SG11201508968XA - Continuous multistep process for purifying antibodies - Google Patents
Continuous multistep process for purifying antibodiesInfo
- Publication number
- SG11201508968XA SG11201508968XA SG11201508968XA SG11201508968XA SG11201508968XA SG 11201508968X A SG11201508968X A SG 11201508968XA SG 11201508968X A SG11201508968X A SG 11201508968XA SG 11201508968X A SG11201508968X A SG 11201508968XA SG 11201508968X A SG11201508968X A SG 11201508968XA
- Authority
- SG
- Singapore
- Prior art keywords
- multistep process
- purifying antibodies
- continuous multistep
- continuous
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Water Supply & Treatment (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305593 | 2013-05-06 | ||
| PCT/EP2014/059246 WO2014180852A1 (en) | 2013-05-06 | 2014-05-06 | Continuous multistep process for purifying antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201508968XA true SG11201508968XA (en) | 2015-11-27 |
Family
ID=48430636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201508968XA SG11201508968XA (en) | 2013-05-06 | 2014-05-06 | Continuous multistep process for purifying antibodies |
Country Status (19)
Families Citing this family (36)
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| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| MX379269B (es) * | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| CN105555795A (zh) * | 2013-09-17 | 2016-05-04 | 株式会社钟化 | 新抗体纯化方法和由该方法得到的抗体、以及使用了阳离子交换基团的新抗体纯化法和由该方法得到的抗体 |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| GB201503578D0 (en) * | 2015-03-03 | 2015-04-15 | Ge Healthcare Bio Sciences Ab | Sanitization method for affinity chromatography matrices |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| EP3015542A1 (de) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US20170101437A1 (en) * | 2015-10-09 | 2017-04-13 | Hetero Drugs Ltd. | Process for purification of darbepoetin alfa |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US20190211055A1 (en) * | 2016-09-14 | 2019-07-11 | Kinbio Ltd. | Methods of purifying and qualifying antibodies |
| KR20190127655A (ko) | 2016-10-19 | 2019-11-13 | 프로디자인 소닉스, 인크. | 음향학에 의한 친화성 세포 추출 |
| MX2019011343A (es) * | 2017-03-24 | 2019-11-18 | Council Scient Ind Res | Un procedimiento para la purificacion de fragmentos de anticuerpos recombinantes. |
| GB201711481D0 (en) * | 2017-07-17 | 2017-08-30 | Ucb Biopharma Sprl | Protein purification |
| EP3676375A4 (en) * | 2017-08-31 | 2021-04-07 | Green Cross Corporation | PROCESS FOR PURIFYING A SULFATASE PROTEIN |
| US10785574B2 (en) | 2017-12-14 | 2020-09-22 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
| CN111902720B (zh) | 2018-03-21 | 2025-02-07 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| EP3636657A1 (en) | 2018-10-08 | 2020-04-15 | Ablynx N.V. | Chromatography-free antibody purification method |
| WO2020084503A1 (en) * | 2018-10-26 | 2020-04-30 | Cadila Healthcare Limited | A composition comprising antibody with reduced level of basic variants thereof |
| WO2020183332A1 (en) * | 2019-03-11 | 2020-09-17 | Intas Pharmaceuticals Ltd. | Purification of adalimumab using tandem chromatography |
| TWI877156B (zh) * | 2019-04-03 | 2025-03-21 | 美商健臻公司 | 重組蛋白的連續式生產 |
| WO2020258704A1 (zh) * | 2019-06-28 | 2020-12-30 | 信达生物制药(苏州)有限公司 | 无缝连续流层析方法 |
| BR112022005410A2 (pt) * | 2019-09-23 | 2022-06-21 | Merck Sharp & Dohme | Métodos e composições compreendendo um anticorpo monoclonal anti-ctla4 com proteínas de célula hospedeira reduzidas e estabilidade de polissorbato 80 aumentada |
| KR102154952B1 (ko) * | 2020-02-21 | 2020-09-10 | 프레스티지바이오로직스 주식회사 | 아달리무맙의 Non-Protein A 정제방법 |
| CN112574321B (zh) * | 2020-12-30 | 2023-10-20 | 上海赛金生物医药有限公司 | 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法 |
| WO2022234412A1 (en) | 2021-05-03 | 2022-11-10 | Lupin Limited | A process for purification of fc-fusion proteins |
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| KR930008447B1 (ko) | 1987-10-23 | 1993-09-04 | 쉐링 코포레이션 | 단백질 정제방법 |
| CA2106612C (en) | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
| ES2126775T3 (es) | 1993-09-21 | 1999-04-01 | Hemosol Inc | Procedimiento cromatografico de desplazamiento y producto de hemoglobina purificada. |
| US5891741A (en) | 1997-05-16 | 1999-04-06 | Coulter International Corp. | Antibody-aminodextran-phycobiliprotein conjugates |
| CN1136317C (zh) | 1999-03-12 | 2004-01-28 | 中国人民解放军第四军医大学 | 单克隆抗体双段和单段的制备方法 |
