SG10201913370PA - Antibodies to tau - Google Patents

Antibodies to tau

Info

Publication number
SG10201913370PA
SG10201913370PA SG10201913370PA SG10201913370PA SG10201913370PA SG 10201913370P A SG10201913370P A SG 10201913370PA SG 10201913370P A SG10201913370P A SG 10201913370PA SG 10201913370P A SG10201913370P A SG 10201913370PA SG 10201913370P A SG10201913370P A SG 10201913370PA
Authority
SG
Singapore
Prior art keywords
tau
antibodies
Prior art date
Application number
SG10201913370PA
Other languages
English (en)
Inventor
David Holtzman
Hong Jiang
Marc Diamond
Najla Kfoury
Brandon Holmes
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of SG10201913370PA publication Critical patent/SG10201913370PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
SG10201913370PA 2012-07-03 2013-07-03 Antibodies to tau SG10201913370PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667515P 2012-07-03 2012-07-03
US201261694989P 2012-08-30 2012-08-30

Publications (1)

Publication Number Publication Date
SG10201913370PA true SG10201913370PA (en) 2020-03-30

Family

ID=49882495

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201408626YA SG11201408626YA (en) 2012-07-03 2013-07-03 Antibodies to tau
SG10201708959WA SG10201708959WA (en) 2012-07-03 2013-07-03 Antibodies to tau
SG10201913370PA SG10201913370PA (en) 2012-07-03 2013-07-03 Antibodies to tau

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG11201408626YA SG11201408626YA (en) 2012-07-03 2013-07-03 Antibodies to tau
SG10201708959WA SG10201708959WA (en) 2012-07-03 2013-07-03 Antibodies to tau

Country Status (17)

