SG11201401032YA - (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators - Google Patents
(4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulatorsInfo
- Publication number
- SG11201401032YA SG11201401032YA SG11201401032YA SG11201401032YA SG11201401032YA SG 11201401032Y A SG11201401032Y A SG 11201401032YA SG 11201401032Y A SG11201401032Y A SG 11201401032YA SG 11201401032Y A SG11201401032Y A SG 11201401032YA SG 11201401032Y A SG11201401032Y A SG 11201401032YA
- Authority
- SG
- Singapore
- Prior art keywords
- phenylimidazol
- sodium channel
- derivatives useful
- channel modulators
- ethylamine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551628P | 2011-10-26 | 2011-10-26 | |
| PCT/IB2012/055610 WO2013061205A2 (fr) | 2011-10-26 | 2012-10-15 | Composés chimiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201401032YA true SG11201401032YA (en) | 2014-07-30 |
Family
ID=47278356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201401032YA SG11201401032YA (en) | 2011-10-26 | 2012-10-15 | (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9079878B2 (fr) |
| EP (1) | EP2771335A2 (fr) |
| JP (1) | JP5946538B2 (fr) |
| KR (1) | KR101586966B1 (fr) |
| CN (1) | CN103906746B (fr) |
| AP (1) | AP2014007579A0 (fr) |
| AU (1) | AU2012328034B2 (fr) |
| BR (1) | BR112014009102A2 (fr) |
| CA (1) | CA2850925C (fr) |
| CL (1) | CL2014000956A1 (fr) |
| CO (1) | CO6940427A2 (fr) |
| CR (1) | CR20140185A (fr) |
| CU (1) | CU20140046A7 (fr) |
| DO (1) | DOP2014000085A (fr) |
| EA (1) | EA023375B1 (fr) |
| EC (1) | ECSP14013324A (fr) |
| GT (1) | GT201400079A (fr) |
| HK (1) | HK1198650A1 (fr) |
| IL (1) | IL232267A (fr) |
| MD (1) | MD20140037A2 (fr) |
| MX (1) | MX337469B (fr) |
| NI (1) | NI201400031A (fr) |
| PE (1) | PE20141682A1 (fr) |
| SG (1) | SG11201401032YA (fr) |
| TN (1) | TN2014000147A1 (fr) |
| UA (1) | UA109220C2 (fr) |
| WO (1) | WO2013061205A2 (fr) |
| ZA (1) | ZA201402281B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103827124B (zh) * | 2011-09-14 | 2017-06-06 | 陶氏益农公司 | 用于形成硼酸类及其中间体的方法和系统 |
| AP2016009287A0 (en) | 2013-12-13 | 2016-06-30 | Vertex Pharma | Prodrugs of pyridone amides useful as modulators of sodium channels |
| KR102192572B1 (ko) | 2014-06-09 | 2020-12-18 | 삼성전자주식회사 | 광원 모듈의 불량 검사방법, 광원 모듈의 제조 방법 및 광원 모듈 검사장치 |
| EP3209303A1 (fr) * | 2014-10-24 | 2017-08-30 | Avectas Limited | Administration à travers des membranes plasmiques de cellules |
| EP3258925B1 (fr) | 2015-02-19 | 2023-03-29 | Purdue Pharma LP | Méthodes et compositions pour réduire la vidange gastrique |
| IS2977B (is) | 2015-02-23 | 2017-07-15 | Actavis Group Ptc Ehf. | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
| CN116676292A (zh) | 2015-12-30 | 2023-09-01 | 阿维塔斯有限公司 | 基因编辑蛋白和组合物向细胞和组织的无载体递送 |
| EP3481856A1 (fr) * | 2016-07-06 | 2019-05-15 | Crispr Therapeutics AG | Matériaux et procédés de traitement de troubles liés à la douleur |
| CN109843914B (zh) | 2016-07-06 | 2024-03-15 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛相关病症的材料和方法 |
| EP3625214B1 (fr) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Amides de pyridone deutérés et leurs promédicaments utilisés en tant que modulateurs de canaux sodiques |
| TW201920081A (zh) | 2017-07-11 | 2019-06-01 | 美商維泰克斯製藥公司 | 作為鈉通道調節劑的羧醯胺 |
| CA3091012A1 (fr) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | Methode de traitement de la douleur |
| US20220110923A1 (en) | 2019-01-10 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US20230062053A1 (en) | 2019-01-10 | 2023-03-02 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020176763A1 (fr) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Forme posologique comprenant un promédicament inhibiteur de canal sodique na 1,8 |
| WO2020219867A1 (fr) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Compositions de co-cristaux d'amide de pyridone pour le traitement de la douleur |
| CA3164134A1 (fr) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Tetrahydrofuranes substitues en tant que modulateurs de canaux sodiques |
| CA3222197A1 (fr) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Formes galeniques solides et schemas posologiques comprenant du (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
| EP4347033A1 (fr) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Tétrahydrofuranes à substitution hydroxy et (halo)alkoxy utiles en tant que modulateurs de canaux sodiques |
| EP4347032A1 (fr) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Tétrahydrofuran-2-carboxamides substitués utiles en tant que modulateurs de canaux sodiques |
| JP2024520646A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体 |
| UY39800A (es) | 2021-06-04 | 2023-01-31 | Vertex Pharma | N–(hidroxialquil (hetero)aril) tetrahidrofuran carboxamidas como moduladores de canales de sodio |
