SG11201510297QA - Targeted integration - Google Patents
Targeted integrationInfo
- Publication number
- SG11201510297QA SG11201510297QA SG11201510297QA SG11201510297QA SG11201510297QA SG 11201510297Q A SG11201510297Q A SG 11201510297QA SG 11201510297Q A SG11201510297Q A SG 11201510297QA SG 11201510297Q A SG11201510297Q A SG 11201510297QA SG 11201510297Q A SG11201510297Q A SG 11201510297QA
- Authority
- SG
- Singapore
- Prior art keywords
- targeted integration
- targeted
- integration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/301—Endonuclease
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361837019P | 2013-06-19 | 2013-06-19 | |
| PCT/US2014/043138 WO2014205192A2 (en) | 2013-06-19 | 2014-06-19 | Targeted integration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201510297QA true SG11201510297QA (en) | 2016-01-28 |
Family
ID=52105507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201510297QA SG11201510297QA (en) | 2013-06-19 | 2014-06-19 | Targeted integration |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20160145645A1 (zh) |
| EP (1) | EP3011011A4 (zh) |
| JP (1) | JP2016523084A (zh) |
| KR (1) | KR20160021812A (zh) |
| CN (1) | CN105555948A (zh) |
| AU (1) | AU2014281472A1 (zh) |
| BR (1) | BR112015031639A2 (zh) |
| CA (1) | CA2915467A1 (zh) |
| MX (1) | MX2015017110A (zh) |
| RU (1) | RU2016101246A (zh) |
| SG (1) | SG11201510297QA (zh) |
| WO (1) | WO2014205192A2 (zh) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| HUE040575T2 (hu) | 2013-04-16 | 2019-03-28 | Regeneron Pharma | A patkány genom célzott módosítása |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| MX2016007654A (es) | 2013-12-11 | 2017-08-15 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| LT3152312T (lt) | 2014-06-06 | 2020-04-27 | Regeneron Pharmaceuticals, Inc. | Tikslinio lokuso modifikavimo būdai ir kompozicijos |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| LT3221457T (lt) | 2014-11-21 | 2019-06-10 | Regeneron Pharmaceuticals, Inc. | Nukreipiančios genetinės modifikacijos būdai ir kompozicijos, naudojant suporuotas kreipiančiąsias rnr sekas |
| CN106554943A (zh) * | 2015-09-30 | 2017-04-05 | 北京吉尚立德生物科技有限公司 | 一种重组过表达Creb3L1基因的CHO细胞株CHO-Creb3L1 |
| IL310721A (en) | 2015-10-23 | 2024-04-01 | Harvard College | Nucleobase editors and their uses |
| CN108884475A (zh) * | 2016-04-11 | 2018-11-23 | 应用干细胞有限公司 | 转基因的位点特异性整合 |
| EP4219731A3 (en) * | 2016-05-18 | 2023-08-09 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| US11078481B1 (en) | 2016-08-03 | 2021-08-03 | KSQ Therapeutics, Inc. | Methods for screening for cancer targets |
| CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US11078483B1 (en) | 2016-09-02 | 2021-08-03 | KSQ Therapeutics, Inc. | Methods for measuring and improving CRISPR reagent function |
| CN110214180A (zh) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | 核碱基编辑器的aav递送 |
| CA3046929A1 (en) * | 2016-12-14 | 2018-06-21 | Dow Agrosciences Llc | Reconstruction of site specific nuclease binding sites |
| EP3559236A4 (en) * | 2016-12-20 | 2020-11-04 | Development Center for Biotechnology | TARGETED INTEGRATION SITES IN THE OVARIAL CELL GENOME OF THE CHINESE HAMSTER |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP7048963B2 (ja) * | 2016-12-28 | 2022-04-06 | 学校法人自治医科大学 | 遺伝子発現制御方法及び遺伝子発現制御キット |
| WO2018148196A1 (en) * | 2017-02-07 | 2018-08-16 | Sigma-Aldrich Co. Llc | Stable targeted integration |
| GB201703417D0 (en) | 2017-03-03 | 2017-04-19 | Ge Healthcare Bio Sciences Ab | Method for cell line development |
| GB201703418D0 (en) * | 2017-03-03 | 2017-04-19 | Ge Healthcare Bio Sciences Ab | Method for cell line development |
| GB201703416D0 (en) * | 2017-03-03 | 2017-04-19 | Ge Healthcare Bio Sciences Ab | Method for protein expression |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| EP3601542A4 (en) * | 2017-03-19 | 2021-01-13 | Applied Stemcell, Inc. | NOVEL INTEGRATION POINTS AND USES THEREOF |
| CN110914426A (zh) | 2017-03-23 | 2020-03-24 | 哈佛大学的校长及成员们 | 包含核酸可编程dna结合蛋白的核碱基编辑器 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| KR102531749B1 (ko) * | 2017-08-11 | 2023-05-10 | 베링거 인겔하임 인터내셔날 게엠베하 | Cho 세포 내 통합 부위 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| AU2018352592A1 (en) | 2017-10-16 | 2020-06-04 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| BR112020012591A2 (pt) * | 2017-12-22 | 2020-11-24 | Genentech, Inc. | células hospedeiras de integração direcionada (ti), células hospedeiras ti, métodos para preparar uma célula hospedeira ti, métodos para expressar um polipeptídeo de interesse e vetores |
