SG11201605597VA - Duocarmycin adcs for use in treatment of endometrial cancer - Google Patents

Duocarmycin adcs for use in treatment of endometrial cancer

Info

Publication number
SG11201605597VA
SG11201605597VA SG11201605597VA SG11201605597VA SG11201605597VA SG 11201605597V A SG11201605597V A SG 11201605597VA SG 11201605597V A SG11201605597V A SG 11201605597VA SG 11201605597V A SG11201605597V A SG 11201605597VA SG 11201605597V A SG11201605597V A SG 11201605597VA
Authority
SG
Singapore
Prior art keywords
treatment
endometrial cancer
duocarmycin
adcs
duocarmycin adcs
Prior art date
Application number
SG11201605597VA
Other languages
English (en)
Inventor
Alessandro Davide Santin
Peter Johannes Goedings
Original Assignee
Synthon Biopharmaceuticals Bv
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals Bv, Univ Yale filed Critical Synthon Biopharmaceuticals Bv
Publication of SG11201605597VA publication Critical patent/SG11201605597VA/en

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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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SG11201605597VA 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer SG11201605597VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14150791 2014-01-10
PCT/EP2015/050332 WO2015104373A2 (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer

Publications (1)

Publication Number Publication Date
SG11201605597VA true SG11201605597VA (en) 2016-08-30

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Application Number Title Priority Date Filing Date
SG11201605597VA SG11201605597VA (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer

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US (2) US9427480B2 (zh)
EP (1) EP2948183B1 (zh)
JP (1) JP6224268B2 (zh)
KR (2) KR20160099725A (zh)
CN (1) CN105899237B (zh)
AU (1) AU2015205588B2 (zh)
CA (1) CA2935430C (zh)
CL (1) CL2016001743A1 (zh)
CY (1) CY1117712T1 (zh)
DK (1) DK2948183T3 (zh)
ES (1) ES2578831T3 (zh)
HR (1) HRP20160797T1 (zh)
HU (1) HUE029672T2 (zh)
MX (1) MX368234B (zh)
MY (1) MY189713A (zh)
PL (1) PL2948183T3 (zh)
PT (1) PT2948183T (zh)
RU (1) RU2686085C2 (zh)
SG (1) SG11201605597VA (zh)
WO (1) WO2015104373A2 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
RU2578719C9 (ru) 2010-04-21 2016-10-10 Синтарга Б.В. Новые конъюгаты аналогов сс-1065 и бифункциональные линкеры
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
PL3069735T3 (pl) * 2014-01-10 2018-08-31 Synthon Biopharmaceuticals B.V. ADC duokarmycyny do zastosowania w leczeniu raka pęcherza
CA2935430C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Duocarmycin adcs for use in treatment of endometrial cancer
PL3151865T3 (pl) 2014-05-22 2022-01-03 Byondis B.V. Koniugacja w określonym miejscu leków-łączników z przeciwciałami oraz powstałe w jej wyniku koniugaty przeciwciało-lek (ADCs)
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗ｈｅｒ２表位之單株抗體及其使用之方法
US9808528B2 (en) 2014-06-18 2017-11-07 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates and methods of using same
JP6522806B2 (ja) 2015-07-10 2019-05-29 シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． 抗体デュオカルマイシン薬物複合体を含む組成物
JP6607634B2 (ja) * 2015-09-04 2019-11-20 学校法人 岩手医科大学 腫瘍の再発を抑制するための標的分子としてのｔａｆ１５遺伝子およびその産物
KR101704379B1 (ko) * 2015-10-27 2017-02-08 (주)알테오젠 항체-약물 접합체 및 그 제조방법
DE102016105449A1 (de) * 2015-10-29 2017-05-04 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Bifunktionale Prodrugs
US10668166B2 (en) 2016-05-30 2020-06-02 Toxinvent Ou Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment
RS64690B1 (sr) 2018-03-13 2023-11-30 Zymeworks Bc Inc Konjugati biparatopskog anti-her2 antitela i leka i postupci za njihovu upotrebu
US20210369705A1 (en) 2018-10-15 2021-12-02 Merck Patent Gmbh Combination therapy utilizing dna alkylating agents and atr inhibitors
US20220387618A1 (en) 2019-11-15 2022-12-08 Seagen Inc. Methods of treating her2 positive breast cancer with tucatinib in combination with an anti-her2 antibody-drug conjugate
US20230092648A1 (en) * 2020-02-06 2023-03-23 Byondis B.V. Combination containing a duocarmycin derivative-comprising antibody-drug conjugate and thiosulfate
WO2024127332A1 (en) 2022-12-14 2024-06-20 Pheon Therapeutics Ltd Cytotoxic compounds