Country Link
US (2) US9834596B2 (fr)
EP (2) EP3838921A3 (fr)
JP (3) JP6345655B2 (fr)
KR (3) KR102494798B1 (fr)
CN (2) CN104781278B (fr)
AU (3) AU2013286680B2 (fr)
BR (1) BR112014033116B1 (fr)
CA (1) CA2877397A1 (fr)
HK (1) HK1209768A1 (fr)
IL (3) IL236409B (fr)
IN (1) IN2015KN00007A (fr)
MX (2) MX359555B (fr)
MY (1) MY171473A (fr)
NZ (2) NZ703423A (fr)
RU (2) RU2018132044A (fr)
SG (3) SG11201408626YA (fr)
WO (1) WO2014008404A1 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6345655B2 (ja) 2012-07-03 2018-06-20 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ タウに対する抗体
ME03667B (fr) 2012-08-16 2020-10-20 Ipierian Inc Méthodes de traitement d'une tauopathie
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
EP2970453B1 (fr) * 2013-03-13 2019-12-04 Prothena Biosciences Limited Immunothérapie contre tau
NZ630610A (en) 2014-02-14 2019-05-31 Ipierian Inc Tau peptides, anti-tau antibodies, and methods of use thereof
WO2015165961A1 (fr) 2014-04-29 2015-11-05 Affiris Ag Traitement et prévention de la maladie d'alzheimer
ZA201608812B (en) 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
KR20170023151A (ko) * 2014-06-26 2017-03-02 얀센 백신스 앤드 프리벤션 비.브이. 미세소관-연관 단백질 타우에 특이적으로 결합하는 항체 및 항원-결합 단편
TW202136296A (zh) * 2014-06-27 2021-10-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
CA2962969C (fr) 2014-09-30 2023-03-21 Washington University Mesures cinetiques de tau
MA41451A (fr) * 2015-02-04 2017-12-12 Univ Washington Constructions anti-tau
JO3576B1 (ar) 2015-02-26 2020-07-05 Lilly Co Eli أجسام مضادة لـ tau واستخداماتها
JP6793134B2 (ja) 2015-06-05 2020-12-02 ジェネンテック， インコーポレイテッド 抗ｔａｕ抗体及び使用方法
PE20180499A1 (es) 2015-07-06 2018-03-09 Ucb Biopharma Sprl Anticuerpos de union a tau
BR112017028102A2 (pt) 2015-07-06 2018-09-04 Ucb Biopharma Sprl anticorpos de ligação à tau
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
ES2954969T3 (es) * 2015-08-13 2023-11-27 Univ New York Moléculas basadas en anticuerpos selectivas para el epítopo {p}Ser404 de Tau y sus usos en el diagnóstico y tratamiento de la tauopatía
CN105158483A (zh) * 2015-09-16 2015-12-16 北京九强生物技术股份有限公司 一种人肌钙蛋白i的超敏定量测定试剂盒及其检测方法
KR20230070336A (ko) 2016-05-02 2023-05-22 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
WO2017191559A1 (fr) 2016-05-02 2017-11-09 Prothena Biosciences Limited Immunothérapie anti-tau
UA124148C2 (uk) 2016-05-02 2021-07-28 Протена Біосайенсіс Лімітед Антитіла, що розпізнають тау
LT3484916T (lt) 2016-07-12 2021-04-26 H. Lundbeck A/S Antikūnai, būdingi hiperfosforilintam tau, ir jų naudojimo būdai
EP3496750A2 (fr) 2016-08-09 2019-06-19 Eli Lilly and Company Polythérapie
WO2018091444A1 (fr) 2016-11-15 2018-05-24 H. Lundbeck A/S Agents, utilisations et procédés pour le traitement d'une synucléinopathie
AR110321A1 (es) 2016-12-07 2019-03-20 Genentech Inc Anticuerpos antitau y métodos de uso
JP2020511937A (ja) 2016-12-07 2020-04-23 ジェネンテック， インコーポレイテッド 抗ｔａｕ抗体及び使用方法
CN106749658B (zh) * 2016-12-15 2019-11-12 北京师范大学 抑制Tau蛋白聚集的抗体型分子伴侣
US11325968B2 (en) 2016-12-16 2022-05-10 H. Lundbeck A/S Alpha-synuclein antibodies
US10364286B2 (en) * 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
WO2018152359A1 (fr) * 2017-02-17 2018-08-23 Denali Therapeutics Inc. Anticorps anti-tau et leurs procédés d'utilisation
WO2018165015A1 (fr) * 2017-03-09 2018-09-13 The Board Of Trustees Of The Leland Stanford Junior University Traitement de tumeurs cérébrales pédiatriques avec ciblage de la voie cd47
BR112019022906A2 (pt) 2017-05-02 2020-05-26 Prothena Biosciences Limited Anticorpos que reconhecem tau
TWI809562B (zh) 2017-10-16 2023-07-21 日商衛材R&D企管股份有限公司 抗tau抗體及其用途
CA3094934A1 (fr) 2018-03-23 2019-09-26 AbbVie Deutschland GmbH & Co. KG Formulations aqueuses stables d'anticorps anti-tau
EP3784687A1 (fr) * 2018-04-27 2021-03-03 Ecole Polytechnique Federale De Lausanne (Epfl) Procédé de préparation d'agrégats de protéine tau de type phfs
JP2021530552A (ja) 2018-07-31 2021-11-11 イーライ リリー アンド カンパニー 併用療法
CN109613242A (zh) * 2018-11-01 2019-04-12 深圳天辰医疗科技有限公司 一种肌酸激酶同工酶检测试剂盒及其制备方法
SG11202108414UA (en) 2019-03-03 2021-08-30 Prothena Biosciences Ltd Antibodies recognizing tau
US11781131B2 (en) 2019-03-18 2023-10-10 Regeneron Pharmaceuticals, Inc. CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
CN113631700A (zh) * 2019-03-18 2021-11-09 瑞泽恩制药公司 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台
CN110055280A (zh) * 2019-03-19 2019-07-26 深圳大学 一种稳定表达mCherry-tau的细胞系及其构建方法与应用
WO2021010712A1 (fr) * 2019-07-15 2021-01-21 주식회사 아델 Anticorps anti-tau et son utilisation
US20220299527A1 (en) * 2019-08-13 2022-09-22 Washington University Methods to detect mtbr tau isoforms and use thereof
BR112022005963A2 (pt) 2019-10-09 2022-06-28 Bluerock Therapeutics Lp Células com expressão de transgenes sustentada
JP2023504699A (ja) * 2019-12-04 2023-02-06 エイシー イミューン ソシエテ アノニム 治療および診断のための新規な分子
US20220145363A1 (en) * 2020-11-09 2022-05-12 Meso Scale Technologies, Llc. Methods and kits for detecting tau
WO2022144406A1 (fr) 2020-12-29 2022-07-07 Neurimmune Ag Anticorps anti-tau humains
WO2022201123A1 (fr) 2021-03-26 2022-09-29 Janssen Biotech, Inc. Anticorps anti-tau et leurs utilisations
US20240166731A1 (en) 2021-03-26 2024-05-23 Janssen Biotech, Inc. Humanized antibodies against paired helical filament tau and uses thereof
WO2024044637A2 (fr) * 2022-08-23 2024-02-29 Washington University Anticorps anti-tau mtbr et méthodes de détection de fragments clivés de tau et leurs utilisations

