SG11201503757RA - Methods and materials for biosynthesis of mogroside compounds - Google Patents

Methods and materials for biosynthesis of mogroside compounds

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Publication number
SG11201503757RA
SG11201503757RA SG11201503757RA SG11201503757RA SG11201503757RA SG 11201503757R A SG11201503757R A SG 11201503757RA SG 11201503757R A SG11201503757R A SG 11201503757RA SG 11201503757R A SG11201503757R A SG 11201503757RA SG 11201503757R A SG11201503757R A SG 11201503757RA
Authority
SG
Singapore
Prior art keywords
biosynthesis
materials
methods
mogroside compounds
mogroside
Prior art date
Application number
SG11201503757RA
Other languages
English (en)
Inventor
Yaoquan Liu
Jørgen Hansen
Jens Houghton-Larsen
Muthuswamy Panchapagesa Murali
Sathish Kumar
Nina Nicoline Rasmussen
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of SG11201503757RA publication Critical patent/SG11201503757RA/en

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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y303/00—Hydrolases acting on ether bonds (3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99033—Cucurbitadienol synthase (5.4.99.33)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13132—Squalene monooxygenase (1.14.13.132)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
SG11201503757RA 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds SG11201503757RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261733220P 2012-12-04 2012-12-04
PCT/EP2013/075510 WO2014086842A1 (en) 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds

Publications (1)

Publication Number Publication Date
SG11201503757RA true SG11201503757RA (en) 2015-06-29

Family

ID=49709683

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SG11201503757RA SG11201503757RA (en) 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds
SG10201704575XA SG10201704575XA (en) 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201704575XA SG10201704575XA (en) 2012-12-04 2013-12-04 Methods and materials for biosynthesis of mogroside compounds

Country Status (10)

