SG11201407327VA - Azetidinium-containing copolymers and uses thereof - Google Patents
Azetidinium-containing copolymers and uses thereofInfo
- Publication number
- SG11201407327VA SG11201407327VA SG11201407327VA SG11201407327VA SG11201407327VA SG 11201407327V A SG11201407327V A SG 11201407327VA SG 11201407327V A SG11201407327V A SG 11201407327VA SG 11201407327V A SG11201407327V A SG 11201407327VA SG 11201407327V A SG11201407327V A SG 11201407327VA
- Authority
- SG
- Singapore
- Prior art keywords
- georgia
- international
- lllll
- iii
- llll
- Prior art date
Links
- 229920001577 copolymer Polymers 0.000 title abstract 3
- HONIICLYMWZJFZ-UHFFFAOYSA-O azetidin-1-ium Chemical compound C1C[NH2+]C1 HONIICLYMWZJFZ-UHFFFAOYSA-O 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000017 hydrogel Substances 0.000 abstract 2
- 229920001296 polysiloxane Polymers 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 125000002348 vinylic group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/24—Homopolymers or copolymers of amides or imides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F26/06—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00865—Applying coatings; tinting; colouring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F224/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/12—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes
- C08F283/124—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes on to polysiloxanes having carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/24—Homopolymers or copolymers of amides or imides
- C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D137/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen; Coating compositions based on derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D139/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Coating compositions based on derivatives of such polymers
- C09D139/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D151/00—Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers
- C09D151/08—Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C09D151/085—Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Coating compositions based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds on to polysiloxanes
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2500/00—Characteristics or properties of obtained polyolefins; Use thereof
- C08F2500/26—Use as polymer for film forming
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Paints Or Removers (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Surface Treatment Of Optical Elements (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659592P | 2012-06-14 | 2012-06-14 | |
| PCT/US2013/044938 WO2013188274A2 (en) | 2012-06-14 | 2013-06-10 | Azetidinium-containing copolymers and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407327VA true SG11201407327VA (en) | 2014-12-30 |
Family
ID=48672835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407327VA SG11201407327VA (en) | 2012-06-14 | 2013-06-10 | Azetidinium-containing copolymers and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9422447B2 (enExample) |
| EP (1) | EP2861413B1 (enExample) |
| JP (3) | JP6306576B2 (enExample) |
| KR (1) | KR102051174B1 (enExample) |
| CN (1) | CN104364070B (enExample) |
| AU (1) | AU2013274549B2 (enExample) |
| BR (1) | BR112014028700B1 (enExample) |
| CA (1) | CA2870333C (enExample) |
| IN (1) | IN2014DN09755A (enExample) |
| MX (1) | MX366036B (enExample) |
| MY (1) | MY168781A (enExample) |
| NZ (1) | NZ700848A (enExample) |
| RU (1) | RU2647728C2 (enExample) |
| SG (1) | SG11201407327VA (enExample) |
| TW (1) | TWI555761B (enExample) |
| WO (1) | WO2013188274A2 (enExample) |
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| SG11201504592YA (en) * | 2012-12-11 | 2015-07-30 | Novartis Ag | Method for applying a coating onto a silicone hydrogel lens |
| AU2015306901B2 (en) * | 2014-08-26 | 2017-10-12 | Alcon Inc. | Poly(oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and uses thereof |
| KR101947421B1 (ko) * | 2014-10-20 | 2019-02-14 | (주)엘지하우시스 | 표면코팅용 수성 조성물 및 이를 적용한 자동차용 시트 |
| EP3268804B1 (en) * | 2015-03-11 | 2020-11-04 | University of Florida Research Foundation, Inc. | Mesh size control of lubrication in gemini hydrogels |
| EP3344302B1 (en) * | 2015-09-04 | 2022-04-13 | Alcon Inc. | Soft silicone medical devices with durable lubricious coatings thereon |