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO884368L (no) 1987-10-02 1989-04-03 Du Pont Immunanalyse ved anvendelse av igg-innfangelsesantistoff og multippel, monoklonalt antistoffpaavisningssystem.
EP0600951A4 (en) 1991-08-01 1996-10-30 Paul H Voorheis Diagnostic method for alzheimer's disease.
US5733734A (en) 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
EP0610330B1 (fr) 1991-10-25 1997-06-18 N.V. Innogenetics S.A. Anticorps monoclonaux diriges contre la proteine tau associee aux microtubules
US7408027B1 (en) 1991-12-06 2008-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften Tools for the diagnosis and treatment of Alzheimer's disease
ES2136654T3 (es) 1991-12-06 1999-12-01 Max Planck Gesellschaft Herramientas para el diagnostico y tratamiento de la enfermedad de alzheimer.
JPH06239899A (ja) 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
CA2195672A1 (fr) 1994-07-29 1996-02-15 Eugeen Vanmechelen Anticorps monoclonaux specifiques d'un epitope d'une sous-classe ou forme particuliere de tau phosphorylee, hybridomes les secretant, reconnaissance par les antigenes de ces anticorps et leurs applications
US20020086009A1 (en) 1996-03-13 2002-07-04 Koichi Ishiguro Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same
WO1998022120A1 (fr) 1996-11-19 1998-05-28 The Wistar Institute Of Anatomy & Biology Reactifs pour traiter et diagnostiquer la maladie d'alzheimer
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
RU2238947C2 (ru) * 1998-07-14 2004-10-27 Янссен Фармацевтика Н.В. Нейротрофический фактор роста человека (эновин), кодирующая его выделенная молекула нуклеиновой кислоты, вектор (варианты), фармацевтическая композиция (варианты), антитело, способ обнаружения фактора роста, набор, способ идентификации агониста или антагониста (варианты)
EP1112500B1 (fr) 1998-09-08 2004-09-22 Innogenetics N.V. Tau utilise comme marqueur dans le diagnostic precoce de lesions du systeme nerveux central
US6495376B1 (en) * 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US6589746B1 (en) 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
US20020182660A1 (en) 2000-02-18 2002-12-05 Fong Kei-Lai L. N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43)
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
WO2003057881A1 (fr) 2001-12-28 2003-07-17 Chugai Seiyaku Kabushiki Kaisha Procede de stabilisation d'une proteine
PL224150B1 (pl) 2002-05-02 2016-11-30 Wyeth Corp Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
DK1521831T3 (da) 2002-07-12 2008-06-30 Axon Neuroscience Transgent dyr der udtrykker trunkeret alzheimers tauprotein
AU2003257850A1 (en) 2002-08-14 2004-03-03 Mitsubishi Kagaku Iatron, Inc. ANTIBODY SPECIFIC TO CENTRAL Tau-PROTEIN
FI20030652A0 (fi) 2003-04-30 2003-04-30 Susann Eriksson Parannettu immunomääritys
AU2004266159A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
WO2005080986A1 (fr) 2004-02-18 2005-09-01 University Of Iowa Research Foundation Anticorps contre tau phosphorylee, procedes de fabrication et d'utilisation
KR20100036324A (ko) 2005-02-19 2010-04-07 주식회사 피플바이오 멀티머-형성 폴리펩타이드의 모노머로부터 멀티머를 분별 검출하는 방법
US20070134724A1 (en) 2005-08-04 2007-06-14 Peter Davies Phosphorylation of tau by abl
ES2321996B1 (es) 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias.
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
WO2008140639A2 (fr) 2007-02-08 2008-11-20 Oligomerix, Inc. Biomarqueurs et dosages pour la maladie d'alzheimer
MX2010011209A (es) 2008-04-24 2010-11-12 Squibb Bristol Myers Co Uso de epotilona d en el tratamiento de enfermedades asociadas a tau incluyendo enfermedad de alzheimer.
CN101307108B (zh) 2008-06-25 2012-04-04 南京川博生物技术有限公司 抗磷酸化Tau蛋白抗体及其在AD症异常磷酸化Tau蛋白水平测定上的用途
CN102292078A (zh) * 2008-11-11 2011-12-21 得克萨斯大学体系董事会 哺乳动物雷帕霉素靶蛋白的抑制
US20110305706A1 (en) 2009-02-23 2011-12-15 Scott Thomas Brady Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta
US9605054B2 (en) 2009-02-23 2017-03-28 The Board Of Trustees Of The University Of Illinois Composition and method for treating a tauopathy
UA107571C2 (xx) 2009-04-03 2015-01-26 Фармацевтична композиція
WO2010129674A2 (fr) 2009-05-05 2010-11-11 New York University Immunothérapie à destination des anomalies de conformation partagées des peptides/protéines amyloïdogènes
EP2440234A4 (fr) 2009-06-10 2013-11-06 Univ New York Ciblage immunologique de protéines tau pathologiques
WO2011013034A1 (fr) * 2009-07-30 2011-02-03 Pfizer Vaccines Llc Peptides tau antigéniques et leurs utilisations
