SG10202002591QA - Treatment of coagulation disease by administration of recombinant vwf - Google Patents

Treatment of coagulation disease by administration of recombinant vwf

Info

Publication number
SG10202002591QA
SG10202002591QA SG10202002591QA SG10202002591QA SG10202002591QA SG 10202002591Q A SG10202002591Q A SG 10202002591QA SG 10202002591Q A SG10202002591Q A SG 10202002591QA SG 10202002591Q A SG10202002591Q A SG 10202002591QA SG 10202002591Q A SG10202002591Q A SG 10202002591QA
Authority
SG
Singapore
Prior art keywords
administration
treatment
recombinant vwf
coagulation disease
coagulation
Prior art date
Application number
SG10202002591QA
Other languages
English (en)
Inventor
Friedrich Scheiflinger
Peter Turecek
Bruce Ewenstein
Wing Wong
Tobias Suiter
Original Assignee
Baxalta GmbH
Baxalta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH, Baxalta Inc filed Critical Baxalta GmbH
Publication of SG10202002591QA publication Critical patent/SG10202002591QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10202002591QA 2011-06-10 2012-06-11 Treatment of coagulation disease by administration of recombinant vwf SG10202002591QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161495884P 2011-06-10 2011-06-10
US201161511901P 2011-07-26 2011-07-26
US201161523790P 2011-08-15 2011-08-15

Publications (1)

Publication Number Publication Date
SG10202002591QA true SG10202002591QA (en) 2020-05-28

Family

ID=46321496

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201604684WA SG10201604684WA (en) 2011-06-10 2012-06-11 Treatment of coagulation disease by administration of recombinant vwf
SG10202002591QA SG10202002591QA (en) 2011-06-10 2012-06-11 Treatment of coagulation disease by administration of recombinant vwf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201604684WA SG10201604684WA (en) 2011-06-10 2012-06-11 Treatment of coagulation disease by administration of recombinant vwf

Country Status (24)

Country Link
US (2) US9272021B2 (zh)
EP (3) EP3858375B1 (zh)
JP (3) JP6347468B2 (zh)
KR (3) KR102319868B1 (zh)
CN (3) CN103732244A (zh)
AR (1) AR086904A1 (zh)
AU (5) AU2012267458A1 (zh)
BR (1) BR112013031795A2 (zh)
CA (1) CA2838845C (zh)
DK (3) DK3858375T3 (zh)
ES (2) ES2860450T3 (zh)
FI (1) FI3858375T3 (zh)
HK (1) HK1257436A1 (zh)
HR (1) HRP20180962T1 (zh)
HU (1) HUE039317T2 (zh)
LT (1) LT2717905T (zh)
MX (2) MX350582B (zh)
PL (3) PL3412305T3 (zh)
PT (3) PT3412305T (zh)
RU (2) RU2628537C2 (zh)
SG (2) SG10201604684WA (zh)
SI (1) SI2717905T1 (zh)
TR (1) TR201808823T4 (zh)
WO (1) WO2012171031A1 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102319868B1 (ko) * 2011-06-10 2021-11-01 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의한 응고 질환의 치료
CN102776260B (zh) * 2012-07-26 2015-04-29 上海泰龙生物医药科技有限公司 一种高效表达重组人凝血八因子的方法
ES2657291T3 (es) * 2013-04-22 2018-03-02 Csl Ltd. Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
FR3034669B1 (fr) * 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
HUE065455T2 (hu) 2016-04-15 2024-05-28 Takeda Pharmaceuticals Co Eljárás és berendezés egy farmakokinetikai gyógyszer adagolási rendjének biztosítására
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
RU2766118C2 (ru) 2017-07-07 2022-02-08 Такеда Фармасьютикал Компани Лимитед Лечение пациентов с тяжелой формой болезни фон виллебранда, подвергающихся плановому хирургическому вмешательству, путем введения рекомбинантного ффв
WO2019010497A1 (en) 2017-07-07 2019-01-10 Baxalta Incorporated TREATMENT OF GASTROINTESTINAL BLEEDING IN PATIENTS WITH A SEVERE FORM OF VON WILLEBRAND'S DISEASE BY RECOMBINANT VWF ADMINISTRATION
EP3749696A1 (en) 2018-02-06 2020-12-16 Ablynx N.V. Methods of treating initial episode of ttp with immunoglobulin single variable domains
WO2019183290A1 (en) * 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods
JP2022524291A (ja) 2019-02-01 2022-05-02 武田薬品工業株式会社 組換えVWF(rVWF)を使用する予防治療法
US20220401524A1 (en) 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
EP4100048A1 (en) 2020-02-04 2022-12-14 Takeda Pharmaceutical Company Limited Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4638028A (en) 1985-04-08 1987-01-20 Goodyear Tire & Rubber Company Rubber polymerases and methods for their production and use
JPS62502589A (ja) 1985-04-11 1987-10-08 ザ・チヤイルドレンズ・メデイカル・センタ−・コ−ポレ−シヨン フオン・ビルブラント因子
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) * 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT406373B (de) * 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT405403B (de) * 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
US6531577B1 (en) 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6864403B1 (en) 1998-10-15 2005-03-08 E. I. Du Pont De Nemours And Company Plant protein disulfide isomerases
US20040014657A1 (en) * 2001-11-05 2004-01-22 Jan Ohrstrom Use of blood coagulation factor XIII for treating haemophilia A
WO2005012354A1 (en) 2003-07-31 2005-02-10 Zlb Behring Gmbh Method for extending the half-life of fviii
EP1593388A1 (en) 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
DK1835938T3 (da) * 2004-12-27 2013-11-04 Baxter Int Polymer-von Willebrand-faktor-konjugater
EP2522717B1 (en) 2006-01-04 2014-04-02 Baxter International Inc Oligopeptide-free cell culture media
WO2008151817A1 (en) * 2007-06-13 2008-12-18 Csl Behring Gmbh Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders
EP2222329A1 (en) 2007-11-09 2010-09-01 Baxter International Inc. Modified recombinant factor viii and von willebrand factor and methods of use
JP2009127455A (ja) 2007-11-20 2009-06-11 Bando Kiko Co Ltd 往復動エンジン
EP2244814B1 (en) * 2007-12-28 2021-06-02 Takeda Pharmaceutical Company Limited Recombinant vwf formulations
ES2298096B1 (es) * 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
PL2291523T3 (pl) * 2008-06-24 2015-05-29 Csl Behring Gmbh Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo
NZ592704A (en) * 2008-10-21 2013-02-22 Baxter Int Lyophilized recombinant von willebrand factor (rVWF) formulation comprising buffering agents, amino acids, stabilising agents and surfactants
AU2010279463A1 (en) * 2009-08-04 2012-03-01 Baxter Healthcare S.A. Transgenic mouse knockout for FVIII and VWF - model of hemophilia A
TR201815211T4 (tr) 2010-07-08 2018-11-21 Baxalta GmbH Hücre kültüründe rekombinant adamts13 üretmeye yönelik yöntem.
US20120006800A1 (en) 2010-07-09 2012-01-12 Illinois Tool Works Inc. Weld bead feature communication systems and devices
KR102319868B1 (ko) * 2011-06-10 2021-11-01 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의한 응고 질환의 치료

