SG11201507510PA - Isolation of non-embryonic stem cells and uses thereof - Google Patents

Isolation of non-embryonic stem cells and uses thereof

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Publication number
SG11201507510PA
SG11201507510PA SG11201507510PA SG11201507510PA SG11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA SG 11201507510P A SG11201507510P A SG 11201507510PA
Authority
SG
Singapore
Prior art keywords
isolation
stem cells
embryonic stem
embryonic
cells
Prior art date
Application number
SG11201507510PA
Other languages
English (en)
Inventor
Wa Xian
Original Assignee
Jackson Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson Lab filed Critical Jackson Lab
Publication of SG11201507510PA publication Critical patent/SG11201507510PA/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/37—Digestive system
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/39—Pancreas; Islets of Langerhans
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
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    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201507510PA 2013-03-15 2014-03-14 Isolation of non-embryonic stem cells and uses thereof SG11201507510PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792027P 2013-03-15 2013-03-15
US201361912795P 2013-12-06 2013-12-06
PCT/US2014/027207 WO2014152321A1 (fr) 2013-03-15 2014-03-14 Isolement de cellules souches non embryonnaires et leurs utilisations

Publications (1)

Publication Number Publication Date
SG11201507510PA true SG11201507510PA (en) 2015-10-29

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ID=50639961

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SG11201507510PA SG11201507510PA (en) 2013-03-15 2014-03-14 Isolation of non-embryonic stem cells and uses thereof
SG10201708332WA SG10201708332WA (en) 2013-03-15 2014-03-14 Isolation of non-embryonic stem cells and uses thereof

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Application Number Title Priority Date Filing Date
SG10201708332WA SG10201708332WA (en) 2013-03-15 2014-03-14 Isolation of non-embryonic stem cells and uses thereof

Country Status (8)