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238907A (en) 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4771128A (en) 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography
MX9203460A (es) 1988-09-12 1992-09-01 Upjohn Co Nuevos analogos cc-1065 que tienen dos subunidades cpi.
AU648313B2 (en) 1990-04-25 1994-04-21 Pharmacia & Upjohn Company Novel CC-1065 analogs
JPH05268205A (ja) 1992-03-19 1993-10-15 Fujitsu Ltd クロック切換え回路
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
JP3514490B2 (ja) 1992-08-21 2004-03-31 杏林製薬株式会社 トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法
GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
AU689566B2 (en) 1994-04-01 1998-04-02 Kyowa Hakko Kogyo Co. Ltd. DC-89 derivatives
US5502068A (en) 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
DE19503320A1 (de) 1995-02-02 1996-08-08 Boehringer Mannheim Gmbh Neue Benzodiazepinkonjugate
US5843937A (en) 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
EP0938474B1 (en) 1996-09-12 2005-11-23 Auckland Uniservices Limited Cyclopropylindole compounds and their use as prodrugs
WO1998025900A1 (fr) 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Composes presentant une activite antitumorale
US20030036629A1 (en) 1997-12-12 2003-02-20 Barry Foster Novel tgf-beta protein purification methods
DE50104114D1 (de) 2000-05-02 2004-11-18 Tietze Lutz F Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo f]chinolin-derivaten für eine selektive krebstherapie
JP5010089B2 (ja) 2000-09-19 2012-08-29 スピロジェン リミテッド Ｃｃ−１０６５およびデュオカルマイシンのアキラルアナログの組成物およびその使用方法
EP1363908A4 (en) 2001-01-24 2004-05-06 Auckland Uniservices Ltd ANTI-CANCER COMPLEXES 2,3-DIHYDRO-1H-PYRROLO 3,2-F] COBALT AND CHROME QUINOLINE
US7192977B2 (en) 2001-02-22 2007-03-20 School Of Pharmacy Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment
CN101671335A (zh) * 2001-05-31 2010-03-17 梅达莱克斯公司 细胞毒素、其有用的前体药物、连接基团和稳定剂
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
WO2003022806A2 (en) 2001-09-07 2003-03-20 The Scripps Research Institute Cbi analogues of cc-1065 and the duocarmycins
WO2003026577A2 (en) * 2001-09-24 2003-04-03 Seattle Genetics, Inc. P-amidobenzylethers in drug delivery agents
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
AU2003228173A1 (en) 2002-05-17 2003-12-02 Auckland Uniservices Limited Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-(ring fused indol-5-yl(amine-derived)) compounds and analogues thereof, and to products obtained therefrom
US20050180972A1 (en) * 2002-07-31 2005-08-18 Wahl Alan F. Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
CA2506080A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
WO2004069201A2 (en) 2003-02-03 2004-08-19 Medlogics Device Corporation Compounds useful in coating stents to prevent and treat stenosis and restenosis
DK1594542T3 (da) 2003-02-20 2010-10-11 Seattle Genetics Inc Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer
US20050026987A1 (en) 2003-05-13 2005-02-03 The Scripps Research Institute CBI analogues of the duocarmycins and CC-1065
WO2005032594A2 (en) 2003-10-03 2005-04-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Alkylators linked to polyamides as dna binding agents
ES2533695T3 (es) * 2004-03-02 2015-04-14 Seattle Genetics, Inc. Anticuerpos cargados parcialmente y métodos para su conjugación
MXPA06013413A (es) 2004-05-19 2007-01-23 Medarex Inc Enlazadores quimicos y conjugados de los mismos.
US20100202941A1 (en) 2004-07-02 2010-08-12 Hideki Chikada Liquid Fuel Reforming Device
