SG11201602063UA - Multiaptamer target detection - Google Patents
Multiaptamer target detectionInfo
- Publication number
- SG11201602063UA SG11201602063UA SG11201602063UA SG11201602063UA SG11201602063UA SG 11201602063U A SG11201602063U A SG 11201602063UA SG 11201602063U A SG11201602063U A SG 11201602063UA SG 11201602063U A SG11201602063U A SG 11201602063UA SG 11201602063U A SG11201602063U A SG 11201602063UA
- Authority
- SG
- Singapore
- Prior art keywords
- multiaptamer
- target detection
- target
- detection
- multiaptamer target
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881629P | 2013-09-24 | 2013-09-24 | |
| PCT/US2014/057143 WO2015048084A1 (en) | 2013-09-24 | 2014-09-24 | Multiaptamer target detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201602063UA true SG11201602063UA (en) | 2016-04-28 |
Family
ID=52744404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201602063UA SG11201602063UA (en) | 2013-09-24 | 2014-09-24 | Multiaptamer target detection |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9926566B2 (de) |
| EP (1) | EP3049523B1 (de) |
| JP (1) | JP6506768B2 (de) |
| KR (1) | KR102348283B1 (de) |
| CN (2) | CN114703193A (de) |
| AU (1) | AU2014326975B2 (de) |
| BR (1) | BR112016005957A2 (de) |
| CA (1) | CA2924987C (de) |
| HK (1) | HK1218765A1 (de) |
| IL (1) | IL244284B (de) |
| MX (1) | MX361451B (de) |
| SG (1) | SG11201602063UA (de) |
| WO (1) | WO2015048084A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2924987C (en) | 2013-09-24 | 2022-08-16 | Somalogic, Inc. | Multiaptamer target detection |
| JP6768651B2 (ja) | 2014-11-24 | 2020-10-14 | ソマロジック, インコーポレイテッドSomaLogic, Inc. | 増殖分化因子１１と結合するための核酸化合物 |
| ES2911421T3 (es) * | 2015-12-08 | 2022-05-19 | Twinstrand Biosciences Inc | Adaptadores, métodos y composiciones mejorados para secuenciación dúplex |
| WO2017160672A1 (en) | 2016-03-14 | 2017-09-21 | Somalogic, Inc. | Compounds and methods for the synthesis of 5-(n-protected-tryptaminocarboxyamide)-2'-deoxyuridine phosphoramidate for incorporation into a nucleic sequence |
| JP2019521680A (ja) * | 2016-06-17 | 2019-08-08 | プロクシミティー バイオサイエンシズ，エルエルシー | アプタマーペアを選択する方法 |
| DK3478843T3 (da) * | 2016-07-01 | 2021-08-30 | Somalogic Inc | Oligonukleotider omfattende modificerede nukleosider |
| JP2020514746A (ja) | 2016-12-01 | 2020-05-21 | ノーティラス バイオテクノロジー インコーポレイテッド | タンパク質をアッセイする方法 |
| WO2019103131A1 (ja) * | 2017-11-24 | 2019-05-31 | 国立大学法人 東京大学 | アプタマーの結合部位判別方法、アプタマーペアおよび目的物質からなる三元錯体の解離定数等の測定方法並びに最適なアプタマーペアの選択方法 |
| BR112020026129B1 (pt) * | 2018-06-22 | 2023-10-10 | Somalogic Operating Co., Inc | Métodos para melhorar o desempenho de ensaios proteômicos multiplex |
| WO2021252800A1 (en) | 2020-06-11 | 2021-12-16 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CA3203106A1 (en) | 2021-01-20 | 2022-07-28 | Parag Mallick | Systems and methods for biomolecule quantitation |
| EP4281775A1 (de) | 2021-01-21 | 2023-11-29 | Nautilus Subsidiary, Inc. | Systeme und verfahren zur biomolekülherstellung |
| KR20230169143A (ko) | 2021-03-11 | 2023-12-15 | 노틸러스 서브시디어리, 인크. | 생체분자 보유를 위한 시스템 및 방법 |
| AU2022341171A1 (en) | 2021-09-09 | 2024-02-22 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| CA3227592A1 (en) | 2021-09-22 | 2023-03-30 | Gregory KAPP | Methods and systems for determining polypeptide interactions |
| US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| US20230360732A1 (en) | 2022-04-25 | 2023-11-09 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| US20240094215A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240183858A1 (en) | 2022-11-15 | 2024-06-06 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| WO2024124073A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001257091A1 (en) * | 2000-04-18 | 2001-10-30 | Gilead Sciences, Inc. | Aptamer based two-site binding assay |
| EP2351855A1 (de) * | 2000-09-26 | 2011-08-03 | Duke University | RNA-Aptamere und Verfahren zu ihrer Identifizierung |