Country Link
US (2) US20160060594A1 (fr)
EP (1) EP2970892A1 (fr)
JP (2) JP6602745B2 (fr)
AU (1) AU2014239954B2 (fr)
CA (1) CA2906643A1 (fr)
SG (2) SG11201507510PA (fr)
TW (1) TW201522637A (fr)
WO (1) WO2014152321A1 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
KR101592182B1 (ko) 2007-11-27 2016-02-05 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
KR101731474B1 (ko) 2008-02-21 2017-05-11 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
PL2942392T3 (pl) 2008-06-30 2019-02-28 Janssen Biotech, Inc Różnicowanie pluripotencjalnych komórek macierzystych
US9234178B2 (en) 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
JP5719305B2 (ja) 2008-11-20 2015-05-13 ヤンセン バイオテツク，インコーポレーテツド 平面支持体上での細胞付着及び培養のための方法及び組成物
AU2009316580B2 (en) 2008-11-20 2016-04-14 Janssen Biotech, Inc. Pluripotent stem cell culture on micro-carriers
WO2011011300A2 (fr) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Différentiation de cellules souches embryonnaires humaines
US9150833B2 (en) 2009-12-23 2015-10-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
RU2607380C2 (ru) 2010-03-01 2017-01-10 Янссен Байотек, Инк. Способы очистки клеток, производных от плюрипотентных стволовых клеток
WO2011143299A2 (fr) 2010-05-12 2011-11-17 Centocor Ortho Biotech Inc. Différentiation de cellules souches embryonnaires humaines
US9506036B2 (en) 2010-08-31 2016-11-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
RU2705001C2 (ru) 2011-12-22 2019-11-01 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
CN104160018A (zh) 2012-03-07 2014-11-19 詹森生物科技公司 用于扩增和维持多能干细胞的成分确定的培养基
ES2690118T3 (es) 2012-06-08 2018-11-19 Janssen Biotech, Inc. Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas
BR112015015770A2 (pt) 2012-12-31 2017-07-11 Janssen Biotech Inc cultivo de células-tronco embrionárias humanas na interface ar-líquido para diferenciação em células pancreáticas endócrinas
CA2896750A1 (fr) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Mise en suspension et agregation de cellules pluripotentes humaines pour la differenciation en cellules endocrines du pancreas
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
US20160237400A1 (en) * 2013-03-15 2016-08-18 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
CA2906643A1 (fr) * 2013-03-15 2014-09-25 The Jackson Laboratory Isolement de cellules souches non embryonnaires et leurs utilisations
WO2015175307A1 (fr) 2014-05-16 2015-11-19 Janssen Biotech, Inc. Utilisation de petites molécules pour améliorer l'expression du gène mafa dans des cellules endocrines pancréatiques
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
SG11201707970XA (en) 2015-04-03 2017-10-30 Propagenix Inc Ex vivo proliferation of epithelial cells
US10087417B2 (en) 2015-04-22 2018-10-02 William J. Freed Three-dimensional model of human cortex
WO2016200340A1 (fr) 2015-06-12 2016-12-15 Agency For Science, Technology And Research Dérivation de cellules souches hépatiques et types de cellules hépatiques ainsi qu'utilisations associées
US10066201B2 (en) 2015-09-11 2018-09-04 Propagenix Inc. Ex vivo proliferation of epithelial cells
EP3426772A4 (fr) 2016-03-09 2019-08-28 Beijing Percans Oncology Co. Ltd. Cultures en suspension de cellules tumorales et procédés associés
CN112522184B (zh) * 2016-04-08 2023-08-04 苏州吉美瑞生医学科技有限公司 用于分离获得肺脏干细胞的试剂盒及方法
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
JP6840774B2 (ja) * 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
KR102476709B1 (ko) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
AU2017367003B2 (en) * 2016-12-02 2021-03-25 EMULATE, Inc. In vitro gastrointestinal model comprising lamina propria-derived cells
AU2017366833B2 (en) 2016-12-02 2020-02-20 EMULATE, Inc. In vitro epithelial models comprising lamina propria-derived cells
WO2018204913A1 (fr) * 2017-05-05 2018-11-08 Tract Pharmaceuticals, Inc. Cellules souches associées à la maladie inflammatoire de l'intestin, agents ciblant lesdites cellules souches et utilisations associées
KR102277147B1 (ko) * 2017-12-13 2021-07-13 건국대학교 산학협력단 섬유아 성장인자 유래 펩타이드의 골 또는 연골 분화 촉진 용도
WO2019133810A1 (fr) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Systèmes de culture de cellules souches pour cellules souches épithéliales colonnaires, et leurs utilisations
US20200362312A1 (en) * 2018-01-18 2020-11-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Generation, proliferation and expansion of epithelial cells from primary tissue into mucosoid cultures
US20210147811A1 (en) * 2018-04-09 2021-05-20 Cedars-Sinai Medical Center Methods for in vitro expansion of adult tissue stem cells
EP3775170A4 (fr) * 2018-04-13 2022-01-26 Shanghai Lide Biotech Co., Ltd. Procédé d'obtention d'un modèle animal à partir de cellules reprogrammées conditionnellement et utilisation du modèle animal pour le criblage de médicaments antitumoraux
BR112020022168A2 (pt) * 2018-04-30 2021-01-26 Avita International Ltd. células-tronco imaturas de polpa dentária e métodos de uso para tratar falência da medula óssea
US20210371810A1 (en) * 2018-05-10 2021-12-02 Agency For Science, Technology And Research Cell Culture Medium
AU2019271028A1 (en) 2018-05-14 2020-12-03 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
CN111254118A (zh) * 2018-11-30 2020-06-09 中国科学院大连化学物理研究所 一种hiPSCs来源的类脑组织产生方法
WO2020132248A1 (fr) * 2018-12-21 2020-06-25 The Board Of Trustees Of The Leland Stanford Junior University Compositions et méthodes de régénération des tissus des voies respiratoires
CN109652365A (zh) * 2019-02-01 2019-04-19 南京大学 一种斑马鱼胚胎单细胞悬液的制备方法
CN114585728A (zh) * 2019-08-27 2022-06-03 联合治疗公司 用于培养肺泡细胞的方法和组合物
EP4041259A4 (fr) * 2019-10-10 2023-10-25 University of Houston System Systèmes de culture de cellules souches nourricières et exempt de cellules souches nourricières pour cellules souches épithéliales stratifiées et leurs utilisations
CN111471643B (zh) * 2020-04-09 2020-12-29 创芯国际生物科技(广州)有限公司 一种通用型上呼吸道粘膜类器官的培养基及培养方法
KR20230016653A (ko) 2020-05-27 2023-02-02 오츠카 세이야쿠 가부시키가이샤 폐 상피 세포 또는 폐암 세포로부터의 오르가노이드의 제조 방법
CN111560376B (zh) * 2020-06-15 2022-03-25 浙江大学 一种特异抑制OLFM4基因表达的siRNA及其应用
CN111808795A (zh) * 2020-06-28 2020-10-23 广东省医疗器械研究所 一种肝细胞体外共培养体系及其构建方法与应用
US20240041011A1 (en) * 2020-12-07 2024-02-08 The Jackson Laboratory Infectious disease mouse models
CN112725259B (zh) * 2021-01-07 2023-08-29 福州市皮肤病防治院 一种干细胞向汗腺样细胞分化的诱导培养基和诱导方法
KR102574856B1 (ko) * 2021-02-05 2023-09-07 연세대학교 산학협력단 신장 질환의 예방 또는 치료용 조성물