| US20020009445A1 (en) | 2000-07-12 | 2002-01-24 | Yansheng Du | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
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| CN1504482A (zh) * | 2002-12-03 | 2004-06-16 | 北京优力凯生物技术有限责任公司 | 无细胞百日咳抗原蛋白的分离纯化方法 |
| EP2439213B1 (en) | 2004-04-21 | 2018-12-12 | The Brigham and Women's Hospital, Inc. | Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding antibodies and methods of use thereof |
| KR101243425B1 (ko) * | 2004-10-21 | 2013-03-13 | 지이 헬스케어 바이오-사이언시스 에이비 | 항체의 정제 방법 |
| EP3312196B1 (en) | 2005-03-23 | 2019-07-17 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
| CN1814775A (zh) | 2005-12-06 | 2006-08-09 | 中国海洋大学 | 一种抗病毒活性寡聚肽的制备方法 |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| RU2493163C2 (ru) | 2007-07-11 | 2013-09-20 | Ново Нордиск А/С | Способ очистки белка фактора свертывания viii и способ стабилизации белка фактора viii |
| HRP20171292T1 (hr) | 2007-11-16 | 2017-12-15 | The Rockfeller University | Polipeptidi i konjugati klorotoksina i njihove uporabe |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| US20110129468A1 (en) * | 2008-02-29 | 2011-06-02 | Biogen Idec Ma Inc. | Purified immunoglobulin fusion proteins and methods of their purification |
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| WO2011017514A1 (en) * | 2009-08-07 | 2011-02-10 | Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
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| EP2490780A4 (en) * | 2009-10-20 | 2014-04-09 | Merck Sharp & Dohme | USE OF A MIXED MODE CHROMATOGRAPHY FOR THE DETECTION AND PURIFICATION OF BASIC ANTIBODY PRODUCTS |
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| ES2534936T3 (es) | 2010-08-02 | 2015-04-30 | Ratiopharm Gmbh | Método para producir y purificar una sialiltransferasa soluble activa |
| WO2012125735A1 (en) * | 2011-03-15 | 2012-09-20 | Abott Laboratories | An integrated approach to the isolation and purification of antibodies |
| AU2012236486B2 (en) * | 2011-03-29 | 2016-06-23 | Glaxosmithkline Llc | Buffer system for protein purification |
| JP6121409B2 (ja) | 2011-06-17 | 2017-04-26 | ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド | 生体試料の組織処理のための溶液 |
| WO2013028330A2 (en) * | 2011-08-19 | 2013-02-28 | Emd Millipore Corporation | Methods of reducing level of one of more impurities in a sample during protein purification |
| EP2578286A1 (en) * | 2011-10-04 | 2013-04-10 | Merck Patent GmbH | Method and apparatus for chromatographic purification |
| PE20141413A1 (es) * | 2011-10-25 | 2014-10-25 | Onclave Therapeutics Ltd | Formulaciones de anticuerpo y metodos |
| WO2013075740A1 (en) | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
-
2014
- 2014-05-06 NO NO14722194A patent/NO2994485T3/no unknown
- 2014-05-06 MX MX2015015482A patent/MX368177B/es active IP Right Grant
- 2014-05-06 HU HUE17200909A patent/HUE057119T2/hu unknown
- 2014-05-06 EP EP14722194.9A patent/EP2994485B1/en active Active
- 2014-05-06 TW TW107117528A patent/TWI675041B/zh not_active IP Right Cessation
- 2014-05-06 BR BR112015027812-4A patent/BR112015027812B1/pt active IP Right Grant
- 2014-05-06 CN CN202310118200.6A patent/CN116003579A/zh active Pending
- 2014-05-06 US US14/889,397 patent/US10793622B2/en active Active
- 2014-05-06 HU HUE14722194A patent/HUE038741T2/hu unknown
- 2014-05-06 CN CN201480038360.9A patent/CN105358572A/zh active Pending
- 2014-05-06 CA CA2911462A patent/CA2911462C/en active Active
- 2014-05-06 KR KR1020157032904A patent/KR102272851B1/ko active Active
- 2014-05-06 JP JP2016512344A patent/JP6463734B2/ja active Active
- 2014-05-06 EP EP17200909.4A patent/EP3301115B1/en active Active
- 2014-05-06 WO PCT/EP2014/059246 patent/WO2014180852A1/en active Application Filing
- 2014-05-06 SG SG11201508968XA patent/SG11201508968XA/en unknown
- 2014-05-06 RU RU2015151869A patent/RU2662668C2/ru active
- 2014-05-06 DK DK14722194.9T patent/DK2994485T3/en active
- 2014-05-06 TW TW103116153A patent/TWI631132B/zh not_active IP Right Cessation
- 2014-05-06 ES ES17200909T patent/ES2905675T3/es active Active
- 2014-05-06 DK DK17200909.4T patent/DK3301115T3/da active
- 2014-05-06 AU AU2014264697A patent/AU2014264697B2/en active Active
- 2014-05-06 ES ES14722194.9T patent/ES2665645T3/es active Active
-
2015
- 2015-11-02 IL IL242408A patent/IL242408B/en active IP Right Grant
-
2019
- 2019-01-10 JP JP2019002288A patent/JP2019104735A/ja active Pending
-
2022
- 2022-02-09 CY CY20221100113T patent/CY1125281T1/el unknown
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