SG11201502748RA - Methods for treatment of alport syndrome - Google Patents

Methods for treatment of alport syndrome

Info

Publication number
SG11201502748RA
SG11201502748RA SG11201502748RA SG11201502748RA SG11201502748RA SG 11201502748R A SG11201502748R A SG 11201502748RA SG 11201502748R A SG11201502748R A SG 11201502748RA SG 11201502748R A SG11201502748R A SG 11201502748RA SG 11201502748R A SG11201502748R A SG 11201502748RA
Authority
SG
Singapore
Prior art keywords
treatment
methods
alport syndrome
alport
syndrome
Prior art date
Application number
SG11201502748RA
Other languages
English (en)
Inventor
Jeremy Duffield
Balkrishen Bhat
Deidre Mackenna
Original Assignee
Regulus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of SG11201502748RA publication Critical patent/SG11201502748RA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/313Phosphorodithioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3233Morpholino-type ring
SG11201502748RA 2012-10-09 2013-10-08 Methods for treatment of alport syndrome SG11201502748RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261711514P 2012-10-09 2012-10-09
US201361779137P 2013-03-13 2013-03-13
PCT/US2013/063884 WO2014058881A1 (en) 2012-10-09 2013-10-08 Methods for treatment of alport syndrome

Publications (1)

Publication Number Publication Date
SG11201502748RA true SG11201502748RA (en) 2015-05-28

Family

ID=49382663

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201502748RA SG11201502748RA (en) 2012-10-09 2013-10-08 Methods for treatment of alport syndrome

Country Status (35)

Country Link
US (7) US9012423B2 (uk)
EP (2) EP3620522B1 (uk)
JP (4) JP6272880B2 (uk)
KR (4) KR102165189B1 (uk)
CN (1) CN104718295B (uk)
AR (1) AR092940A1 (uk)
AU (3) AU2013329427B2 (uk)
BR (1) BR112015007709B1 (uk)
CA (1) CA2885605A1 (uk)
CL (1) CL2015000873A1 (uk)
CR (1) CR20150236A (uk)
CY (1) CY1122479T1 (uk)
DK (1) DK2906698T3 (uk)
EA (1) EA201590711A1 (uk)
ES (2) ES2753174T3 (uk)
HK (1) HK1212378A1 (uk)
HR (1) HRP20191948T1 (uk)
HU (1) HUE045858T2 (uk)
IL (2) IL237768B (uk)
LT (1) LT2906698T (uk)
MX (1) MX356340B (uk)
MY (1) MY183921A (uk)
NZ (1) NZ630596A (uk)
PH (1) PH12015500781A1 (uk)
PL (1) PL2906698T3 (uk)
PT (1) PT2906698T (uk)
RS (1) RS60014B1 (uk)
SG (1) SG11201502748RA (uk)
SI (1) SI2906698T1 (uk)
TN (1) TN2015000099A1 (uk)
TW (1) TWI641388B (uk)
UA (1) UA116639C2 (uk)
UY (1) UY35069A (uk)
WO (1) WO2014058881A1 (uk)
ZA (1) ZA201502087B (uk)

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Publication number Publication date
TN2015000099A1 (en) 2016-06-29
EP2906698A1 (en) 2015-08-19
HUE045858T2 (hu) 2020-01-28
JP2022110140A (ja) 2022-07-28
TWI641388B (zh) 2018-11-21
US20170369879A1 (en) 2017-12-28
JP2015536301A (ja) 2015-12-21
IL237768B (en) 2018-10-31
CY1122479T1 (el) 2021-01-27
PH12015500781B1 (en) 2015-06-15
AR092940A1 (es) 2015-05-06
AU2019210494A1 (en) 2019-08-15
KR102165189B1 (ko) 2020-10-14
WO2014058881A1 (en) 2014-04-17
US20200283765A1 (en) 2020-09-10
AU2013329427B2 (en) 2019-05-02
MX356340B (es) 2018-05-23
US9688986B2 (en) 2017-06-27
HK1212378A1 (en) 2016-06-10
NZ630596A (en) 2017-05-26
ZA201502087B (en) 2016-06-29
EP2906698B1 (en) 2019-07-31
JP2020073479A (ja) 2020-05-14
US20180298385A1 (en) 2018-10-18
HRP20191948T1 (hr) 2020-04-03
KR20230136686A (ko) 2023-09-26
US20140100263A1 (en) 2014-04-10
US20150299704A1 (en) 2015-10-22
CR20150236A (es) 2015-06-30
PL2906698T3 (pl) 2020-05-18
CN104718295B (zh) 2020-03-13
BR112015007709A2 (pt) 2017-08-08
CN104718295A (zh) 2015-06-17
EP3620522A1 (en) 2020-03-11
IL262200A (en) 2018-11-29
JP6272880B2 (ja) 2018-01-31
US9970011B2 (en) 2018-05-15
MY183921A (en) 2021-03-17
PT2906698T (pt) 2019-11-05
BR112015007709B1 (pt) 2022-05-17
SI2906698T1 (sl) 2019-11-29
US20160319283A1 (en) 2016-11-03
TW201420120A (zh) 2014-06-01
UY35069A (es) 2014-04-30
KR20220005634A (ko) 2022-01-13
DK2906698T3 (da) 2019-11-04
JP2018080190A (ja) 2018-05-24
EA201590711A1 (ru) 2015-07-30
ES2753174T3 (es) 2020-04-07
KR20200118245A (ko) 2020-10-14
US20220098582A1 (en) 2022-03-31
MX2015004460A (es) 2015-11-23
US9012423B2 (en) 2015-04-21
AU2021269404A1 (en) 2021-12-16
LT2906698T (lt) 2019-11-11
RS60014B1 (sr) 2020-04-30
EP3620522B1 (en) 2023-07-26
PH12015500781A1 (en) 2015-06-15
KR20150064072A (ko) 2015-06-10
ES2960488T3 (es) 2024-03-05
CA2885605A1 (en) 2014-04-17
KR102349184B1 (ko) 2022-01-07
US9359609B2 (en) 2016-06-07
UA116639C2 (uk) 2018-04-25
CL2015000873A1 (es) 2015-08-14
AU2013329427A1 (en) 2015-04-02

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