| WO2022256676A1 (fr) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Analogues de tétrahydrofurane substitués utiles en tant que modulateurs de canaux sodiques |
| WO2023205468A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryle pour le traitement de la douleur |
| US20230382910A1 (en) | 2022-04-22 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205463A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| WO2023205465A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| WO2023211990A1 (fr) | 2022-04-25 | 2023-11-02 | Siteone Therapeutics, Inc. | Inhibiteurs d'amides hétérocycliques bicycliques de na v1.8 pour le traitement de la douleur |
| WO2024123815A1 (fr) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Procédé de synthèse de modulateurs de tétrahydrofurane substitués de canaux sodiques |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Liberation amelioree d'agents medicamenteux actifs par un enrobage de chewing-gum |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| TWI292316B (en) * | 1999-10-11 | 2008-01-11 | Sod Conseils Rech Applic | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
| US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| US7112366B2 (en) | 2001-01-05 | 2006-09-26 | The Ohio State University | Chemical monolayer and micro-electronic junctions and devices containing same |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| FR2842808B1 (fr) * | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
| US7456164B2 (en) * | 2004-05-07 | 2008-11-25 | Pfizer, Inc | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands |
| GEP20094826B (en) * | 2004-05-07 | 2009-11-10 | Warner Lambert Co | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands |
| EP2371954A1 (fr) | 2004-10-27 | 2011-10-05 | Schering Corporation | Compositions et procédés d'inhibition par des petits acides nucléiques interférents dirigés contre NAv1.8 |
| US7855227B2 (en) | 2005-12-22 | 2010-12-21 | Newron Pharmaceuticals S.P.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
| EP2076508B1 (fr) | 2006-10-18 | 2011-01-05 | Pfizer Products Inc. | Composés d'urée de bisaryle éther |
| ES2340640T3 (es) | 2007-03-23 | 2010-06-07 | Icagen, Inc. | Inhibidores de canales de iones. |
| WO2008135826A2 (fr) | 2007-05-03 | 2008-11-13 | Pfizer Limited | Dérivés de la pyridine |
| JP2010526051A (ja) * | 2007-05-03 | 2010-07-29 | ファイザー・リミテッド | 疼痛を治療するためのｎａｖ１．８チャネルモジュレーターとしてのｎ−［６−アミノ−５−（フェニル）ピラジン−２−イル］−イソオキサゾール−４−カルボキサミド誘導体および関連化合物 |
| CA2693588C (fr) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Inhibiteurs des canaux sodiques |
-
2012
- 2012-10-15 SG SG11201401032YA patent/SG11201401032YA/en unknown
- 2012-10-15 CA CA2850925A patent/CA2850925C/fr not_active Expired - Fee Related
- 2012-10-15 AU AU2012328034A patent/AU2012328034B2/en not_active Ceased
- 2012-10-15 MD MDA20140037A patent/MD20140037A2/ro not_active Application Discontinuation
- 2012-10-15 AP AP2014007579A patent/AP2014007579A0/xx unknown
- 2012-10-15 EA EA201490864A patent/EA023375B1/ru not_active IP Right Cessation
- 2012-10-15 WO PCT/IB2012/055610 patent/WO2013061205A2/fr active Application Filing
- 2012-10-15 MX MX2014004738A patent/MX337469B/es active IP Right Grant
- 2012-10-15 CN CN201280052591.6A patent/CN103906746B/zh not_active Expired - Fee Related
- 2012-10-15 BR BR112014009102A patent/BR112014009102A2/pt active Search and Examination
- 2012-10-15 KR KR1020147010826A patent/KR101586966B1/ko not_active IP Right Cessation
- 2012-10-15 PE PE2014000605A patent/PE20141682A1/es not_active Application Discontinuation
- 2012-10-15 US US14/351,893 patent/US9079878B2/en not_active Expired - Fee Related
- 2012-10-15 EP EP12794777.8A patent/EP2771335A2/fr not_active Withdrawn
- 2012-10-15 UA UAA201404440A patent/UA109220C2/uk unknown
- 2012-10-15 JP JP2014537760A patent/JP5946538B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-27 ZA ZA2014/02281A patent/ZA201402281B/en unknown
- 2014-04-08 TN TNP2014000147A patent/TN2014000147A1/fr unknown
- 2014-04-14 CL CL2014000956A patent/CL2014000956A1/es unknown
- 2014-04-23 NI NI201400031A patent/NI201400031A/es unknown
- 2014-04-24 CR CR20140185A patent/CR20140185A/es unknown
- 2014-04-24 CU CU2014000046A patent/CU20140046A7/es unknown
- 2014-04-25 EC ECSP14013324 patent/ECSP14013324A/es unknown
- 2014-04-25 DO DO2014000085A patent/DOP2014000085A/es unknown
- 2014-04-25 GT GT201400079A patent/GT201400079A/es unknown
- 2014-04-27 IL IL232267A patent/IL232267A/en not_active IP Right Cessation
- 2014-04-28 CO CO14090473A patent/CO6940427A2/es active IP Right Grant
- 2014-12-03 HK HK14112181.8A patent/HK1198650A1/xx not_active IP Right Cessation
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