| WO2017103793A1 (en) | 2015-12-15 | 2017-06-22 | Novartis Ag | Method for applying stable coating on silicone hydrogel contact lenses |
| CN109690360B (zh) | 2016-09-20 | 2023-04-25 | 爱尔康公司 | 用于生产在其上具有耐用润滑涂层的接触镜片的方法 |
| EP3515993B1 (en) * | 2016-09-20 | 2021-11-10 | Alcon Inc. | Method for producing a water-soluble thermally-crosslinkable polymeric material |
| MY189376A (en) | 2016-09-20 | 2022-02-08 | Alcon Inc | Colored hydrogel contact lenses with lubricious coating thereon |
| WO2018055490A1 (en) * | 2016-09-20 | 2018-03-29 | Novartis Ag | Hydrogel contact lenses with lubricious coating thereon |
| US10618986B2 (en) | 2016-10-19 | 2020-04-14 | Alcon Inc. | Hydrophilic copolymer with pendant thiol groups |
| HUE051063T2 (hu) * | 2016-10-19 | 2021-03-01 | Alcon Inc | Hidrofil kopolimer egyetlen tiol-tartalmú lánczáró csoporttal |
| CN109844570A (zh) | 2016-10-26 | 2019-06-04 | 诺华股份有限公司 | 在其上具有共价附接的润滑涂层的软性接触镜片 |
| TWI607768B (zh) * | 2017-03-31 | 2017-12-11 | 晶碩光學股份有限公司 | 隱形眼鏡用組成物及隱形眼鏡的保養方法 |
| WO2019016696A1 (en) | 2017-07-18 | 2019-01-24 | Novartis Ag | COPOLYMERS BASED ON POLY (METH) ACRYLAMIDE HAVING SIDE CHAINS WITH CARBOXYL TERMINATION |
| US10676608B2 (en) | 2017-07-18 | 2020-06-09 | Alcon Inc. | Phosphorylcholine-containing poly(meth)acrylamide-based copolymers |
| CN117492232A (zh) | 2017-12-13 | 2024-02-02 | 爱尔康公司 | 周抛和月抛水梯度接触镜片 |
| WO2019198034A1 (en) | 2018-04-13 | 2019-10-17 | Alcon Inc. | Evaluation method for the coverage of a coating on a contact lens surface |
| MY208051A (en) | 2018-12-03 | 2025-04-11 | Alcon Inc | Method for producing coated silicone hydrogel contact lenses |
| MY208061A (en) | 2018-12-03 | 2025-04-11 | Alcon Inc | Method for making coated silicone hydrogel contact lenses |
| WO2020208576A1 (en) | 2019-04-10 | 2020-10-15 | Alcon Inc. | Method for producing coated contact lenses |
| JP7564197B2 (ja) | 2019-11-04 | 2024-10-08 | アルコン インク. | 異なる柔軟性を有する表面を有するコンタクトレンズ |
| CN111205462B (zh) * | 2020-01-10 | 2021-03-30 | 山东大学 | 一种含全氟环丁基芳基醚结构硅树脂的制备方法 |
| EP4189469B1 (en) | 2020-07-28 | 2024-09-25 | Alcon Inc. | Contact lenses with softer lens surfaces |
| CN113150225B (zh) * | 2021-05-11 | 2022-01-04 | 西南石油大学 | 双功能配体、3d聚合物分子刷及其制备方法 |
| TW202338399A (zh) | 2021-09-01 | 2023-10-01 | 瑞士商愛爾康公司 | 用於生產可潤濕矽酮水凝膠接觸鏡片之方法 |
| CN120418072A (zh) | 2023-02-02 | 2025-08-01 | 爱尔康公司 | 水梯度硅氧烷水凝胶隐形眼镜 |
| KR20250124858A (ko) | 2023-02-27 | 2025-08-20 | 알콘 인코포레이티드 | 습윤성 실리콘 하이드로겔 콘택트 렌즈를 제조하는 방법 |
| WO2024211100A2 (en) * | 2023-04-07 | 2024-10-10 | Enchroma, Inc. | Contact lenses with pva film |
| US20240393501A1 (en) | 2023-05-25 | 2024-11-28 | Alcon Inc. | Coated silicone hydrogel contact lenses and method for making the same |
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| US7249848B2 (en) | 2004-09-30 | 2007-07-31 | Johnson & Johnson Vision Care, Inc. | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents |
| WO2007064594A2 (en) | 2005-11-29 | 2007-06-07 | Bausch & Lomb Incorporated | New coatings on ophthalmic lenses |
| US8044112B2 (en) | 2006-03-30 | 2011-10-25 | Novartis Ag | Method for applying a coating onto a silicone hydrogel lens |
| US7858000B2 (en) | 2006-06-08 | 2010-12-28 | Novartis Ag | Method of making silicone hydrogel contact lenses |
| US20080142038A1 (en) | 2006-12-15 | 2008-06-19 | Bausch & Lomb Incorporated | Surface treatment of medical devices |
| CN101568354B (zh) | 2006-12-21 | 2013-05-22 | 诺瓦提斯公司 | 涂覆生物医学器件的方法 |
| CA2676294C (en) | 2007-02-09 | 2014-10-21 | Novartis Ag | Cross-linkable polyionic coatings for contact lenses |
| US20090145091A1 (en) | 2007-12-11 | 2009-06-11 | Richard Connolly | Method for treating ophthalmic lenses |
| US20090145086A1 (en) | 2007-12-11 | 2009-06-11 | Reynolds Ger M | Method for treating ophthalmic lenses |
| CA2712477C (en) | 2008-01-23 | 2016-10-11 | Novartis Ag | Method for coating silicone hydrogels |
| CN103396756B (zh) * | 2008-04-08 | 2015-01-21 | Lg化学株式会社 | 粘合剂组合物以及使用该粘合剂组合物的光学膜 |
| TWI483996B (zh) * | 2009-12-08 | 2015-05-11 | Novartis Ag | 具有共價貼合塗層之聚矽氧水凝膠鏡片 |
| KR101724984B1 (ko) | 2010-07-30 | 2017-04-07 | 노파르티스 아게 | 가교된 친수성 코팅을 갖는 실리콘 히드로겔 렌즈 |
| WO2012170603A1 (en) * | 2011-06-09 | 2012-12-13 | Novartis Ag | Silicone hydrogel lenses with nano-textured surfaces |
| CN104271029B (zh) * | 2012-05-08 | 2017-07-18 | 普诺帝戈医疗有限公司 | 用来覆盖被切断胸骨的暴露端部的装置 |
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