MX371012B - Formas polimórficas de un compuesto similar a un esteroide y métodos para la preparación y su uso. - Google Patents
Formas polimórficas de un compuesto similar a un esteroide y métodos para la preparación y su uso.Info
- Publication number
- MX371012B MX371012B MX2016007718A MX2016007718A MX371012B MX 371012 B MX371012 B MX 371012B MX 2016007718 A MX2016007718 A MX 2016007718A MX 2016007718 A MX2016007718 A MX 2016007718A MX 371012 B MX371012 B MX 371012B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- preparation
- another aspect
- present
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title 2
- 229960000890 hydrocortisone Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 230000003637 steroidlike Effects 0.000 abstract 3
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En la presente se proporcionan múltiples formas sólidas de un compuesto similar a un esteroide definido y métodos para la preparación y su uso. En un aspecto, se proporciona una forma cristalina de dicho compuesto similar a un esteroide, y métodos para la preparación y su uso. En otro aspecto, se proporciona una forma sustancialmente amorfa de dicho compuesto similar a un esteroide, y métodos para la preparación y su uso. En aun otro aspecto, se proporcionan composiciones que contienen compuestos de acuerdo con la presente invención. En determinados aspectos, tales composiciones son adecuadas para la administración de agentes activos de acuerdo con la presente invención a un sujeto que lo necesita. En otro aspecto de la invención, se proporcionan métodos para el tratamiento de una variedad de indicaciones, que incluyen glaucoma, hipertensión ocular y similares. En aun otro aspecto de la presente invención, se proporcionan kits que contienen compuestos de acuerdo con la presente invención y/o composiciones que los contienen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915589P | 2013-12-13 | 2013-12-13 | |
| PCT/US2014/070147 WO2015089471A2 (en) | 2013-12-13 | 2014-12-12 | Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016007718A MX2016007718A (es) | 2016-09-09 |
| MX371012B true MX371012B (es) | 2020-01-10 |
Family
ID=52293229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016007718A MX371012B (es) | 2013-12-13 | 2014-12-12 | Formas polimórficas de un compuesto similar a un esteroide y métodos para la preparación y su uso. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10065984B2 (es) |
| EP (1) | EP3080140A2 (es) |
| JP (1) | JP2016540001A (es) |
| KR (1) | KR20160098338A (es) |
| CN (1) | CN105814071A (es) |
| AR (1) | AR098747A1 (es) |
| AU (1) | AU2014361790B2 (es) |
| CA (1) | CA2933371A1 (es) |
| CL (1) | CL2016001429A1 (es) |
| IL (1) | IL246059A0 (es) |
| MX (1) | MX371012B (es) |
| PH (1) | PH12016501098A1 (es) |
| SA (1) | SA516371308B1 (es) |
| SG (2) | SG11201604786QA (es) |
| TW (1) | TWI659041B (es) |
| UA (1) | UA121203C2 (es) |
| WO (1) | WO2015089471A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019055028A1 (en) * | 2017-09-15 | 2019-03-21 | Kala Pharmaceuticals, Inc. | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC APPLICATIONS AND / OR OTHER APPLICATIONS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6605514A (es) * | 1966-04-25 | 1967-10-26 | ||
| IT1056711B (it) * | 1967-04-01 | 1982-02-20 | Vismara F Spa | Derivati dell idrocortisone |
| JPS52136157A (en) * | 1976-04-14 | 1977-11-14 | Taisho Pharmaceut Co Ltd | Preparation of steroid 17-esters |
| JPS54151958A (en) * | 1978-05-19 | 1979-11-29 | Taisho Pharmaceut Co Ltd | Preparation of pregnane steroid 17alpha-ester |
| US8501800B2 (en) * | 2009-03-05 | 2013-08-06 | Insite Vision Incorporated | Controlled-release ophthalmic vehicles |
| US9464078B2 (en) * | 2010-09-23 | 2016-10-11 | Abbvie Inc. | Monohydrate of azaadamantane derivatives |
| UA111867C2 (uk) * | 2011-11-11 | 2016-06-24 | Аллерган, Інк. | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ |
| CN104640856B (zh) * | 2012-05-11 | 2017-09-15 | 复位治疗公司 | 作为隐花色素调节剂的含有咔唑的磺酰胺类 |
-
2014
- 2014-12-12 SG SG11201604786QA patent/SG11201604786QA/en unknown
- 2014-12-12 SG SG10201709987QA patent/SG10201709987QA/en unknown
- 2014-12-12 MX MX2016007718A patent/MX371012B/es active IP Right Grant
- 2014-12-12 JP JP2016538591A patent/JP2016540001A/ja active Pending
- 2014-12-12 EP EP14824667.1A patent/EP3080140A2/en not_active Ceased
- 2014-12-12 UA UAA201606521A patent/UA121203C2/uk unknown
- 2014-12-12 AU AU2014361790A patent/AU2014361790B2/en not_active Ceased
- 2014-12-12 AR ARP140104647A patent/AR098747A1/es unknown
- 2014-12-12 WO PCT/US2014/070147 patent/WO2015089471A2/en not_active Ceased
- 2014-12-12 CA CA2933371A patent/CA2933371A1/en not_active Abandoned
- 2014-12-12 KR KR1020167018491A patent/KR20160098338A/ko not_active Ceased
- 2014-12-12 US US14/568,450 patent/US10065984B2/en not_active Expired - Fee Related
- 2014-12-12 TW TW103143530A patent/TWI659041B/zh not_active IP Right Cessation
- 2014-12-12 CN CN201480067887.4A patent/CN105814071A/zh active Pending
-
2016
- 2016-06-06 IL IL246059A patent/IL246059A0/en unknown
- 2016-06-09 PH PH12016501098A patent/PH12016501098A1/en unknown
- 2016-06-10 CL CL2016001429A patent/CL2016001429A1/es unknown
- 2016-06-13 SA SA516371308A patent/SA516371308B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015089471A2 (en) | 2015-06-18 |
| SA516371308B1 (ar) | 2019-07-08 |
| CL2016001429A1 (es) | 2016-12-23 |
| JP2016540001A (ja) | 2016-12-22 |
| WO2015089471A3 (en) | 2015-11-19 |
| UA121203C2 (uk) | 2020-04-27 |
| AU2014361790B2 (en) | 2019-05-23 |
| CN105814071A (zh) | 2016-07-27 |
| PH12016501098A1 (en) | 2016-08-15 |
| SG11201604786QA (en) | 2016-07-28 |
| SG10201709987QA (en) | 2018-01-30 |
| CA2933371A1 (en) | 2015-06-18 |
| MX2016007718A (es) | 2016-09-09 |
| US10065984B2 (en) | 2018-09-04 |
| EP3080140A2 (en) | 2016-10-19 |
| TWI659041B (zh) | 2019-05-11 |
| AR098747A1 (es) | 2016-06-08 |
| US20150166597A1 (en) | 2015-06-18 |
| AU2014361790A1 (en) | 2016-07-07 |
| KR20160098338A (ko) | 2016-08-18 |
| TW201609788A (zh) | 2016-03-16 |
| IL246059A0 (en) | 2016-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |