SG11201504874QA - Sample analysis for mass cytometry - Google Patents

Sample analysis for mass cytometry

Info

Publication number
SG11201504874QA
SG11201504874QA SG11201504874QA SG11201504874QA SG11201504874QA SG 11201504874Q A SG11201504874Q A SG 11201504874QA SG 11201504874Q A SG11201504874Q A SG 11201504874QA SG 11201504874Q A SG11201504874Q A SG 11201504874QA SG 11201504874Q A SG11201504874Q A SG 11201504874QA
Authority
SG
Singapore
Prior art keywords
sample analysis
mass cytometry
cytometry
mass
sample
Prior art date
Application number
SG11201504874QA
Other languages
English (en)
Inventor
Alexandre Loboda
Original Assignee
Fluidigm Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Canada Inc filed Critical Fluidigm Canada Inc
Publication of SG11201504874QA publication Critical patent/SG11201504874QA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
SG11201504874QA 2013-04-17 2014-04-17 Sample analysis for mass cytometry SG11201504874QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361812893P 2013-04-17 2013-04-17
PCT/CA2014/050387 WO2014169394A1 (en) 2013-04-17 2014-04-17 Sample analysis for mass cytometry

Publications (1)

Publication Number Publication Date
SG11201504874QA true SG11201504874QA (en) 2015-07-30

Family

ID=51730644

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201808165YA SG10201808165YA (en) 2013-04-17 2014-04-17 Sample analysis for mass cytometry
SG11201504874QA SG11201504874QA (en) 2013-04-17 2014-04-17 Sample analysis for mass cytometry

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201808165YA SG10201808165YA (en) 2013-04-17 2014-04-17 Sample analysis for mass cytometry

Country Status (8)

Country Link
US (6) US9589779B2 (ru)
EP (2) EP3690923A1 (ru)
JP (1) JP6230693B2 (ru)
CN (1) CN105190829B (ru)
CA (2) CA3191952A1 (ru)
RU (1) RU2637795C2 (ru)
SG (2) SG10201808165YA (ru)
WO (1) WO2014169394A1 (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201507853QA (en) 2013-03-22 2015-10-29 Eth Zuerich Laser ablation cell
US9589779B2 (en) 2013-04-17 2017-03-07 Fluidigm Canada Inc. Sample analysis for mass cytometry
CN105658310A (zh) 2013-09-13 2016-06-08 斯坦福大学托管董事会 使用质量标签和次级离子质谱术的组织复用成像
GB201403625D0 (en) * 2014-02-28 2014-04-16 Asrepresented By The Sec Dep Of Health And Human Services The Multiplexed imaging of tissue samples by mass cytometry
EP3195346B1 (en) * 2014-09-18 2020-05-06 Universiteit Gent Laser ablation probe
WO2016109603A1 (en) * 2014-12-29 2016-07-07 Fluidigm Canada Inc. Mass cytometry apparatus and methods
US9963667B2 (en) 2014-12-31 2018-05-08 Fluidigm Canada Inc. Structured biological samples for analysis by mass cytometry
US20160260598A1 (en) * 2015-02-04 2016-09-08 Fluidigm Canada Inc. Laser enabled imaging mass cytometry
EP3274719B1 (en) 2015-03-25 2021-02-24 The Board of Trustees of the Leland Stanford Junior University Single cell analysis using secondary ion mass spectrometry
WO2016172215A1 (en) 2015-04-23 2016-10-27 The Board Of Trustees Of The Leland Stanford Junior University Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals
CN109791868A (zh) * 2016-08-02 2019-05-21 富鲁达加拿大公司 激光烧蚀系统
JP2020506736A (ja) * 2016-12-22 2020-03-05 アドバンスト オステオトミー ツールズ − エーオーティー アーゲー レーザデバイスおよび組織特徴解析方法
US11092519B1 (en) * 2017-02-06 2021-08-17 Elemental Scientific Lasers, Llc System and method for automated sampling and analysis
JP7078382B2 (ja) * 2017-11-22 2022-05-31 藤太郎 今坂 飛行時間型質量分析装置及び質量分析方法
EP3779399A4 (en) * 2018-04-18 2021-11-24 S.T.Japan Inc. LASER ABLATION DEVICE AND ANALYZER
CN113678227A (zh) 2018-06-18 2021-11-19 富鲁达加拿大公司 高分辨率成像设备和方法
EP3850329A4 (en) * 2018-09-10 2022-06-22 Fluidigm Canada Inc. AUTOFOCUS PROBE IMAGING DEVICE AND METHOD
KR102577694B1 (ko) * 2018-09-11 2023-09-12 주식회사 엘지에너지솔루션 검출 감도 향상을 위한 레이저 탈착-dart-ms 시스템 및 이에 사용되는 인터페이스 유닛
US11488816B2 (en) 2018-09-11 2022-11-01 Lg Energy Solution, Ltd. Interface unit
WO2020092236A1 (en) * 2018-10-29 2020-05-07 Fluidigm Canada Inc. Inductively coupled plasma torch with reverse vortex flow and method of operation
CN109668818B (zh) * 2018-12-26 2024-07-12 宁波大学 基于激光烧蚀的细胞分析装置及方法
WO2020150236A1 (en) * 2019-01-15 2020-07-23 Fluidigm Canada Inc. Direct ionization in imaging mass spectrometry
EP3712923A1 (en) * 2019-03-18 2020-09-23 ETH Zurich Ion source for inductively coupled plasma mass spectrometry
CN114207775B (zh) * 2019-05-15 2023-06-06 上海宸安生物科技有限公司 用于质谱法的样品输送装置
CN114599968A (zh) * 2019-06-18 2022-06-07 富鲁达加拿大公司 改进型质谱流式细胞术
EP4107826A4 (en) * 2020-02-19 2024-03-20 Elemental Scientific Lasers, LLC VARIABLE BEAM SIZE VIA A HOMQGENIZER MOVEMENT
EP3943197A1 (en) * 2020-07-20 2022-01-26 The Provost, Fellows, Scholars and other Members of Board of Trinity College Dublin Jet deposition using laser-produced dry aerosol
CA3193031A1 (en) 2020-09-18 2022-03-24 Fluidigm Canada Inc. Inductively coupled plasma based atomic analysis systems and methods
US11443933B1 (en) * 2020-10-30 2022-09-13 Agilent Technologies, Inc. Inductively coupled plasma mass spectrometry (ICP-MS) with ion trapping
JP2022131579A (ja) 2021-02-26 2022-09-07 キオクシア株式会社 分析装置および分析方法
CN113218846A (zh) * 2021-03-18 2021-08-06 上海交通大学 一种面向于单细胞质谱流式分析的icp装置
CN117501408A (zh) * 2021-04-14 2024-02-02 吉米亚分析公司 为icp-ms生成高产率负离子的系统
AT525093B1 (de) * 2021-10-05 2022-12-15 Univ Wien Tech Vorrichtung zur Aufnahme eines Feststoff-Probenmaterials

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740692A (en) * 1985-06-13 1988-04-26 Mitsubishi Denki Kabushiki Kaisha Laser mass spectroscopic analyzer and method
DE4108462C2 (de) * 1991-03-13 1994-10-13 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung zum Erzeugen von Ionen aus thermisch instabilen, nichtflüchtigen großen Molekülen
DE4200497A1 (de) 1992-01-10 1993-07-15 Bayer Ag Verfahren und vorrichtung zur schnellen identifizierung von kunststoffen mit hilfe der massenspektrometrie
JP2870364B2 (ja) * 1993-06-29 1999-03-17 日本鋼管株式会社 レーザー気化分析方法及び装置
US5526110A (en) 1994-07-08 1996-06-11 Iowa State University Research Foundation, Inc. In situ calibration of inductively coupled plasma-atomic emission and mass spectroscopy
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
JPH11201945A (ja) * 1998-01-09 1999-07-30 Jeol Ltd レーザーアブレーション装置
US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
CA2460567C (en) * 2001-09-17 2010-11-02 Mds Inc. Method and apparatus for cooling and focusing ions
US6683277B1 (en) 2002-12-20 2004-01-27 Osram Opto Semiconductors Laser ablation nozzle assembly
EP1574849B1 (en) * 2004-01-22 2012-09-26 Thermo Finnigan Llc Method and apparatus for FAIMS with a laser-based ionization source
JPWO2005095942A1 (ja) 2004-03-30 2008-02-21 独立行政法人理化学研究所 レーザーアブレーションを用いた生体試料の分析方法およびその装置
US7180058B1 (en) * 2005-10-05 2007-02-20 Thermo Finnigan Llc LDI/MALDI source for enhanced spatial resolution
US8283624B2 (en) 2006-08-15 2012-10-09 Dvs Sciences Inc. Apparatus and method for elemental analysis of particles by mass spectrometry
US9465036B2 (en) 2006-11-02 2016-10-11 Fluidigm Canada Inc. Particles containing detectable elemental code
US20110024615A1 (en) 2006-12-29 2011-02-03 Tanner Scott D Cell injector for flow cytometer having mass spectrometer detector and method for using same
US8174691B1 (en) * 2007-03-15 2012-05-08 Arkansas State University—Jonesboro Detection of a component of interest with an ultraviolet laser and method of using the same
US9079268B2 (en) * 2007-09-14 2015-07-14 Robert C. Fry Analytical laser ablation of solid samples for ICP, ICP-MS, and FAG-MS analysis
US8207494B2 (en) * 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
US9383260B1 (en) * 2008-05-05 2016-07-05 Applied Spectra, Inc. Laser ablation analysis system
DE102008049833A1 (de) * 2008-10-01 2010-04-22 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Durchführung einer quantitativen ortsaufgelösten Lokal- und Verteilunganalyse chemischer Elemente und in-situ Charakterisierung der ablatierten Oberflächenregionen
ES2741664T3 (es) * 2009-02-02 2020-02-11 Light Matter Interaction Inc Método y sistema de desorción ablativa blanda
DE102009016512B4 (de) * 2009-04-08 2011-05-12 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Durchführung einer quantitativen ortsaufgelösten Lokal- und Verteilungsanalyse chemischer Elemente und in-situ Charakterisierung der ablatierten Oberflächenregionen
US8319964B2 (en) * 2009-07-10 2012-11-27 University Of Florida Research Foundation, Inc. Method and apparatus to laser ablation—laser induced breakdown spectroscopy
DE202010010932U1 (de) * 2010-04-19 2011-10-07 Witec Wissenschaftliche Instrumente Und Technologie Gmbh Vorrichtung zur Abbildung einer Probenoberfläche
US8519330B2 (en) * 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8598488B2 (en) * 2011-12-23 2013-12-03 Electro Scientific Industries, Inc. Method and apparatus for adjusting radiation spot size
US8879064B2 (en) * 2011-12-23 2014-11-04 Electro Scientific Industries, Inc. Apparatus and method for transporting an aerosol
EP2948974A2 (en) * 2013-01-28 2015-12-02 Westfälische Wilhelms-Universität Münster Laser ablation atmospheric pressure ionization mass spectrometry
US9412574B2 (en) * 2013-01-28 2016-08-09 Westfaelische Wilhelms-Universitaet Muenster Parallel elemental and molecular mass spectrometry analysis with laser ablation sampling
US10285255B2 (en) * 2013-02-14 2019-05-07 Elemental Scientific Lasers, Llc Laser ablation cell and injector system for a compositional analysis system
US20140268134A1 (en) * 2013-03-15 2014-09-18 Electro Scientific Industries, Inc. Laser sampling methods for reducing thermal effects
SG11201507853QA (en) * 2013-03-22 2015-10-29 Eth Zuerich Laser ablation cell
US9589779B2 (en) 2013-04-17 2017-03-07 Fluidigm Canada Inc. Sample analysis for mass cytometry
US20160260598A1 (en) * 2015-02-04 2016-09-08 Fluidigm Canada Inc. Laser enabled imaging mass cytometry