JP6124591B2 (ja) 2009-08-28 2017-05-10 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム タウオリゴマーに結合する抗体
EP2478360B1 (fr) * 2009-09-14 2018-06-27 Banyan Biomarkers, Inc. Autoanticorps comme marqueurs pour le diagnostic d'une lésion traumatique cerebrale
CN102549438B (zh) 2009-09-24 2014-10-29 国家健康与医学研究院 Fkbp52-tau相互作用作为新颖治疗靶点用于治疗涉及tau机能失调的神经障碍
US20130095492A1 (en) 2010-03-05 2013-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
MX338421B (es) 2010-10-07 2016-04-15 Ac Immune Sa Anticuerpos fosfoespecificos que reconocen la proteina tau.
AU2013205313B2 (en) 2010-10-07 2016-05-19 Ac Immune S.A. Phosphospecific antibodies recognising tau
ES2686550T3 (es) * 2010-10-11 2018-10-18 Biogen International Neuroscience Gmbh Anticuerpos anti-tau humanos
CA2826286C (fr) * 2011-01-31 2021-09-21 Intellect Neurosciences Inc. Traitement de tauopathies
EP2701743A4 (fr) 2011-04-27 2015-08-19 Univ Northwestern Anticorps sélectifs pour des dimères pathologiques de tau et des oligomères pathologiques pré-fibrillaires de tau et leur utilisation dans le traitement, le diagnostic et la surveillance de tauopathies
US20120321594A1 (en) 2011-05-06 2012-12-20 New York University Methods of controlling axon or dendrite development of neuronal cells
US9506051B2 (en) 2011-05-20 2016-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
GB201111361D0 (en) * 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
US9926353B2 (en) 2011-07-19 2018-03-27 New York University Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
UA115657C2 (uk) 2011-09-19 2017-12-11 Аксон Ньюросайєнс Сє Виділене антитіло, яке зв'язується з одним або декількома епітопами тау, фармацевтична композиція, що його містить, спосіб лікування та спосіб діагностики хвороби альцгеймера на основі виділеного антитіла
RU2639537C2 (ru) 2011-10-07 2017-12-21 Ац Иммуне С.А. Фосфоспецифичные антитела, распознающие тау
WO2013063086A1 (fr) 2011-10-24 2013-05-02 Intellect Neurosciences, Inc. Compositions et méthodes de traitement de protéinopathies
MY178142A (en) 2011-12-20 2020-10-05 Janssen Biotech Inc Anti-phf-tau antibodies and their uses
EP2834270B1 (fr) 2012-04-05 2019-10-30 AC Immune S.A. Anticorps tau humanisé
WO2013177104A2 (fr) 2012-05-21 2013-11-28 Felder Mitchell S Traitement de tauopathies
MY172458A (en) 2012-05-31 2019-11-26 Teijin Pharma Ltd Therapeutic agent or prophylactic agent for dementia
JP6345655B2 (ja) 2012-07-03 2018-06-20 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ タウに対する抗体
ME03667B (fr) 2012-08-16 2020-10-20 Ipierian Inc Méthodes de traitement d'une tauopathie
EP2887955B1 (fr) 2012-08-21 2020-08-19 Institute for Molecular Medicine, Inc. Compositions et procédés se rapportant à des maladies associées à des dépôts amyloïdes, de protéine tau et de protéine alpha-synucléine
US20140056901A1 (en) 2012-08-21 2014-02-27 The Institute For Molecular Medicine Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
EP2906596B1 (fr) 2012-10-12 2023-12-27 Arizona Board of Regents on behalf of Arizona State University Réactifs à base d'anticorps qui reconnaissent spécifiquement des formes oligomériques toxiques de tau
US9910048B2 (en) 2012-12-03 2018-03-06 Washington University Method for detection of aggregates in biological samples
US8921150B2 (en) 2012-12-06 2014-12-30 Taiwan Semiconductor Manufacturing Co., Ltd. Process to achieve contact protrusion for single damascene via
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
WO2014096321A1 (fr) 2012-12-21 2014-06-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps spécifiques de la protéine tau phosphorylée à la sérine 422 et leurs utilisations pour traiter et diagnostiquer les tauopathies
ES2816700T3 (es) 2012-12-21 2021-04-05 Biogen Ma Inc Anticuerpos anti-tau humanos
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
EP2970453B1 (fr) 2013-03-13 2019-12-04 Prothena Biosciences Limited Immunothérapie contre tau
WO2014159244A2 (fr) 2013-03-14 2014-10-02 Merck Patent Gmbh Anticorps tau d'o-glcnac et son utilisation
EP2968548B1 (fr) 2013-03-15 2020-09-09 Beth Israel Deaconess Medical Center, Inc. Procédés et compositions pour la génération et l'utilisation d'anticorps spécifiques à une conformation
RU2661111C2 (ru) 2013-03-15 2018-07-11 Ац Иммуне С.А. Антитела к тау и способы применения
TW202136296A (zh) 2014-06-27 2021-10-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體

