SG11201500371VA - Methods of detecting dna, rna and protein in biological samples - Google Patents
Methods of detecting dna, rna and protein in biological samplesInfo
- Publication number
- SG11201500371VA SG11201500371VA SG11201500371VA SG11201500371VA SG11201500371VA SG 11201500371V A SG11201500371V A SG 11201500371VA SG 11201500371V A SG11201500371V A SG 11201500371VA SG 11201500371V A SG11201500371V A SG 11201500371VA SG 11201500371V A SG11201500371V A SG 11201500371VA
- Authority
- SG
- Singapore
- Prior art keywords
- rna
- protein
- methods
- biological samples
- detecting dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/551,190 US20140024024A1 (en) | 2012-07-17 | 2012-07-17 | Methods of detecting dna, rna and protein in biological samples |
| PCT/US2013/050218 WO2014014754A1 (en) | 2012-07-17 | 2013-07-12 | Methods of detecting dna, rna and protein in biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201500371VA true SG11201500371VA (en) | 2015-02-27 |
Family
ID=48808555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201500371VA SG11201500371VA (en) | 2012-07-17 | 2013-07-12 | Methods of detecting dna, rna and protein in biological samples |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140024024A1 (zh) |
| EP (1) | EP2875353B1 (zh) |
| JP (1) | JP6499960B2 (zh) |
| KR (1) | KR102073117B1 (zh) |
| CN (1) | CN104620107B (zh) |
| AU (1) | AU2013290532B2 (zh) |
| CA (1) | CA2879412C (zh) |
| RU (1) | RU2014153257A (zh) |
| SG (1) | SG11201500371VA (zh) |
| WO (1) | WO2014014754A1 (zh) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107422127A (zh) | 2009-10-21 | 2017-12-01 | 斯克里普斯研究所 | 用非稀有细胞检测稀有细胞的方法 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| US8568991B2 (en) | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| JP2016513794A (ja) | 2013-03-06 | 2016-05-16 | ゼネラル・エレクトリック・カンパニイ | Ｈ＆ｅ染色された生体試料を分析する方法 |
| EA201691496A1 (ru) | 2014-01-27 | 2016-12-30 | Эпик Сайенсиз, Инк. | Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток |
| US10545151B2 (en) * | 2014-02-21 | 2020-01-28 | Epic Sciences, Inc. | Methods for analyzing rare circulating cells |
| US10240146B2 (en) | 2014-07-30 | 2019-03-26 | President And Fellows Of Harvard College | Probe library construction |
| CN104458386B (zh) * | 2014-11-25 | 2017-04-26 | 广州医科大学附属第一医院 | 一种血栓成分的染色方法及其应用 |
| EP3248012B8 (en) | 2015-01-23 | 2019-11-13 | Bio-Rad Laboratories, Inc. | Immunoblotting systems and methods |
| US9708349B2 (en) | 2015-02-13 | 2017-07-18 | General Electric Company | Borates for photoactivated chemical bleaching |
| US10101322B2 (en) | 2015-02-13 | 2018-10-16 | General Electric Company | Photoactivated chemical bleaching of dyes using borates |
| US10839509B2 (en) | 2015-07-10 | 2020-11-17 | 3Scan Inc. | Spatial multiplexing of histological stains |
| CN106872243A (zh) * | 2015-12-10 | 2017-06-20 | 深圳大学 | 组织芯片的rna-蛋白质-dna原位多重染色方法 |
| US10337051B2 (en) * | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CN116515950A (zh) * | 2016-07-18 | 2023-08-01 | 赛尔伊迪克斯公司 | 抗原偶联的杂交试剂 |
| US10613005B2 (en) | 2016-10-31 | 2020-04-07 | Agilent Technologies, Inc. | Deparaffinization of tissue by electric field generation and ionization |
| CN106568750B (zh) * | 2016-10-31 | 2019-12-03 | 陕西脉元生物科技有限公司 | 一种基于荧光能量共振转移法的gfap检测方法 |
| CN110192140A (zh) * | 2016-11-16 | 2019-08-30 | 华盛顿大学 | 用于循环荧光成像的系统和方法 |
| US10246738B2 (en) * | 2017-03-31 | 2019-04-02 | Ultivue, Inc. | DNA-antigen exchange and amplification |
| CN108956241B (zh) * | 2017-05-26 | 2021-04-30 | 深圳大学 | 组织芯片的多重染色方法 |
| US11788123B2 (en) | 2017-05-26 | 2023-10-17 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| ES2702432B2 (es) | 2017-08-31 | 2019-08-05 | Venegas Pedro Manuel Medina | Método y dispositivo para el análisis de ácidos nucleicos |
| WO2019103996A1 (en) * | 2017-11-21 | 2019-05-31 | Expansion Technologies | Expansion microscopy compatible and multiplexed in situ hybridization of formalin fixed paraffin embedded tissue sections for spatially resolved transcriptomics |
| US11525759B2 (en) | 2018-04-24 | 2022-12-13 | Agilent Technologies, Inc. | Deparaffinization of tissue utilizing electric field |