Country Link
US (4) US9932619B2 (enrdf_load_stackoverflow)
EP (1) EP2929043A1 (enrdf_load_stackoverflow)
JP (1) JP2015536157A (enrdf_load_stackoverflow)
AU (3) AU2015200486A1 (enrdf_load_stackoverflow)
BR (1) BR112015013129A2 (enrdf_load_stackoverflow)
CA (1) CA2893462A1 (enrdf_load_stackoverflow)
HK (1) HK1215053A1 (enrdf_load_stackoverflow)
MX (1) MX367859B (enrdf_load_stackoverflow)
SG (2) SG11201503757RA (enrdf_load_stackoverflow)
WO (1) WO2014086842A1 (enrdf_load_stackoverflow)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2783009B1 (en) 2011-11-23 2016-04-13 Evolva SA Methods and materials for enzymatic synthesis of mogroside compounds
US9932619B2 (en) * 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
US10633685B2 (en) * 2012-12-04 2020-04-28 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
IL287789B2 (en) 2014-09-11 2024-05-01 The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo Mogroside compounds, methods for their preparation, preparations including them and their uses
US10407706B2 (en) 2014-10-17 2019-09-10 Suntory Holdings Limited Mogrol glycosyltransferase and gene encoding same
CN104988167A (zh) * 2014-11-21 2015-10-21 中国科学院天津工业生物技术研究所 罗汉果葫芦二烯醇合成酶基因SgCbQ及其应用
CN105801658B (zh) * 2014-12-30 2019-03-19 北京农学院 甜甙及其类似物的制备及作为stat3、erk信号通路靶位点药物在抗肿瘤中的应用
CN106350564A (zh) * 2015-07-20 2017-01-25 中国科学院天津工业生物技术研究所 罗汉果醇合成途径中萜类化合物及其糖基化产物的合成方法
AU2016344131A1 (en) 2015-10-29 2018-05-10 Senomyx, Inc. High intensity sweeteners
CN105713060A (zh) * 2016-01-29 2016-06-29 滁州润海甜叶菊高科有限公司 一种罗汉果中提取糖分工艺
CN105713061A (zh) * 2016-03-03 2016-06-29 湖南绿蔓生物科技股份有限公司 一种罗汉果苷v含量≥95％的罗汉果提取物的制备方法
CN105777837A (zh) * 2016-05-06 2016-07-20 深圳以诺生物制药有限公司 一种新型罗汉果醇衍生物单体
BR112018073662A2 (pt) * 2016-05-16 2019-02-19 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
EP3441457B1 (en) * 2017-03-01 2021-01-06 Guilin Layn Natural Ingredients Corp. Method for increasing content of mogroside v in siraitia grosvenorii suspended cells
JP7285786B2 (ja) * 2017-05-03 2023-06-02 フィルメニッヒ インコーポレイテッド 高強度の甘味料の製造方法
WO2021214008A1 (en) 2020-04-20 2021-10-28 Givaudan Sa Compositions
MX2019014119A (es) 2017-06-02 2020-02-07 Givaudan Sa Composiciones.
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
CN109385377A (zh) * 2017-08-04 2019-02-26 中国科学院天津工业生物技术研究所 用于生产葫芦二烯醇的工程菌及其制备方法与应用
CN112041457A (zh) * 2018-02-27 2020-12-04 马努斯生物合成股份有限公司 包括罗汉果苷在内的三萜类化合物的微生物产生
JP6814182B2 (ja) * 2018-09-10 2021-01-13 アナリティコン ディスカバリー ゲーエムベーハー 甘味料または甘味増強剤として使用される新規なトリペルテングリコシド
CN109679987A (zh) * 2018-09-27 2019-04-26 怀化兴科创生物技术有限公司 一个提高甜甙含量相关基因的应用
CN113316394A (zh) * 2018-11-07 2021-08-27 弗门尼舍公司 制备高强度甜味剂的方法
BR112021008944A2 (pt) 2018-11-07 2021-08-17 Firmenich Incorporated métodos para fazer edulcorantes de alta intensidade
JP7498708B2 (ja) 2018-11-09 2024-06-12 ギンゴー バイオワークス， インコーポレイテッド モグロシドの生合成
CN110066785B (zh) * 2019-01-30 2021-01-26 中国医学科学院药用植物研究所 一种罗汉果葫芦二烯醇合酶突变体及其构建方法和应用
AU2020227746A1 (en) * 2019-02-26 2021-09-16 The Coca-Cola Company Novel mogrosides and uses of the same
JP7707084B2 (ja) * 2019-06-25 2025-07-14 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア トリテルペンの製造
CN112194568B (zh) * 2019-07-08 2023-04-14 福建中医药大学 一种长链三萜类化合物及其制备方法和用途
CN110283224B (zh) * 2019-07-16 2020-08-28 湖南华诚生物资源股份有限公司 一种罗汉果甜苷v的半合成方法
AU2020408684A1 (en) * 2019-12-16 2022-07-14 Manus Bio, Inc. Microbial production of Mogrol and Mogrosides
WO2021188703A1 (en) * 2020-03-17 2021-09-23 The Coca-Cola Company Novel mogroside production system and methods
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112903835B (zh) * 2021-01-12 2022-08-12 广州泽力医药科技有限公司 罗汉果橘红固体饮料的指纹图谱构建方法及检测方法
WO2022212924A1 (en) * 2021-04-02 2022-10-06 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
US20240218403A1 (en) * 2021-04-02 2024-07-04 Ginkgo Bioworks, Inc. Biosynthesis of isoprenoids and precursors thereof
US20240240222A1 (en) 2021-06-29 2024-07-18 Firmenich Incorporated Methods for making high intensity sweeteners
WO2023278226A1 (en) * 2021-06-29 2023-01-05 Firmenich Incorporated Mogroside compounds and their comestible use
CN113755355A (zh) * 2021-09-30 2021-12-07 河北维达康生物科技有限公司 一种以葡萄糖为底物生物合成罗汉果醇的工程菌株、构建及其应用
AU2023245787A1 (en) * 2022-03-31 2024-10-10 National Taiwan University A method of preparing triterpenoid compound
CN114854722B (zh) * 2022-05-11 2024-01-09 成都普睿法药物研发有限公司 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用
WO2024218244A1 (en) 2023-04-20 2024-10-24 Dsm Ip Assets B.V. Strains and methods for the production of mogrosides
WO2025144795A1 (en) 2023-12-28 2025-07-03 Dsm Ip Assets B.V. Cells and methods for the production of glycosylated compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399321B1 (en) 1999-08-18 2002-06-04 National Research Council Of Canada Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT
EP1510573A1 (en) 2003-09-01 2005-03-02 Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung Method for detoxification of mycotoxins
US7569389B2 (en) * 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
WO2007087815A2 (en) * 2004-12-17 2007-08-09 Metanomics Gmbh Process for the control of production of fine chemicals
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8956677B2 (en) 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
RU2455853C2 (ru) 2005-11-23 2012-07-20 Дзе Кока-Кола Компани Композиция интенсивного подсластителя с пищевой клетчаткой и подслащенные ею композиции
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008062165A2 (en) 2006-11-22 2008-05-29 The University Of York Monoterpenoid modifying enzymes
WO2008065370A2 (en) 2006-12-01 2008-06-05 The University Of York Sesquiterpenoid modifying enzymes
AU2008300548B2 (en) * 2007-09-21 2015-04-09 Basf Plant Science Gmbh Plants with increased yield
GB0904639D0 (en) 2009-03-18 2009-04-29 Univ York Assay
KR101971818B1 (ko) * 2010-06-02 2019-04-23 에볼바, 인크. 스테비올 글리코시드의 재조합 생산
EP2783009B1 (en) * 2011-11-23 2016-04-13 Evolva SA Methods and materials for enzymatic synthesis of mogroside compounds
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds

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Publication number Publication date
US20180346953A1 (en) 2018-12-06
US20150322473A1 (en) 2015-11-12
WO2014086842A1 (en) 2014-06-12
EP2929043A1 (en) 2015-10-14
WO2014086842A9 (en) 2015-06-18
SG10201704575XA (en) 2017-07-28
US10465222B2 (en) 2019-11-05
US20180251806A1 (en) 2018-09-06
US9932619B2 (en) 2018-04-03
US10011859B2 (en) 2018-07-03
US10662458B2 (en) 2020-05-26
US20150064743A1 (en) 2015-03-05
AU2022204430A1 (en) 2022-07-14
CA2893462A1 (en) 2014-06-12
JP2015536157A (ja) 2015-12-21
AU2019250137B2 (en) 2022-03-24
MX2015007039A (es) 2016-02-25
HK1215053A1 (zh) 2016-08-12
AU2015200486A1 (en) 2015-03-05
BR112015013129A2 (pt) 2017-07-11
AU2019250137A1 (en) 2019-10-31
MX367859B (es) 2019-09-09

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