Also Published As

Publication number Publication date
JP2015530971A (ja) 2015-10-29
US20180037641A1 (en) 2018-02-08
IL236409A0 (en) 2015-02-26
AU2020223765A1 (en) 2020-09-17
IL236409B (en) 2020-10-29
BR112014033116A2 (pt) 2018-03-06
IL277643A (en) 2020-11-30
KR102494798B1 (ko) 2023-02-06
AU2013286680A1 (en) 2015-01-22
CN108623682A (zh) 2018-10-09
US20150183855A1 (en) 2015-07-02
AU2018229564A1 (en) 2018-10-04
IN2015KN00007A (fr) 2015-07-31
CA2877397A1 (fr) 2014-01-09
IL289241A (en) 2022-02-01
AU2013286680B2 (en) 2018-07-05
CN104781278B (zh) 2018-06-12
SG11201408626YA (en) 2015-03-30
EP2870176A1 (fr) 2015-05-13
EP3838921A2 (fr) 2021-06-23
MY171473A (en) 2019-10-15
WO2014008404A1 (fr) 2014-01-09
JP6345655B2 (ja) 2018-06-20
HK1209768A1 (en) 2016-04-08
KR20150036346A (ko) 2015-04-07
NZ703423A (en) 2018-02-23
JP2018184398A (ja) 2018-11-22
MX2022000026A (es) 2022-03-22
EP2870176A4 (fr) 2016-09-28
CN104781278A (zh) 2015-07-15
RU2015103228A (ru) 2016-08-20
EP3838921A3 (fr) 2021-09-01
MX359555B (es) 2018-10-02
MX2014016024A (es) 2015-04-13
NZ739622A (en) 2020-01-31
JP2020125310A (ja) 2020-08-20
RU2015103228A3 (fr) 2018-03-05
BR112014033116B1 (pt) 2021-12-21
RU2018132044A (ru) 2018-10-19
KR20200013072A (ko) 2020-02-05
RU2668159C2 (ru) 2018-09-26
KR20200134339A (ko) 2020-12-01
SG10201708959WA (en) 2017-11-29
US9834596B2 (en) 2017-12-05

Similar Documents

Publication Publication Date Title
IL289241A (en) Antibodies to tau
IL264558A (en) Anti–il–23p19 antibodies
ZA201407509B (en) Anti-fcrn antibodies
HK1204571A1 (en) Protease-regulated antibodies
HK1210192A1 (en) Anti-siglec-15 antibodies siglec-15
EP2844290A4 (fr) Nouveaux anticorps
EP2930240A4 (fr) Anticorps anti-folr1
EP2832855A4 (fr) Nouvel anticorps anti-siglec-15
EP2837685A4 (fr) Anticorps anti-fgfr2
EP2826790A4 (fr) Anticorps anti-gremlin 1
HK1210186A1 (en) Anti-h7cr antibodies h7cr
PL2935330T3 (pl) Przeciwciała przeciw notch3
HK1202454A1 (en) Anti-p-selectin antibody formulation -p-
EP2804876A4 (fr) Nouveaux anticorps
GB201220242D0 (en) Antibody
EP2848633A4 (fr) Anticorps anti-cxadr
EP2811018A4 (fr) ANTI-CORPS ANTI-sAPPß
IL235188A0 (en) Antibodies against c-pdgf
GB201209584D0 (en) Modified antibodies