NZ580115A (en) 2004-09-23 2010-10-29 Genentech Inc Cysteine engineered antibody light chains and conjugates
WO2006037052A2 (en) 2004-09-27 2006-04-06 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Modulating mxa expression
NZ536107A (en) 2004-10-22 2007-06-29 Auckland Uniservices Ltd Nitrobenzindoles and their use in cancer therapy
JP2008531542A (ja) 2005-02-24 2008-08-14 ファイザー・プロダクツ・インク 抗癌剤として有用な二環式複素芳香族誘導体
EA016577B1 (ru) 2005-09-26 2012-06-29 Медарекс, Инк. Конъюгаты антитело-лекарство и их применение
DK1940789T3 (da) 2005-10-26 2012-03-19 Medarex Inc Fremgangsmåder og forbindelser til fremstilling af CC-1065-analoger
MX2008009956A (es) 2006-02-02 2008-12-12 Syntarga Bv Analogos de cc-1065 solubles en agua y sus conjugados.
EP1832577A1 (en) 2006-03-07 2007-09-12 Sanofi-Aventis Improved prodrugs of CC-1065 analogs
AU2007322261B2 (en) 2006-11-01 2014-01-23 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US20100150950A1 (en) 2006-12-14 2010-06-17 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
EP2121667B1 (en) 2007-02-21 2016-06-08 E. R. Squibb & Sons, L.L.C. Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
EP2173739B1 (en) 2007-08-01 2013-07-31 Syntarga B.V. Substituted cc-1065 analogs and their conjugates
ES2441115T3 (es) 2007-11-13 2014-01-31 The Scripps Research Institute Derivados de CBI sujetos a activación reductora
US20090162372A1 (en) 2007-11-30 2009-06-25 Medarex, Inc. Fibronectin ed-b antibodies, conjugates thereof, and methods of use
NZ571028A (en) 2008-09-03 2011-01-28 Auckland Uniservices Ltd Nitrobenzindole compounds and their use in cancer treatment
JP5675619B2 (ja) 2008-09-17 2015-02-25 エンドサイト, インク.Endocyte, Inc. 葉酸拮抗薬の葉酸受容体結合性コンジュゲート
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
WO2011022316A1 (en) 2009-08-20 2011-02-24 The Regents Of The University Of Colorado, A Body Corporate Mirnas dysregulated in triple-negative breast cancer
RU2578719C9 (ru) 2010-04-21 2016-10-10 Синтарга Б.В. Новые конъюгаты аналогов сс-1065 и бифункциональные линкеры
EP2380909A1 (en) * 2010-04-26 2011-10-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PTK-7 protein involved in breast cancer
CA2832387A1 (en) * 2011-04-20 2012-10-26 Genmab A/S Bispecifc antibodies against her2
DK2764351T3 (en) 2011-09-29 2019-01-28 Seattle Genetics Inc Determination of intact mass of protein-conjugated drug compounds
CN116236569A (zh) * 2011-10-14 2023-06-09 霍夫曼-拉罗奇有限公司 Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品
CA3111357A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
EP2814512A1 (en) 2012-02-16 2014-12-24 UCL Business Plc. Lysosome-cleavable linker
PL3069735T3 (pl) 2014-01-10 2018-08-31 Synthon Biopharmaceuticals B.V. ADC duokarmycyny do zastosowania w leczeniu raka pęcherza
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
CA2935430C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Duocarmycin adcs for use in treatment of endometrial cancer
PE20170517A1 (es) * 2014-04-30 2017-05-18 Pfizer Conjugados de anticuerpo-farmaco-anti-ptk7
PL3151865T3 (pl) 2014-05-22 2022-01-03 Byondis B.V. Koniugacja w określonym miejscu leków-łączników z przeciwciałami oraz powstałe w jej wyniku koniugaty przeciwciało-lek (ADCs)
PL3152191T3 (pl) 2014-06-05 2019-10-31 Synthon Biopharmaceuticals Bv Ulepszony sposób wytwarzania proleków duokarmycyny
EP3197919A1 (en) 2014-09-22 2017-08-02 Synthon Biopharmaceuticals B.V. Pan-reactive antibodies to duocarmycins
JP6522806B2 (ja) 2015-07-10 2019-05-29 シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． 抗体デュオカルマイシン薬物複合体を含む組成物

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