Also Published As

Publication number Publication date
JP2019048892A (ja) 2019-03-28
WO2012171031A1 (en) 2012-12-13
US9272021B2 (en) 2016-03-01
CA2838845C (en) 2019-08-06
CN107412743A (zh) 2017-12-01
HUE039317T2 (hu) 2018-12-28
HK1257436A1 (zh) 2019-10-18
EP3858375B1 (en) 2024-03-20
KR102319868B1 (ko) 2021-11-01
RU2017102679A3 (zh) 2018-12-19
FI3858375T3 (fi) 2024-04-17
RU2019103386A (ru) 2020-08-07
RU2628537C2 (ru) 2017-08-18
AR086904A1 (es) 2014-01-29
US20160184403A1 (en) 2016-06-30
LT2717905T (lt) 2018-10-10
EP2717905B1 (en) 2018-05-23
AU2016202299A1 (en) 2016-05-05
AU2012267458A1 (en) 2014-01-09
AU2016202299B2 (en) 2017-07-20
AU2017206235A1 (en) 2017-08-03
DK2717905T3 (en) 2018-07-02
AU2017206235B2 (en) 2019-10-17
TR201808823T4 (tr) 2018-07-23
US20120316116A1 (en) 2012-12-13
ES2860450T3 (es) 2021-10-05
EP3412305B1 (en) 2021-01-06
MX350582B (es) 2017-09-11
KR20140039285A (ko) 2014-04-01
CA2838845A1 (en) 2012-12-13
AU2020200026A1 (en) 2020-01-30
KR20190041032A (ko) 2019-04-19
JP6527114B2 (ja) 2019-06-05
AU2022201518A1 (en) 2022-03-24
MX2013014543A (es) 2014-06-11
JP2014516088A (ja) 2014-07-07
RU2680402C2 (ru) 2019-02-21
PL2717905T3 (pl) 2018-10-31
DK3858375T3 (da) 2024-04-15
PL3858375T3 (pl) 2024-05-20
KR20200091476A (ko) 2020-07-30
BR112013031795A2 (pt) 2016-12-20
ES2682249T3 (es) 2018-09-19
RU2014100107A (ru) 2015-07-20
NZ618790A (en) 2015-07-31
EP3858375A1 (en) 2021-08-04
DK3412305T3 (da) 2021-03-01
CN103732244A (zh) 2014-04-16
PT2717905T (pt) 2018-07-02
JP2017019788A (ja) 2017-01-26
SI2717905T1 (sl) 2018-09-28
EP3412305A1 (en) 2018-12-12
JP6347468B2 (ja) 2018-06-27
PL3412305T3 (pl) 2021-05-31
CN108210889A (zh) 2018-06-29
PT3858375T (pt) 2024-04-18
CN107412743B (zh) 2021-07-02
RU2019103386A3 (zh) 2022-01-24
KR101969515B1 (ko) 2019-04-16
HRP20180962T1 (hr) 2018-10-19
RU2017102679A (ru) 2018-12-19
SG10201604684WA (en) 2016-07-28
MX2020000083A (es) 2020-08-06
EP2717905A1 (en) 2014-04-16
PT3412305T (pt) 2021-01-29

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