| CN110607326B (zh) * | 2018-06-15 | 2022-11-29 | 江苏省农业科学院 | 非强启动式的外源基因表达法及其在具有毒性的目标蛋白表达中的应用 |
| US11851663B2 (en) * | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| AU2019403279A1 (en) * | 2018-12-21 | 2021-07-01 | Genentech, Inc. | Targeted integration of nucleic acids |
| AU2020242032A1 (en) | 2019-03-19 | 2021-10-07 | Massachusetts Institute Of Technology | Methods and compositions for editing nucleotide sequences |
| WO2020215077A2 (en) * | 2019-04-18 | 2020-10-22 | Sigma-Aldrich Co. Llc | Stable targeted integration |
| MX2021015536A (es) * | 2019-06-19 | 2022-02-10 | Hoffmann La Roche | Metodo para la generacion de una celula que expresa proteina mediante integracion dirigida usando acido ribonucleico mensajero (arnm) de cre. |
| CA3141233A1 (en) | 2019-06-26 | 2020-12-30 | Shahram Misaghi | Randomized configuration targeted integration of nucleic acids |
| CN114787358A (zh) * | 2019-07-18 | 2022-07-22 | 罗切斯特大学 | 细胞的细胞类型选择性免疫保护 |
| CN111088282B (zh) * | 2020-03-23 | 2020-08-28 | 上海安民生物技术有限公司 | Aavs1和h11安全港位点在重组表达蛋白中的应用 |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN116096907A (zh) * | 2020-06-24 | 2023-05-09 | 基因泰克公司 | 核酸的靶向整合 |
| US20240018493A1 (en) * | 2020-11-10 | 2024-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Knock-in of large dna for long-term high genomic expression |
| CN112458059B (zh) * | 2020-11-25 | 2021-07-23 | 杭州景杰生物科技股份有限公司 | 一种识别H3 K18la兔单克隆抗体稳转细胞株及其构建方法 |
| AU2022334794A1 (en) * | 2021-08-25 | 2024-03-28 | Iontas Limited | Preparation of libraries of protein variants expressed in eukaryotic cells |
| CN113881703B (zh) * | 2021-10-11 | 2022-06-21 | 中国人民解放军军事科学院军事医学研究院 | 一种提高cho细胞同源重组效率的方法及其相关产品和应用 |
| WO2023122246A1 (en) * | 2021-12-22 | 2023-06-29 | Genentech, Inc. | Multi-vector recombinase mediated cassette exchange |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1439234A1 (en) * | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Targeted transgenesis using the rosa26 locus |
| CA2791116A1 (en) * | 2010-02-26 | 2011-09-01 | Olivier Danos | Use of endonucleases for inserting transgenes into safe harbor loci |
| BR112012027532A2 (pt) * | 2010-04-26 | 2020-10-13 | Sangamo Biosciences, Inc. | edição de genoma de um locus rosa usando nucleases de dedo de zinco. |
| US8980579B2 (en) * | 2011-04-05 | 2015-03-17 | The Scripps Research Institute | Chromosomal landing pads and related uses |
| CN103305504B (zh) * | 2012-03-14 | 2016-08-10 | 江苏吉锐生物技术有限公司 | 在仓鼠细胞中定点重组的组合物和方法 |
-
2014
- 2014-06-19 CA CA2915467A patent/CA2915467A1/en not_active Abandoned
- 2014-06-19 MX MX2015017110A patent/MX2015017110A/es unknown
- 2014-06-19 SG SG11201510297QA patent/SG11201510297QA/en unknown
- 2014-06-19 BR BR112015031639A patent/BR112015031639A2/pt not_active Application Discontinuation
- 2014-06-19 AU AU2014281472A patent/AU2014281472A1/en not_active Abandoned
- 2014-06-19 KR KR1020167000496A patent/KR20160021812A/ko not_active Application Discontinuation
- 2014-06-19 EP EP14814484.3A patent/EP3011011A4/en not_active Withdrawn
- 2014-06-19 US US14/899,405 patent/US20160145645A1/en not_active Abandoned
- 2014-06-19 WO PCT/US2014/043138 patent/WO2014205192A2/en active Application Filing
- 2014-06-19 CN CN201480046042.7A patent/CN105555948A/zh active Pending
- 2014-06-19 RU RU2016101246A patent/RU2016101246A/ru not_active Application Discontinuation
- 2014-06-19 JP JP2016521569A patent/JP2016523084A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3011011A2 (en) | 2016-04-27 |
| US20160145645A1 (en) | 2016-05-26 |
| MX2015017110A (es) | 2016-08-03 |
| AU2014281472A1 (en) | 2016-01-21 |
| CN105555948A (zh) | 2016-05-04 |
| BR112015031639A2 (pt) | 2019-09-03 |
| KR20160021812A (ko) | 2016-02-26 |
| JP2016523084A (ja) | 2016-08-08 |
| WO2014205192A3 (en) | 2015-03-19 |
| RU2016101246A (ru) | 2017-07-24 |
| EP3011011A4 (en) | 2017-05-31 |
| WO2014205192A2 (en) | 2014-12-24 |
| RU2016101246A3 (zh) | 2018-04-03 |
| CA2915467A1 (en) | 2014-12-24 |
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