Also Published As

Publication number Publication date
US10705006B2 (en) 2020-07-07
CA2895360C (en) 2023-05-02
JP2016522887A (ja) 2016-08-04
RU2015123440A (ru) 2017-05-22
RU2637795C2 (ru) 2017-12-07
CA2895360A1 (en) 2014-10-23
CN105190829A (zh) 2015-12-23
US20220178809A1 (en) 2022-06-09
US20200408662A1 (en) 2020-12-31
US11630050B2 (en) 2023-04-18
CA3191952A1 (en) 2014-10-23
US9589779B2 (en) 2017-03-07
CN105190829B (zh) 2018-04-03
US20180306695A1 (en) 2018-10-25
US9952132B2 (en) 2018-04-24
EP2987177B1 (en) 2020-01-08
SG10201808165YA (en) 2018-10-30
US20190271630A1 (en) 2019-09-05
EP3690923A1 (en) 2020-08-05
US10241023B2 (en) 2019-03-26
EP2987177A1 (en) 2016-02-24
JP6230693B2 (ja) 2017-11-15
US20170248507A1 (en) 2017-08-31
US20160056031A1 (en) 2016-02-25
EP2987177A4 (en) 2016-11-30
US11099116B2 (en) 2021-08-24
WO2014169394A1 (en) 2014-10-23

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