-oxindole MDM2 antagonists
US9376425B2 (en) 2011-09-27 2016-06-28 Amgen, Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
ES2764223T3 (es) * 2013-09-04 2020-06-02 Daiichi Sankyo Co Ltd Procedimiento de producción de un derivado de espirooxindol
AU2015247646B2 (en) * 2014-04-17 2019-06-06 The Regents Of The University Of Michigan MDM2 inhibitors and therapeutic methods using the same

Also Published As

Publication number Publication date
JP2020100662A (ja) 2020-07-02
SG10201913742TA (en) 2020-03-30
IL269462B (en) 2021-05-31
EP3131544A1 (en) 2017-02-22
EP3131544A4 (en) 2017-08-30
MX2016013457A (es) 2017-05-04
CA2945527C (en) 2022-05-17
IL248211A0 (en) 2016-11-30
CN106794171B (zh) 2020-03-24
US20150299211A1 (en) 2015-10-22
AU2015247646A1 (en) 2016-10-27
KR20160136450A (ko) 2016-11-29
JP6909323B2 (ja) 2021-07-28
JP2017511360A (ja) 2017-04-20
US9745314B2 (en) 2017-08-29
KR102599945B1 (ko) 2023-11-09
NZ724963A (en) 2021-10-29
KR20220054697A (ko) 2022-05-03
JP6694827B2 (ja) 2020-05-20
ES2712973T3 (es) 2019-05-17
IL248211B (en) 2019-10-31
CN106794171A (zh) 2017-05-31
CA2945527A1 (en) 2015-10-22
IL269462A (en) 2019-11-28
MX2020003939A (es) 2020-08-13
WO2015161032A1 (en) 2015-10-22
CN111718354A (zh) 2020-09-29
EP3131544B1 (en) 2018-12-12
AU2015247646B2 (en) 2019-06-06
KR102389552B1 (ko) 2022-04-22

Similar Documents

Publication Publication Date Title
IL269462A (en) MDM2 inhibitors and therapeutic methods that use them
IL258931A (en) Medicinal compounds and methods
IL277239B (en) mdm2 inhibitors and combinations thereof
HK1243073A1 (zh) 治療性化合物及其用途
IL250573B (en) Methods and devices related to electrical stimulation
ZA201504902B (en) Bcl-2bcl-xl inhibitors and therapeutic methods using the same
SI3215147T1 (sl) Nevroatenuacijske spojine norketamina in postopki
SG11201607031SA (en) Verification methods and verification devices
EP3110820A4 (en) Tyk2 inhibitors and uses thereof
GB201403093D0 (en) Therapeutic compounds and their use
GB201404470D0 (en) Therapeutic methods and materials
IL255530A (en) Efflux-pump inhibitors and therapeutic uses thereof
HK1243342A1 (zh) 化合物和方法
IL247325A0 (en) Therapeutic methods using noribogaine and related compounds
IL270011B (en) Medicinal compounds and methods
GB201418809D0 (en) Therapeutic agents and uses thereof
GB201513590D0 (en) Devices and methods
ZA201703580B (en) Therapeutic homodimer and uses thereof
PL3229772T3 (pl) 6-arylo-9-glikozylopuryny i ich zastosowanie
GB201513060D0 (en) Methods and devices
GB201416899D0 (en) Medical devices and related methods
GB201419559D0 (en) Therapeutic compositions and methods
GB201504770D0 (en) Medical devices and methods
GB201410387D0 (en) Compounds and their therapeutic use
GB201403496D0 (en) Compounds and their therapeutic use