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US6133027A (en) 1996-08-07 2000-10-17 City Of Hope Inducible expression system
US6207455B1 (en) 1997-05-01 2001-03-27 Lung-Ji Chang Lentiviral vectors
EP0981636B1 (fr) 1997-05-13 2005-03-23 University Of North Carolina At Chapel Hill Vecteurs de transfert de gene comportant un lentivirus
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
DE19909769A1 (de) 1999-03-05 2000-09-07 Bundesrepublik Deutschland Let Von SIVagm abgeleitete lentivirale Vektoren, Verfahren zu ihrer Herstellung und ihre Verwendung zur Genübertragung in Säugerzellen
US8075881B2 (en) * 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
CA2402459A1 (fr) 2000-12-01 2002-06-06 Central Institute For Experimental Animals Procede pour produire une souris adaptee aux greffes, a la differenciation et a la proliferation de cellules heterogenes, souris obtenue selon cette methode et utilisation de la souris
WO2003030959A1 (fr) * 2001-10-06 2003-04-17 Btg International Limited Dispositif de reparation de la cornee
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
NZ567082A (en) * 2005-10-14 2012-08-31 Univ Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
EP1999253B1 (fr) * 2006-03-02 2019-05-22 Viacyte, Inc. Cellules précurseurs endocrines, cellules exprimant des hormones pancréatiques et procédés de productions associés
WO2007121263A2 (fr) * 2006-04-14 2007-10-25 Wako Pure Chemical Industries, Ltd Structure destinée à introduire plusieurs solutions, dispositif microfluidique comportant une telle structure et procédé destiné à introduire une solution
EP2108043A4 (fr) * 2007-01-18 2010-04-21 Suomen Punainen Risti Veripalv Nouveaux procedes et reactifs pour la production de cellules
US8383349B2 (en) 2007-03-16 2013-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bone morphogenetic protein antagonist and uses thereof
WO2009148170A1 (fr) * 2008-06-06 2009-12-10 独立行政法人理化学研究所 Procédé de culture de cellule souche
US20110165130A1 (en) * 2008-06-25 2011-07-07 Inserm Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells
EP3061808B1 (fr) * 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Milieu de culture de cellules souches épithéliales et organoïdes comprenant lesdites cellules souches
EP2412800A1 (fr) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Organoïde du foie, ses utilisations et son procédé de culture pour l'obtenir
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP2420566A4 (fr) * 2009-04-17 2014-01-15 Univ Tohoku Procédé de préparation de cellules souches de tissu pulmonaire humain et procédé d'induction de la différenciation en cellules épithéliales alvéolaires humaines
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
SG188666A1 (en) * 2010-09-30 2013-05-31 Agency Science Tech & Res Methods and reagents for detection and treatment of esophageal metaplasia
WO2012168434A1 (fr) * 2011-06-08 2012-12-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Reprogrammation partielle de cellules somatiques en cellules souches tissulaires induites (its)
WO2014151456A2 (fr) * 2013-03-15 2014-09-25 The Jackson Laboratory Traitement de maladies inflammatoires
CA2906643A1 (fr) * 2013-03-15 2014-09-25 The Jackson Laboratory Isolement de cellules souches non embryonnaires et leurs utilisations

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US20180179492A1 (en) 2018-06-28
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AU2014239954A1 (en) 2015-11-05
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AU2014239954B2 (en) 2020-07-16
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