SG10201902429PA - Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers - Google Patents

Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

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Publication number
SG10201902429PA
SG10201902429PA SG10201902429PA SG10201902429PA SG10201902429PA SG 10201902429P A SG10201902429P A SG 10201902429PA SG 10201902429P A SG10201902429P A SG 10201902429PA SG 10201902429P A SG10201902429P A SG 10201902429PA SG 10201902429P A SG10201902429P A SG 10201902429PA
Authority
SG
Singapore
Prior art keywords
cancers
treatment
active agents
pharmaceutically active
additional pharmaceutically
Prior art date
Application number
SG10201902429PA
Other languages
English (en)
Inventor
Sean Caenepeel
Jude Canon
Paul Hughes
Jonathan D Oliner
Richard J Rickles
Anne Y Saiki
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201902429PA publication Critical patent/SG10201902429PA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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  • Engineering & Computer Science (AREA)
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  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
SG10201902429PA 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers SG10201902429PA (en)

Applications Claiming Priority (1)

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US201361902717P 2013-11-11 2013-11-11

Publications (1)

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SG10201902429PA true SG10201902429PA (en) 2019-04-29

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SG10201902429PA SG10201902429PA (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

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US (3) US20160287569A1 (bg)
EP (2) EP4039256A1 (bg)
JP (5) JP2016535795A (bg)
KR (3) KR20220167335A (bg)
CN (2) CN105934255A (bg)
AP (1) AP2016009243A0 (bg)
AU (3) AU2014346354A1 (bg)
BR (1) BR112016010564A2 (bg)
CA (1) CA2930244A1 (bg)
CL (1) CL2016001131A1 (bg)
DK (1) DK3068393T5 (bg)
EA (2) EA036942B1 (bg)
ES (1) ES2916721T3 (bg)
HR (1) HRP20220718T1 (bg)
HU (1) HUE059351T2 (bg)
IL (2) IL245568B (bg)
LT (1) LT3068393T (bg)
MA (1) MA39094B1 (bg)
MX (6) MX2016006025A (bg)
MY (1) MY192088A (bg)
NZ (2) NZ720766A (bg)
PH (1) PH12016500871A1 (bg)
PL (1) PL3068393T3 (bg)
PT (1) PT3068393T (bg)
RS (1) RS63348B9 (bg)
SG (1) SG10201902429PA (bg)
SI (1) SI3068393T1 (bg)
TN (1) TN2016000176A1 (bg)
UA (1) UA120750C2 (bg)
WO (1) WO2015070224A2 (bg)

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CA2906538C (en) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
AP2016009243A0 (en) * 2013-11-11 2016-05-31 Amgen Inc Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
JP2018528949A (ja) * 2015-08-28 2018-10-04 ノバルティス アーゲー Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法
EP3340989B1 (en) * 2015-08-28 2023-08-16 Novartis AG Mdm2 inhibitors and combinations thereof
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