SG10201902813XA - Methods and materials for biosynthesis of mogroside compounds - Google Patents
Methods and materials for biosynthesis of mogroside compoundsInfo
- Publication number
- SG10201902813XA SG10201902813XA SG10201902813XA SG10201902813XA SG10201902813XA SG 10201902813X A SG10201902813X A SG 10201902813XA SG 10201902813X A SG10201902813X A SG 10201902813XA SG 10201902813X A SG10201902813X A SG 10201902813XA SG 10201902813X A SG10201902813X A SG 10201902813XA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- biosynthesis
- materials
- mogroside compounds
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229930189775 mogroside Natural products 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04J—MULTIPLEX COMMUNICATION
- H04J14/00—Optical multiplex systems
- H04J14/02—Wavelength-division multiplex systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Computer Networks & Wireless Communication (AREA)
- Signal Processing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/504,109 US10011859B2 (en) | 2012-12-04 | 2014-10-01 | Methods and materials for biosynthesis of mogroside compounds |
| US201462059136P | 2014-10-02 | 2014-10-02 | |
| US201462087726P | 2014-12-04 | 2014-12-04 | |
| US201462090836P | 2014-12-11 | 2014-12-11 | |
| US201462091895P | 2014-12-15 | 2014-12-15 | |
| US201562199115P | 2015-07-30 | 2015-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201902813XA true SG10201902813XA (en) | 2019-04-29 |
Family
ID=55631719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201902813XA SG10201902813XA (en) | 2014-10-01 | 2015-09-30 | Methods and materials for biosynthesis of mogroside compounds |
| SG11201702123SA SG11201702123SA (en) | 2014-10-01 | 2015-09-30 | Methods and materials for biosynthesis of mogroside compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201702123SA SG11201702123SA (en) | 2014-10-01 | 2015-09-30 | Methods and materials for biosynthesis of mogroside compounds |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10633685B2 (https=) |
| EP (1) | EP3201315A2 (https=) |
| JP (1) | JP2017529860A (https=) |
| CN (1) | CN107466320B (https=) |
| AU (2) | AU2015326892B2 (https=) |
| CA (2) | CA2963300C (https=) |
| IL (2) | IL251380B (https=) |
| SG (2) | SG10201902813XA (https=) |
| WO (1) | WO2016050890A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2972739A1 (en) * | 2014-09-11 | 2016-03-17 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of producing mogrosides and compositions comprising same and uses thereof |
| CN105801658B (zh) * | 2014-12-30 | 2019-03-19 | 北京农学院 | 甜甙及其类似物的制备及作为stat3、erk信号通路靶位点药物在抗肿瘤中的应用 |
| CA3003163A1 (en) | 2015-10-29 | 2017-05-04 | Senomyx, Inc. | High intensity sweeteners |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11060124B2 (en) * | 2017-05-03 | 2021-07-13 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CN109402163A (zh) * | 2018-09-26 | 2019-03-01 | 怀化兴科创生物技术有限公司 | 新的罗汉果角鲨烯环氧酶基因（Sgsqe）的应用 |
| CN109439676A (zh) * | 2018-09-26 | 2019-03-08 | 怀化兴科创生物技术有限公司 | 罗汉果环氧化物水解酶Sgeph5基因的应用 |
| JP2022512931A (ja) * | 2018-11-07 | 2022-02-07 | フィルメニッヒ インコーポレイテッド | 高甘味度甘味料の製造方法 |
| CA3118467A1 (en) * | 2018-11-07 | 2020-05-14 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| EP3877519B1 (en) * | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN110066785B (zh) * | 2019-01-30 | 2021-01-26 | 中国医学科学院药用植物研究所 | 一种罗汉果葫芦二烯醇合酶突变体及其构建方法和应用 |
| CN110357936B (zh) * | 2019-07-16 | 2020-10-16 | 湖南华诚生物资源股份有限公司 | 半合成罗汉果甜苷v的方法 |
| TWI711385B (zh) * | 2019-09-26 | 2020-12-01 | 國立臺灣大學 | 將羅漢果皂苷萃取物生物轉化為賽門苷ｉ之方法 |
| CA3158430A1 (en) * | 2019-10-25 | 2021-04-29 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| WO2021126960A1 (en) * | 2019-12-16 | 2021-06-24 | Manus Bio, Inc. | Microbial production of mogrol and mogrosides |
| MX2022011627A (es) * | 2020-03-17 | 2022-12-15 | Coca Cola Co | Nuevo sistema y métodos de producción de mogrósidos. |
| CA3191387A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| KR20240005708A (ko) * | 2021-04-02 | 2024-01-12 | 징코 바이오웍스, 인크. | 이소프레노이드 및 그의 전구체의 생합성 |
| EP4314272A1 (en) * | 2021-04-02 | 2024-02-07 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN113388590B (zh) * | 2021-06-07 | 2022-02-25 | 山西农业大学 | 一种细胞色素P450s的突变体 |
