SG11201402247PA - 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions - Google Patents

4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions

Info

Publication number
SG11201402247PA
SG11201402247PA SG11201402247PA SG11201402247PA SG11201402247PA SG 11201402247P A SG11201402247P A SG 11201402247PA SG 11201402247P A SG11201402247P A SG 11201402247PA SG 11201402247P A SG11201402247P A SG 11201402247PA SG 11201402247P A SG11201402247P A SG 11201402247PA
Authority
SG
Singapore
Prior art keywords
pregenen
triol
treatment
dione derivatives
ocular conditions
Prior art date
Application number
SG11201402247PA
Other languages
English (en)
Inventor
Jeffrey L Edelman
Alissar Nehme
Thomas C Malone
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47179019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201402247P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of SG11201402247PA publication Critical patent/SG11201402247PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201402247PA 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions SG11201402247PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161558775P 2011-11-11 2011-11-11
PCT/US2012/064293 WO2013071009A1 (en) 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions

Publications (1)

Publication Number Publication Date
SG11201402247PA true SG11201402247PA (en) 2014-06-27

Family

ID=47179019

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201402225RA SG11201402225RA (en) 2011-11-11 2012-11-09 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11ß-17-21-TRIOL-3,20-DIONE DERIVATIVES
SG11201402247PA SG11201402247PA (en) 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions
SG10201603766PA SG10201603766PA (en) 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201402225RA SG11201402225RA (en) 2011-11-11 2012-11-09 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11ß-17-21-TRIOL-3,20-DIONE DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201603766PA SG10201603766PA (en) 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions

Country Status (24)

Country Link
US (7) US8906892B2 (enrdf_load_stackoverflow)
EP (2) EP2776041A1 (enrdf_load_stackoverflow)
JP (2) JP6216719B2 (enrdf_load_stackoverflow)
KR (2) KR102049615B1 (enrdf_load_stackoverflow)
CN (2) CN104203247B (enrdf_load_stackoverflow)
AR (1) AR088846A1 (enrdf_load_stackoverflow)
AU (3) AU2012335589B2 (enrdf_load_stackoverflow)
BR (2) BR112014011333B1 (enrdf_load_stackoverflow)
CA (3) CA2855290C (enrdf_load_stackoverflow)
CL (2) CL2014001244A1 (enrdf_load_stackoverflow)
CO (2) CO6970598A2 (enrdf_load_stackoverflow)
ES (1) ES2806603T3 (enrdf_load_stackoverflow)
HK (1) HK1200366A1 (enrdf_load_stackoverflow)
IL (2) IL232534A0 (enrdf_load_stackoverflow)
IN (2) IN2014CN03919A (enrdf_load_stackoverflow)
MX (3) MX365859B (enrdf_load_stackoverflow)
MY (2) MY172227A (enrdf_load_stackoverflow)
PH (2) PH12014501079A1 (enrdf_load_stackoverflow)
RU (2) RU2683775C2 (enrdf_load_stackoverflow)
SG (3) SG11201402225RA (enrdf_load_stackoverflow)
TW (1) TWI584809B (enrdf_load_stackoverflow)
UA (2) UA111867C2 (enrdf_load_stackoverflow)
WO (2) WO2013071010A1 (enrdf_load_stackoverflow)
ZA (2) ZA201403431B (enrdf_load_stackoverflow)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