| US20070071744A1 (en) * | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| WO2007056250A2 (en) | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| WO2008039642A2 (en) | 2006-09-26 | 2008-04-03 | Replidyne, Inc. | Methods and compounds for treatment of clostridium based infection |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| KR101747665B1 (ko) * | 2007-07-17 | 2017-06-15 | 소마로직, 인크. | 시료의 다중분석 |
| WO2009037264A2 (en) | 2007-09-17 | 2009-03-26 | Da Volterra | Colonic delivery of antimicrobial agents |
| US8569252B2 (en) | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| EP2534164A4 (de) | 2010-02-11 | 2013-09-11 | Intelligent Med Devices Inc | Oligonukleotide im zusammenhang mit für toxin b, toxin a oder binäres toxin kodierenden clostridium-difficile-genen |
| GB201002627D0 (en) | 2010-02-16 | 2010-03-31 | Loxbridge Res Llp | Aptamer based analyte detection method |
| EP2558586B1 (de) * | 2010-04-12 | 2016-10-12 | Somalogic, Inc. | APTAMERE FÜR ß-NGF UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON DURCH ß-NGF VERMITTELTEN KRANKHEITEN UND LEIDEN |
| US8785132B2 (en) * | 2010-04-23 | 2014-07-22 | Postech Academy-Industry Foundation | Aptamer sandwich assays |
| US20150031585A1 (en) | 2011-03-10 | 2015-01-29 | Somalogic, Inc. | Multiaptamer Target Detection |
| KR20140015455A (ko) * | 2011-03-10 | 2014-02-06 | 소마로직, 인크. | 클로스트리디움 디피실 진단을 위한 압타머 |
| AU2012249658A1 (en) * | 2011-04-26 | 2013-05-09 | Regado Biosciences, Inc. | A method for manufacturing pegylated oligonucleotides |
| MX2014003153A (es) * | 2011-09-30 | 2014-04-30 | Somalogic Inc | Prediccion de riesgo de evento cardiovascular y usos del mismo. |
| US9651556B2 (en) | 2011-12-30 | 2017-05-16 | Quest Diagnostics Investments Incorporated | Aptamers and diagnostic methods for detecting the EGF receptor |
| CA2924987C (en) | 2013-09-24 | 2022-08-16 | Somalogic, Inc. | Multiaptamer target detection |
-
2014
- 2014-09-24 CA CA2924987A patent/CA2924987C/en active Active
- 2014-09-24 SG SG11201602063UA patent/SG11201602063UA/en unknown
- 2014-09-24 WO PCT/US2014/057143 patent/WO2015048084A1/en active Application Filing
- 2014-09-24 MX MX2016003320A patent/MX361451B/es active IP Right Grant
- 2014-09-24 US US15/023,182 patent/US9926566B2/en active Active
- 2014-09-24 CN CN202210264586.7A patent/CN114703193A/zh active Pending
- 2014-09-24 BR BR112016005957A patent/BR112016005957A2/pt not_active IP Right Cessation
- 2014-09-24 EP EP14847780.5A patent/EP3049523B1/de active Active
- 2014-09-24 KR KR1020167006262A patent/KR102348283B1/ko active IP Right Grant
- 2014-09-24 JP JP2016544355A patent/JP6506768B2/ja active Active
- 2014-09-24 AU AU2014326975A patent/AU2014326975B2/en active Active
- 2014-09-24 CN CN201480051210.1A patent/CN105555957A/zh active Pending
-
2016
- 2016-02-25 IL IL244284A patent/IL244284B/en active IP Right Grant
- 2016-06-13 HK HK16106780.3A patent/HK1218765A1/zh unknown
-
2018
- 2018-02-13 US US15/895,723 patent/US10392621B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9926566B2 (en) | 2018-03-27 |
| EP3049523B1 (de) | 2019-08-07 |
| HK1218765A1 (zh) | 2017-03-10 |
| CA2924987C (en) | 2022-08-16 |
| KR20160058777A (ko) | 2016-05-25 |
| CN105555957A (zh) | 2016-05-04 |
| MX361451B (es) | 2018-12-06 |
| WO2015048084A1 (en) | 2015-04-02 |
| EP3049523A4 (de) | 2017-05-17 |
| CN114703193A (zh) | 2022-07-05 |
| AU2014326975A1 (en) | 2016-04-07 |
| US10392621B2 (en) | 2019-08-27 |
| JP6506768B2 (ja) | 2019-04-24 |
| AU2014326975B2 (en) | 2020-05-07 |
| EP3049523A1 (de) | 2016-08-03 |
| CA2924987A1 (en) | 2015-04-02 |
| AU2014326975A2 (en) | 2017-01-05 |
| BR112016005957A2 (pt) | 2017-09-26 |
| US20160237435A1 (en) | 2016-08-18 |
| US20180187197A1 (en) | 2018-07-05 |
| IL244284B (en) | 2019-12-31 |
| MX2016003320A (es) | 2016-05-31 |
| IL244284A0 (en) | 2016-04-21 |
| JP2016531593A (ja) | 2016-10-13 |
| KR102348283B1 (ko) | 2022-01-10 |
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