| WO2023278976A2 (en) | 2021-06-29 | 2023-01-05 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN114854722B (zh) * | 2022-05-11 | 2024-01-09 | 成都普睿法药物研发有限公司 | 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用 |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| US20240229055A9 (en) * | 2022-09-19 | 2024-07-11 | Elo Life Systems | Mogroside compositions and methods of producing same |
| CN115896136B (zh) * | 2022-12-22 | 2025-12-16 | 云南农业大学 | 与葫芦二烯醇羟化相关的细胞色素p450基因及其编码产物 |
| WO2024218244A1 (en) | 2023-04-20 | 2024-10-24 | Dsm Ip Assets B.V. | Strains and methods for the production of mogrosides |
| CN117417949B (zh) * | 2023-10-19 | 2024-12-20 | 云南农业大学 | 雪胆细胞色素氧化酶HcCYP81Q58转基因酵母工程菌及其应用 |
| WO2025144795A1 (en) | 2023-12-28 | 2025-07-03 | Dsm Ip Assets B.V. | Cells and methods for the production of glycosylated compounds |
| CN117887599A (zh) * | 2024-01-11 | 2024-04-16 | 桂林莱茵合成生物技术有限公司 | 一种从头合成罗汉果甜苷的工程酵母的构建方法 |
| US20250290110A1 (en) * | 2024-03-18 | 2025-09-18 | Elo Life Systems | Mogroside compositions and methods of producing same |
| CN118185998A (zh) * | 2024-04-17 | 2024-06-14 | 上海吉罗恩生物科技有限公司 | 一种表达系统及其使用方法、用途 |
| CN118995457A (zh) * | 2024-08-15 | 2024-11-22 | 北京化工大学 | 生产罗汉果甜苷的酿酒酵母工程菌及其构建方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6399321B1 (en) | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
| EP1510573A1 (en) | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2437573C2 (ru) | 2005-11-23 | 2011-12-27 | Дзе Кока-Кола Компани | Композиция интенсивного подсластителя с кальцием и подслащенные ею композиции |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| WO2008062165A2 (en) | 2006-11-22 | 2008-05-29 | The University Of York | Monoterpenoid modifying enzymes |
| US20100132073A1 (en) | 2006-12-01 | 2010-05-27 | The University Of York | Sesquiterpenoid modifying enzymes |
| CA2725175A1 (en) * | 2008-05-23 | 2009-11-26 | Cibus Oils, Llc | Production of squalene using yeast |
| GB0904639D0 (en) | 2009-03-18 | 2009-04-29 | Univ York | Assay |
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| BR112014012543A2 (pt) * | 2011-11-23 | 2017-06-13 | Evolva Sa | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
| EP2885420B1 (en) | 2012-08-17 | 2018-12-05 | Evolva SA | Increased production of terpenes and terpenoids |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
-
2015
- 2015-09-30 CA CA2963300A patent/CA2963300C/en active Active
- 2015-09-30 CN CN201580062037.XA patent/CN107466320B/zh active Active
- 2015-09-30 WO PCT/EP2015/072645 patent/WO2016050890A2/en not_active Ceased
- 2015-09-30 JP JP2017517783A patent/JP2017529860A/ja active Pending
- 2015-09-30 SG SG10201902813XA patent/SG10201902813XA/en unknown
- 2015-09-30 US US15/511,565 patent/US10633685B2/en active Active
- 2015-09-30 CA CA3232630A patent/CA3232630A1/en active Pending
- 2015-09-30 SG SG11201702123SA patent/SG11201702123SA/en unknown
- 2015-09-30 AU AU2015326892A patent/AU2015326892B2/en active Active
- 2015-09-30 EP EP15797018.7A patent/EP3201315A2/en active Pending
-
2017
- 2017-03-26 IL IL251380A patent/IL251380B/en active IP Right Grant
-
2020
- 2020-03-02 US US16/806,812 patent/US11091787B2/en active Active
- 2020-08-18 IL IL276781A patent/IL276781A/en unknown
-
2022
- 2022-06-09 AU AU2022204012A patent/AU2022204012C1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3201315A2 (en) | 2017-08-09 |
| US11091787B2 (en) | 2021-08-17 |
| AU2015326892A1 (en) | 2017-03-30 |
| CN107466320B (zh) | 2021-11-05 |
| IL251380B (en) | 2020-09-30 |
| US10633685B2 (en) | 2020-04-28 |
| CA2963300A1 (en) | 2016-04-07 |
| JP2017529860A (ja) | 2017-10-12 |
| AU2022204012B2 (en) | 2024-06-27 |
| IL276781A (en) | 2020-10-29 |
| CN107466320A (zh) | 2017-12-12 |
| AU2022204012C1 (en) | 2024-09-05 |
| SG11201702123SA (en) | 2017-04-27 |
| WO2016050890A3 (en) | 2016-06-30 |
| US20170247735A1 (en) | 2017-08-31 |
| US20200325517A1 (en) | 2020-10-15 |
| WO2016050890A2 (en) | 2016-04-07 |
| AU2015326892B2 (en) | 2022-03-10 |
| AU2015326892A2 (en) | 2017-05-25 |
| CA3232630A1 (en) | 2016-04-07 |
| AU2022204012A1 (en) | 2022-06-30 |
| IL251380A0 (en) | 2017-05-29 |
| CA2963300C (en) | 2024-04-30 |
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