UA111867C2 (uk) 2011-11-11 2016-06-24 Аллерган, Інк. ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ
EP2934594B1 (en) 2012-12-18 2019-09-04 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities .
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
MX371012B (es) * 2013-12-13 2020-01-10 Allergan Inc Formas polimórficas de un compuesto similar a un esteroide y métodos para la preparación y su uso.
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
HK1245135A1 (zh) * 2015-03-05 2018-08-24 Allergan, Inc. 用於眼科药物递送的自乳化药物递送体系(sedds)
WO2018053321A1 (en) * 2016-09-16 2018-03-22 Kala Pharmaceuticals, Inc. Particles, compositions, and methods for ophthalmic and/or other applications
WO2019055028A1 (en) * 2017-09-15 2019-03-21 Kala Pharmaceuticals, Inc. PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC APPLICATIONS AND / OR OTHER APPLICATIONS
CN116023425B (zh) * 2023-03-28 2023-06-20 南京师范大学 曲安西龙衍生物及其医药用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6605514A (enrdf_load_stackoverflow) * 1966-04-25 1967-10-26
IT1056711B (it) * 1967-04-01 1982-02-20 Vismara F Spa Derivati dell idrocortisone
US3484436A (en) * 1967-09-07 1969-12-16 Syntex Corp Bicyclo(2.2.2)octane - 1 - -carboxylate esters of delta**4 - pregnene corticoid steroids
GB1227992A (enrdf_load_stackoverflow) * 1968-01-23 1971-04-15 Koninklijke Gist Spiritus
US3693032A (en) 1971-04-23 1972-09-19 Ibm Antisaturation technique for ttl circuits
US3984544A (en) * 1975-02-28 1976-10-05 Schering Corporation Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
JPS52136157A (en) * 1976-04-14 1977-11-14 Taisho Pharmaceut Co Ltd Preparation of steroid 17-esters
JPS60994B2 (ja) * 1976-07-26 1985-01-11 大正製薬株式会社 プレグナン系化合物の１７α―エステル類の製造法
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
US4221778A (en) * 1979-01-08 1980-09-09 Pennwalt Corporation Prolonged release pharmaceutical preparations
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
US6011023A (en) * 1997-08-27 2000-01-04 Alcon Laboratories, Inc. Angiostatic steroids
CA2387600C (en) * 1999-10-15 2007-08-21 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab) Novel fusidic acid derivatives
US6395721B1 (en) 2000-01-05 2002-05-28 Leonard Bloom Low potency unpreserved sterile topical corticosteroid compositions for dermatitis
KR20050036982A (ko) * 2002-08-29 2005-04-20 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체
JP2005008596A (ja) * 2003-06-20 2005-01-13 Kobayashi Pharmaceut Co Ltd 眼科用組成物
US20050245497A1 (en) * 2004-04-08 2005-11-03 Penfold Philip L Treatment of ophthalmic conditions
US20060009498A1 (en) * 2004-07-12 2006-01-12 Allergan, Inc. Ophthalmic compositions and methods for treating ophthalmic conditions
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
DK2319517T3 (da) 2006-06-01 2013-12-09 Novagali Pharma Sa Anvendelse af prodrugs til okulær, intravenøs administration
ES2493641T3 (es) * 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
JP2009053880A (ja) 2007-08-27 2009-03-12 Sony Broadband Solution Corp 情報処理装置、ならびにｃｐｕユニット
PE20091525A1 (es) * 2007-12-21 2009-09-25 Schering Corp Agonista del receptor glucocorticoide c-20-c21 sustituido
CN105147608B (zh) * 2008-06-26 2019-12-10 安特里奥公司 真皮递送
UA111867C2 (uk) * 2011-11-11 2016-06-24 Аллерган, Інк. ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ

Also Published As

Publication number Publication date
US9433631B2 (en) 2016-09-06
US20170182062A1 (en) 2017-06-29
JP6216719B2 (ja) 2017-10-18
US10493082B2 (en) 2019-12-03
IL232535B (en) 2019-09-26
TW201325596A (zh) 2013-07-01
RU2683775C2 (ru) 2019-04-02
MX363669B (es) 2019-03-29
BR112014011333A2 (pt) 2017-05-02
MY182222A (en) 2021-01-18
RU2014123472A (ru) 2015-12-20
EP2776040A1 (en) 2014-09-17
CL2014001243A1 (es) 2014-11-28
UA111867C2 (uk) 2016-06-24
JP2014533275A (ja) 2014-12-11
JP6158201B2 (ja) 2017-07-05
CN104203247A (zh) 2014-12-10
BR112014011341A2 (pt) 2017-05-02
NZ624920A (en) 2017-06-30
US9717743B2 (en) 2017-08-01
CA2855290A1 (en) 2013-05-16
KR102049615B1 (ko) 2019-11-28
CA2991883A1 (en) 2013-05-16
JP2014533274A (ja) 2014-12-11
IL232534A0 (en) 2014-06-30
AR088846A1 (es) 2014-07-10
MX2019006877A (es) 2019-08-22
ZA201403430B (en) 2016-05-25
CL2014001244A1 (es) 2014-11-14
NZ624919A (en) 2016-10-28
RU2688159C2 (ru) 2019-05-20
KR20140095549A (ko) 2014-08-01
EP2776040B1 (en) 2020-04-22
US20180147217A1 (en) 2018-05-31
HK1200366A1 (en) 2015-08-07
CN104185472A (zh) 2014-12-03
RU2014123471A (ru) 2015-12-20
UA116622C2 (uk) 2018-04-25
MX2014005679A (es) 2014-12-10
CN104185472B (zh) 2017-06-13
US20150005519A1 (en) 2015-01-01
US20130123223A1 (en) 2013-05-16
MY172227A (en) 2019-11-18
WO2013071009A1 (en) 2013-05-16
CN104203247B (zh) 2017-06-06
IN2014CN03903A (enrdf_load_stackoverflow) 2015-10-16
EP2776041A1 (en) 2014-09-17
KR20140095548A (ko) 2014-08-01
AU2012335590B2 (en) 2017-10-19
US10188667B2 (en) 2019-01-29
MX365859B (es) 2019-06-18
PH12014501079B1 (en) 2014-07-28
PH12014501078B1 (en) 2014-07-28
US8865691B2 (en) 2014-10-21
ES2806603T3 (es) 2021-02-18
CA2855929A1 (en) 2013-05-16
HK1200367A1 (en) 2015-08-07
PH12014501079A1 (en) 2014-07-28
CO6970609A2 (es) 2014-06-13
CA2855929C (en) 2018-03-27
CO6970598A2 (es) 2014-06-13
TWI584809B (zh) 2017-06-01
AU2012335590A1 (en) 2014-05-29
CA2991883C (en) 2020-03-10
AU2012335589B2 (en) 2017-08-31
US20130123226A1 (en) 2013-05-16
AU2018200436A1 (en) 2018-02-08
MX2014005678A (es) 2014-12-10
PH12014501078A1 (en) 2014-07-28
US20150057258A1 (en) 2015-02-26
ZA201403431B (en) 2016-05-25
SG11201402225RA (en) 2014-06-27
BR112014011333B1 (pt) 2020-04-28
AU2012335589A1 (en) 2014-05-29
US8906892B2 (en) 2014-12-09
AU2018200436B2 (en) 2019-10-24
CA2855290C (en) 2017-02-28
SG10201603766PA (en) 2016-07-28
IL232535A0 (en) 2014-06-30
WO2013071010A1 (en) 2013-05-16
US20190365786A1 (en) 2019-12-05
IN2014CN03919A (enrdf_load_stackoverflow) 2015-09-04

Similar Documents

Publication Publication Date Title
LTC2785706I2 (lt) Pakeistieji 4-fenil-piridinai, skirti su nk-receptoriumi susijusių ligų gydymui
HUS1900040I1 (hu) Makrociklusos származékok proliferatív betegségek kezelésére
ZA201403430B (en) 4-pregenen- 11ss -17 - 21-triols-3, 20- dione derivatives for the treatment of ocular conditions
ZA201405820B (en) Piperidino-pyrimidine derivatives for the treatment of viral infections
ZA201403795B (en) Formulations for the treatment of diabetes
IL230830A0 (en) Cellular preparations for the treatment of degenerative diseases of the retina
IL230635A (en) An outgrowth of 4,3,2,1-tetrahydroquinoline used to treat diabetes
EP2882387A4 (en) EYE NECKLACE STENT FOR TREATING IRIDO-CORNEAN ANGLE SHRINKAGE
SG2014014724A (en) METHODS FOR THE TREATMENT OF IL-1ß RELATED CONDITIONS
AP2013007179A0 (en) Glycoside derivatives and their uses for the treatment of diabetes
IL230960A0 (en) A device for the treatment of eye disease
ZA201403736B (en) Process for the preparation of sterol derivatives
ZA201306613B (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme
PL2538918T3 (pl) Cytocholina do leczenia jaskry
IL230959A0 (en) A device for the treatment of eye disease
PL395469A1 (pl) Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
PT2777699T (pt) Dietilamina-2,5-di-hidroxibenzenossulfonato para o tratamento de degeneração macular relacionada com a idade
HK1193343A (en) Methods for treating diseases of the retina
IL228973A0 (en) Oxymetazoline for the treatment of anorectal disorders
HK1189818A (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme
HK1188955A (en) Methods for treating diseases of the retina
GB201108301D0 (en) IVlg treatment for patients with Myeloma
HK1197236B (en) Compounds for the treatment of addiction
IL232294B (en) Preparations for the treatment of diabetes
AU2011903756A0 (en) Orifice treatment means