| WO2019219651A1 (en) * | 2018-05-15 | 2019-11-21 | Ventana Medical Systems, Inc. | Quantitation of signal in stain aggregates |
| JP2020071152A (ja) * | 2018-10-31 | 2020-05-07 | ソニー株式会社 | 免疫染色方法、免疫染色システム、および免疫染色キット |
| CN109540632A (zh) * | 2018-11-12 | 2019-03-29 | 滨州医学院 | 一种免疫组织化学染色方法 |
| KR20220026596A (ko) * | 2019-07-01 | 2022-03-04 | 다빈치 바이오 인코포레이티드 | 대용량 분자 검출 |
| US11513118B2 (en) | 2019-10-17 | 2022-11-29 | C2Sense, Inc. | Temporal thermal sensing and related methods |
| CN114729890A (zh) * | 2019-10-17 | 2022-07-08 | C2感官有限公司 | 用于感测和/或认证的发光成像 |
| WO2021243035A1 (en) * | 2020-05-27 | 2021-12-02 | The Regents Of The University Of California | Non-invasive exhaled breath (eb) collection apparatus |
| CN112198036A (zh) * | 2020-09-16 | 2021-01-08 | 佛山科学技术学院 | 一种改良的猪脑组织石蜡切片免疫组化染色方法 |
| WO2022066655A1 (en) * | 2020-09-22 | 2022-03-31 | Applied Materials, Inc. | Probes and assays for fluorescent in-situ hybridization imaging using multiplexed fluorescent switching |
| WO2022072051A1 (en) * | 2020-09-30 | 2022-04-07 | Agilent Technologies, Inc. | Electric field aided sample preparation |
| CN112964877B (zh) * | 2021-03-09 | 2023-07-21 | 河南赛诺特生物技术有限公司 | 一种用于鉴别套细胞淋巴瘤的免疫组化多重染色试剂盒及染色程序 |
| US20220310202A1 (en) * | 2021-03-25 | 2022-09-29 | Applied Materials, Inc. | Utilization of sparce codebook in multiplexed fluorescent in-situ hybridization imaging |
| CN113324968A (zh) * | 2021-04-01 | 2021-08-31 | 吉林大学 | 一种基于拉曼光谱的结直肠癌错配修复蛋白表达的检测方法 |
| CN113584133B (zh) * | 2021-08-30 | 2024-03-26 | 中国药科大学 | 基于颜色编码与可编程性荧光探针的多重靶标原位检测方法 |
| CN114839363A (zh) * | 2022-03-28 | 2022-08-02 | 杭州迪英加科技有限公司 | 一种增强免疫组化Ki-67抗体试剂的制备及其应用 |
| WO2024102484A1 (en) * | 2022-11-11 | 2024-05-16 | New York University | Methods for improved risk stratification of adult and pediatric acute myeloid leukemia patients using inflammation gene signatures |
| CN116042782A (zh) * | 2023-03-08 | 2023-05-02 | 成都西囡妇科医院有限公司 | 特定核酸序列荧光原位杂交联合多重免疫组化实验方法 |
| CN117887820B (zh) * | 2024-03-15 | 2024-07-05 | 北京大学第三医院（北京大学第三临床医学院） | 一种同时原位荧光检测人类rna、dna、蛋白质的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253716C (zh) * | 2004-01-08 | 2006-04-26 | 中南大学湘雅医学院肿瘤研究所 | 一种用于肿瘤早期诊断的组织芯片及制备器具 |
| US8060348B2 (en) * | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US20080032321A1 (en) * | 2006-08-07 | 2008-02-07 | General Electric Company | System and methods for analyzing images of tissue samples |
| US8131476B2 (en) * | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US20080299555A1 (en) * | 2007-05-30 | 2008-12-04 | Hiroaki Nitta | Multicolor chromogenic detection of biomarkers |
| CN101587043B (zh) * | 2008-05-20 | 2013-10-02 | 北京莱尔生物医药科技有限公司 | 从生物体液样本中富集与检测稀有细胞的整合方法 |
| EP2561102A1 (en) * | 2010-12-02 | 2013-02-27 | Katholieke Universiteit Leuven K.U. Leuven R&D | Irak-related interventions and diagnosis |
-
2012
- 2012-07-17 US US13/551,190 patent/US20140024024A1/en not_active Abandoned
-
2013
- 2013-07-12 KR KR1020157003801A patent/KR102073117B1/ko active IP Right Grant
- 2013-07-12 CA CA2879412A patent/CA2879412C/en active Active
- 2013-07-12 SG SG11201500371VA patent/SG11201500371VA/en unknown
- 2013-07-12 RU RU2014153257A patent/RU2014153257A/ru not_active Application Discontinuation
- 2013-07-12 AU AU2013290532A patent/AU2013290532B2/en not_active Ceased
- 2013-07-12 WO PCT/US2013/050218 patent/WO2014014754A1/en active Application Filing
- 2013-07-12 EP EP13739591.9A patent/EP2875353B1/en active Active
- 2013-07-12 JP JP2015523140A patent/JP6499960B2/ja active Active
- 2013-07-12 CN CN201380048061.9A patent/CN104620107B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015524267A (ja) | 2015-08-24 |
| AU2013290532A1 (en) | 2015-02-05 |
| CA2879412A1 (en) | 2014-01-23 |
| US20140024024A1 (en) | 2014-01-23 |
| WO2014014754A1 (en) | 2014-01-23 |
| AU2013290532B2 (en) | 2018-07-26 |
| EP2875353B1 (en) | 2016-09-14 |
| CA2879412C (en) | 2021-07-13 |
| KR20150036583A (ko) | 2015-04-07 |
| EP2875353A1 (en) | 2015-05-27 |
| CN104620107A (zh) | 2015-05-13 |
| JP6499960B2 (ja) | 2019-04-10 |
| RU2014153257A (ru) | 2016-09-10 |
| KR102073117B1 (ko) | 2020-02-04 |
| CN104620107B (zh) | 2016-10-26 |
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