SG11201605602XA - Duocarmycin adcs showing improved in vivo antitumor activity - Google Patents
Duocarmycin adcs showing improved in vivo antitumor activityInfo
- Publication number
- SG11201605602XA SG11201605602XA SG11201605602XA SG11201605602XA SG11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA
- Authority
- SG
- Singapore
- Prior art keywords
- antitumor activity
- vivo antitumor
- showing improved
- duocarmycin
- duocarmycin adcs
- Prior art date
Links
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title 1
- 229960005501 duocarmycin Drugs 0.000 title 1
- 229930184221 duocarmycin Natural products 0.000 title 1
- 230000005917 in vivo anti-tumor Effects 0.000 title 1
Classifications
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
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EP14150791 | 2014-01-10 | ||
EP14188450 | 2014-10-10 | ||
PCT/EP2015/050350 WO2015104385A2 (fr) | 2014-01-10 | 2015-01-09 | Conjugués anticorps-médicament de duocarmycine présentant une meilleure activité antitumorale in vivo |
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SG11201605602XA true SG11201605602XA (en) | 2016-08-30 |
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SG11201605602XA SG11201605602XA (en) | 2014-01-10 | 2015-01-09 | Duocarmycin adcs showing improved in vivo antitumor activity |
SG10201911860VA SG10201911860VA (en) | 2014-01-10 | 2015-01-09 | Duocarmycin adcs showing improved in vivo antitumor activity |
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SG10201911860VA SG10201911860VA (en) | 2014-01-10 | 2015-01-09 | Duocarmycin adcs showing improved in vivo antitumor activity |
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EP (2) | EP2948184B1 (fr) |
JP (2) | JP6342517B2 (fr) |
KR (2) | KR102344354B1 (fr) |
CN (1) | CN105899236B (fr) |
AU (2) | AU2015205509B2 (fr) |
BR (1) | BR112016015848A2 (fr) |
CA (1) | CA2935433C (fr) |
CL (1) | CL2016001760A1 (fr) |
CY (2) | CY1117687T1 (fr) |
DK (2) | DK2948184T3 (fr) |
ES (2) | ES2668984T3 (fr) |
HR (2) | HRP20160697T1 (fr) |
HU (2) | HUE029255T2 (fr) |
LT (1) | LT3069735T (fr) |
MX (2) | MX368396B (fr) |
NO (1) | NO3069735T3 (fr) |
PL (2) | PL3069735T3 (fr) |
PT (2) | PT3069735T (fr) |
RU (2) | RU2689779C2 (fr) |
SG (2) | SG11201605602XA (fr) |
WO (1) | WO2015104385A2 (fr) |
ZA (2) | ZA201604535B (fr) |
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RU2578719C9 (ru) | 2010-04-21 | 2016-10-10 | Синтарга Б.В. | Новые конъюгаты аналогов сс-1065 и бифункциональные линкеры |
ES2714951T3 (es) | 2012-12-21 | 2019-05-30 | Bioalliance Cv | Enlazadores autoinmoladores hidrófilos y conjugados de los mismos |
PL3069735T3 (pl) | 2014-01-10 | 2018-08-31 | Synthon Biopharmaceuticals B.V. | ADC duokarmycyny do zastosowania w leczeniu raka pęcherza |
PL3092010T3 (pl) | 2014-01-10 | 2019-01-31 | Synthon Biopharmaceuticals B.V. | Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek |
CA2935430C (fr) | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Conjugues anticorps-medicaments a base de duocarmycine utilisables dans le cadre du traitement du cancer de l'endometre |
PL3151865T3 (pl) | 2014-05-22 | 2022-01-03 | Byondis B.V. | Koniugacja w określonym miejscu leków-łączników z przeciwciałami oraz powstałe w jej wyniku koniugaty przeciwciało-lek (ADCs) |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
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KR20170020868A (ko) | 2014-06-20 | 2017-02-24 | 바이오얼라이언스 씨.브이. | 항-폴레이트 수용체 알파 (fra) 항체-약물 컨쥬게이트 및 그것의 사용 방법 |
JP6522806B2 (ja) | 2015-07-10 | 2019-05-29 | シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. | 抗体デュオカルマイシン薬物複合体を含む組成物 |
PL3352857T3 (pl) * | 2015-09-22 | 2021-08-02 | Byondis B.V. | Leczenie SYD985 pacjentów z rakiem opornym na T-DM1 |
CN106729743B (zh) | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
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TWI753875B (zh) | 2016-01-08 | 2022-02-01 | 美商美國全心醫藥生技股份有限公司 | 四價抗psgl-1抗體及其用途 |
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